Protein Folding Kinetics

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Protein Folding Kinetics

Author : Bengt Nölting
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 52,6 Mb
Release : 2005-12-05
Category : Science
ISBN : 9783540272786

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Protein Folding Kinetics by Bengt Nölting Pdf

First methods book which includes many detailed descriptions Absolutely needed and thus timely for the scientific community Comprises 15% more content and includes the mentioned special features

Protein Folding Kinetics

Author : Bengt Nölting
Publisher : Unknown
Page : 190 pages
File Size : 49,9 Mb
Release : 1999
Category : Chemical kinetics
ISBN : OCLC:1176441485

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Protein Folding Kinetics by Bengt Nölting Pdf

Protein Folding

Author : Cláudio M. Gomes,Patrícia F.N. Faísca
Publisher : Springer
Page : 63 pages
File Size : 41,6 Mb
Release : 2019-02-25
Category : Science
ISBN : 9783319008820

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Protein Folding by Cláudio M. Gomes,Patrícia F.N. Faísca Pdf

This snapshot volume is designed to provide a smooth entry into the field of protein folding. Presented in a concise manner, each section introduces key concepts while providing a brief overview of the relevant literature. Outlook subsections will pinpoint specific aspects related to emerging methodologies, concepts and trends.

Computational Methods for Protein Folding, Volume 120

Author : Richard A. Friesner
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 43,7 Mb
Release : 2004-04-07
Category : Science
ISBN : 9780471465232

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Computational Methods for Protein Folding, Volume 120 by Richard A. Friesner Pdf

Since the first attempts to model proteins on a computer began almost thirty years ago, our understanding of protein structure and dynamics has dramatically increased. Spectroscopic measurement techniques continue to improve in resolution and sensitivity, allowing a wealth of information to be obtained with regard to the kinetics of protein folding and unfolding, and complementing the detailed structural picture of the folded state. Concurrently, algorithms, software, and computational hardware have progressed to the point where both structural and kinetic problems may be studied with a fair degree of realism. Despite these advances, many major challenges remain in understanding protein folding at both the conceptual and practical levels. Computational Methods for Protein Folding seeks to illuminate recent advances in computational modeling of protein folding in a way that will be useful to physicists, chemists, and chemical physicists. Covering a broad spectrum of computational methods and practices culled from a variety of research fields, the editors present a full range of models that, together, provide a thorough and current description of all aspects of protein folding. A valuable resource for both students and professionals in the field, the book will be of value both as a cutting-edge overview of existing information and as a catalyst for inspiring new studies. Computational Methods for Protein Folding is the 120th volume in the acclaimed series Advances in Chemical Physics, a compilation of scholarly works dedicated to the dissemination of contemporary advances in chemical physics, edited by Nobel Prize-winner Ilya Prigogine.

Protein Folding

Author : Charis Ghelis
Publisher : Academic Press
Page : 580 pages
File Size : 46,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323140928

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Protein Folding by Charis Ghelis Pdf

Protein Folding aims to collect the most important information in the field of protein folding and probes the main principles that govern formation of the three-dimensional structure of a protein from a nascent polypeptide chain, as well as how the functional properties appear. This text is organized into three sections and consists of 15 chapters. After an introductory chapter where the main problems of protein folding are considered at the cellular level in the context of protein biosynthesis, the discussion turns to the conformation of native globular proteins. Definitions and rules of nomenclature are given, including the structural organization of globular proteins deduced from X-ray crystallographic data. Folding mechanisms are tentatively deduced from the observation of invariants in the architecture of folded proteins. The next chapters focus on the energetics of protein conformation and structure, indicating the principles of thermodynamic stability of the native structure, along with theoretical computation studies of protein folding, structure prediction, and folding simulation. The reader is also introduced to various experimental approaches; the reversibility of the unfolding-folding process; equilibrium and kinetic studies; and detection and characterization of intermediates in protein folding. This text concludes with a chapter dealing with problems specific to oligomeric proteins. This book is intended for research scientists, specialists, biochemists, and students of biochemistry and biology.

Protein Folding

Author : Victor Muñoz
Publisher : Humana
Page : 0 pages
File Size : 54,9 Mb
Release : 2022-12-14
Category : Science
ISBN : 1071617184

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Protein Folding by Victor Muñoz Pdf

This volume provides comprehensive protocols on experimental and computational methods that are used to study probe protein folding reactions and mechanisms. Chapters divided into five parts detail protein engineering, protein chemistry, experimental approaches to investigate the thermodynamics and kinetics of protein folding transitions, probe protein folding at the single molecule, analysis and interpretation of computer simulations, procedures and tools for the prediction of protein folding properties. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Folding: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

Folding/unfolding Kinetics of Lattice Proteins by Applying a Simple Statistical Mechanical Model for Protein Folding

Author : Hiroshi Wako,Haruo Abe
Publisher : Nova Biomedical Books
Page : 0 pages
File Size : 40,7 Mb
Release : 2011
Category : Chemical models
ISBN : 1617619221

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Folding/unfolding Kinetics of Lattice Proteins by Applying a Simple Statistical Mechanical Model for Protein Folding by Hiroshi Wako,Haruo Abe Pdf

The folding/unfolding kinetics of a three-dimensional lattice protein was studied using a simple statistical mechanical model for protein folding that was previously developed. The model considers the specificity of an amino acid sequence and the native structure of a given protein. The characteristic relaxation rate on the free energy surface was calculated starting from a completely unfolded structure (or native structure) that is assumed to associate with a folding rate (or an unfolding rate). To elucidate the roles of individual amino acid residues in protein folding/unfolding kinetics, the kinetic properties for all possible single amino acid substitutions of these proteins were calculated and their responses were examined. This book presents and discusses research results in the kinetics of protein folding/unfolding.

