Genomics Circuits And Pathways In Clinical Neuropsychiatry

Author : Thomas Lehner,Bruce L. Miller,Matthew W. State
Publisher : Academic Press
Page : 796 pages
File Size : 49,7 Mb
Release : 2016-06-07
Category : Science
ISBN : 9780128005309

Get Book

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry by Thomas Lehner,Bruce L. Miller,Matthew W. State Pdf

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Author : Kursad Turksen
Publisher : Springer Nature
Page : 163 pages
File Size : 41,6 Mb
Release : 2020-08-27
Category : Science
ISBN : 9783030549176

Get Book

Cell Biology and Translational Medicine, Volume 9 by Kursad Turksen Pdf

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the ninth volume of a continuing series.

Author : Suellen Thomson-Link
Publisher : Springer Nature
Page : 203 pages
File Size : 45,8 Mb
Release : 2023-10-26
Category : Psychology
ISBN : 9783031403200

Get Book

Complex Trauma Regulation in Children by Suellen Thomson-Link Pdf

This book outlines both the theory and application of regulation intervention strategies for children with complex trauma history. National statistics identify that 1:7 children in the United States are subjected to child abuse or neglect. The age group with the highest reported incidences are in the 1-3 year old age group. The primary perpetrators of this abuse are the child’s caregivers. This age is closely associated with the critical period of development in the areas of the brain, the child’s physiology and their social/emotional well being. When primary attachment is disrupted, delays and disruptions across many domains occur. When the perpetrator of their trauma is the same person who should be ensuring their safety, a child develops behaviors in an attempt to make sense of their world. The behaviors serve a purpose. Behavioral approaches which rely on positive and negative consequences do not adequately address the cause of the behavior and are therefore ineffective. Other existing trauma interventions rely on the individual to cognitively process information. However, when dysregulated, retrieval of information from the frontal lobe of the brain is not physiologically possible. All these approaches also intervene on the assumption that the child knows what normal regulation feels like. Most of these children however have only known chaos and fear novelty. This attachment based intervention model incorporates neurological, physiological, observational and practical regulation intervention strategies for anyone working with children with complex trauma history. It is able to be applied in home, school, community and in therapy environments. When a child feels regulated and safe, the effectiveness of the child’s trauma treatment can be enhanced.

Author : Joao Quevedo,Andre Ferrer Carvalho,Eduard Vieta
Publisher : Academic Press
Page : 472 pages
File Size : 45,7 Mb
Release : 2020-11-25
Category : Medical
ISBN : 9780128191835

Get Book

Neurobiology of Bipolar Disorder by Joao Quevedo,Andre Ferrer Carvalho,Eduard Vieta Pdf

The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Author : Richard McCarty
Publisher : Oxford University Press
Page : 384 pages
File Size : 40,9 Mb
Release : 2020-04-01
Category : Psychology
ISBN : 9780190697273

Get Book

Stress and Mental Disorders by Richard McCarty Pdf

Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.

Author : Michael S. Wolfe
Publisher : Academic Press
Page : 676 pages
File Size : 51,9 Mb
Release : 2016-05-27
Category : Medical
ISBN : 9780128021644

Get Book

Developing Therapeutics for Alzheimer's Disease by Michael S. Wolfe Pdf

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Author : Rolando T. Lazaro,Sandra G. Reina-Guerra,Myla Quiben
Publisher : Elsevier Health Sciences
Page : 1414 pages
File Size : 49,5 Mb
Release : 2019-12-05
Category : Medical
ISBN : 9780323641944

Get Book

Umphred's Neurological Rehabilitation - E-Book by Rolando T. Lazaro,Sandra G. Reina-Guerra,Myla Quiben Pdf

Develop problem-solving strategies for individualized, effective neurologic care! Under the new leadership of Rolando Lazaro, Umphred’s Neurological Rehabilitation, 7th Edition, covers the therapeutic management of people with activity limitations, participation restrictions, and quality of life issues following a neurological event. This comprehensive reference reviews basic theory and addresses the best evidence for evaluation tools and interventions commonly used in today's clinical practice. It applies a time-tested, evidence-based approach to neurological rehabilitation that is perfect for both the classroom and the clinic. Now fully searchable with additional case studies through Student Consult, this edition includes updated chapters and the latest advances in neuroscience. Comprehensive reference offers a thorough understanding of all aspects of neurological rehabilitation. Expert authorship and editors lend their experience and guidance for on-the-job success. UNIQUE! A section on neurological problems accompanying specific system problems includes hot topics such as poor vision, vestibular dysfunction, dementia and problems with cognition, and aging with a disability. A problem-solving approach helps you apply your knowledge to examinations, evaluations, prognoses, and intervention strategies. Evidence-based research sets up best practices, covering topics such as the theory of neurologic rehabilitation, screening and diagnostic tests, treatments and interventions, and the patient's psychosocial concerns. Case studies use real-world examples to promote problem-solving skills. Comprehensive coverage of neurological rehabilitation across the lifespan — from pediatrics to geriatrics. Terminology adheres to the best practices, follows The Guide to Physical Therapy Practice and the WHO-ICF World Health model. NEW! enhanced eBook on Student Consult. UPDATED! Color photos and line drawings clearly demonstrate important concepts and clinical conditions students will encounter in practice. NEW and EXPANDED! Additional case studies and videos illustrate how concepts apply to practice. Updated chapters incorporate the latest advances and the newest information in neurological rehabilitation strategies. NEW and UNIQUE! New chapter on concussion has been added. Separate and expanded chapters on two important topics: Balance and Vestibular.

