Protein Targeting Transport And Translocation

Author : Ross Dalbey,Gunnar von Heijne
Publisher : Elsevier
Page : 336 pages
File Size : 46,8 Mb
Release : 2002-04-09
Category : Science
ISBN : 0080480500

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Protein Targeting, Transport, and Translocation by Ross Dalbey,Gunnar von Heijne Pdf

Protein Targeting, Transport, and Translocation presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields. Basic principles and techniques Targeting adn sorting sequences Protein export in bacteria Membrane protein integration into ER and bacterial membranes Protein translocation across the ER Disulfide bond formation in prokaryotes and eukaryotes Quality control in the export pathway Import of proteins into organelles The secretory pathway Vesicular transport Spectacular color throughout

Author : D. A. Phoenix
Publisher : Princeton University Press
Page : 305 pages
File Size : 52,8 Mb
Release : 2014-07-14
Category : Science
ISBN : 9781400865017

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Protein Targeting and Translocation by D. A. Phoenix Pdf

Protein targeting is a fast-moving field that has encompassed areas from biophysics to molecular biology to try to gain insight into how proteins are directed to their final functional location and how such macromolecules are able to cross semi-permeable membrane barriers during their journey. This text reviews our current state of knowledge regarding the interaction of proteins at the membrane interface and the assembly of proteins into biological membranes, before proceeding to look at targeting pathways in both prokaryotic and eukaryotic systems. The reviews have been written by some of the leading researchers in the field, with contributions from around the world and with more than 1,800 references. The text is aimed at graduate students and at researchers with an interest in protein targeting, but may also be of use to final-year undergraduates. Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 47,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Jerry Eichler
Publisher : Springer Science & Business Media
Page : 147 pages
File Size : 44,9 Mb
Release : 2007-02-26
Category : Science
ISBN : 9780387308715

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Protein Movement Across Membranes by Jerry Eichler Pdf

This book addresses the most recent advances in the transport of proteins across a variety of biological membranes. In addressing this topic, this volume includes several new twists not previously addressed in the literature. In the last few years, the study of protein translocation has been revolutionized by the availability of structural information on many of the components and complexes involved in the process. Unlike earlier books written on protein translocation, this volume considers these advances. In addition, several chapters discuss facets of protein translocation from a systems biology perspective, considered by many to be the next paradigm for biological study. Readers of this book will come away with a deeper understanding of the problems facing researchers of protein translocation and see how the most modern biological techniques and approaches are being recruited to answer those questions. The chapters are also written such that problems awaiting future investigation are clearly presented.

Author : F.U. Hartl
Publisher : Elsevier
Page : 355 pages
File Size : 51,7 Mb
Release : 1997-02-24
Category : Science
ISBN : 0080877001

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Protein Targeting to Mitochondria by F.U. Hartl Pdf

A large number of newly-synthesized polypeptides must cross one or several intracellular membranes to reach their functional locations in the eukaryotic cell. The mechanisms of protein trafficking, in particular the post-translational targeting and membrane translocation of proteins, are of fundamental biological importance and are the focus of intensive research world-wide. For more than 15 years, mitochondria have served as the paradigm organelle system to study these processes. Although key questions, such as how precisely proteins cross a membrane, still remain to be answered, exciting progress has been made in understanding the basic pathways of protein import into mitochondria and the components involved. In addition to a fascinating richness and complexity in detail, the analysis of mitochondrial protein import has revealed mechanistic principles of general significance: Major discoveries include the demonstration of the requirement of an unfolded state for translocation and of the essential role of molecular chaperones on both sides of the membranes in maintaining a translocation-competent conformation and in protein folding after import. It is becoming clear how a polypeptide chain is "reeled" across the membrane in an ATP-dependent process by the functional cooperation of membrane proteins, presumably constituting part of a transmembrane channel, with peripheral components at the trans-side of the membrane. In this volume, eminent experts in the field take the time to review the central aspects of mitochondrial biogenesis. The logical order of the 16 chapters is determined by the sequence of steps during protein import, starting with the events taking place in the cytosol, followed by the recognition of targeting signals, the translocation of precursor proteins across the outer and inner membranes, their proteolytic processing and intramitochondrial sorting, and finally their folding and oligomeric assembly. In addition, the mechanisms involved in the export of mitochondrially encoded proteins as well as recent advances in understanding the division and inheritance of mitochondria will be discussed.

