Proteomic Biology Using Lc Ms

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Proteomic Biology Using LC/MS

Nobuhiro Takahashi,Toshiaki Isobe,Dominic M. Desiderio,Nico M. Nibbering
Proteomic Biology Using LC MS Book PDF

Author : Nobuhiro Takahashi,Toshiaki Isobe,Dominic M. Desiderio,Nico M. Nibbering
Publisher : John Wiley & Sons
Page : 275 pages
File Size : 48,8 Mb
Release : 2007-08-31
Category : Science
ISBN : 9780470149645

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Proteomic Biology Using LC/MS by Nobuhiro Takahashi,Toshiaki Isobe,Dominic M. Desiderio,Nico M. Nibbering Pdf

This is one of the first books to focus on the dynamic aspect of proteomes. The book introduces proteomics to the newcomer, reviews the theoretical aspects of proteomics and its state-of-the art technologies, along with a number of biological applications using "classical" proteomic technology. The book also presents a new concept, the Dynamome, or the expression of a comprehensive molecular set that participates in the whole dynamic process of a series of cellular events.

LC-MS/MS in Proteomics

Pedro R. Cutillas,John F. Timms
LC MS MS in Proteomics Book PDF

Author : Pedro R. Cutillas,John F. Timms
Publisher : Humana Press
Page : 330 pages
File Size : 42,8 Mb
Release : 2011-04-06
Category : Science
ISBN : 1607617811

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LC-MS/MS in Proteomics by Pedro R. Cutillas,John F. Timms Pdf

With the development of new quantitative strategies and powerful bioinformatics tools to cope with the analysis of the large amounts of data generated in proteomics experiments, liquid chromatography with tandem mass spectrometry (LC-MS/MS) is making possible the analysis of proteins on a global scale, meaning that proteomics can now start competing with cDNA microarrays for the analysis of whole genomes. In LC-MS/MS in Proteomics: Methods and Applications, experts in the field provide protocols and up-to-date reviews of the applications of LC-MS/MS, with a particular focus on MS-based methods of protein and peptide quantification and the analysis of post-translational modifications. Beginning with overviews of the use of LC-M/MS in protein analysis, the book continues with topics such as protocols for the analysis of post-translational modifications, with particular focus on phosphorylation and glycosylation, popular techniques for quantitative proteomics, such as multiple reaction monitoring, metabolic labelling, and chemical tagging, biomarker discovery in biological fluids, as well as novel applications of LC-MS/MS. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective subjects, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, LC-MS/MS in Proteomics: Methods and Applications presents the techniques and concepts necessary in order to aid proteomic practitioners in the application of LC-MS/MS to essentially any biological problem.

LC-MS/MS in Proteomics

Pedro R. Cutillas,John F. Timms
LC MS MS in Proteomics Book PDF

Author : Pedro R. Cutillas,John F. Timms
Publisher : Humana
Page : 357 pages
File Size : 51,9 Mb
Release : 2016-08-23
Category : Science
ISBN : 1493957449

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LC-MS/MS in Proteomics by Pedro R. Cutillas,John F. Timms Pdf

With the development of new quantitative strategies and powerful bioinformatics tools to cope with the analysis of the large amounts of data generated in proteomics experiments, liquid chromatography with tandem mass spectrometry (LC-MS/MS) is making possible the analysis of proteins on a global scale, meaning that proteomics can now start competing with cDNA microarrays for the analysis of whole genomes. In LC-MS/MS in Proteomics: Methods and Applications, experts in the field provide protocols and up-to-date reviews of the applications of LC-MS/MS, with a particular focus on MS-based methods of protein and peptide quantification and the analysis of post-translational modifications. Beginning with overviews of the use of LC-M/MS in protein analysis, the book continues with topics such as protocols for the analysis of post-translational modifications, with particular focus on phosphorylation and glycosylation, popular techniques for quantitative proteomics, such as multiple reaction monitoring, metabolic labelling, and chemical tagging, biomarker discovery in biological fluids, as well as novel applications of LC-MS/MS. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective subjects, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, LC-MS/MS in Proteomics: Methods and Applications presents the techniques and concepts necessary in order to aid proteomic practitioners in the application of LC-MS/MS to essentially any biological problem.

