Protein Conformation

Author : G.D. Fasman
Publisher : Springer Science & Business Media
Page : 796 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461315711

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Prediction of Protein Structure and the Principles of Protein Conformation by G.D. Fasman Pdf

The prediction of the conformation of proteins has developed from an intellectual exercise into a serious practical endeavor that has great promise to yield new stable enzymes, products of pharmacological significance, and catalysts of great potential. With the application of predic tion gaining momentum in various fields, such as enzymology and immunology, it was deemed time that a volume be published to make available a thorough evaluation of present methods, for researchers in this field to expound fully the virtues of various algorithms, to open the field to a wider audience, and to offer the scientific public an opportunity to examine carefully its successes and failures. In this manner the practitioners of the art could better evaluate the tools and the output so that their expectations and applications could be more realistic. The editor has assembled chapters by many of the main contributors to this area and simultaneously placed their programs at three national resources so that they are readily available to those who wish to apply them to their personal interests. These algorithms, written by their originators, when utilized on pes or larger computers, can instantaneously take a primary amino acid sequence and produce a two-or three-dimensional artistic image that gives satisfaction to one's esthetic sensibilities and food for thought concerning the structure and function of proteins. It is in this spirit that this volume was envisaged.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 45,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Linda B. Roswell
Publisher : Nova Publishers
Page : 280 pages
File Size : 50,7 Mb
Release : 2008
Category : Medical
ISBN : 1604562196

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Protein Conformation by Linda B. Roswell Pdf

Protein structure is the characteristic 3-dimensional shape of a protein, imposed upon it by the secondary and tertiary structure of the peptide chain. This stage in the structure of a protein describes the highest level of organisation in overall structure assumed by multimeric proteins (aggregates of more than one polypeptide chain). This is the fourth folding level of protein building. This new book presents the latest research in the field.

Author : Derek J. Chadwick,Kate Widdows
Publisher : John Wiley & Sons
Page : 282 pages
File Size : 48,5 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470514153

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Protein Conformation by Derek J. Chadwick,Kate Widdows Pdf

How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.

Author : Franco Celada,Verne N. Schumaker,Eli E. Sercarz
Publisher : Springer Science & Business Media
Page : 500 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461337782

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Protein Conformation as an Immunological Signal by Franco Celada,Verne N. Schumaker,Eli E. Sercarz Pdf

This volume is the collection of papers presented during a four day meeting, the EMBO workshop "Protein Conformation as an Immunological Signal" that took place at Portovenere (La Spezia), Italy, October 1-4, 1981. The motivation that drove us to organize this meeting was the feeling that distinct groups of researchers, active in key areas of modern immunology, sometimes fail to communicate with each other simply because of different traditional affiliations. Yet it is urgent that "molecular" and "cellular" people cooperate more if immunology is to continue the exportation of new concepts to other disciplines. In fact, the deep meaning of molecule-molecule and cell-cell interaction, the generation of signals and their effective transmission which results in elicitation, control or suppression of responses cannot be unraveled without the experts on antibody structure or complement activation sharing their views with the experts on T cell, B cell and macrophage membrane receptors as well as the experts on factors that carry the information released by these cells. Whether the meeting was scientifically fruitful, the reader can judge after having digested these pages. We, the organizers, are not sure whether the optimal amount·of interaction had taken place; especially considering how hard it is to overcome the scientist's catch 22: You have to know something quite well before you get really interested in it. In any event, we are convinced that Portovenere was one of the most successful attempts we have witnessed.

Author : Ke-li Han,Xin Zhang,Ming-jun Yang
Publisher : Springer Science & Business Media
Page : 488 pages
File Size : 40,6 Mb
Release : 2014-01-20
Category : Medical
ISBN : 9783319029702

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Protein Conformational Dynamics by Ke-li Han,Xin Zhang,Ming-jun Yang Pdf

This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.

Author : Engelbert Buxbaum
Publisher : Springer
Page : 521 pages
File Size : 51,8 Mb
Release : 2015-11-27
Category : Science
ISBN : 9783319199207

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Fundamentals of Protein Structure and Function by Engelbert Buxbaum Pdf

This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.