Author : Anonim
Publisher : Elsevier
Page : 318 pages
File Size : 48,7 Mb
Release : 2023-11-07
Category : Science
ISBN : 9780443136924

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The Enzymes by Anonim Pdf

The Enzymes, Volume 54 highlights new advances in enzymes, with new chapters on a variety of topics, including the History of The Enzymes, Impact of The Enzymes in chronicling biochemical processes and pathways, Metabolism and Catalysis, Mitochondrial ATP synthase, The respiratory chain, A century of mitochondrial research, Five decades of metalloenzymology, Mechanisms of catalysis, Mitochondrial fatty acid synthesis and associated processes, Signaling, MAPK cascades: Origins, mechanisms and current status, Sphingolipids: From structural components to signaling hubs, Protein Homeostasis and Hydrolysis, Mitochondrial AAA+ proteases, Hsp70 and JDP proteins: structure-function perspective on molecular chaperone activity. Other sections cover DNA Replication and Repair, Structure-function studies of DNA replication proteins, and Helicases required for nucleotide excision repair. Provides the authority and expertise of leading contributors from an international board of authors Updated release includes the latest information on enzymes

Author : Anthony Pubsley
Publisher : Academic Press
Page : 304 pages
File Size : 46,7 Mb
Release : 1989-06-28
Category : Science
ISBN : UOM:39015014893815

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Protein Targeting by Anthony Pubsley Pdf

Protein Targeting reviews different aspects of protein targeting, including similarities and differences in the pathways involved. The early stages of protein export and secretion in prokaryotes and eukaryotes are examined, along with the targeting of mitochondrial and chloroplast proteins as well as some important differences in the biogenesis of the two organelles. Comprised of nine chapters, this book begins with an overview of terminology and basic principles of protein targeting, focusing on protein traffic in eukaryotic and bacterial cells. The reader is then introduced to the basic principles and techniques of protein targeting, including protein identification and posttranslational modification. Subsequent chapters deal with the early stages in the secretory pathway; later stages in the prokaryotic and eukaryotic secretory pathways; targeting of mitochondrial, chloroplast, and peroxisomal proteins; and targeting of nuclear proteins. The book also discusses endocytosis before concluding with a description of applications of protein targeting. This monograph will be of value to scientists and biotechnologists, as well as to students of cell biology, biochemistry, microbiology, and molecular biology.

Author : Markus Kunze,Andrey L. Karamyshev,Inhwan Hwang,Anastassios Economou,Nathan Alder
Publisher : Frontiers Media SA
Page : 233 pages
File Size : 48,9 Mb
Release : 2023-12-14
Category : Science
ISBN : 9782832541722

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Targeting Signals in Protein Trafficking and Transport by Markus Kunze,Andrey L. Karamyshev,Inhwan Hwang,Anastassios Economou,Nathan Alder Pdf

Author : W. Neupert,R. Lill
Publisher : Elsevier
Page : 340 pages
File Size : 43,8 Mb
Release : 1992-12-09
Category : Science
ISBN : 0080860826

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Membrane Biogenesis and Protein Targetting by W. Neupert,R. Lill Pdf

This book provides a comprehensive overview of recent developments in the fast moving field of protein transport across and into intracellular membranes. The soluble and membrane-bound components assisting in these processes are introduced, and their functions described. Besides a detailed analysis of protein translocation across the bacterial plasma membrane, the mechanisms of protein targeting within the eukaryotic cell are discussed with special focus on the transport of proteins to the endoplasmic reticulum, vacuoles, peroxisomes, mitochondria, and chloroplasts. Providing stimulating hypotheses and models, the book is well suited for advanced students, graduate students, and for newcomers to the field seeking a general, yet accurate introduction to present knowledge in membrane transport of proteins.

Author : Maria Sandkvist,Eric Cascales,Peter J. Christie
Publisher : John Wiley & Sons
Page : 128 pages
File Size : 53,5 Mb
Release : 2020-07-02
Category : Science
ISBN : 9781683670285

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Protein Secretion in Bacteria by Maria Sandkvist,Eric Cascales,Peter J. Christie Pdf

Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial antagonism and collaboration, host invasion and disruption, and immune evasion. A broad repertoire of mechanisms and macromolecular machines are required to deliver protein substrates across bacterial cell membranes for intended effects. Some machines are common to most, if not all bacteria, whereas others are specific to Gram-negative or Gram-positive species or species with unique cell envelope properties such as members of Actinobacteria and Spirochetes. Protein Secretion in Bacteria, authored and edited by an international team of experts, draws together the many distinct functions and mechanisms involved in protein translocation in one concise tome. This comprehensive book presents updated information on all aspects of bacterial protein secretion encompassing: Individual secretory systems–Sec, Tat, and T1SS through the newly discovered T9SS Mechanisms, structures, and functions of bacterial secretion systems Lipoprotein sorting pathways, outer membrane vesicles, and the sortase system Structures and roles of surface organelles, including flagella, pili, and curli Emerging technologies and translational implications Protein Secretion in Bacteria serves as both an introductory guide for students and postdocs and a ready reference for seasoned researchers whose work touches on protein export and secretion. This volume synthesizes the diversity of mechanisms of bacterial secretion across the microbial world into a digestible resource to stimulate new research, inspire continued identification and characterization of novel systems, and bring about new ways to manipulate these systems for biotechnological, preventative, and therapeutic applications.

Author : Anonim
Publisher : Springer Science & Business Media
Page : 708 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642782671

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GTPases in Biology I by Anonim Pdf

The GTPase switch appears to be almost as old as life itself, and nature has adapted it to a variety of purposes. This two-volume work surveys the major classes of GTPases, including their role in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer. 80 chapters contain much previously unpublished data and, at the rate the extended family of GTPases is growing, it is unlikely that it will again sit for a group portrait such as this. Thus, this could well become the standard reference work.

Author : Reiner Peters,Michael Trendelenburg
Publisher : Springer Science & Business Media
Page : 296 pages
File Size : 44,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642715655

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Nucleocytoplasmic Transport by Reiner Peters,Michael Trendelenburg Pdf

Author : Keith Verner,Jeanette Beers
Publisher : Unknown
Page : 198 pages
File Size : 55,5 Mb
Release : 1995
Category : Medical
ISBN : WISC:89057154874

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Intracellular Protein Transport and Membrane Biogenesis by Keith Verner,Jeanette Beers Pdf

This book is about membrane biogenesis and protein transport across biological membranes. Both prokaryotic and eukaryotic membrane transport systems are considered. The characteristics of targeting signals and membrane receptors on various intracellular organelles are described. Protein targeting to the endoplasmic reticulum and secretion via vesicular transport are discussed. In addition, recent developments in protein targeting and membrane transport to mitochondria, chloroplasts, peroxisomes and the nucleus are described. An introductory chapter on biological membranes is included as a review while a chapter on the transport of lipids to intracellular membranes precedes discussions on protein transport and membrane translocation.

Author : Nava Segev
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 55,8 Mb
Release : 2010-05-30
Category : Science
ISBN : 9780387938776

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Trafficking Inside Cells by Nava Segev Pdf

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Author : Gáspár Jékely
Publisher : Springer
Page : 0 pages
File Size : 46,5 Mb
Release : 2010-10-27
Category : Science
ISBN : 1441925414

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Eukaryotic Membranes and Cytoskeleton by Gáspár Jékely Pdf

The presence/absence of gene families with central roles in endomembrane and cytoskeleton dynamics in a variety of eukaryotic taxa and an understanding of eukaryote phylogeny allow the cellular machineries present in the last common ancestor of eukaryotes to be accurately reconstructed. Such a reconstruction is fundamental in order to understand eukaryotic diversification, since this is the ancestral cell from which all diversity arose. This book discusses the evolutionary origin and diversification of eukaryotic endomembranes and cytoskeleton from a cell biological and comparative genomic perspective.