Author : Mardi J. Horowitz
Publisher : American Psychiatric Pub
Page : 110 pages
File Size : 44,8 Mb
Release : 2020-09-06
Category : Medical
ISBN : 9781615373673

Get Book

Treatment of Stress Response Syndromes by Mardi J. Horowitz Pdf

Stress is a universal condition. However, severe stress related to loss, trauma, and/or terror necessitates an integrated approach, one that was pioneered nearly 20 years ago with the publication of Treatment of Stress Response Syndromes. This classic text has been updated and revised for our times, reflecting changes in DSM-5, which introduced a new category of diagnoses called trauma- and stressor-related disorders. This new edition updates treatment recommendations for these disorders and emphasizes formulation for determining appropriate therapeutic strategies. The author's method is assessment-based and does not compartmentalize its recommendations into treatment modalities such as cognitive-behavioral therapy, prolonged exposure, or cognitive processing therapy. Instead, the book takes an integrative and transtheoretical approach that emphasizes repeated assessments, resulting in treatment plans that are individualized, flexible, and more responsive to patient changes. Clinicians plan interventions based on the current state of mind of patients as they progress through the processing of traumatic events. The new edition reflects evolution in the field, including the following: The cross-theoretical approach helps practitioners integrate previously acquired clinical concepts without limiting them to one treatment modality or school of thought, enhancing their ability to respond to patient needs. Assessment can be used throughout all phases of treatment, which leads to the possibility of enhancing emotional control, advancing attachment models, and consolidating identity. Because of the financial constraints of insurance coverage or military troop availability, many treatment guidelines for PTSD focus on brief therapy; however, this book stresses the need for therapies of the length required to provide full benefit to patients and to lead to personality growth. In addition, the inclusion of illustrative cases anchors techniques to pragmatic actions, engaging readers and focusing them on the most critically important concepts. End-of-chapter summaries allow review of key principles, and pertinent tables and figures condense essential information for easy understanding and retrieval. Of great practical value for psychotherapists and other mental health professionals working with patients experiencing the effects of serious life events, Treatment of Stress Response Syndromes is the definitive guide to the psychotherapy and management of acute stress and PTSD, combining clear and compelling case descriptions with the eloquent presentation of therapeutic technique.

Author : Jessica D. Tenenbaum,Piper A. Ranallo
Publisher : Springer Nature
Page : 540 pages
File Size : 40,7 Mb
Release : 2021-11-18
Category : Medical
ISBN : 9783030705589

Get Book

Mental Health Informatics by Jessica D. Tenenbaum,Piper A. Ranallo Pdf

This textbook provides a detailed resource introducing the subdiscipline of mental health informatics. It systematically reviews the methods, paradigms, tools and knowledge base in both clinical and bioinformatics and across the spectrum from research to clinical care. Key foundational technologies, such as terminologies, ontologies and data exchange standards are presented and given context within the complex landscape of mental health conditions, research and care. The learning health system model is utilized to emphasize the bi-directional nature of the translational science associated with mental health processes. Descriptions of the data, technologies, paradigms and products that are generated by and used in each process and their limitations are discussed. Mental Health Informatics: Enabling a Learning Mental Healthcare System is a comprehensive introductory resource for students, educators and researchers in mental health informatics and related behavioral sciences. It is an ideal resource for use in a survey course for both pre- and post-doctoral training programs, as well as for healthcare administrators, funding entities, vendors and product developers working to make mental healthcare more evidence-based.

Author : Mark S. Fife,John A. Hammond,Andrea B. Doeschl-Wilson
Publisher : Frontiers Media SA
Page : 192 pages
File Size : 40,5 Mb
Release : 2020-02-14
Category : Electronic
ISBN : 9782889635238

Get Book

Animal Genetics and Diseases: Advances in Farming and Livestock Systems by Mark S. Fife,John A. Hammond,Andrea B. Doeschl-Wilson Pdf

The new Animal Genetics and Disease 2017 conference committee organized a Research Topic for the proceedings of this inaugural conference. The meeting brought together specialists working on the interface between genomics, genetic engineering, and infectious disease, with the aims of improving animal and human health and welfare. This conference was funded by Advanced Courses and Scientific Conference at the Wellcome Genome Campus, Hinxton, UK. The conference will highlight breakthroughs in genomic technologies that are rapidly increasing our understanding of the fundamental role that host and pathogen genetics play in infections and epidemics. This Research Topic focuses on how infections spread and how they further affect the productivity of livestock systems and food supply chains. Thanks to technological advances, we now have the tools for real-time surveillance of zoonoses affecting wildlife, farm animals and animal-to-human disease transmission.

