Proteins And Proteomics

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Proteins and Proteomics of Leishmania and Trypanosoma

André L.S. Santos,Marta H. Branquinha,Claudia M. d’Avila-Levy,Lucimar F. Kneipp,Cátia L. Sodré
Proteins and Proteomics of Leishmania and Trypanosoma Book PDF

Author : André L.S. Santos,Marta H. Branquinha,Claudia M. d’Avila-Levy,Lucimar F. Kneipp,Cátia L. Sodré
Publisher : Springer Science & Business Media
Page : 387 pages
File Size : 55,8 Mb
Release : 2013-11-22
Category : Medical
ISBN : 9789400773059

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Proteins and Proteomics of Leishmania and Trypanosoma by André L.S. Santos,Marta H. Branquinha,Claudia M. d’Avila-Levy,Lucimar F. Kneipp,Cátia L. Sodré Pdf

This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteomics of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.

Proteomics

Lucio Comai,Jonathan E. Katz,Parag Mallick
Proteomics Book PDF

Author : Lucio Comai,Jonathan E. Katz,Parag Mallick
Publisher : Humana
Page : 0 pages
File Size : 50,8 Mb
Release : 2017-02-11
Category : Science
ISBN : 1493967452

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Proteomics by Lucio Comai,Jonathan E. Katz,Parag Mallick Pdf

This volume aims to provide protocols on a wide range of biochemical methods, analytical approaches, and bioinformatics tools developed to analyze the proteome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Proteomics: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Neuroproteomics

Oscar Alzate
Neuroproteomics Book PDF

Author : Oscar Alzate
Publisher : CRC Press
Page : 356 pages
File Size : 41,7 Mb
Release : 2009-10-26
Category : Medical
ISBN : 9781420076264

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Neuroproteomics by Oscar Alzate Pdf

In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Proteomics and Protein-Protein Interactions

Gabriel Waksman
Proteomics and Protein Protein Interactions Book PDF

Author : Gabriel Waksman
Publisher : Springer Science & Business Media
Page : 325 pages
File Size : 51,5 Mb
Release : 2006-12-22
Category : Medical
ISBN : 9780387245324

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Proteomics and Protein-Protein Interactions by Gabriel Waksman Pdf

Gabriel Waksman Institute of Structural Molecular Biology, Birkbeck and University College London, Malet Street, London WC1E 7HX, United Kingdom Address for correspondence: Professor Gabriel Waksman Institute of Structural Molecular Biology Birkbeck and University College London Malet Street London WC1E 7H United Kingdom Email: g. waksman@bbk. ac. uk and g. waksman@ucl. ac. uk Phone: (+44) (0) 207 631 6833 Fax: (+44) (0) 207 631 6833 URL: http://people. cryst. bbk. ac. uk/?ubcg54a Gabriel Waksman is Professor of Structural Molecular Biology at the Institute of Structural Molecular Biology at UCL/Birkbeck, of which he is also the director. Before joining the faculty of UCL and Birkbeck, he was the Roy and Diana Vagelos Professor of Biochemistry and Molecular Biophysics at the Washington University School of Medicine in St Louis (USA). The rapidly evolving ?eld of protein science has now come to realize the ubiquity and importance of protein–protein interactions. It had been known for some time that proteins may interact with each other to form functional complexes, but it was thought to be the property of only a handful of key proteins. However, with the advent of hi- throughput proteomics to monitor protein–protein interactions at an organism level, we can now safely state that protein–protein interactions are the norm and not the exception.

Principles of Proteomics

Richard Twyman
Principles of Proteomics Book PDF

Author : Richard Twyman
Publisher : Garland Science
Page : 266 pages
File Size : 43,9 Mb
Release : 2004-05-01
Category : Science
ISBN : 9780203507391

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Principles of Proteomics by Richard Twyman Pdf

Principles of Proteomics is designed specifically to explain the different stages of proteomic analysis, their complexities and their jargon to students and researchers in a non-technical overview of the field. The author describes the broad range of problems which proteomics can address, including structural proteomics, interaction proteomics, protein modification analysis and functional proteomics. Methodologies are described in user-friendly language, from the more traditional two-dimensional gel electrophoresis to the new developments in protein chip technologies. These are well presented in the context of overall strategies which can be adopted to address the different aspects of large-scale protein analysis.