Mechanisms of Protein Folding

Author : Roger H. Pain
Publisher : Oxford University Press, USA
Page : 486 pages
File Size : 49,9 Mb
Release : 2000
Category : Protein folding
ISBN : UOM:39015055709250

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Mechanisms of Protein Folding by Roger H. Pain Pdf

The process by which newly synthesized polypeptide chains become their final 3-dimensional protein forms is clearly explained, providing students and researchers of various backgrounds with both a conceptual and technical understanding of the subject. The new Second Edition incorporates the significant improvements in the field such as advances in interpreting observed kinetic data, the development of technology to observe fast folding reactions, the molten globule state, and the vital role of chaperone proteins in protein folding. The emphasis on experimental approaches has been maintained but this edition does so within the explicit context of simulations and energy surfaces. New discoveries of the central importance of protein folding and unfolding reactions in biology and medicine (including mutation and 'misfolding') are carefully explored. Three case studies elucidate the difficulties of studying protein folding in vivo.

Protein Folding, Evolution and Design

Author : R. A. Broglia,Eugene I. Shakhnovich,Guido Tiana
Publisher : IOS Press
Page : 378 pages
File Size : 49,6 Mb
Release : 2001
Category : Science
ISBN : 158603166X

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Protein Folding, Evolution and Design by R. A. Broglia,Eugene I. Shakhnovich,Guido Tiana Pdf

This text presents the results of broad interdisciplinary effort to study proteins in physical and evolutionary prospectives. Among the authors are physicists, chemists, crystallographers, and evolutionary biologists. Experimental and theoretical developments from molecules to cells are presented providing a broad picture of modern biophysical chemistry.

Protein Actions: Principles and Modeling

Author : Ivet Bahar,Robert L. Jernigan,Ken A. Dill
Publisher : Garland Science
Page : 336 pages
File Size : 51,7 Mb
Release : 2017-02-14
Category : Science
ISBN : 9781351815017

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Protein Actions: Principles and Modeling by Ivet Bahar,Robert L. Jernigan,Ken A. Dill Pdf

Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.

Lectures on Statistical Physics and Protein Folding

Author : Kerson Huang
Publisher : World Scientific
Page : 160 pages
File Size : 53,9 Mb
Release : 2005-05-30
Category : Science
ISBN : 9789814481069

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Lectures on Statistical Physics and Protein Folding by Kerson Huang Pdf

' This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestions on possible research directions, as developed by the author in collaboration with C C Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix. Contents:EntropyMaxwell–Boltzmann DistributionFree EnergyChemical PotentialPhase TransitionsKinetics of Phase TransitionsThe Order ParameterCorrelation FunctionStochastic ProcessesLangevin EquationThe Life ProcessSelf-AssemblyKinetics of Protein FoldingPower Laws in Protein FoldingSelf-Avoiding Walk and TurbulenceConvergent Evolution in Protein Folding Readership: Graduate students, researchers and academics interested in statistical physics and molecular biology. Keywords:Statistical Physics;Protein Folding;BiophysicsReviews:“My particularly favorite is the chapter on order parameters, explaining with simplicity and clarity this subject so frequently difficult and confusing for the beginning students … the book makes a strong attempt to place the protein folding problem where it really belongs — in the context of fundamental statistical mechanics. Whether the attempt is successful or not is a matter of a reader's opinion, but the very direction is both timely and welcome.”Professor Alexander Grosberg University of Minnesota '

Protein Folding

Author : Victor Muñoz
Publisher : Humana
Page : 419 pages
File Size : 55,9 Mb
Release : 2021-11-30
Category : Science
ISBN : 107161715X

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Protein Folding by Victor Muñoz Pdf

This volume provides comprehensive protocols on experimental and computational methods that are used to study probe protein folding reactions and mechanisms. Chapters divided into five parts detail protein engineering, protein chemistry, experimental approaches to investigate the thermodynamics and kinetics of protein folding transitions, probe protein folding at the single molecule, analysis and interpretation of computer simulations, procedures and tools for the prediction of protein folding properties. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Folding: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

Protein Folding, Misfolding and Aggregation

Author : Victor Muñoz
Publisher : Royal Society of Chemistry
Page : 290 pages
File Size : 53,8 Mb
Release : 2008
Category : Science
ISBN : 9780854042579

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Protein Folding, Misfolding and Aggregation by Victor Muñoz Pdf

Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods h.

Total Chemical Synthesis of Proteins

Author : Ashraf Brik,Philip Dawson,Lei Liu
Publisher : John Wiley & Sons
Page : 624 pages
File Size : 42,5 Mb
Release : 2021-03-16
Category : Science
ISBN : 9783527823581

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Total Chemical Synthesis of Proteins by Ashraf Brik,Philip Dawson,Lei Liu Pdf

How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: Contains valuable insights from the pioneers in the field of chemical protein synthesis Presents proven synthetic approaches for a range of protein families Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.

Protein Structure, Stability, and Folding

Author : Kenneth P. Murphy
Publisher : Springer Science & Business Media
Page : 258 pages
File Size : 41,5 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592591930

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Protein Structure, Stability, and Folding by Kenneth P. Murphy Pdf

In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.