Pseudomonas Aeruginosa The Opportunist

Author : Robert B. Fick, Jr.
Publisher : CRC Press
Page : 280 pages
File Size : 44,9 Mb
Release : 1992-12-07
Category : Medical
ISBN : 0849348110

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Pseudomonas Aeruginosa the Opportunist by Robert B. Fick, Jr. Pdf

Pseudomonas aeruginosa the Opportunist provides an in depth analysis of clinically relevant pathogenetic mechanisms and selected disease states. The book presents the most current discussion of pathogenic mechanisms logically arranged from the microbiology of the Pseudomonadaceae and initial mucosal adherence, progessing to microcolony formation and release of a wide assortment of virulence factors, and closing with the contribution of host cells to the disease process. Cellular and molecular disease mechanisms are covered, including genetic regulation of virulence-associated bacterial products. Future research trends are highlighted as well. Pseudomonas aeruginosa the Opportunist is an excellent reference for bacteriologists, clinical investigators, and practicing clinicians representing a variety of specialties, including ophthalmology, pediatrics, and transplantation.

Author : Mario Campa,Mauro Bendinelli,Herman Friedman
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461530367

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Pseudomonas aeruginosa as an Opportunistic Pathogen by Mario Campa,Mauro Bendinelli,Herman Friedman Pdf

Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It will provide a deeper understanding of the pathogen to physicians and surgeons caring for patients infected, or at risk of becoming infected, with Pseudomonas Aeruginosa.

Author : Dara W. Frank
Publisher : Frontiers E-books
Page : 164 pages
File Size : 50,7 Mb
Release : 2012-02-02
Category : Electronic
ISBN : 9782889190164

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Pseudomonas Aeruginosa, Biology, Genetics, and Host-pathogen Interactions by Dara W. Frank Pdf

The opportunistic pathogen Pseudomonas aeruginosa offers a rich variety of biologically relevant topics to explore and serves as a model system to understand the interactions of Gram-negative bacteria with human hosts. The organism adapts readily to most environments. It has a large and variable genome with a great deal of metabolic potential. P. aeruginosa encodes a variety of regulatory systems to fine tune gene expression and integrate environmental signals. This organism can infect both plants and animals and produces a plethora of enzymes and factors that can overcome host defenses. Moreover, it has the ability to change between the states of a sedentary colonizer to an invasive and highly motile organism. Clinically, the bacterium is resistant to many antibiotics making it difficult to treat and impossible to eradicate from the lungs of patients with cystic fibrosis. Intrinsic antibiotic resistance combined with an armamentarium of tissue degradative enzymes makes it imperative to possess a comprehensive understanding of the biology, genetics and pathogenesis of this organism so that novel therapeutics based on virulence product neutralization can be designed and implemented. This Research Topics issue will be devoted to updating the current understanding of P. aeruginosa systems as they relate to its different lifestyles in different environments. The underlying theme is to provide broad overviews and to integrate protein structure-function and gene regulation as it relates to the biology of this bacterium.

Author : Daniella Azulai
Publisher : Unknown
Page : 0 pages
File Size : 42,7 Mb
Release : 2017
Category : Antibiotics
ISBN : OCLC:1430588614

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The Co-Occurrence of Antibiotic Resistance and Virulence in the Opportunistic Pathogen Pseudomonas Aeruginosa by Daniella Azulai Pdf

The development of antibiotic resistance within microbial communities, especially in clinical settings, is currently an important public health issue. Human activity, such as the clinical overuse of therapeutic antibiotics, as well as the spread of antibiotics in the environment by anthropogenic pollution, is mainly responsible for this observed rise in resistance. Furthermore, it is predicted that as antibiotic resistance increases in bacterial populations, as will virulence: the capacity of these microbes to infect. This is due to the selection of antibiotic resistance, through widespread antibiotic use, co-selecting for virulence via shared cellular mechanisms between the two factors. We investigated the proposed link between antibiotic resistance and virulence by utilizing larval zebrafish and Pseudomonas aeruginosa of varying degrees of antibiotic resistance as a host-pathogen model. We were successful in developing a novel method to test virulence via static immersion. Using this technique, we found that there was no significant correlation between antibiotic resistance and virulence in the P. aeruginosa strains that we tested. We conclude that the developed method of static immersion will prove useful in understanding host-pathogen interactions, and can be utilized in future studies moving forward. Lastly, we suggest that further P. aeruginosa strains should be tested, as the lack of correlation between antibiotic resistance and virulence could be due to the small sample size used in this study. Investigating the connection between antibiotic resistance and virulence is crucial in understanding the impacts and consequences of society's current antibiotic use, and potentially in remediating the human activity responsible for the rise of antibiotic resistance in microbial populations.

