Ras And Cancer In The 21st Century

Author : Linda VanAelst,Frank McCormick
Publisher : Perspectives Cshl
Page : 300 pages
File Size : 40,7 Mb
Release : 2018
Category : Medical
ISBN : 1621822214

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Ras and Cancer in the 21st Century by Linda VanAelst,Frank McCormick Pdf

Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally active Ras proteins are common in human cancers, particularly those of the pancreas, lung, and colon. These cancers can be difficult to treat because Ras oncoproteins have long been considered 'undruggable.' Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids). The authors also discuss how organoids and mouse models are being used to study tumor progression and therapeutic efficacy. This volume is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with understanding and treating Ras-driven cancers.

Author : Steven Ransom
Publisher : Unknown
Page : 249 pages
File Size : 48,5 Mb
Release : 2002
Category : Cancer
ISBN : 1904015077

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Great News about Cancer by Steven Ransom Pdf

Author : Antonio Llombart-Bosch,Vicente Felipo
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461500810

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New Trends in Cancer for the 21st Century by Antonio Llombart-Bosch,Vicente Felipo Pdf

Given the latest advances in cancer research, which includes basic research and its derived diagnostic, clinical, and therapeutic applications, the book New Trends in Cancer for the 21st Century is written by individuals such as molecular biologists, whose tasks are to decipher, after sequencing the human genome, those new genes and pathways involved in the carcinogenesis process; clinical and molecular pathologists, who apply these discoveries for the molecular diagnosis and characterization of the tumor; and clinical oncologists, who treat patients. Pharmacogenetics introduces new perspectives in the translational fields with the design of drugs against specific targets, which at this moment are in clinical trials phases. This book achieves a state of the art in every field of cancer research and discusses the new perspectives that will open the future for cancer treatment (basic research, new technologies, new drugs, therapies...). For this reason, the book is intended for pathologists, clinicians, and biologists, as well as fellows and students of physiology and medicine.

Author : Pier Paolo Claudio,Paraskevi Vogiatzi
Publisher : Bentham Science Publishers
Page : 529 pages
File Size : 49,7 Mb
Release : 2014-04-23
Category : Medical
ISBN : 9781608058808

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Cutting Edge Therapies for Cancer in the 21st Century by Pier Paolo Claudio,Paraskevi Vogiatzi Pdf

Cancer is a broad group of diseases involving unregulated cell growth with elevated death rates as more people live in old age with mass lifestyle changes occurring in the world. The causes of cancer are diverse, complex, and still only partially understood. The chances of surviving the disease vary remarkably by the type and location of the malignancy and the extent of disease at the start of treatment. Early cancer detection is proving to be a valid approach. Cancer can be detected in a number of ways, including the presence of certain signs and symptoms, screening tests, or medical imaging. Cancer therapy is dynamically changing and revision and change in patient management is constant as our knowledge increases. Cancer is routinely treated with chemotherapy, radiation therapy and surgery. Tailored cancer targeted therapy is becoming an emerging objective of today. In this book, a constructive group of cancer research experts bring the reader their shared vision, to give an extensive and realistic view of individual tumors such as breast, oral, prostate, gastric, and neuroendocrine tumors. New and contemporary terms and concepts in genetics and epigenetics, diet, anticancer treatments, and anticancer drug delivery systems are introduced in this volume. This reference highlights present experimental strategies and key findings that enhance our understanding of cancer and of future therapies. This eBook is aimed at a broad audience of undergraduates, medical students, PhDs, cancer researchers, and also cancer patient families with the goal to conceive a curiosity about the subjects presented that will hopefully lead to further studies.

