Psychiatric Genetics And Genomics

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Psychiatric Genetics and Genomics

Peter McGuffin,Michael J Owen,Irving I Gottesman
Psychiatric Genetics and Genomics Book PDF

Author : Peter McGuffin,Michael J Owen,Irving I Gottesman
Publisher : Oxford University Press
Page : 508 pages
File Size : 43,7 Mb
Release : 2004-09-23
Category : Medical
ISBN : 0198564864

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Psychiatric Genetics and Genomics by Peter McGuffin,Michael J Owen,Irving I Gottesman Pdf

From reviews of the hardback:'It is timely to see such an excellent textbook... Aimed at graduate level students, this book is complex enough to be thorough, but clear with enough background to be accessible... the coverage is comprehensive and the flow logical... The text is uniformly well written and achieves a successful integration.' -The Lancet'A good introduction and reference book for professionals interested in psychiatric genetics such as psychiatrists, clinical psychologists and neuroscientists... the book you want to have on your bookshelf to look up material and obtain a complete and balanced picture of the field.' -Psychological MedicineRevised for paperback edition, with new appendicesGenetics promises to provide one of the most powerful approaches to understanding the functional pathology of the human brain. This book presents a critical review of the evidence for a genetic contribution to common psychiatric conditions and the rarer single-gene disorders that may have psychiatric presentations.The first section of the book introduces the reader to molecular biology and the techniques of molecular genetics. The coverage then moves on to consider the genetics of normal and abnormal development, followed by a look at the genetics of abnormal behaviour in adults. This section includes, amongst others, consideration of personality disorders, schizophrenia and the dementias. The final section considers the applications of the work and covers issues such as counselling and ethics, closing with a look to the future.The editors are internationally renowned figures in this field and they have invited a team of equally eminent chapter authors.Readership: Psychiatrists, clinical psychologists, geneticists, neuroscientists and neurologists

Psychiatric Genomics

Evangelia Eirini Tsermpini,Martin Alda,George P. Patrinos
Psychiatric Genomics Book PDF

Author : Evangelia Eirini Tsermpini,Martin Alda,George P. Patrinos
Publisher : Academic Press
Page : 416 pages
File Size : 43,9 Mb
Release : 2022-03-18
Category : Medical
ISBN : 9780128214008

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Psychiatric Genomics by Evangelia Eirini Tsermpini,Martin Alda,George P. Patrinos Pdf

Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, offering methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues. Finally, methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks, to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research. Thoroughly examines the genetic mechanisms underlying a broad range of psychiatric disorders Offers genomic methodologies and analytical approaches supporting new research and clinical translation, including personalized diagnosis and treatment models Features chapter contributions from international leaders in the field

Psychiatric Genetics

Thomas G. Schulze,Francis J. McMahon
Psychiatric Genetics Book PDF

Author : Thomas G. Schulze,Francis J. McMahon
Publisher : Oxford University Press
Page : 241 pages
File Size : 44,8 Mb
Release : 2018
Category : Medical
ISBN : 9780190221973

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Psychiatric Genetics by Thomas G. Schulze,Francis J. McMahon Pdf

Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of take home points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Thomas Lehner,Bruce L. Miller,Matthew W. State
Genomics Circuits and Pathways in Clinical Neuropsychiatry Book PDF

Author : Thomas Lehner,Bruce L. Miller,Matthew W. State
Publisher : Academic Press
Page : 796 pages
File Size : 53,9 Mb
Release : 2016-06-07
Category : Science
ISBN : 9780128005309

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Genomics, Circuits, and Pathways in Clinical Neuropsychiatry by Thomas Lehner,Bruce L. Miller,Matthew W. State Pdf

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Research Advances in Genetics and Genomics

Nancy C. Andreasen
Research Advances in Genetics and Genomics Book PDF

Author : Nancy C. Andreasen
Publisher : American Psychiatric Pub
Page : 164 pages
File Size : 52,8 Mb
Release : 2007-05-03
Category : Medical
ISBN : 9781585627103

