Proteomics And Metabolomics In Psychiatry

Author : D. Martins-de-Souza
Publisher : Karger Medical and Scientific Publishers
Page : 152 pages
File Size : 42,6 Mb
Release : 2014-05-23
Category : Medical
ISBN : 9783318026009

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Proteomics and Metabolomics in Psychiatry by D. Martins-de-Souza Pdf

This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections – Schizophrenia/Psychotic Disorders and Mood Disorders – deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.

Author : Paul C. Guest
Publisher : Unknown
Page : 328 pages
File Size : 45,8 Mb
Release : 2019
Category : Biological models
ISBN : 3030055434

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Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders by Paul C. Guest Pdf

This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.

Author : Niruj Agrawal,Rafey Faruqui,Mayur Bodani
Publisher : Oxford University Press
Page : 601 pages
File Size : 47,9 Mb
Release : 2020-08-25
Category : Medical
ISBN : 9780192605153

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Oxford Textbook of Neuropsychiatry by Niruj Agrawal,Rafey Faruqui,Mayur Bodani Pdf

A survey of over 900 trainees at the Royal College of Psychiatrists (RCPsych) in the United Kingdom showed that over three-quarters of psychiatry trainees desired some knowledge and training in the field of neuropsychiatry. Recent years have given rise to a substantial global focus on integrating neurosciences and neuropsychiatry in psychiatric training. Neuropsychiatry forms an important part of the psychiatric curriculum and is examined in theory and in clinical exams. Similarly, neuropsychiatry is also of interest to neurology trainees, and it is increasingly recognised that all neurology trainees should have some knowledge and experience in neuropsychiatry. Despite this growing interest, there is a dearth of neuropsychiatry textbooks specifically geared towards trainees and other clinicians who are not specialist in the field. Part of the Oxford Textbooks in Psychiatry series, the Oxford Textbook of Neuropsychiatry helps to bridge the gap between general psychiatric textbooks and reference texts in neuropsychiatry. Organised into four sections, the book covers the basic knowledge and skills relevant to neuropsychiatry, the various neuropsychiatric conditions, the principles of treatment, and perspectives for neuropsychiatry worldwide. Chapters have been written by international experts who are leaders in their own fields with the view to taking an evidence-based, up-to-date, global perspective on neuropsychiatric problems and treatment. The book is relevant to trainees in psychiatry, neurology, neurorehabilitation and also to various allied professionals in neuroscience and mental health. It covers core knowledge and skills for practice in all psychiatric disciplines including core knowledge for training in neuropsychiatry. The book meets curriculum requirements for various international training programmes and examinations, and serves as an essential training text book for all psychiatric and neurology trainees worldwide.

Author : Paul C. Guest
Publisher : Springer
Page : 328 pages
File Size : 40,7 Mb
Release : 2019-02-12
Category : Science
ISBN : 9783030055424

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Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders by Paul C. Guest Pdf

This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.

Author : Paul C. Guest
Publisher : Springer
Page : 370 pages
File Size : 53,7 Mb
Release : 2017-03-28
Category : Science
ISBN : 9783319524795

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Proteomic Methods in Neuropsychiatric Research by Paul C. Guest Pdf

Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care. The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine. It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.

Author : Anonim
Publisher : Academic Press
Page : 377 pages
File Size : 54,6 Mb
Release : 2014-07-03
Category : Business & Economics
ISBN : 9780128005958

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Proteomics in Biomedicine and Pharmacology by Anonim Pdf

Volume 95 of Advances in Protein Chemistry and Structural Biology focuses on advances in proteomic techniques and their application in biomedicine and pharmacology. This volume describes in detail the applications of these techniques in studying a number of diseases and specific protein modifications and profiles, including phosphoproteomics, glycoproteomics, and more. Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of powerful techniques in translational research (biomedicine and pharmacology) Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables

Author : Judith Pratt,Jeremy Hall
Publisher : Springer
Page : 437 pages
File Size : 54,9 Mb
Release : 2019-01-05
Category : Medical
ISBN : 9783319996424

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Biomarkers in Psychiatry by Judith Pratt,Jeremy Hall Pdf

This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.

