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Protein Design From In Silico To In Vivo Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Protein Design From In Silico To In Vivo book. This book definitely worth reading, it is an incredibly well-written.
Author : Arnab Bula Chowdry
Publisher : Unknown
Page : 242 pages
File Size : 40,9 Mb
Release : 2008
Category : Electronic
ISBN : UCAL:C3486962
Author : Huimin Zhao
Publisher : John Wiley & Sons
Page : 41 pages
File Size : 41,7 Mb
Release : 2021-08-23
Category : Science
ISBN : 9783527344703
A one-stop reference that reviews protein design strategies to applications in industrial and medical biotechnology Protein Engineering: Tools and Applications is a comprehensive resource that offers a systematic and comprehensive review of the most recent advances in the field, and contains detailed information on the methodologies and strategies behind these approaches. The authors—noted experts on the topic—explore the distinctive advantages and disadvantages of the presented methodologies and strategies in a targeted and focused manner that allows for the adaptation and implementation of the strategies for new applications. The book contains information on the directed evolution, rational design, and semi-rational design of proteins and offers a review of the most recent applications in industrial and medical biotechnology. This important book: Covers technologies and methodologies used in protein engineering Includes the strategies behind the approaches, designed to help with the adaptation and implementation of these strategies for new applications Offers a comprehensive and thorough treatment of protein engineering from primary strategies to applications in industrial and medical biotechnology Presents cutting edge advances in the continuously evolving field of protein engineering Written for students and professionals of bioengineering, biotechnology, biochemistry, Protein Engineering: Tools and Applications offers an essential resource to the design strategies in protein engineering and reviews recent applications.
Author : Pratik Talukder,Ritesh Tandon,Uttam Pal
Publisher : CRC Press
Page : 435 pages
File Size : 45,8 Mb
Release : 2024-04-25
Category : Science
ISBN : 9781040010075
This book on medical biotechnology offers a wide array of topics and cutting-edge research in the field featuring contributions from multiple authors, each specializing in their respective areas, making it highly valuable to science students and enthusiasts. The book provides comprehensive coverage on a diverse range of topics including sequence analysis, network pharmacology, drug discovery, CRISPR-Cas technology, precision medicine, neuroimaging biomarkers, therapeutics for neurodegenerative diseases, molecular pathogenesis of various diseases, plant-derived antioxidants, genetic approaches for disease diagnosis, cancer progression, immunotherapy, cancer biomarker identification, RNA Interference (RNAi) and nanotechnology in drug discovery and delivery, thus giving a holistic understanding of medical biotechnology. Each chapter delves into the latest research and developments in its respective field and offers readers insights into cutting-edge advancements in medical biotechnology. This up-to-date information will be invaluable to science students and enthusiasts who want to stay at the forefront of the field. The book adopts an interdisciplinary approach by incorporating elements of biology, genetics, computational techniques, nanotechnology and more, which enables readers to see the interconnectedness of different scientific disciplines and how they contribute to medical biotechnology. The book emphasizes practical applications, such as drug discovery, disease treatment, gene editing and targeted drug delivery. This focus on real-world applications is useful to readers interested in applying biotechnological techniques in the medical field. The book also acknowledges the serious challenges faced in the field of medical biotechnology and offers potential solutions to overcome these challenges to foster innovative thinking. As a reader, you will gain a comprehensive understanding of various aspects of medical biotechnology, equipping you with knowledge that can contribute to technological breakthroughs, advancements in medicine and the betterment of human life.
Author : Ilan Samish
Publisher : Humana
Page : 0 pages
File Size : 43,9 Mb
Release : 2016-12-03
Category : Science
ISBN : 1493966359
The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Protein Design aims to ensure successful results in the further study of this vital field.
Author : S.R. Hameroff
Publisher : Elsevier
Page : 380 pages
File Size : 40,6 Mb
Release : 2014-04-11
Category : Computers
ISBN : 9780444600097
The possibility of direct interfacing between biological and technological information devices could result in a merger of mind and machine - Ultimate Computing. This book, a thorough consideration of this idea, involves a number of disciplines, including biochemistry, cognitive science, computer science, engineering, mathematics, microbiology, molecular biology, pharmacology, philosophy, physics, physiology, and psychology.
Author : Inamuddin,Tariq Altalhi,Jorddy Neves Cruz,Moamen Salah El-Deen Refat
Publisher : John Wiley & Sons
Page : 388 pages
File Size : 42,6 Mb
Release : 2022-10-04
Category : Medical
ISBN : 9781394167234
DRUG DESIGN USING MACHINE LEARNING The use of machine learning algorithms in drug discovery has accelerated in recent years and this book provides an in-depth overview of the still-evolving field. The objective of this book is to bring together several chapters that function as an overview of the use of machine learning and artificial intelligence applied to drug development. The initial chapters discuss drug-target interactions through machine learning for improving drug delivery, healthcare, and medical systems. Further chapters also provide topics on drug repurposing through machine learning, drug designing, and ultimately discuss drug combinations prescribed for patients with multiple or complex ailments. This excellent overview Provides a broad synopsis of machine learning and artificial intelligence applications to the advancement of drugs; Details the use of molecular recognition for drug development through various mathematical models; Highlights classical as well as machine learning-based approaches to study target-drug interactions in the field of drug discovery; Explores computer-aided technics for prediction of drug effectiveness and toxicity. Audience The book will be useful for information technology professionals, pharmaceutical industry workers, engineers, university researchers, medical practitioners, and laboratory workers who have a keen interest in the area of machine learning and artificial intelligence approaches applied to drug advancements.
Author : Lisa B. English
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 51,9 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592592852
The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.