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Research Advances in Genetics and Genomics by Nancy C. Andreasen Pdf

Research Advances in Genetics and Genomics: Implications for Psychiatry introduces mental health professionals to exciting breakthroughs in endophenotypes, animal models, microarrays, and genetic mapping, as well as general strategies for identifying the genetic mechanisms of mental illnesses. Uniquely valuable both as summary and signpost, this concise volume provides a fascinating overview of recent cutting-edge developments in the application of molecular genetics, genomics, and proteomics to the study of psychiatric populations. By reading Research Advances in Genetics and Genomics, you will gain a better understanding of Psychiatric Genetics -- Reviews and assesses the major research paradigms that have emerged in the field of psychiatric genetics over the several past decades, exploring the major conceptual and philosophical issues they pose and the value of their integration. Molecular Structure of Nucleic Acids -- An overview of the double-helix discovery and provides a context for current endeavors, the original one-page April 1953 Nature paper by Watson and Crick, which sparked a revolution in the life sciences. Psychiatry in the Genomics Era -- Posits that one of the most important consequences of genomics will be the development of individualized treatments that allow a clinician to tailor therapy on the basis of the unique genotype of each patient rather than on the mean responses of groups of unrelated patients. The Genomics Revolution -- Details the implications of the genome for future medical practice, including the potential for developing methods and tools to better understand, treat, and prevent major mental disorders. The Endophenotype Concept in Psychiatry -- Explains the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics, such as schizophrenia. The Genes and Brains of Mice and Men -- Shows why a detailed assessment of brain function in mice is so important for advancing psychiatric research in humans. Humans and mice share numerous features-in fact, for an estimated 99% of human genes a mouse version may be identified-of brain organization and behavioral responses to many pharmacological agents. Microarray Technology -- Asserts that microarrays present a methodology for identifying genes or pathways for new and unique potential drug targets, determining premorbid diagnosis, predicting drug responsiveness for individual patients, and, eventually, initiating gene therapy and prevention strategies. Meticulously referenced, this volume is exceptionally useful as a starting point for understanding the impact of genetics and genomics on psychiatry, serving to introduce psychiatrists, psychologists, neurologists, and geneticists to this exciting field.

Psychiatric Genetics

Jordan W. Smoller,Beth Rosen Sheidley,Ming T. Tsuang
Psychiatric Genetics Book PDF

Author : Jordan W. Smoller,Beth Rosen Sheidley,Ming T. Tsuang
Publisher : American Psychiatric Pub
Page : 340 pages
File Size : 44,7 Mb
Release : 2009-02-20
Category : Medical
ISBN : 9781585628797

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Psychiatric Genetics by Jordan W. Smoller,Beth Rosen Sheidley,Ming T. Tsuang Pdf

As more patients seek information about family risks of psychiatric illness -- an interest likely to increase as gene-identification studies are publicized -- most psychiatrists agree it is their role to discuss these issues but admit they are ill-prepared to do so. Psychiatric Genetics addresses that need as the first book to focus on clinical applications of genetics in psychiatry. It covers issues involved in genetic counseling, the interpretation of familial and genetic information for clinical use, information regarding risks associated with specific psychiatric disorders, risk/benefit considerations related to medication use during pregnancy, and the ethical and social implications of psychiatric genetic knowledge and research -- including the prospects for genetic testing. While other books have been written for the genetics community, this volume is addressed to practitioners: a clinically relevant resource that can help them understand the often bewildering flood of information about genetics -- information difficult to interpret, let alone integrate into practice -- and enable them to respond to patients' requests to predict the risk of recurrence of psychiatric illness or provide information about reproductive and pregnancy-related issues. Experts from psychiatry, genetic epidemiology, molecular genetics, genetic counseling, cognitive psychology, and ethics focus on issues that have received little attention elsewhere yet are of increasing importance to clinicians. Written at a level that assumes no particular expertise in genetics, the book features these immediately applicable benefits: It offers a framework for understanding and critically evaluating the psychiatric genetic research literature, enabling clinicians to better understand the meaning and limitations of genetic discoveries when patients raise questions about media reports. It provides a resource for clinicians who would like more information about the role and content of genetic counseling, outlining a typical counseling session while demonstrating how risks are estimated and discussed. It summarizes genetic aspects of major psychiatric conditions -- from childhood-onset disorders through psychotic, mood, and anxiety disorders to dementia -- as well as neuropsychiatric manifestations of other genetic disorders. It alerts clinicians to risk/benefit considerations related to medication use during pregnancy. It covers the ethical, legal, and social implications of genetic research and counseling, illustrating the dilemmas that arise with new advances. Whether used as a clinical guide, reference, or ancillary text, this book sets the standard for the application of psychiatric genetic knowledge in everyday practice. Psychiatrists, mental health clinicians, and genetic counselors will find it an essential resource for all patient encounters in which genetic issues arise.

