Proteases In Physiology And Pathology

Author : Sajal Chakraborti,Naranjan S. Dhalla
Publisher : Springer
Page : 619 pages
File Size : 46,9 Mb
Release : 2017-09-14
Category : Medical
ISBN : 9789811025136

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Proteases in Physiology and Pathology by Sajal Chakraborti,Naranjan S. Dhalla Pdf

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.

Author : Sajal Chakraborti,Naranjan S. Dhalla
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 49,6 Mb
Release : 2013-12-04
Category : Science
ISBN : 9781461492337

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Proteases in Health and Disease by Sajal Chakraborti,Naranjan S. Dhalla Pdf

In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.

Author : Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla
Publisher : Springer
Page : 513 pages
File Size : 44,6 Mb
Release : 2017-07-13
Category : Medical
ISBN : 9789811031625

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Proteases in Human Diseases by Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla Pdf

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Author : Walter H. Hörl,August Heidland
Publisher : Springer
Page : 600 pages
File Size : 47,6 Mb
Release : 1988
Category : Medical
ISBN : UCAL:B4530894

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Proteases II by Walter H. Hörl,August Heidland Pdf

The Proceedings of the Second International symposium "Proteases: Potential Role in Health and Disease" which was held in Rothenburg ob der Tauber (FRG) during May 17-20, 1987. The topics discussed those dealing with the physiology and pathophysiology of proteases and their inhibitors, the interactions of proteases and hormones, the kallikrein-Kinin, complement and coagulation system, the function of proteases in arthritis, malignoma, Pancreatitis, intestinal tract, lung and kidney disease as well in hypercatabolic states (acute renal failure, multiple trauma and septicemia). Furthermore some reports dealed with the role of proteases during extracorporeal circulation. The paper presented answered many questions, but reised many more concerning the significance of proteases and their inhibitors in clinical medicine. It was unfortiunately impossible in this volume, to include the extended, lively and stimulating discussions which were enjoyed by the participiants during the conference. The meeting has provided a unique framework for close interaction between scientists from various disciplines, including molecular biology, biology, biochemistry, physiology, surgery, anaesthesiology, endocrinology, hematology, pneumatology and nephrology.

Author : Martin Fusek,Vaclav Vetvicka
Publisher : CRC Press
Page : 324 pages
File Size : 40,8 Mb
Release : 2019-10-10
Category : Medical
ISBN : 9780429536007

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Aspartic Proteinases Physiology and Pathology by Martin Fusek,Vaclav Vetvicka Pdf

Published in 1995: Aspartic Proteinases: Physiology and Pathology focuses on the advantages and limitations of the use of proteinases and their inhibitors in human pathology. A virus-specific aspartic proteinase enzyme is required for the maturation of a virus. If the enzyme can be eliminated, so can the maturation of the virus. This book reviews the wealth of recently published information sparked by the renewed interest in these enzymes.

Author : Stephen Pandol
Publisher : Morgan & Claypool Publishers
Page : 66 pages
File Size : 55,9 Mb
Release : 2011
Category : Medical
ISBN : 9781615041381

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The Exocrine Pancreas by Stephen Pandol Pdf

The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.

Author : Nigel M. Hooper,Uwe Lendeckel
Publisher : Springer
Page : 0 pages
File Size : 44,9 Mb
Release : 2011-01-05
Category : Science
ISBN : 1441937757

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The ADAM Family of Proteases by Nigel M. Hooper,Uwe Lendeckel Pdf

The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.

Author : Anil K. Sharma,Poonam Bansal
Publisher : Walter de Gruyter GmbH & Co KG
Page : 221 pages
File Size : 52,6 Mb
Release : 2023-10-23
Category : Science
ISBN : 9783111325286

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Serine Proteases by Anil K. Sharma,Poonam Bansal Pdf

Serine proteases play significant roles in healh and human disease. Abnormal expression and activities of serine proteases have been linked to the pathogenesis of many diseases. The book presents correlation between serine proteases and human diseases. It helps the reader understand classification, catalytic mechanism and types of serine proteases and their role in human disease pathogenesis at mechanistic level. The chapters explain the role of serine proteases in various diseases including respiratory disorders and cancer. It also covers the therapeutic importance of serine proteases as drug target and explains the mechanistic insights of serine proteases inhibitors. Serine protease are known to play crucial role in biological processes but disturbance in their equilibrium can result in serious health conditions. To maintain homeostasis, serine protease inhibitors come in action and inhibit proteases. Several serine protease inhibitors have been identified and many more are being designed as novel compounds for inhibitions of proteases that provide management of comorbidities. Therefore, this book will serve as a useful reference for students and researchers to understand physiological role of serine proteases and their association with initiation and progression of human diseases. It will also help to develop some strategies to develop serine proteases inhibitors as drug target of serine proteases at cellular and molecular level.

Author : Proceedings of the National Academy of Sciences
Publisher : National Academies Press
Page : 293 pages
File Size : 43,8 Mb
Release : 1999
Category : Cell physiology
ISBN : 9780309066457

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Colloquium on Proteolytic Processing and Physiological Regulation by Proceedings of the National Academy of Sciences Pdf

Author : Xing Wang,Matthew Kuruc
Publisher : Humana Press
Page : 477 pages
File Size : 50,8 Mb
Release : 2018-10-01
Category : Science
ISBN : 1493988131

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Functional Proteomics by Xing Wang,Matthew Kuruc Pdf

This book seeks to fill in the current technology gap with a specific collection of technologies developed for the study of protein function at a proteome scale. Chapters explore topics from protein functions to other aspects of protein analysis, especially in post-translational modification, as most proteomes use this mechanism in some capacity to carry out their unique role in cellular regulation. By comparing functional proteomes, this presents a bridge to other levels of system biology research including genomics and metabolomics in order to provide readers with a relatively complete picture for how one might study the biological system of their interest. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Functional Proteomics: Methods and Protocols collects these novel technologies in the hope that new frontiers in biological research will be created, important drug targets can be identified, and clinically validated biomarkers and diagnostic tests can be further developed.

Author : Eva Böttcher-Friebertshäuser,Wolfgang Garten,Hans Dieter Klenk
Publisher : Springer
Page : 0 pages
File Size : 46,9 Mb
Release : 2018-05-31
Category : Medical
ISBN : 3319754734

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Activation of Viruses by Host Proteases by Eva Böttcher-Friebertshäuser,Wolfgang Garten,Hans Dieter Klenk Pdf

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.

Author : Anonim
Publisher : Unknown
Page : 1164 pages
File Size : 40,8 Mb
Release : 1981
Category : Medicine
ISBN : MINN:30000008789186

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Research Awards Index by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 50,5 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Gianni Marone,Lawrence M. Lichtenstein,Federica J. Galli
Publisher : Academic Press
Page : 738 pages
File Size : 46,9 Mb
Release : 2000-05-25
Category : Medical
ISBN : 9780080535852

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Mast Cells and Basophils by Gianni Marone,Lawrence M. Lichtenstein,Federica J. Galli Pdf

Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

Author : Douglas R. Green
Publisher : Cambridge University Press
Page : 470 pages
File Size : 49,8 Mb
Release : 2011-08-22
Category : Science
ISBN : 9781139498739

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Apoptosis by Douglas R. Green Pdf

Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.