Author : R Fraser
Publisher : Elsevier
Page : 648 pages
File Size : 49,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323143998

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Conformation in Fibrous Proteins and Related Synthetic Polypeptides by R Fraser Pdf

Conformation in Fibrous Proteins: And Related Synthetic Polypeptides provides a comprehensive and critical account of conformation in fibrous proteins and synthetic polypeptides in the solid state. Physical methods of determining conformation are discussed, and relevant results from studies of synthetic polypeptides and fibrous proteins are presented. Comprised of 18 chapters divided into three sections, this book opens with a discussion on the theory and technique of X-ray diffraction applicable to the study of conformation in fibrous materials, along with electron diffraction, electron microscopy, optical diffraction, and infrared spectrophotometry. The procedures used for conformation analysis and prediction are also outlined. The following chapters consider optimization techniques and other methods for elucidating conformation in fibrous proteins and synthetic polypeptides; the use of synthetic polypeptides as models of fibrous proteins; and conformation in fibrous proteins such as silks, collagens, myofibrillar proteins, and keratins. This monograph will be a valuable source of information for molecular biologists.

Author : Stephen H White
Publisher : Springer
Page : 403 pages
File Size : 40,8 Mb
Release : 2013-05-27
Category : Science
ISBN : 9781461475156

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Membrane Protein Structure by Stephen H White Pdf

Studies of receptors, ion channels, and other membrane proteins require a solid understanding of the structural principles of these important biomolecules. Membrane protein structure is, however, a very challenging field. The structures of only three types of transmembrane proteins have been determined to moderate or high resolution during the last two decades, a period during which the amino acid sequences of hundreds, if not thousands, of membrane proteins have been reported. As a result, the creation of structural models to serve as guides for studies of receptors, channels, and other membrane proteins has become crucially important. This book has been assembled in order to share the experiences and findings of expert researchers in protein structure and structure-prediction methods as well as membrane biophysics and lipid physical chemistry, whose work establishes the basis for the development of suitable model structures. The reviews presented here emphasize fundamental ideas and provide an entry to the diverse and complex literature. The four major sections deal with the general nature of the membrane protein structure problem, biochemical and molecular biological approaches to protein topology, direct structural methods, and model and physicochemical approaches. The work will be of interest to physiologists, cellular and molecular biologists, biophysicists, and biochemists working on the function of membrane proteins such as receptors, ion channels, and transporters, as well as senior graduate students and independent investigators.

Author : Anonim
Publisher : John Wiley & Sons
Page : 508 pages
File Size : 49,9 Mb
Release : 2013-02-13
Category : Science
ISBN : 9783527631858

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Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides by Anonim Pdf

This is the last of five books in the Amino Acids, Peptidesand Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series tocover this important topic in organic and biochemistry. Drawingupon the combined expertise of the international "who's who" inamino acid research, these volumes represent a real benchmark foramino acid chemistry, providing a comprehensive discussion of theoccurrence, uses and applications of amino acids and, by extension,their polymeric forms, peptides and proteins. The practical value of each volume is heightened by theinclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry,Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides Volume 5 of this series presents a wealth of methods to analyzeamino acids and peptides. Classical approaches are described, suchas X-ray analysis, chromatographic methods, NMR, AFM, massspectrometry and 2D-gel electrophoresis, as well as newerapproaches, including Surface Plasmon Resonance and arraytechnologies. Originally planned as a six volume series, Amino Acids,Peptides and Proteins in Organic Chemistry now completes withfive volumes but remains comprehensive in both scope andcoverage. ahref="http://eu.wiley.com/WileyCDA/WileyTitle/productCd-3527335463.html"Furtherinformation about the 5 Volume Set and purchasing details can beviewed here./a

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 702 pages
File Size : 43,9 Mb
Release : 1995
Category : Subject headings
ISBN : UOM:39015033243281

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Medical Subject Headings by National Library of Medicine (U.S.) Pdf

Author : Anthony Charles Thomas North
Publisher : Unknown
Page : 272 pages
File Size : 54,9 Mb
Release : 1978
Category : Proteins
ISBN : UCAL:B4494653

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Characterisation of Protein Conformation and Function by Anthony Charles Thomas North Pdf

Author : G.E. Schulz,R.H. Schirmer
Publisher : Springer Science & Business Media
Page : 328 pages
File Size : 47,9 Mb
Release : 2013-12-01
Category : Science
ISBN : 9781461261377

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Principles of Protein Structure by G.E. Schulz,R.H. Schirmer Pdf

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses.

Author : Anonim
Publisher : Unknown
Page : 864 pages
File Size : 45,7 Mb
Release : 1989
Category : Medicine
ISBN : OSU:32435019638154

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Biomedical Index to PHS-supported Research by Anonim Pdf

Author : Hans Neurath,Robert L. Hill
Publisher : Unknown
Page : 716 pages
File Size : 40,7 Mb
Release : 1975
Category : Glycoproteins
ISBN : UCLA:L0064471238

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The Proteins by Hans Neurath,Robert L. Hill Pdf

The Proteins Pt 3.