Quinolone Antibacterials

Author : Jochen Kuhlmann,A. Dalhoff,H.-J. Zeiler
Publisher : Springer Science & Business Media
Page : 505 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642803642

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Quinolone Antibacterials by Jochen Kuhlmann,A. Dalhoff,H.-J. Zeiler Pdf

It has been over 30 years since the first clinically important member of the quinolone class, nalidixic acid, was introduced into medical practice. The modification produced in the quinolone nucleus by introducing a fluorine at the 6-position led to the discovery of the newer fluoroquinolones with enhanced antibacterial activities as compared to nalidixic acid. By now a great deal of preclinical and clinical experience has been obtained with these agents. The intense interest in this class of antibacterial agents by chemists, micro biologists, toxicologists, pharmacologists, clinical pharmacologists, and clini cians in various disciplines encouraged us to summarize the information on the history, chemistry, mode of action and in vitro properties, kinetics and efficacy in animals, mechanisms of resistance, toxicity, clinical pharmacology, clinical experience, and future prospects in one volume of the Handbook of Experimental Pharmacology. As this series deals predominantly with "experimental" characteristics of drugs, our volume is dedicated specifically to quinolones and emphasizes principally their preclinical and clinical phar macological characteristics, despite the existence of several summaries on quinolones. The chemistry of the quinolones is described in detail. The chapter on the mode of action of quinolones reports the conclusive evidence that gyrase is the intracellular target of the quinolones; however, another enzyme, topoisomerase IV, may also be a target for quinolones, and the exact mechanisms by which quinolones act bactericidally are far from being understood.

Author : Vincent T. Andriole
Publisher : Academic Press
Page : 275 pages
File Size : 48,6 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483216034

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The Quinolones by Vincent T. Andriole Pdf

The Quinolones covers reviews on the history, chemistry and mechanism of action, in vitro properties, pharmacokinetics, clinical overview, toxicity, adverse effects and drug interactions, and future prospects of the 4-quinolones. The book discusses the microbiology of quinolones, particularly with consideration of the development of resistance, pharmacology, toxicology, and clinical uses. Chemists, microbiologists, pharmacologists and clinicians will find the book useful.

Author : David C. Hooper,John S. Wolfson
Publisher : Unknown
Page : 572 pages
File Size : 42,6 Mb
Release : 1993
Category : Medical
ISBN : UOM:39015032097993

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Quinolone Antimicrobial Agents by David C. Hooper,John S. Wolfson Pdf

Quinolones remain the most important class of antimicrobial agents discovered in recent years – over 1000 have been synthesized and evaluated. Since the publication of the original edition, considerable strides have been made in the research on structure–activity relationships, mechanism of action, resistance, pharmacodynamics and drug interactions. This edition consolidates and substantially updates our current state of knowledge of quinolones, with thirteen new chapters having been added.

Author : Geoff C. Crumplin
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781447134497

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The 4-Quinolones: Anti Bacterial Agents in Vitro by Geoff C. Crumplin Pdf

The 4-quinolone antibacterial agents have been under development and in use for over 25 years, but despite an enormous body of research work there are still many basic questions that remain unanswered. For example, we do not know how these agents kill susceptible cells - or even how the drugs interact with the target mol- ecule(s). However, we do know that the 4-quinolones display many properties which are not shared with any other group of antibacterial agents. This book raises the unanswered questions and assesses the potential significance to future chemotherapy of their unique features. The book also raises matters which are significant for physicians as well as for the pharmaceutical industry and the assessment of these agents by legislative bodies concerned with drug safety.

Author : Allan R. Ronald,Donald Low
Publisher : Birkhäuser
Page : 263 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034881036

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Fluoroquinolone Antibiotics by Allan R. Ronald,Donald Low Pdf

The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, they became important agents for treating hospital-acquired infections. This volume covers their mechanisms of action, resistance mechanisms and epidemiology, pharmacokinetics, safety and clinical applications. Their effectiveness for respiratory, urinary, sexually transmitted, skin, soft tissue, bone and joint infections, infections of the eyes, ears, nose and throat, and less common infections such as mycobacterial, Brucella and others are reviewed. Also described is their use in pediatric, oncology and immunocompromised patients. The quinolone story continues to be intriguing with exciting future implications.This monograph is an important comprehensive review and update for researchers and clinicians in pharmacology, clinical medicine, molecular and cell biology, epidemiology and the pharmaceutical industry.