Author : Barry L. Stoddard
Publisher : Humana
Page : 0 pages
File Size : 52,7 Mb
Release : 2016-04-20
Category : Science
ISBN : 1493935674
This volume provides a collection of protocols and approaches for the creation of novel ligand binding proteins, compiled and described by many of today's leaders in the field of protein engineering. Chapters focus on modeling protein ligand binding sites, accurate modeling of protein-ligand conformational sampling, scoring of individual docked solutions, structure-based design program such as ROSETTA, protein engineering, and additional methodological approaches. Examples of applications include the design of metal-binding proteins and light-induced ligand binding proteins, the creation of binding proteins that also display catalytic activity, and the binding of larger peptide, protein, DNA and RNA ligands. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Author : Harry Yang,Jianchun Zhang,Binbing Yu,Wei Zhao
Publisher : CRC Press
Page : 259 pages
File Size : 55,9 Mb
Release : 2015-07-17
Category : Mathematics
ISBN : 9781498700351
Develop Effective Immunogenicity Risk Mitigation StrategiesImmunogenicity assessment is a prerequisite for the successful development of biopharmaceuticals, including safety and efficacy evaluation. Using advanced statistical methods in the study design and analysis stages is therefore essential to immunogenicity risk assessment and mitigation stra
Author : Swati Joshi,Ashok Pandey,Ranjna Sirohi,Sung Hoon Park
Publisher : Elsevier
Page : 526 pages
File Size : 46,6 Mb
Release : 2022-04-29
Category : Technology & Engineering
ISBN : 9780323885126
Designer Microbial Cell Factories: Metabolic Engineering and Applications, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a detailed overview of the biotechnological approaches and strategies used to generate engineered microbes and to facilitate the acceleration, modulation and diversion of metabolic pathways to get desired output such as production of value-added compound or biodegradation of xenobiotic pollutant. The book also highlights applied aspects of designer microbes in fields as diverse as agriculture, pharmaceuticals and bioremediation. Designer microbes generated through reprogramming the microbial cell factories (MCFs) provide an edge over their natural counterparts in terms of increased molecular diversity and selective chemistry. These bugs are becoming instrumental in several areas, including agriculture, environment and human health. Engineering microbes through directed evolution not only gives freedom from evolutionary constrains but also allow introduction of regulated and foreseeable functions into MCFs. Dedicated to the designing of microbes, covering state-of-the-art technological advancements in the field Includes applications of metabolic engineering in the field of agriculture, bioremediation, value-added products, therapeutics, and more Contains chapters dedicated to innovative approaches surrounding engineered microbial consortia Provides comprehensive details and helps users understand concepts
Author : Anonim
Publisher : Academic Press
Page : 820 pages
File Size : 52,6 Mb
Release : 2018-07-28
Category : Medical
ISBN : 9780128144244
Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries. Examines the history and recent developments in drug dosage forms for pharmaceutical sciences Focuses on physicochemical aspects, prefomulation solid state properties and polymorphism Contains extensive references for further discovery and learning that are appropriate for advanced undergraduates, graduate students and those interested in drug dosage design
Author : Cristina Martinez-Villaluenga,Blanca Hernandez-Ledesma
Publisher : Elsevier
Page : 479 pages
File Size : 48,7 Mb
Release : 2024-04-19
Category : Technology & Engineering
ISBN : 9780443154676
Protein Digestion-Derived Peptides: Chemistry, Bioactivity, and Health Effects presents the latest international advances in fundamental and applied research on the impact of gastrointestinal digestion on the release of bioactive peptides from food sources. This book covers the fundamentals and applications of gastrointestinal digestion and absorption models as well as the impact of food matrices, their components and protein characteristics, and peptide bioaccessibility and bioavailability released during digestion. Developed for nutrition researchers, food scientists, and pharmaceutical scientists, this book is sure to be a welcomed for those who wish to understand the impact of peptides on chronic disease. Includes applications, literature reviews, recent developments, and methods Expands coverage on in vitro and in vivo approaches to simulate gastrointestinal digestion of food proteins and absorption models to evaluate the bioaccessibility and bioavailability of released peptides Offers an overview of the main bioactivities of peptides released during the gastrointestinal digestion of food proteins Highlights the mechanisms of action and health benefits of bioactive peptides released during gastrointestinal digestion
Author : Shobha N. Bhattachar,John S. Morrison,Daniel R. Mudra,David M. Bender
Publisher : Springer
Page : 461 pages
File Size : 45,8 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9783319500423
Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies—this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.
Author : Vijai Singh
Publisher : Academic Press
Page : 487 pages
File Size : 43,8 Mb
Release : 2022-01-12
Category : Science
ISBN : 9780323859868
New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas. Offers basic understanding and knowledge in several aspects of synthetic biology Covers state-of-the-art tools and technologies of synthetic biology, including promoter design, DNA synthesis, DNA sequencing, genome design, directed evolution, protein engineering, computational tools, phage design, CRISPR-Cas systems, and more Discusses the applications of synthetic biology for smart drugs, vaccines, therapeutics, drug discovery, self-assembled materials, cell free systems, microfluidics, and more
Author : Girish Kumar Gupta,Mohammad Hassan Baig
Publisher : Walter de Gruyter GmbH & Co KG
Page : 274 pages
File Size : 42,8 Mb
Release : 2022-05-09
Category : Science
ISBN : 9783110492453
In Silico Chemistry and Biology: Current and Future Prospects provides a compact overview on recent advances in this highly dynamic branch of chemistry. Various methods of protein modelling and computer-assisted drug design are presented, including fragment- and ligand-based approaches. Many successful practical applications of these techniques are demonstrated. The authors also look to the future and describe the main challenges of the field.