Author : Almir Badnjević,Lejla Gurbeta Pokvić
Publisher : Springer Nature
Page : 773 pages
File Size : 54,5 Mb
Release : 2024-01-03
Category : Technology & Engineering
ISBN : 9783031490682

Get Book

MEDICON’23 and CMBEBIH’23 by Almir Badnjević,Lejla Gurbeta Pokvić Pdf

This book presents cutting-edge research and developments in the broad field of medical, biological engineering and computing. It gathers the second volume of the joint proceedings of the Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON) and the International Conference on Medical and Biological Engineering (CMBEBIH), which were held together on September 14-16, 2023, in Sarajevo, Bosnia and Herzegovina. Contributions report on innovative research and practices in molecular biology, tissue engineering and biotechnologies, covering not only medical but also industrial applications. Further, they describe advances in health technologies and medical devices, telemedicine, and robotic applications in clinical medicine and rehabilitation.

Author : Mohammad Amjad Kamal,Athanasios Alexiou,Asma Perveen
Publisher : Frontiers Media SA
Page : 202 pages
File Size : 45,8 Mb
Release : 2024-04-15
Category : Science
ISBN : 9782832547731

Get Book

The Alzheimer's Disease Challenge, Volume II by Mohammad Amjad Kamal,Athanasios Alexiou,Asma Perveen Pdf

Given the success of Volume I of this Research Topic, we are pleased to announce the launch of Volume II: “The Alzheimer's Disease Challenge”. The repeated failure of clinical trials on the amyloid-based medications and the pessimistic calculations of Alzheimer's disease cost burden for the next few decades present a severe challenge to humankind with severe social implications. In recent years, several alternative diagnostic and treatment procedures have been presented to treat and manage Alzheimer’s disease as it has been nearly impossible to suggest a holistic solution. Several revelations in human biology have highlighted the multiparametric character of the disease. Besides the amyloid aggregation and neurofibrillary tangles that result in Aβ toxicity and tau phosphorylation, processes such as Gene Mutations, Proteins Misfolding, Brain Biochemical and Histopathological Changes, Behavioral Changes, Nutrition and Metabolism Alterations, and Autonomic Dysfunctions due to Central Nervous System dysregulations are common signs and probably early diagnostic biomarkers in most of the Alzheimer's classification categories.

Author : Bruce Miller,Ian Robertson,Niall Kavanagh,Victor Valcour
Publisher : Frontiers Media SA
Page : 142 pages
File Size : 49,8 Mb
Release : 2024-03-12
Category : Science
ISBN : 9782832546192

Get Book

The Neurobiology of Values by Bruce Miller,Ian Robertson,Niall Kavanagh,Victor Valcour Pdf

Author : Hilary Burton,Alison Hall,M. Kroese,Sobia Raza
Publisher : Unknown
Page : 37 pages
File Size : 40,9 Mb
Release : 2017
Category : Electronic
ISBN : 190719830X

Get Book

Genomics in Mainstream Clinical Pathways by Hilary Burton,Alison Hall,M. Kroese,Sobia Raza Pdf

Author : Carol A. Tamminga MD,Jim van Os MD, PhD, MRCPsych,Ulrich Reininghaus PhD, MSc, Dipl.-Psych.,Elena Ivleva MD, PhD
Publisher : Oxford University Press
Page : 400 pages
File Size : 49,8 Mb
Release : 2020-10-20
Category : Medical
ISBN : 9780190653293

Get Book

Psychotic Disorders by Carol A. Tamminga MD,Jim van Os MD, PhD, MRCPsych,Ulrich Reininghaus PhD, MSc, Dipl.-Psych.,Elena Ivleva MD, PhD Pdf

Psychotic Disorders: Comprehensive Conceptualization and Treatments emphasizes a dimensional approach to psychosis--one of the most fascinating manifestations of altered brain behavior--that cuts across a broad array of psychiatric diagnoses from schizophrenia to affective psychosis and organic disorders like epilepsy and dementias. Written by an international roster of over seventy leading experts in the field, this volume comprehensively reviews, critiques, and integrates available knowledge on the etiology, mechanisms, and treatments of psychotic disorders, and outlines ways forward in both research and clinical practice towards more objective, mechanistically-based definitions of psychotic disorders. Chapters address topics such as psychosis phenomenology, biomarkers and treatments, the overlaps and interfaces between psychiatric disorders within the psychosis dimension, and novel disease definitions. Furthermore, the volume incorporates findings on potential mechanisms, bridges between various system levels (i.e., genetic, epigenetic, molecular and cellular, brain circuit and function, psychological, social, environmental and cultural) and their interactions, as well as the potential role in causation and/or mediation in psychotic disorders. Finally, the volume outlines a broad array of treatment approaches, from the readily available (e.g., psychopharmacology, various modalities of psychotherapy) to the experimental (e.g., cognitive interventions, neuromodulation). With a concluding section of forward perspectives conjecturing future directions and related challenges, this book aspires to stimulate new knowledge, generate novel frameworks, and carry new directions forward on psychotic disorders.