Principles of Psychiatric Genetics

John I. Nurnberger, Jr,Wade Berrettini
Principles of Psychiatric Genetics Book PDF

Author : John I. Nurnberger, Jr,Wade Berrettini
Publisher : Cambridge University Press
Page : 415 pages
File Size : 44,9 Mb
Release : 2012-09-13
Category : Medical
ISBN : 9780521896498

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Principles of Psychiatric Genetics by John I. Nurnberger, Jr,Wade Berrettini Pdf

A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.

Psychiatric Genetics

Michael Arribas-Ayllon,Andrew Bartlett,Jamie Lewis
Psychiatric Genetics Book PDF

Author : Michael Arribas-Ayllon,Andrew Bartlett,Jamie Lewis
Publisher : Routledge
Page : 234 pages
File Size : 43,6 Mb
Release : 2019-02-21
Category : Social Science
ISBN : 9781317329633

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Psychiatric Genetics by Michael Arribas-Ayllon,Andrew Bartlett,Jamie Lewis Pdf

Psychiatric genetics has become ‘Big Biology’. This may come as a surprising development to those familiar with its controversial history. From eugenic origins and contentious twin studies to a global network of laboratories employing high-throughput genetic and genomic technologies, biological research on psychiatric disorders has become an international, multidisciplinary assemblage of massive data resources. How did psychiatric genetics achieve this scale? How is it socially and epistemically organized? And how do scientists experience this politics of scale? Psychiatric Genetics: From Hereditary Madness to Big Biology develops a sociological approach of exploring the origins of psychiatric genetics by tracing several distinct styles of scientific reasoning that coalesced at the beginning of the twentieth century. These styles of reasoning reveal, among other things, a range of practices that maintain an extraordinary stability in the face of radical criticism, internal tensions and scientific disappointments. The book draws on a variety of methods and materials to explore these claims. Combining genealogical analysis of historical literature, rhetorical analysis of scientific review articles, interviews with scientists, ethnographic observations of laboratory practices and international conferences, this book offers a comprehensive and detailed exploration of both local and global changes in the field of psychiatric genetics.

Psychiatric Genetics

Kenneth S. Kendler,Lindon J. Eaves
Psychiatric Genetics Book PDF

Author : Kenneth S. Kendler,Lindon J. Eaves
Publisher : American Psychiatric Pub
Page : 260 pages
File Size : 49,8 Mb
Release : 2007-05-03
Category : Medical
ISBN : 9781585627066

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Psychiatric Genetics by Kenneth S. Kendler,Lindon J. Eaves Pdf