Author : Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee to Study Priorities for Vaccine Development
Publisher : National Academies Press
Page : 473 pages
File Size : 53,8 Mb
Release : 2001-03-21
Category : Medical
ISBN : 9780309056465

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Vaccines for the 21st Century by Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee to Study Priorities for Vaccine Development Pdf

Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

Author : E.C. Beuvery,W.P. Zeijlemaker,J.B. Griffiths
Publisher : Springer Science & Business Media
Page : 1083 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401104371

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Animal Cell Technology: Developments towards the 21st Century by E.C. Beuvery,W.P. Zeijlemaker,J.B. Griffiths Pdf

Animal cell technology is a discipline of growing importance, which aims not merely at understanding structure, function and behaviour of differentiated animal cells, but especially at the development of their abilities useful for clinical application. Topics of interest in this regard include: viral vaccines, pharmaceutical proteins and novel applications such as gene therapy and organ culture. Undoubtedly, these Proceedings of the joint Meeting of the European Society for Animal Cell Technology and the Japanese Association for Animal Cell Technology (Veldhoven, The Netherlands, September 1994) review the most recent status of the field, and will be most valuable to anyone actively involved in the culture of animal cells and its applications. The contributions to this volume were strictly selected on the basis of quality and novelty of contents. Kluwer is honoured to be able to add this work to its strongly developing publication programme in cell and tissue culture, which now has its connections to all major Societies in this field worldwide. Audience: Cell biologists, biochemists, molecular biologists, immunologists, virologists and all other disciplines related to animal cell technology, working in an academic environment, as well as in (biotechnology or pharmaceutical) industry.

Author : Vijay Kumar,Alexandro Aguilera Salgado,Seyyed Shamsadin Athari
Publisher : BoD – Books on Demand
Page : 304 pages
File Size : 53,7 Mb
Release : 2022-01-26
Category : Medical
ISBN : 9781839686412

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Inflammation in the 21st Century by Vijay Kumar,Alexandro Aguilera Salgado,Seyyed Shamsadin Athari Pdf

The present book includes 17 chapters covering different fields of inflammation that can be classified into acute or chronic in response to trauma, infection, and exposure to other noninfectious agents, including allergens and xenobiotics. Inflammation is a self-healing process, upon the clearance of the foreign particle and helps to protect the host. However, when it is not resolved and becomes chronic, it may lead to cancer and autoimmune diseases. This book includes different topics of autoimmune diseases, cancer, and other sterile inflammatory conditions originating in the absence of allergens as well as autoimmune disease and generates inflammatory immune response. Hence, the book will prove beneficial to researchers and scientists involved in inflammation research.

Author : Krishnansu S Tewari,Bradley J Monk
Publisher : Springer
Page : 211 pages
File Size : 40,5 Mb
Release : 2015-01-13
Category : Medical
ISBN : 9783319080666

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The 21st Century Handbook of Clinical Ovarian Cancer by Krishnansu S Tewari,Bradley J Monk Pdf

A thorough review on ovarian cancer, treatment guidelines and emerging therapies available for the disease. The book was originally commissioned due to recent developments in therapies for ovarian cancer. This concise pocket book will review ovarian cancer’s epidemiology, clinical features, diagnosis and medical management. Busy healthcare professionals will benefit from this text, which will not only cover the foundation of ovarian cancer management, but discuss up-to-date national and international treatment guidelines and upcoming therapies.

Author : Yvonne Rue
Publisher : Royal Society of Medicine Press
Page : 260 pages
File Size : 46,5 Mb
Release : 1988
Category : Biology
ISBN : UOM:39015013223451

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A Perspective on Biology and Medicine in the 21st Century by Yvonne Rue Pdf

Author : G. Creatsas,George Mastorakos,George P. Chrousos
Publisher : Unknown
Page : 472 pages
File Size : 45,6 Mb
Release : 2000
Category : Adolescent gynecology
ISBN : UVA:X004443515

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The Young Woman at the Rise of the 21st Century by G. Creatsas,George Mastorakos,George P. Chrousos Pdf

This volume explores the recent advances in basic research on the gynecological issues facing young women, and how they apply clinically. Topics examined include neuroendocrinology of the menstural cycle; the endocrinolgy of implantation; prenatal diagnosis; the endocrinology of human gestation and parturition; molecular biology and genetics relative to the estrogen receptor, ovarian dysfunction and gynecologic cancer; perinatal care in maternal and fetal well being; obesity and the polycstic ovarian syndrome; anemia and pregnancy; oral contraceptives and their effects on arteries and veins; the estrogen-deficiency syndrome; osteoporosis in young women; endoscopic surgery; sexually transmitted diseases in common practice; and fertility potential in young women.