Introduction to Proteomics

Daniel Liebler
Introduction to Proteomics Book PDF

Author : Daniel Liebler
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 55,9 Mb
Release : 2001-12-04
Category : Medical
ISBN : 9780896039919

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Introduction to Proteomics by Daniel Liebler Pdf

Daniel C. Liebler masterfully introduces the science of proteomics by spelling out the basics of how one analyzes proteins and proteomes, and just how these approaches are then employed to investigate their roles in living systems. He explains the key concepts of proteomics, how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes. Also discussed are how protein and peptide separation techniques are applied in proteomics, how mass spectrometry is used to identify proteins, and how data analysis software enables protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression, characterizing proteomic diversity, and dissecting protein-protein interactions and networks.

Proteomics in Systems Biology

Jennifer Geddes-McAlister
Proteomics in Systems Biology Book PDF

Author : Jennifer Geddes-McAlister
Publisher : Springer Nature
Page : 372 pages
File Size : 42,8 Mb
Release : 2022-05-25
Category : Science
ISBN : 9781071621240

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Proteomics in Systems Biology by Jennifer Geddes-McAlister Pdf

This detailed book highlights the diverse techniques and applications of proteomics in an accessible, informative, and concise manner. The collection features sample preparation from distinct extraction, quantification, enrichment, modification, as well as interactome methodology for the in-depth exploration of biological systems, and the application of proteomics to clinical, infectious disease, and agricultural practices. Moreover, cutting-edge bioinformatics tools, encompassing machine learning and data integration strategies, are explored, as are techniques expanding beyond proteomics into the realm of metabolomics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting known pitfalls. Comprehensive and practical, Proteomics in Systems Biology: Methods and Protocols emphasizes the importance of proteomics and demonstrates a plethora of approaches for investigating diverse biological entities from a systems perspective.

Biological Mass Spectrometry

A.L. Burlingame
Biological Mass Spectrometry Book PDF

Author : A.L. Burlingame
Publisher : Gulf Professional Publishing
Page : 520 pages
File Size : 50,9 Mb
Release : 2005-11-28
Category : Science
ISBN : 0121828077

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Biological Mass Spectrometry by A.L. Burlingame Pdf

Describes and integrates the techniques of many advances in both chromatographic and mass spectrometric technologies. This book also covers various biophysical applications, such as H/D exchange for study of conformations, protein-protein and protein-metal and ligand interactions. It also describes atto-to-zepto-mole quantitation of 14C and 3H.

Mass Spectrometry Data Analysis in Proteomics

Rune Matthiesen
Mass Spectrometry Data Analysis in Proteomics Book PDF

Author : Rune Matthiesen
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 41,5 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781597452755

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Mass Spectrometry Data Analysis in Proteomics by Rune Matthiesen Pdf

This is an in-depth guide to the theory and practice of analyzing raw mass spectrometry (MS) data in proteomics. The volume outlines available bioinformatics programs, algorithms, and databases available for MS data analysis. General guidelines for data analysis using search engines such as Mascot, Xtandem, and VEMS are provided, with specific attention to identifying poor quality data and optimizing search parameters.

Proteome Analysis

David W Speicher
Proteome Analysis Book PDF

Author : David W Speicher
Publisher : Elsevier
Page : 394 pages
File Size : 48,5 Mb
Release : 2004-05-18
Category : Science
ISBN : 9780080515304

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Proteome Analysis by David W Speicher Pdf

