Protein Phosphorylation

Author : D. Grahame Hardie
Publisher : IRL Press
Page : 336 pages
File Size : 43,5 Mb
Release : 1993
Category : Science
ISBN : UOM:39015029947499

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Protein Phosphorylation by D. Grahame Hardie Pdf

Reversible phosphorylation is one of the major mechanisms by which protein activity is controlled in all eukaryotic cells. Networks of protein kinases and phosphatases, which catalyze phosphorylation and dephosphorylation respectively, are responsible for switching between different pathways of cell division, development, or differentiation in response to hormones or growth factors. This book provides a comprehensive description of current methods for studying protein phosphorylation and the protein kinases and phosphatases which catalyze it. It includes detailed protocols for studying phosphorylation in intact cells, approaches using enzyme inhibitors, purification of serine/threonine-specific protein kinases/phosphatases, analysis of kinase/phosphatase specificity, and cloning relevant cDNAs. Protein Phosphorylation: A Practical Approach will be of great value to all researchers in the fields of intracellular and intercellular signalling, including biochemists, molecular biologists and pharmacologists.

Author : L.M.G. Heilmeyer
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 41,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781475701661

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Signal Transduction and Protein Phosphorylation by L.M.G. Heilmeyer Pdf

Author : B.E. Kemp
Publisher : CRC Press
Page : 332 pages
File Size : 42,7 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351083898

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Peptides and Protein Phosphorylation by B.E. Kemp Pdf

This comprehensive volume focuses on the ways in which synthetic peptides have been exploited in order to expand our understanding of the molecular mechanisms involved in protein phosphorylation. It recognizes that virtually all physiological processes are regulated by protein phosphorylation. It discusses the use of synthetic peptides in studying the catalytic mechanism and regulation of protein kinases. It also includes the chemical synthesis of phosphorylated peptides and preparation of specific antisera. This incredible work has lead to the development of a new generation of peptide inhibitors with potencies of greater magnitude than those previously known. Everyone involved with biochemistry and molecular biology will find this one-of-a-kind resource fascinating and filled with useful information.

Author : Tony Hunter,Bartholomew M. Sefton
Publisher : Elsevier
Page : 808 pages
File Size : 43,7 Mb
Release : 1991
Category : Molecular cloning
ISBN : 0121821013

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Protein Phosphorylation by Tony Hunter,Bartholomew M. Sefton Pdf

This volume provides a compilation of recent methods for studying protein phosphorylation.

Author : Michael J. Clemens
Publisher : CRC Press
Page : 300 pages
File Size : 45,6 Mb
Release : 1996-12-03
Category : Medical
ISBN : 9057020300

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Protein Phosphorylation in Cell Growth Regulation by Michael J. Clemens Pdf

The aim of this text is to integrate the processes of protein phosphorylation and dephosphorylation into the complex pathways by which cellular proliferation is driven, bringing together the many different systems of control implicated in the regulation of cell growth. Presents a survey of protein phosphorylation roles in the control of cellular proliferation and differentiation. A large number of protein kinases and phosphatases have been characterised in higher cells, and have been shown to be involved in signal transduction pathways by which growth factors, mitogens, and extracellular agents exert proliferative effects on cells. Important subjects covered include control of gene expression at the transcriptional and translational levels, and roles of the cdk kinases and cyclins in cell cycles regulation. Describes all major families of protein kinases of significance to growth regulation.

Author : Cai Huang
Publisher : BoD – Books on Demand
Page : 482 pages
File Size : 44,9 Mb
Release : 2012-09-06
Category : Medical
ISBN : 9789535107378

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Protein Phosphorylation in Human Health by Cai Huang Pdf

15 chapters on protein phosphorylation and human health written by expert scientists. Covers most important research hot points, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases. Detailed and comprehensive text with excellent figure illustration.

Author : Shirish Shenolikar
Publisher : Academic Press
Page : 464 pages
File Size : 43,7 Mb
Release : 2012-02-28
Category : Medical
ISBN : 9780123964564

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Protein Phosphorylation in Health and Disease by Shirish Shenolikar Pdf

This volume explores some of the most exciting recent advances in basic research on protein phosphorylation in health and disease and how this knowledge is leading to advances in the various fields. Contributions from leading authorities Informs and updates on all the latest developments in the field

Author : Allegra Via,Andreas Zanzoni
Publisher : Frontiers Media SA
Page : 124 pages
File Size : 48,9 Mb
Release : 2016-08-11
Category : Genetics
ISBN : 9782889199006

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Protein Phosphorylation in Health and Disease by Allegra Via,Andreas Zanzoni Pdf