Author : Jón Karlsson,James D. F. Calder,C. N. van Dijk,Nicola Maffulli,Hajo Thermann
Publisher : Unknown
Page : 426 pages
File Size : 40,9 Mb
Release : 2014
Category : Achilles tendon
ISBN : 0955887348

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Achilles Tendon Disorders by Jón Karlsson,James D. F. Calder,C. N. van Dijk,Nicola Maffulli,Hajo Thermann Pdf

Author : David C. Hooper,Ethan Runbinstein
Publisher : Unknown
Page : 485 pages
File Size : 46,9 Mb
Release : 2003
Category : Bacterial diseases
ISBN : 1555817815

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Quinolone Antimicrobial Agents by David C. Hooper,Ethan Runbinstein Pdf

Author : Anonim
Publisher : ScholarlyEditions
Page : 59 pages
File Size : 51,9 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464942792

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Fluoroquinolone Antibiotics: Advances in Research and Application: 2011 Edition by Anonim Pdf

Fluoroquinolone Antibiotics: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Fluoroquinolone Antibiotics in a concise format. The editors have built Fluoroquinolone Antibiotics: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Fluoroquinolone Antibiotics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fluoroquinolone Antibiotics: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Johannes Ring,Bernhard Przybilla
Publisher : Springer Science & Business Media
Page : 577 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642467172

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New Trends in Allergy III by Johannes Ring,Bernhard Przybilla Pdf

The international symposium "New Trends in Allergy", held in Munich from July 13 to 15, 1990, brought together for the third time since 1980 some of the most experienced researchers working in the field of allergy. This volume comprises the papers presented at this meeting. All over the world, and not merely in the industrialized countries, allergy is becoming a cause of evermore serious diseases. In recent years, research in the field of allergy has provided numerous impor tant and fascinating results extending our knowledge considerably. Despite the new insights into basic mechanisms of allergic reactions, improved diagnostic methods, and new therapeutic approaches, how ever, many questions remain to be answered, including: Are allergies really increasing in frequency? If so, what are the reasons? Especially, does environmental pollution playa role? Which factors influence IgE synthesis? Can the IgE immune response be switched off? Does the nervous system interact with allergic reactions? If so, what are the mechanisms? Are new approaches in allergy prophylaxis and allergy therapy effi cient? What measures have proven useful and deserve to be employed in daily practice? In this volume, these questions and other current topics are dealt with. As each issue is covered by authors competent in the respective fields, the result is an extensive and critical review of the state of the art. Going through these papers, one comes to the conviction that allergy research is a multifacetted, explosively expanding, most stimulating field of work.

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 43,9 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Author : S.L. Dax
Publisher : Springer Science & Business Media
Page : 409 pages
File Size : 48,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400900974

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Antibacterial Chemotherapeutic Agents by S.L. Dax Pdf

Over the past 50 years a wide variety of antibacterial substances have been discovered and synthesised, and their use in treating bacterial infection has been spectacularly successful. Today there are several general classes of antibacterial drugs, each having a well established set of uses, and together they form the mainstay of modern antibacterial chemotherapy. In search for new and improved agents, the pharmaceutical researcher needs to be well informed on many topics, including existing agents, their modes of action and pharmacology, and possible synthetic approaches. In this new book the author has brought together a wide range of information on the principal classes of antibacterial agents, and he covers, for each group, their history, mode of action, key structural features, synthesis and bacterial resistance. The result is a compact and concise overview of these very important classes of antibacterial agents.

Author : Anonim
Publisher : ScholarlyEditions
Page : 51 pages
File Size : 43,6 Mb
Release : 2013-06-21
Category : Medical
ISBN : 9781481687935

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Fluoroquinolone Antibiotics—Advances in Research and Application: 2013 Edition by Anonim Pdf

Fluoroquinolone Antibiotics—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Ciprofloxacin in a concise format. The editors have built Fluoroquinolone Antibiotics—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ciprofloxacin in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fluoroquinolone Antibiotics—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Varaprasad Bobbarala
Publisher : BoD – Books on Demand
Page : 212 pages
File Size : 54,5 Mb
Release : 2015-12-09
Category : Medical
ISBN : 9789535122326

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Concepts, Compounds and the Alternatives of Antibacterials by Varaprasad Bobbarala Pdf

This edition is intended to provide better understanding of antibacterial drugs and their mechanism, the role of a few metal drug complexes as antibacterials, cross-checking of a few compounds and biomaterials against drug-resistant bacterial strains as well as a few alternative approaches using medicinal plant based formulations in the control of antibiotic-resistant bacteria. The information in this book provides clues for upcoming trends in treating antibiotic resistance problems with which one can explore new approaches in the treatment of common infections with drug-resistant strains.

Author : Neil Kaplowitz
Publisher : CRC Press
Page : 784 pages
File Size : 47,7 Mb
Release : 2002-10-16
Category : Medical
ISBN : 9780203909126

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Drug-Induced Liver Disease by Neil Kaplowitz Pdf

Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.

Author : Roger Finch,Peter Davey,Mark H. Wilcox,William Irving
Publisher : OUP Oxford
Page : 409 pages
File Size : 40,7 Mb
Release : 2012-01-05
Category : Medical
ISBN : 9780191628658

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Antimicrobial Chemotherapy by Roger Finch,Peter Davey,Mark H. Wilcox,William Irving Pdf

Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the need for a thorough understanding of the advantages and risks associated with specific antibiotic choices. This sixth edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs. This new edition is updated to include the most recently licensed agents, notably in the treatment of viral infections including HIV/AIDS, and contains new guidance on prescribing practice and infection control practices that limit the development and spread of resistant organisms.