This book explores the current status of proteomics, an exciting new discipline, which is less than 10 years old. This new field has rapidly grown into a major commercial and research enterprise with great prospects for dramatically advancing our knowledge of basic biological and disease processes. The contributors to this book are an international panel of proteomics experts, who review and discuss the current status of specific technologies and approaches. Proteomics represents an exciting new way to pursue biological and biomedical science at an unprecedented pace. Proteomics takes a broad, comprehensive, systematic approach to understanding biology that is generally unbiased and not dependent upon existing knowledge. The major components of proteomics from basic discovery using a range of alternative analytical methods to discovery validation and use for clinical applications are discussed. State-of-the-art protein profiling methods include high resolution two-dimensional gels, two-dimensional differential in-gel electrophoresis, LC-MS and LC-MS/MS using accurate mass tags, and protein identifications of proteins from gels using mass spectrometry methods are discussed in depth. Other chapters describe comprehensive characterization of proteomes using electrophoretic prefractionation and analyses of sub-proteomes based on specific posttranslational modifications including the phospho-proteome, the glyco-proteome, and nitrated proteins. These conventional proteome analysis chapters are complemented by discussion of emerging technologies and approaches such as affinity based biosensor proteomics as well as the use of protein microarrays, microfluidics and nanotechnology. Strategies for improving throughput by automation are also discussed. Additional chapters address the application of current proteome techniques to clinical problems and the availability of protein expression library resources for proteome studies. · Authored by international experts in the field · Covers a wide range of topics including 2-D gels, global proteomics using accurate mass tags, global proteomics using electrophoretic prefractionation, microfluidics, and nanotechnology · Includes state-of-the-art protein profiling methods, and emerging technologies

Proteomics and Peptidomics

Gyorgy Marko-Varga
Proteomics and Peptidomics Book PDF

Author : Gyorgy Marko-Varga
Publisher : Elsevier
Page : 663 pages
File Size : 45,5 Mb
Release : 2005-12-23
Category : Language Arts & Disciplines
ISBN : 9780444518101

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Proteomics and Peptidomics by Gyorgy Marko-Varga Pdf

Proteomics and peptidomics is the detailed understanding of the role that proteins and peptides play in health and disease and is a necessary compliment to genetic analysis. The functional expression analysis of both proteins and peptides plays a central role in modern drug discovery as well as drug development, and is also a key research area in systems biology. Proteomics and Peptidomics captures the width as well as the depth within the area and exemplifies the variety as well as the traditional basis of analytical chemistry that is needed in order to move forward in expression analysis studies. As a fast emerging field, it gives and overview of parts within the field combined with highly specialized and dedicated topics that are intended to compliment each other.

Proteomic Applications in Biology

Joshua Heazlewood,Christopher J. Petzold
Proteomic Applications in Biology Book PDF

Author : Joshua Heazlewood,Christopher J. Petzold
Publisher : BoD – Books on Demand
Page : 280 pages
File Size : 49,5 Mb
Release : 2012-01-18
Category : Science
ISBN : 9789533076133

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Proteomic Applications in Biology by Joshua Heazlewood,Christopher J. Petzold Pdf

The past decade has seen the field of proteomics expand from a highly technical endeavor to a widely utilized technique. The objective of this book is to highlight the ways in which proteomics is currently being employed to address issues in the biological sciences. Although there have been significant advances in techniques involving the utilization of proteomics in biology, fundamental approaches involving basic sample visualization and protein identification still represent the principle techniques used by the vast majority of researchers to solve problems in biology. The work presented in this book extends from overviews of proteomics in specific biological subject areas to novel studies that have employed a proteomics-based approach. Collectively they demonstrate the power of established and developing proteomic techniques to characterize complex biological systems.

Serum/Plasma Proteomics

David W. Greening,Richard J. Simpson
Serum Plasma Proteomics Book PDF

Author : David W. Greening,Richard J. Simpson
Publisher : Springer Nature
Page : 591 pages
File Size : 41,9 Mb
Release : 2023-02-13
Category : Science
ISBN : 9781071629789

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Serum/Plasma Proteomics by David W. Greening,Richard J. Simpson Pdf

This third volume provides comprehensive protocols on pre-analytical, analytical, plasma, and serum proteomics. New and updated chapters are divided into nine sections, detailing blood processing and handling strategies, discovery- and targeted-based mass spectrometry, including workflows to aid in discovery and targeted data analysis, in addition to software and bioinformatics for the plasma proteome. This edition further integrates emerging areas in the development of technologies for plasma proteomics and assay platforms in biomarker discovery and translational proteomics, enrichment and detection strategies to understand the plasma proteome, and peptide, lipid and metabolite targeted assays. We also detail the emerging analysis of extracellular vesicles isolated from plasma. Written in the format of the highly successful Methods in Molecular Biology series, each of the 33 chapters includes an introduction to the topic, lists necessary materials and methods, includes hints and tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Serum/Plasma Proteomics: Methods and Protocols, Third Edition aims to be comprehensive guide for researchers.