Author : Peter Gacesa,Nicholas J. Russell
Publisher : Springer Science & Business Media
Page : 242 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400918368

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Pseudomonas Infection and Alginates by Peter Gacesa,Nicholas J. Russell Pdf

The concept of this book arose out of an international workshop, which we organized and held at the University of Wales Conference Centre at Gregynog. The workshop was the first occasion on which researchers from all the different disciplines concerned with the extracellular virulence factors of mucoid strains of Pseudomonas aeruginosa in relation to cystic fibrosis (CF) had met to discuss this multifaceted problem. It was deemed a particularly timely moment to gather together experts for the exchange of facts, ideas and hypotheses. No formal abstracts were presented and no proceedings were published. But during the succeed ing months the organizers were persuaded by a number of participants that a wider audience should benefit from what had proved to be such a fruitful cross-fertilization of expertise. Thus we moved from being workshop organizers to book editors, sure in the knowledge that at least we had a willing and enthusiastic set of contributors! It should be stressed, however, that this book is not a transcript of that workshop. Not all those participants are authors, and some new names have been added. Instead we have focused on alginate as an extracellular virulence factor of P. aeruginosa in CF pulmonary infections. Recent advances in the biochemistry and molecular genetics of alginate bio synthesis, as well as in our understanding of the basic defect in CF and isolation of the gene, mean that the book is even more timely than when first planned.

Author : Mark Lyte,Primrose P.E. Freestone
Publisher : Springer Science & Business Media
Page : 325 pages
File Size : 55,5 Mb
Release : 2010-04-06
Category : Medical
ISBN : 9781441955760

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Microbial Endocrinology by Mark Lyte,Primrose P.E. Freestone Pdf

Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.

Author : Juan-Luis Ramos,Roger C. Levesque
Publisher : Springer Science & Business Media
Page : 367 pages
File Size : 41,5 Mb
Release : 2006-10-04
Category : Science
ISBN : 9780387288819

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Pseudomonas by Juan-Luis Ramos,Roger C. Levesque Pdf

The first three volumes of the Pseudomonas series covered the biology of pseudomonas in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth.Pseudomonas volume 4 is intended to collect some of the most relevant new emerging issues in the field of Pseudomonas that were not assembled in the three previous volumes.This fourth volume covers the following topics:Virulence and PathogensGenomics and ProteomicsPhysiology, Metabolism and Biotechnology.nbsp;Pseudomonas volume 4 will be of use to researchers working on these bacteria, particularly those studying virulence, genomics, physiology, biotechnology, etc. Advanced students in biology, medicine and agronomy will also find this volume a valuable reference during their studies.

Author : Sarah S. Long,Larry K. Pickering,Charles G. Prober
Publisher : Saunders
Page : 1618 pages
File Size : 50,9 Mb
Release : 2008
Category : Medical
ISBN : 0702034681

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Principles and Practice of Pediatric Infectious Diseases by Sarah S. Long,Larry K. Pickering,Charles G. Prober Pdf

"In print, online, or on your mobile device, Principles and Practice of Pediatric Infectious Disease provides the comprehensive and actionable coverage you need to understand, diagnose, and manage the ever-changing, high-risk clinical problems caused by infectious diseases in children and adolescents. With new chapters, expanded and updated coverage, and increased worldwide perspectives, this authoritative medical reference offers the latest need-to-know information in an easily-accessible, high-yield format for quick answers and fast, effective intervention!"--Publisher's website.

Author : Dinesh Sriramulu
Publisher : BoD – Books on Demand
Page : 124 pages
File Size : 41,6 Mb
Release : 2019-10-02
Category : Science
ISBN : 9781789238150

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Pseudomonas Aeruginosa by Dinesh Sriramulu Pdf

Pseudomonas aeruginosa, though unfamiliar as an aggressive invader, has gained importance in the scientific community due to its association with cystic fibrosis (CF) and its ability to construct biofilms resilient to host defense. The chronic nature of CF allows this bacterium to colonize, adapt, and evolve at its own pace, thereby causing further complications in CF patients. With its huge genetic repertoire and plasticity of the genome, P. aeruginosa has been able to alter its contents by way of deletions, insertions, inversions, and so on. Therefore scientists and researchers are eager to study this bacterium in diverse and unusual niches. Written by experts from around the world, this book describes and discusses the various mechanisms of adaptation and evolution displayed by P. aeruginosa.