Author : Jorge Manzanares,Maria S. Garcia-Gutierrez,Francisco Navarrete Rueda,Piotr Gałecki
Publisher : Frontiers Media SA
Page : 205 pages
File Size : 54,9 Mb
Release : 2021-09-14
Category : Medical
ISBN : 9782889713011

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The Search for Biomarkers in Psychiatry by Jorge Manzanares,Maria S. Garcia-Gutierrez,Francisco Navarrete Rueda,Piotr Gałecki Pdf

Author : Sabine Bahn,Paul Guest
Publisher : Academic Press
Page : 471 pages
File Size : 49,6 Mb
Release : 2011-11-09
Category : Medical
ISBN : 9780123877185

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Biomarkers of Neurological and Psychiatric Disease by Sabine Bahn,Paul Guest Pdf

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author : Wael Mohamed,Firas Kobeissy
Publisher : Springer Nature
Page : 392 pages
File Size : 49,5 Mb
Release : 2022-10-03
Category : Medical
ISBN : 9789811950216

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Nutrition and Psychiatric Disorders by Wael Mohamed,Firas Kobeissy Pdf

The book comprehensively reviews the role of nutrition in psychiatric disorders. It provides mechanistic insights into the effects of nutrition on metabolic pathways, mitochondrial nutrients, neurodegeneration and CNS disorders, cell signaling, and neuronal functions. The book further highlights the role of diet in preventing and treating mental health and modifying drug treatment effects. Further, it explores the relationship between nutrition and psychiatric disorders, including depression, autism, anxiety, Attention-Deficit / Hyperactivity Disorder, and OCD. The book further explores the recent advancements in understanding the important role of nutrients as therapeutics in various psychiatric disorders. Lastly, it presents an overview of nutrients as neuroprotective agents along with the main principles of nutrigenomics. The book is essential reading for neuroscientists interested interest in food therapeutic strategies.

Author : Bernhard Baune
Publisher : Academic Press
Page : 604 pages
File Size : 44,8 Mb
Release : 2019-10-16
Category : Medical
ISBN : 9780128131770

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Personalized Psychiatry by Bernhard Baune Pdf

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Author : Rodrigo Machado-Vieira,Jair Soares
Publisher : Academic Press
Page : 529 pages
File Size : 48,5 Mb
Release : 2022-01-16
Category : Medical
ISBN : 9780128213995

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Biomarkers in Bipolar Disorders by Rodrigo Machado-Vieira,Jair Soares Pdf

Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes), prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development. Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder. Describes strategies for the biomarker discovery of relevant proteins differentially expressed in Bipolar Disorder Presents techniques and main findings in transcriptome research related to CNS synaptic function Provides an overview on current behavioral strategies and their validity in drug development in Bipolar Disorder Discusses current genetic findings, integrating tests for treatments leading to personalized treatments

Author : Osbaldo Resendis-Antonio,Christian Diener
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 49,5 Mb
Release : 2017-11-23
Category : Electronic
ISBN : 9782889453337

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Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer by Osbaldo Resendis-Antonio,Christian Diener Pdf

Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options. Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current “omics” technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell’s metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research.

Author : Takashi Nakano,Takahiro A. Kato,Masahiro Takamura,Shin-ichi Kano
Publisher : Frontiers Media SA
Page : 120 pages
File Size : 44,9 Mb
Release : 2023-01-03
Category : Medical
ISBN : 9782832510575

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The Development of Biomarkers in Psychiatry by Takashi Nakano,Takahiro A. Kato,Masahiro Takamura,Shin-ichi Kano Pdf

Author : Felix Tretter,Georg Winterer,Peter J. Gebicke-Haerter,Eduardo R. Mendoza
Publisher : John Wiley & Sons
Page : 378 pages
File Size : 42,6 Mb
Release : 2010-03-30
Category : Medical
ISBN : 3527630287

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Systems Biology in Psychiatric Research by Felix Tretter,Georg Winterer,Peter J. Gebicke-Haerter,Eduardo R. Mendoza Pdf

This first book to provide a comprehensive overview of the recent progress made in this break-through approach includes expert contributions from a variety of disciplines. Particular focus is placed on high-throughput methods and the analysis of data thus obtained, as well as their use in silico experiments so as to gain an insight into the complex biological processes in neuronal systems. A must-have for everyone working in psychiatric research.