Psychiatric Genetics is a concise reference that presents the complexities of this dynamic field in a clearly written, easily accessible format, with numerous tables and illustrations. Ten expert contributors offer a fascinating view of psychiatric genetics in a text that is thorough and scholarly yet also succinct and accessible. The introduction summarizes the field's four distinct paradigms -- and their interrelationships -- that help us understand the role of genetic factors in the etiology of psychiatric disorders: basic genetic epidemiology, which demonstrates heritability; advanced genetic epidemiology, which explores the nature and mode of action of these genetic risk factors; gene finding, which enables us to infer the probability that a locus in the genomic region under investigation contributes to psychiatric disorder liability; and molecular genetics, which traces the biological mechanisms by which the DNA variant identified using gene finding methods contributes to the disorder itself. Psychiatric Genetics illustrates the importance of Appreciating the complex field of psychiatric genetics -- Presents the major conceptual and statistical issues in psychiatric genetics, including many of the basic principles of both genetic epidemiology and gene finding, as well as a brief review of DNA itself. Detailing the results for one disorder where substantial progress had been made in gene finding and molecular genetics -- Covers schizophrenia, because of the substantial progress made during the past few years. Presenting results for a more typical and common set of psychiatric disorders where most of our information comes from basic and advanced genetic epidemiology and where we are just beginning to make advances using gene finding -- Discusses anxiety disorders, which illustrate these sets of issues. Covering disorders where major advances have been made using basic and advanced genetic epidemiology -- Details substance use disorders, where the paradigm has shifted from sociological to genetic factors and where, in contrast to the genetics of more traditional psychiatric disorders, researchers must consider the inherent conditionality of drug abuse. Investigating the role of genetics in personality disorders -- Focuses on the development of conduct and antisocial behavior and how to incorporate developmental processes into analyses of the role of genetics. Psychiatric Genetics draws students, educators, and practitioners alike into the exciting world of psychiatric genetics with a lively discussion of its broad trends and of the strengths and limitations of its methods to provide true insight into the etiology of psychiatric and substance use disorders.

Personalized Psychiatry

Bernhard Baune
Personalized Psychiatry Book PDF

Author : Bernhard Baune
Publisher : Academic Press
Page : 604 pages
File Size : 50,6 Mb
Release : 2019-10-16
Category : Medical
ISBN : 9780128131770

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Personalized Psychiatry by Bernhard Baune Pdf

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Handbook of Psychiatric Genetics

Kenneth Blum,Ernest P. Noble
Handbook of Psychiatric Genetics Book PDF

Author : Kenneth Blum,Ernest P. Noble
Publisher : CRC Press
Page : 530 pages
File Size : 52,6 Mb
Release : 1996-10-29
Category : Science
ISBN : 0849344867

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Handbook of Psychiatric Genetics by Kenneth Blum,Ernest P. Noble Pdf

Psychiatric genetics is an exciting new discipline that explores how our minds and behavior are influenced by our genes. Increased interest in this area of medical genetics has been sparked by advances in molecular genetic techniques, the genome project, the neurosciences, the role of genes in somatic diseases, and the linking of specific genes with complex mental disorders. This Handbook is the definitive resource on this complex, and sometimes controversial, new field.

Psychopathology in the Genome and Neuroscience Era

Charles F. Zorumski,Eugene H. Rubin,American Psychopathological Association
Psychopathology in the Genome and Neuroscience Era Book PDF

Author : Charles F. Zorumski,Eugene H. Rubin,American Psychopathological Association
Publisher : American Psychiatric Pub
Page : 256 pages
File Size : 51,5 Mb
Release : 2007-05-03
Category : Medical
ISBN : 9781585627172

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Psychopathology in the Genome and Neuroscience Era by Charles F. Zorumski,Eugene H. Rubin,American Psychopathological Association Pdf

The fascinating Psychopathology in the Genome and Neuroscience Era brings together selected topics in psychiatric genetics, epidemiology and prevention, and neuroscience and education. This key reference integrates this information across the fields of genetics, epidemiology, and neuroscience to arrive at an understanding of where recent advances in genetics and neuroscience -- advances that promise to enhance our understanding of human behavior and psychopathology -- are likely to influence psychopathology research and education in the near future. How will the field of psychopathology incorporate the coming avalanche of information generated by these recent advances? The answer will influence not only how mental health professionals diagnose and treat patients but also how the next generation of professionals is trained. Chapters in this exciting compilation are based on individual talks by 20 international experts at the conceptual forefront of their respective fields given at the March 2003 American Psychopathological Association annual meeting. Organized into four main sections -- the future of psychiatric genetics, diagnosis and prevention of psychiatric disorders, neurobiology and psychiatric disorders, and the future of psychiatric education -- Psychopathology in the Genome and Neuroscience Era focuses on a broad range of topics: The importance of a conceptual shift from identifying major genes for mental disorders to gaining an understanding of the role of which genes in which contexts, both biological and environmental, confer susceptibility to or protection from mental disorders or components thereof Historical perspective of gene susceptibility to mental disorders, with the same possibilities for use and misuse of genotype data as now exist for significantly heritable traits such as intelligence, and for borderline traits such as criminal behavior and alcoholism Reconceptualization of medicine and medical diagnoses to include molecular genetic components, including the importance of cell loss and neurogenesis in mood disorders Major phenotypic problems inherent in all attempts to measure psychopathology, starting with how to achieve reliability, and how to advance from reliability to validity in future revisions of DSM and ICD classifications Brain structural abnormalities in mood disorders; physiological cell death and whether or not this natural phenomenon can be converted into a pathological process, including the importance of cell loss and neurogenesis in mood disorders The influence of scientific advances, workforce issues, and educational trends on psychiatric training Psychopathology in the Genome and Neuroscience Era is a must-read reference work for anyone -- practitioners, residents, and students alike -- interested in the future of psychiatric genetics, epidemiology, and education.

Psychiatric Genetics

Thomas G. Schulze,Francis J. McMahon
Psychiatric Genetics Book PDF

Author : Thomas G. Schulze,Francis J. McMahon
Publisher : Unknown
Page : 128 pages
File Size : 41,6 Mb
Release : 2018
Category : Affective disorders
ISBN : 0190221984

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Psychiatric Genetics by Thomas G. Schulze,Francis J. McMahon Pdf

A straightforward introduction to the essentials of psychiatric genetics, covering basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of 'take home' points that summarises content, followed by a brief overview of current knowledge and suggestions for further reading.

Psychiatric Genetics

Marion Leboyer,Frank Bellivier
Psychiatric Genetics Book PDF

Author : Marion Leboyer,Frank Bellivier
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 55,6 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592593484

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Psychiatric Genetics by Marion Leboyer,Frank Bellivier Pdf

Psychiatric Genetics provides the reader with a complete view of the methodological problems encountered in psychiatry genetics and proposes solutions to commonly occurring questions. The best European and American specialists have given a thorough review on the advantages and disadvantages of genetic epidemiological methods, the way to choose a genetic marker or a clinical interview and how to ascertain patients, unaffected relatives and controls and what should be the criteria to include a case or a control. New phenotypic methods are described focusing on candidate symptom and endophenotype approaches. Examples coming from cognitive neurosciences, biochemistry, electrophysiology and brain imaging techniques are reviewed. This book will serve as an essential handbook for psychiatrists, psychologists, and geneticists involved in the genetics of psychiatric disorders.

Madness and Genetic Determinism

Patrick D. Hahn
Madness and Genetic Determinism Book PDF

Author : Patrick D. Hahn
Publisher : Springer
Page : 196 pages
File Size : 49,5 Mb
Release : 2019-07-11
Category : Psychology
ISBN : 9783030218669

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Madness and Genetic Determinism by Patrick D. Hahn Pdf

The book covers important topics in the psychiatric genetics (PG) field. Many of these have been overlooked in mainstream accounts, and many contemporary PG researchers have omitted or whitewashed the eugenic and “racial hygiene” origins of the field. The author critically analyzes PG evidence in support of genetic claims which, given the lack of gene discoveries, are based mainly on the results of psychiatric twin and adoption studies. Given that the evidence in favor of genetic influences is much weaker than mainstream sources report, due to serious issues in twin and adoption research, the author points to environmental factors, including trauma, as the main causes of conditions such as schizophrenia.