Author : Thomas Bjarnsholt,Peter Østrup Jensen,Claus Moser,Niels Høiby
Publisher : Springer
Page : 0 pages
File Size : 51,6 Mb
Release : 2014-10-11
Category : Science
ISBN : 1489982280

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Biofilm Infections by Thomas Bjarnsholt,Peter Østrup Jensen,Claus Moser,Niels Høiby Pdf

This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.

Author : Douglas Mayers
Publisher : Springer Science & Business Media
Page : 692 pages
File Size : 47,8 Mb
Release : 2009-07-14
Category : Medical
ISBN : 9781603275958

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Antimicrobial Drug Resistance by Douglas Mayers Pdf

This ? rst edition of Antimicrobial Drug Resistance grew out of a desire by the editors and authors to have a comprehensive resource of information on antimicrobial drug resistance that encompassed the current information available for bacteria, fungi, protozoa and viruses. We believe that this information will be of value to clinicians, epidemiologists, microbiologists, virologists, parasitologists, public health authorities, medical students and fellows in training. We have endeavored to provide this information in a style which would be accessible to the broad community of persons who are concerned with the impact of drug resistance in our cl- ics and across the broader global communities. Antimicrobial Drug Resistance is divided into Volume 1 which has sections covering a general overview of drug resistance and mechanisms of drug resistance ? rst for classes of drugs and then by individual microbial agents including bacteria, fungi, protozoa and viruses. Volume 2 addresses clinical, epidemiologic and public health aspects of drug resistance along with an overview of the conduct and interpretation of speci? c drug resistance assays. Together, these two volumes offer a comprehensive source of information on drug resistance issues by the experts in each topic.

Author : Abba Kastin,Abba J. Kastin
Publisher : Elsevier
Page : 1640 pages
File Size : 41,7 Mb
Release : 2011-04-28
Category : Science
ISBN : 9780080463797

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Handbook of Biologically Active Peptides by Abba Kastin,Abba J. Kastin Pdf

Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar. *Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.

Author : Juan-Luis Ramos
Publisher : Springer Science & Business Media
Page : 837 pages
File Size : 53,9 Mb
Release : 2011-06-28
Category : Science
ISBN : 9781441990860

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Pseudomonas by Juan-Luis Ramos Pdf

Pseudomonas comprises three volumes covering the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth. There has been growing interest in pseudomonads and a particular urge to understand the biology underlying the complex metabolism of these ubiquitous microbes. These bacteria are capable of colonizing a wide range of niches, including the soil, the plant rhizosphere and phylosphere, and animal tissues; more recently they have attracted attention because of their capacity to form biofilms, a characteristic with potentially important medical and environmental implications. The three volumes cover the following topics: - Taxonomy, - Genomics, - Life styles, - Cell Architecture, - Virulence, - Regulation, - Macromolecules, - Alternative Respiratory Substrates, - Catabolism and Biotransformations. Pseudomonas will be of use to all researchers working on these bacteria, particularly those studying microbiology, plant crops, pathogenesis, and chemical engineering. Advanced students in biology, medicine and agronomy will also find these three volumes a valuable reference during their studies.

Author : Theerthankar Das
Publisher : Unknown
Page : 0 pages
File Size : 52,6 Mb
Release : 2021-09
Category : Electronic
ISBN : 1839686472

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Pseudomonas Aeruginosa by Theerthankar Das Pdf

Author : C.I. Kado,J.H. Crosa
Publisher : Springer Science & Business Media
Page : 676 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401107464

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Molecular Mechanisms of Bacterial Virulence by C.I. Kado,J.H. Crosa Pdf

The growing body of information on bacteria pathogenic for humans, mammals and plants generated within the past ten years has shown the interesting conservation of newly identified genes that playa direct role in the pathogenic mechanism. In addition to these genes, there are also genes that confer host specificities and other traits important in pathogenesis on these pathogens. In this volume, we have organized the subject areas to best fit the concept on the way bacterial pathogens recognize, interact and invade the host, on the regulation of genes involved in virulence, on the genes involved in the elaboration of toxins and other pathogenic components such as iron sequestering proteins, and on the mechanisms of circumventing the host defense systems. These areas are divided into Sections. Section I covers the first step when the pathogen seeks its host, and Sections II through VI cover subsequent steps leading to pathogenesis while avoiding host defenses. We conclude this work with a chapter summarizing information on examples of virulence mechanisms that are highly conserved.