Proteomics

Stephen R. Pennington,Michael J. Dunn
Proteomics Book PDF

Author : Stephen R. Pennington,Michael J. Dunn
Publisher : Garland Science
Page : 352 pages
File Size : 48,8 Mb
Release : 2001
Category : Amino acid sequence
ISBN : 1859962963

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Proteomics by Stephen R. Pennington,Michael J. Dunn Pdf

Proteomics is an emerging research area, and the book reviews genome projects in relation to the need for complementary proteomics programmes.

Proteomics

Tsz Kwong Man,Ricardo Flores
Proteomics Book PDF

Author : Tsz Kwong Man,Ricardo Flores
Publisher : BoD – Books on Demand
Page : 454 pages
File Size : 43,7 Mb
Release : 2012-02-10
Category : Science
ISBN : 9789533078328

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Proteomics by Tsz Kwong Man,Ricardo Flores Pdf

Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field. This book covers four important and diverse areas of current proteomic research: Proteomic Discovery of Disease Biomarkers, Proteomic Analysis of Protein Functions, Proteomic Approaches to Dissecting Disease Processes, and Organelles and Secretome Proteomics. We believe that clinicians, students and laboratory researchers who are interested in Proteomics and its applications in the biomedical field will find this book useful and enlightening. The use of proteomic methods in studying proteins in various human diseases has become an essential part of biomedical research.

Protein Biochemistry and Proteomics

Hubert Rehm
Protein Biochemistry and Proteomics Book PDF

Author : Hubert Rehm
Publisher : Academic Press
Page : 252 pages
File Size : 42,9 Mb
Release : 2006
Category : Science
ISBN : 9780120885459

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Protein Biochemistry and Proteomics by Hubert Rehm Pdf

An innovative, tactical, guide to avoid frustration in the biochemical lab!

Proteins and Proteomics

Richard J. Simpson
Proteins and Proteomics Book PDF

Author : Richard J. Simpson
Publisher : CSHL Press
Page : 946 pages
File Size : 48,8 Mb
Release : 2003
Category : Proteins
ISBN : 0879695544

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Proteins and Proteomics by Richard J. Simpson Pdf

Introduction to proteomics; one-dimensional polyacrylamide gel electrophoresis; preparing cellular and subcellular extracts; preparative two-dimensional gel electrophoresis with immobilized pH gradients; reversed-phase high -performance liquid chromatography; amino- and carboxy-terminal sequence analysis; peptide mapping and sequence analysis of gel-resolved proteins; the use of mass spectrometry in proteomics; proteomic methods for phosphorylation site mapping; characterization of protein complexes; making sense of proteomics - using bioinformatics to discover a protein's structure, functions, and interactions.

The Evolution from Protein Chemistry to Proteomics

Roger L. Lundblad
The Evolution from Protein Chemistry to Proteomics Book PDF

Author : Roger L. Lundblad
Publisher : CRC Press
Page : 260 pages
File Size : 43,5 Mb
Release : 2005-10-14
Category : Medical
ISBN : 9781000654042

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The Evolution from Protein Chemistry to Proteomics by Roger L. Lundblad Pdf

Largely driven by major improvements in the analytical capability of mass spectrometry, proteomics is being applied to broader areas of experimental biology, ranging from oncology research to plant biology to environmental health. However, while it has already eclipsed solution protein chemistry as a discipline, it is still essentially an extension

From Proteins to Proteomics

Sanjeeva Srivastava
From Proteins to Proteomics Book PDF

Author : Sanjeeva Srivastava
Publisher : CRC Press
Page : 272 pages
File Size : 55,6 Mb
Release : 2022-12-29
Category : Medical
ISBN : 9781000648676

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From Proteins to Proteomics by Sanjeeva Srivastava Pdf