Author : Gul Erdemli,Birgit T Priest
Publisher : Frontiers Media SA
Page : 68 pages
File Size : 47,8 Mb
Release : 2015-04-21
Category : Science (General)
ISBN : 9782889194698

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Phenotypic screening in the 21st century by Gul Erdemli,Birgit T Priest Pdf

In the genomic era of 1990s-2000s, pharmaceutical research moved to target-based drug discovery which enabled development of a number of small molecule drugs against a wide range of diseases. In many cases however, drugs that arose from genomics failed, questioning the validity of the targets and the suitability of target-based drug discovery as an optimal strategy for all disease states. For monogenic diseases, target-based approaches may be well-suited to the identification of novel therapies. Most diseases, however, are caused by a combination of several genetic and environmental factors and are likely to require simultaneous modulation of multiple molecular targets/pathways for successful treatment. For such diseases, reductionist approaches focusing on individual targets rather than biological networks are unlikely to succeed and new drug development strategies are required. In search of more successful approaches, the pharmaceutical industry is moving towards phenotypic screening beyond individual genes/targets. However, this requires rethinking of diseases and drug discovery approaches from a network and systems biology perspective. Since returning to the pre-genomics era of screening drug candidates in laborious animal models is not a feasible solution, the industry needs to evolve a new paradigm of phenotypic drug discovery within the context of systems biology. Such a paradigm must combine physiologically and disease relevant biological substrates with sufficient throughput, operational simplicity and statistical vigour. Biomarker strategies for translational medicine, as well as preclinical safety and selectivity assessments, would also need to be revised to adapt to the target agnostic style. This focused issue aims to discuss strategies, key concepts and technologies related to systems-based approaches in drug development. Design and implementation of innovative biological assays, featuring multiple target strategies, and rational drug design in the absence of target knowledge during the early drug discovery are illustrated with examples. Specific topics include: • The need for systems-based approaches in drug development • Phenotypic screening strategies • Compound libraries (natural product inspired compound collections) • Target deconvolution and identification • Target agnostic lead discovery and optimization • Multi-target approaches and decoding the phenotype (understanding biological interactions and multiscale systems modelling) • Translational aspects • Early evaluation of selectivity and safety in a target agnostic manner

Author : Anonim
Publisher : BoD – Books on Demand
Page : 164 pages
File Size : 40,9 Mb
Release : 2021-12-08
Category : Medical
ISBN : 9781838809065

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Protein Kinases by Anonim Pdf

For the past two decades, the protein kinase family has been an intense area of research for developing anticancer drugs. Despite tremendous advancements in kinase drug expansion, many kinases are still unexplored. As such, this book includes research and review articles from experts that focus on protein kinase signalling pathways as a molecular drug target. Chapters include illustrations and cover such topics as the mechanism of action and anticancer activity of protein kinase inhibitors on various cancer types. They also discuss new opportunities, challenges, and future perspectives in the field.

Author : Anonim
Publisher : Unknown
Page : 480 pages
File Size : 54,7 Mb
Release : 1998
Category : Electronic
ISBN : UCLA:L0090217803

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Medical Topics in the 21st Century by Anonim Pdf

Author : Institute of Medicine,Board on Health Care Services,Committee on Cancer Clinical Trials and the NCI Cooperative Group Program
Publisher : National Academies Press
Page : 317 pages
File Size : 47,9 Mb
Release : 2010-07-08
Category : Medical
ISBN : 9780309157872

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A National Cancer Clinical Trials System for the 21st Century by Institute of Medicine,Board on Health Care Services,Committee on Cancer Clinical Trials and the NCI Cooperative Group Program Pdf

The National Cancer Institute's (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim to transform the Cooperative Group Program into a dynamic system that efficiently responds to emerging scientific knowledge; involves broad cooperation of stakeholders; and leverages evolving technologies to provide high-quality, practice-changing research.

Author : Japanese Association for Animal Cell Technology
Publisher : Springer Science & Business Media
Page : 402 pages
File Size : 50,6 Mb
Release : 1999-08-31
Category : Medical
ISBN : 9780792358053

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Animal Cell Technology: Challenges for the 21st Century by Japanese Association for Animal Cell Technology Pdf

Animal cell technology aims to understand structures, functions, and behaviors of differentiated animal cells and to ascertain their abilities to be used in industrial and medical purposes. This volume gives readers a complete review of the present state of the art in Japan.