Methods in Animal Proteomics

Philip Whitfield,David Eckersall
Methods in Animal Proteomics Book PDF

Author : Philip Whitfield,David Eckersall
Publisher : John Wiley & Sons
Page : 464 pages
File Size : 50,5 Mb
Release : 2011-07-05
Category : Science
ISBN : 9780470960646

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Methods in Animal Proteomics by Philip Whitfield,David Eckersall Pdf

The study of proteomics provides researchers with a better understanding of disease and physiological processes in animals. Methods in Animal Proteomics will provide animal scientists and veterinarians currently researching these topics in domestic animals a firm foundation in the basics of proteomics methodology, while also reviewing important advances that will be of interest to established researchers in the field. Chapters will provide practical information on a range of topics including protein identification and separation, bioinformatics, and applications to disease and reproduction research. This text will be written by leading international proteomics experts and essential for researchers in the fields of animal biology and veterinary medicine.

Organelle Proteomics

Delphine Pflieger,Jean Rossier
Organelle Proteomics Book PDF

Author : Delphine Pflieger,Jean Rossier
Publisher : Springer Science & Business Media
Page : 423 pages
File Size : 42,6 Mb
Release : 2008-02-19
Category : Science
ISBN : 9781588297792

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Organelle Proteomics by Delphine Pflieger,Jean Rossier Pdf

This is the first book to examine organelle proteomics in depth. It begins by introducing the different analytical strategies developed and successfully utilized to study organelle proteomes, and detailing the use of multidimensional liquid chromatography coupled to tandem mass spectrometry for peptide sample analysis. Detailed protocols are provided and a section is devoted to methods enabling a global estimate of the reliability of the protein list assigned to an organelle.

Neuroproteomics

Oscar Alzate
Neuroproteomics Book PDF

Author : Oscar Alzate
Publisher : CRC Press
Page : 356 pages
File Size : 41,5 Mb
Release : 2009-10-26
Category : Medical
ISBN : 9781420076264

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Neuroproteomics by Oscar Alzate Pdf

In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Modern Proteomics – Sample Preparation, Analysis and Practical Applications

Hamid Mirzaei,Martin Carrasco
Modern Proteomics Sample Preparation Analysis and Practical Applications Book PDF

Author : Hamid Mirzaei,Martin Carrasco
Publisher : Springer
Page : 533 pages
File Size : 47,7 Mb
Release : 2016-12-14
Category : Science
ISBN : 9783319414485

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Modern Proteomics – Sample Preparation, Analysis and Practical Applications by Hamid Mirzaei,Martin Carrasco Pdf

This volume serves as a proteomics reference manual, describing experimental design and execution. The book also shows a large number of examples as to what can be achieved using proteomics techniques. As a relatively young area of scientific research, the breadth and depth of the current state of the art in proteomics might not be obvious to all potential users. There are various books and review articles that cover certain aspects of proteomics but they often lack technical details. Subject specific literature also lacks the broad overviews that are needed to design an experiment in which all steps are compatible and coherent. The objective of this book was to create a proteomics manual to provide scientists who are not experts in the field with an overview of: 1. The types of samples can be analyzed by mass spectrometry for proteomics analysis. 2. Ways to convert biological or ecological samples to analytes ready for mass spectral analysis. 3. Ways to reduce the complexity of the proteome to achieve better coverage of the constituent proteins. 4. How various mass spectrometers work and different ways they can be used for proteomics analysis 5. The various platforms that are available for proteomics data analysis 6. The various applications of proteomics technologies in biological and medical sciences This book should appeal to anyone with an interest in proteomics technologies, proteomics related bioinformatics and proteomics data generation and interpretation. With the broad setup and chapters written by experts in the field, there is information that is valuable for students as well as for researchers who are looking for a hands on introduction into the strengths, weaknesses and opportunities of proteomics.