Proteomics aims to study all the proteins of human and other living systems, as well as their properties to provide an integrated view of cellular processes. The study of proteomics involves the application of rapidly evolving high-throughput technologies and new platforms that are coming forward regularly, providing versatile novel tools for biomedical and pharmaceutical applications. This book provides a detailed understanding of the basics of proteins and proteomics, gel based-proteomics techniques, basics of mass spectrometry and quantitative proteomics, interactomics: basics and applications, and advancements in proteomics. It also covers basic knowledge about sample preparation, mass spectrometry workflow, different chromatography technologies and quantitative proteomics. The text highlights the application and challenges of various high-throughput integrated proteomics technologies capable of fast and accurate screening of thousands of biomolecules, which are found to be very effective for studying disease pathobiology and identification of next-generation biomarkers and potential drug/vaccine targets; and are therefore considered valuable tools for multidisciplinary research. Features Basics of proteins and proteomics techniques In-depth understanding of mass spectrometry and quantitative proteomics An overview of interactomics and its application for translational research Advancement in the field of proteomics and challenges in clinical applications We hope the knowledge gained from reading this book will intrigue and motivate young minds to explore future opportunities in the constantly evolving field of proteomics.

Subcellular Proteomics

Eric Bertrand,Michel Faupel
Subcellular Proteomics Book PDF

Author : Eric Bertrand,Michel Faupel
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 49,6 Mb
Release : 2007-08-29
Category : Science
ISBN : 9781402059438

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Subcellular Proteomics by Eric Bertrand,Michel Faupel Pdf

This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.

Introduction to Proteomics

Daniel Liebler
Introduction to Proteomics Book PDF

Author : Daniel Liebler
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 54,9 Mb
Release : 2001-12-04
Category : Medical
ISBN : 9780896039919

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Introduction to Proteomics by Daniel Liebler Pdf

Daniel C. Liebler masterfully introduces the science of proteomics by spelling out the basics of how one analyzes proteins and proteomes, and just how these approaches are then employed to investigate their roles in living systems. He explains the key concepts of proteomics, how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes. Also discussed are how protein and peptide separation techniques are applied in proteomics, how mass spectrometry is used to identify proteins, and how data analysis software enables protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression, characterizing proteomic diversity, and dissecting protein-protein interactions and networks.

Introducing Proteomics

Josip Lovric
Introducing Proteomics Book PDF

Author : Josip Lovric
Publisher : John Wiley & Sons
Page : 310 pages
File Size : 47,8 Mb
Release : 2011-06-17
Category : Science
ISBN : 9781119957195

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Introducing Proteomics by Josip Lovric Pdf

Introducing Proteomics gives a concise and coherent overview of every aspect of current proteomics technology, which is a rapidly developing field that is having a major impact within the life and medical sciences. This student-friendly book, based on a successful course developed by the author, provides its readers with sufficient theoretical background to be able to plan, prepare, and analyze a proteomics study. The text covers the following: Separation Technologies Analysis of Peptides/Proteins by Mass Spectrometry Strategies in Proteomics This contemporary text also includes numerous examples and explanations for why particular strategies are better than others for certain applications. In addition, Introducing Proteomics includes extensive references and a list of relevant proteomics information sources; essential for any student. This no-nonsense approach to the subject tells students exactly what they need to know, leaving out unnecessary information. The student companion site enhances learning and provides answers to the end of chapter problems. "I think this book will be a popular and valuable resource for students and newcomers to the field who would like to have an overview and initial understanding of what proteomics is about. The contents are well organized and address the major issues." —Professor Walter Kolch, Director, Systems Biology Ireland & Conway Institute, University College Dublin Companion Website www.wiley.com/go/lovric

Posttranslational Modification of Proteins

Christoph Kannicht
Posttranslational Modification of Proteins Book PDF

Author : Christoph Kannicht
Publisher : Springer Science & Business Media
Page : 326 pages
File Size : 52,8 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592591817

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Posttranslational Modification of Proteins by Christoph Kannicht Pdf

Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the posttranslational modifications of protein, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins.