Protein Structural Biology In Biomedical Research

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Protein Structural Biology in Biomedical Research

C. Woodward
Protein Structural Biology in Biomedical Research Book PDF

Author : C. Woodward
Publisher : Elsevier
Page : 626 pages
File Size : 52,5 Mb
Release : 1998-01-16
Category : Science
ISBN : 0080877052

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Protein Structural Biology in Biomedical Research by C. Woodward Pdf

Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject. The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.

Protein Structural Biology in Biomedical Research, Part A

C. Woodward
Protein Structural Biology in Biomedical Research Part A Book PDF

Author : C. Woodward
Publisher : Elsevier Science
Page : 626 pages
File Size : 46,8 Mb
Release : 1998-01-30
Category : Science
ISBN : 0762302836

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Protein Structural Biology in Biomedical Research, Part A by C. Woodward Pdf

Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject. The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.

Structural Genomics and High Throughput Structural Biology

Michael Sundstrom,Martin Norin,Aled Edwards
Structural Genomics and High Throughput Structural Biology Book PDF

Author : Michael Sundstrom,Martin Norin,Aled Edwards
Publisher : CRC Press
Page : 304 pages
File Size : 46,6 Mb
Release : 2005-08-23
Category : Medical
ISBN : 9780849361432

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Structural Genomics and High Throughput Structural Biology by Michael Sundstrom,Martin Norin,Aled Edwards Pdf

Researchers in structural genomics continue to search for biochemical and cellular functions of proteins as well as the ways in which proteins assemble into functional pathways and networks using either experimental or computational approaches. Based on the experience of leading international experts, Structural Genomics and High Throughput Stru

Computational Structural Biology

Manuel Claude Peitsch
Computational Structural Biology Book PDF

Author : Manuel Claude Peitsch
Publisher : World Scientific
Page : 790 pages
File Size : 51,6 Mb
Release : 2008
Category : Science
ISBN : 9789812778772

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Computational Structural Biology by Manuel Claude Peitsch Pdf

This work covers the impact of computational structural biology on protein structure prediction methods, macromolecular function and protein design, and key methods in drug discovery. It also addresses the computational challenges of experimental approaches in structural biology.

Molecular Biology of The Cell

Bruce Alberts
Molecular Biology of The Cell Book PDF

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 49,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Exploring Protein Structure: Principles and Practice

Tim Skern
Exploring Protein Structure Principles and Practice Book PDF

Author : Tim Skern
Publisher : Springer
Page : 255 pages
File Size : 53,5 Mb
Release : 2018-07-04
Category : Science
ISBN : 9783319768588

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Exploring Protein Structure: Principles and Practice by Tim Skern Pdf

This textbook introduces the basics of protein structure and logically explains how to use online software to explore the information in protein structure databases. Readers will find easily understandable, step-by step exercises and video-trainings to support them in grasping the fundamental concepts. After reading this book, readers will have the skills required to independently explore and analyze macromolecular structures, will be versed in extracting information from protein databases and will be able to visualize protein structures using specialized software and on-line algorithms. This book is written for advanced undergraduates and PhD students wishing to use information from structural biology in their assignments and research and will be a valuable source of information for all those interested in applied and theoretical aspects of structural biology.

Protein Structure

Daniel Chasman
Protein Structure Book PDF

Author : Daniel Chasman
Publisher : CRC Press
Page : 534 pages
File Size : 53,9 Mb
Release : 2003-03-18
Category : Medical
ISBN : 9780824748166

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Protein Structure by Daniel Chasman Pdf

This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.

Structural Biology and Functional Genomics

E. Morton Bradbury,Sándor Pongor
Structural Biology and Functional Genomics Book PDF

Author : E. Morton Bradbury,Sándor Pongor
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401146319

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Structural Biology and Functional Genomics by E. Morton Bradbury,Sándor Pongor Pdf

Biomedical research will be revolutionised by the current efforts to sequence the human genome and the genomes of model organisms. Of the newly sequenced genes, 50% code for proteins of unknown functions, while as little as 5% of sequences in mammalian genomes code for proteins. New, genome-wide approaches are needed to draw together the knowledge that is emerging simultaneously in a number of fields of genome research. This volume is a high-level survey of the newly emerging concepts of structural biology and functional genomics for biologists, biochemists and medical researchers interested in genome research. Topics included are chromosome and chromatin organisation, novel DNA and RNA structures, DNA flexibility, supercoiling, prediction of protein functions, strategies for large scale structural analysis, and computer modelling.