Protein phosphorylation is one of the most abundant reversible post-translational modifications in eukaryotes. It is involved in virtually all cellular processes by regulating protein function, localization and stability and by mediating protein-protein interactions. Furthermore, aberrant protein phosphorylation is implicated in the onset and progression of human diseases such as cancer and neurodegenerative disorders. In the last years, tens of thousands of in vivo phosphorylation events have been identified by large-scale quantitative phospho-proteomics experiment suggesting that a large fraction of the proteome might be regulated by phosphorylation. This data explosion is increasingly enabling the development of computational approaches, often combined with experimental validation, aiming at prioritizing phosphosites and assessing their functional relevance. Some computational approaches also address the inference of specificity determinants of protein kinases/phosphatases and the identification of phosphoresidue recognition domains. In this context, several challenging issues are still open regarding phosphorylation, including a better understanding of the interplay between phosphorylation and allosteric regulation, agents and mechanisms disrupting or promoting abnormal phosphorylation in diseases, the identification and modulation of novel phosphorylation inhibitors, and so forth. Furthermore, the determinants of kinase and phosphatase recognition and binding specificity are still unknown in several cases, as well as the impact of disease mutations on phosphorylation-mediated signaling. The articles included in this Research Topic illustrate the very diverse aspects of phosphorylation, ranging from structural changes induced by phosphorylation to the peculiarities of phosphosite evolution. Some also provide a glimpse into the huge complexity of phosphorylation networks and pathways in health and disease, and underscore that a deeper knowledge of such processes is essential to identify disease biomarkers, on one hand, and design more effective therapeutic strategies, on the other.

Author : F Huijing
Publisher : Elsevier
Page : 336 pages
File Size : 50,6 Mb
Release : 2012-12-02
Category : Nature
ISBN : 9780323155342

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Protein Phosphorylation in Control Mechanisms by F Huijing Pdf

Protein Phosphorylation in Control Mechanisms contains the proceedings of the Miami Winter Symposia entitled ""Protein Phosphorylation in Control Mechanisms,"" held on January 15-16, 1973, in Miami, Florida, and organized by the Department of Biochemistry at the University of Miami School of Medicine. The papers explore the role of protein phosphorylation in control mechanisms, including muscle metabolism and function, cell division, and histone and protamine binding to DNA. This volume is comprised of 28 chapters and begins with an overview of Earl W. Sutherland's scientific work and the involvement of cyclic AMP in enzyme inductions. The discussion then turns to the regulation of muscle metabolism and function by protein phosphorylation; the link between hormonally regulated enzymes in adipose tissue and cyclic AMP-dependent protein kinase; and regulation of the mammalian pyruvate dehydrogenase complex by phosphorylation and dephosphorylation. Subsequent chapters focus on the role of histone phosphorylation in cell division; histone phosphorylation and regulation of nuclear function; and protein phosphorylation in retinal photoreceptors. The final chapter is devoted to acetylation of nuclear proteins in rat testis. This book should be a valuable resource for biochemists.

Author : R.L. Khandelwal,J.H. Wang
Publisher : Springer Science & Business Media
Page : 314 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461526001

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Reversible Protein Phosphorylation in Cell Regulation by R.L. Khandelwal,J.H. Wang Pdf

This book, published in association with the journal MOLECULAR AND CELLULAR BIOCHEMISTRY, is dedicated to Ed Krebs and Eddy Fischer in celebration of their 1992 Nobel Prize in Physiology and Medicine. Reversible protein phosphorylation is a research field pioneered and developed by Krebs and Fischer. This book contains short reviews and original research papers contributed by Krebs and Fischer's coworkers, both former and current. The contents reflect the two-way interaction between protein phosphorylation and other biomedical research fields. The chapters are grouped into four sections. The first two deal with structure/function aspects of protein kinases and protein mechanisms. Unlike many other research fields, which undergo periods of intense activity and productivity followed by relative calm, the protein phosphorylation field enjoyed continued growth both in scope and intensity, and the pace of this growth has increased markedly in recent years. This volume will provide a glimpse of the dynamism and diversity of the research activity representative of the current state of the field.

Author : L.M.G. Jr. Heilmeyer
Publisher : Springer Science & Business Media
Page : 461 pages
File Size : 46,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642751424

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Cellular Regulation by Protein Phosphorylation by L.M.G. Jr. Heilmeyer Pdf

Proceedings of the NATO Advanced Study Institute on Cellular Regulation by Protein Phosphorylation held at Chateau La Londe les Maures (France), September 5-15, 1990

Author : M. Weller
Publisher : Unknown
Page : 586 pages
File Size : 40,5 Mb
Release : 1979
Category : Phosphoproteins
ISBN : UOM:39015000303191

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Protein Phosphorylation by M. Weller Pdf

Author : J. Gordon,E. J. Podesta,G. Thomas
Publisher : S. Karger AG (Switzerland)
Page : 256 pages
File Size : 43,9 Mb
Release : 1980
Category : Medical
ISBN : UOM:39015007091781

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Protein Phosphorylation and Bio-regulation by J. Gordon,E. J. Podesta,G. Thomas Pdf

Author : Eric J. Nestler,Paul Greengard
Publisher : Unknown
Page : 426 pages
File Size : 46,9 Mb
Release : 1984-06-14
Category : Medical
ISBN : UOM:39015001593428

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Protein Phosphorylation in the Nervous System by Eric J. Nestler,Paul Greengard Pdf

Considers the role of protein phosphorylation in neuron-specific phenomena. Comprehensively treats the enzymes and molecular biology of phosphorylation and dephosphorylation reactions, examines evidence for the obligatory role of these reactions in neuronal function, and extensively reviews the large number of phosphorylation pathways and their interactions. Original schematic diagrams illustrate principles of the biochemical basis of cell regulation.

Author : Anonim
Publisher : Academic Press
Page : 763 pages
File Size : 41,9 Mb
Release : 1991-08-11
Category : Science
ISBN : 0121821013

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Protein Phosphorylation, Part A by Anonim Pdf

This volume provides a compilation of recent methods for studying protein phosphorylation.