From Protein Structure to Function with Bioinformatics

Daniel John Rigden
From Protein Structure to Function with Bioinformatics Book PDF

Author : Daniel John Rigden
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 43,5 Mb
Release : 2008-12-11
Category : Science
ISBN : 9781402090585

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From Protein Structure to Function with Bioinformatics by Daniel John Rigden Pdf

Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules. An understanding of the structure of a protein can therefore lead us to a much improved picture of its molecular function. This realisation has been a prime motivation of recent Structural Genomics projects, involving large-scale experimental determination of protein structures, often those of proteins about which little is known of function. These initiatives have, in turn, stimulated the massive development of novel methods for prediction of protein function from structure. Since model structures may also take advantage of new function prediction algorithms, the first part of the book deals with the various ways in which protein structures may be predicted or inferred, including specific treatment of membrane and intrinsically disordered proteins. A detailed consideration of current structure-based function prediction methodologies forms the second part of this book, which concludes with two chapters, focusing specifically on case studies, designed to illustrate the real-world application of these methods. With bang up-to-date texts from world experts, and abundant links to publicly available resources, this book will be invaluable to anyone who studies proteins and the endlessly fascinating relationship between their structure and function.

Structural Proteomics and Its Impact on the Life Sciences

Joel Sussman,Israel Silman
Structural Proteomics and Its Impact on the Life Sciences Book PDF

Author : Joel Sussman,Israel Silman
Publisher : World Scientific
Page : 597 pages
File Size : 43,9 Mb
Release : 2008
Category : Medical
ISBN : 9789812772053

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Structural Proteomics and Its Impact on the Life Sciences by Joel Sussman,Israel Silman Pdf

The role played by structural proteomics in the first decade of the 21st century is equivalent to that played by the Human Genome Project in the last decade of the 20th century. The development of high-throughput technologies that permit the solution of hundreds of 3D structures of individual proteins, proteinOCoprotein complexes and proteinOCodrug complexes, just by one laboratory in a single year, will provide a knowledge base which will change the face of structural biology. This will have an immediate influence on medicinal chemistry and molecular pharmacology, as well as an increasing impact on such disciplines as neurobiology, developmental biology, immunology and molecular medicine.This book presents a state-of-the-art overview of the structural proteomics field, ranging from policy issues related to funding and goals, through the high-throughput procedures for protein production, to the solution of the structures of proteins and higher-order entities, via a multidisciplinary approach involving molecular biology, X-ray crystallography, NMR and electron microscopy, as well as bioinformatics analysis. This is the first book to provide such a comprehensive coverage of a rapidly evolving field.

Structural Genomics on Membrane Proteins

Kenneth H. Lundstrom
Structural Genomics on Membrane Proteins Book PDF

Author : Kenneth H. Lundstrom
Publisher : CRC Press
Page : 400 pages
File Size : 45,9 Mb
Release : 2006-02-23
Category : Medical
ISBN : 157444526X

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Structural Genomics on Membrane Proteins by Kenneth H. Lundstrom Pdf

While the genomic revolution has quickly led to the deposit of more than 30,000 structures in the protein data bank (PDB), less than one percent of those contributions represent membrane proteins despite the fact that membrane proteins constitute some 20 percent of all proteins. This discrepancy becomes significantly troublesome when it is coupled with the fact that 60 percent of current drugs are based on targeting this group of proteins, a trend that does not seem likely to reverse. Structural Genomics on Membrane Proteins provides an excellent overview on novel research in bioinformatics and modeling on membranes, as well as the latest technological developments being employed in expression, purification, and crystallography to obtain high-resolution structures on membrane proteins. This cutting-edge work also explains the difficulties facing researchers—both technical and ethical—that have slowed the process. Structural Genomics on Membrane Proteins provides researchers with an unprecedented look at the novel technologies that will ultimately allow them to conquer the last frontier in structural biology, leading to accelerated breakthroughs in drug discovery.

Challenges and Opportunities of Next-generation Sequencing for Biomedical Research

Mark I. Rees
Challenges and Opportunities of Next generation Sequencing for Biomedical Research Book PDF

Author : Mark I. Rees
Publisher : Unknown
Page : 196 pages
File Size : 49,6 Mb
Release : 2012
Category : Biology
ISBN : 6613968595

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Challenges and Opportunities of Next-generation Sequencing for Biomedical Research by Mark I. Rees Pdf

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next.