Re Evaluation Of Drinking Water Guidelines For Diisopropyl Methylphosphonate

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Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on the Toxicity of Diisopropyl Methylphosphonate
Publisher : National Academies Press
Page : 48 pages
File Size : 42,9 Mb
Release : 2000-10-25
Category : Nature
ISBN : 9780309183949

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Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on the Toxicity of Diisopropyl Methylphosphonate Pdf

Diisopropyl Methylphosphonate (DIMP) is a groundwater contaminant at the U.S. Army's Rocky Mountain Arsenal in Colorado. DIMP is a by-product created from the manufacture and detoxification of the nerve agent GB which the arsenal produced from 1953 to 1957. For awhile the Army and the State of Colorado disagreed upon the appropriate drinking-water contaminant guideline for DIMP. A drinking-water guideline of 600 micrograms per liter was established by the U.S. Environmental Protection Agency (EPA) in 1989 but the State of Colorado promulgated a lower guideline of 8 micrograms per liter. The significant difference between the two suggested values arose from the fact that both sides used different studies to determine their values. Colorado used one-generation reproductive toxicity study in mink, whereas EPA used a subchronic toxicity study in dogs. To resolve the disagreement, a two-generation reproductive study in mink was conducted. The Army asked the National Research Council (NRC) to independently evaluate the 1997 study and re-evaluate the drinking-water guideline for DIMP. This task was assigned to the Committee on Toxicology, which established the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate, a multidisciplinary group of experts. The subcommittee evaluated the two-generation reproductive study as well as other studies relevant to the task. Data on the use of mink as a predictive model in toxicology were also reviewed. Re-Evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate is the subcommittee's report which shows that neither party was corrected in their DIMP guidelines. The report includes the subcommittee's evaluation and recommendations concerning the topic.

Fluoride in Drinking Water

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Fluoride in Drinking Water
Publisher : National Academies Press
Page : 531 pages
File Size : 46,9 Mb
Release : 2007-01-22
Category : Nature
ISBN : 9780309101288

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Fluoride in Drinking Water by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Fluoride in Drinking Water Pdf

Most people associate fluoride with the practice of intentionally adding fluoride to public drinking water supplies for the prevention of tooth decay. However, fluoride can also enter public water systems from natural sources, including runoff from the weathering of fluoride-containing rocks and soils and leaching from soil into groundwater. Fluoride pollution from various industrial emissions can also contaminate water supplies. In a few areas of the United States fluoride concentrations in water are much higher than normal, mostly from natural sources. Fluoride is one of the drinking water contaminants regulated by the U.S. Environmental Protection Agency (EPA) because it can occur at these toxic levels. In 1986, the EPA established a maximum allowable concentration for fluoride in drinking water of 4 milligrams per liter, a guideline designed to prevent the public from being exposed to harmful levels of fluoride. Fluoride in Drinking Water reviews research on various health effects from exposure to fluoride, including studies conducted in the last 10 years.

Drinking Water Regulation and Health

Author : Frederick Pontius
Publisher : John Wiley & Sons
Page : 1072 pages
File Size : 55,5 Mb
Release : 2003-08-01
Category : Science
ISBN : 9780471447412

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Drinking Water Regulation and Health by Frederick Pontius Pdf

The Drinking Water Act Amendments of 1996 instituted wide-ranging regulatory changes to the seminal Safe Drinking Water Act (SDWA)-such as providing funding to communities facing health risks, focusing regulatory efforts on contaminants posing such health risks, and adding flexibility to the regulatory process- and the amendments continue to shape regulations and regulatory policy to this day. Editor Frederick Pontius's Drinking Water Regulation and Health provides a comprehensive, up-to-date resource on the current regulatory landscape. Drinking Water Regulation and Health serves as a guide for water utilities, regulators, and consultants, forecasting future trends and explaining the latest developments in regulations. A diverse group of contributors covers topics such as water treatment, water protection, how some of the regulations have been interpreted in the courts, how water utilities can stay in compliance, and how to satisfy customer expectations, especially sensitive subpopulations. Divided into four sections - The SDWA and Public Health, Regulation Development, Contaminant Regulation and Treatment, and Compliance Challenges - the book includes chapters on: * Improving Waterborne Disease Surveillance * Application of Risk Assessments in Crafting Drinking Water Regulations * Control of Drinking Water Pathogens and Disinfection By-Products * Selection of Treatment Technology for SDWA Compliance * Death of the Silent Service: Meeting Consumer Expectations * Achieving Sustainable Water Systems * What Water Suppliers Need to Know About Toxic Tort Litigation

Spacecraft Water Exposure Guidelines for Selected Contaminants

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Spacecraft Exposure Guidelines
Publisher : National Academies Press
Page : 206 pages
File Size : 51,9 Mb
Release : 2008-11-21
Category : Science
ISBN : 9780309177955

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Spacecraft Water Exposure Guidelines for Selected Contaminants by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Spacecraft Exposure Guidelines Pdf

NASA maintains an active interest in the environmental conditions associated with living and working in spacecraft and identifying hazards that might adversely affect the health and well-being of crew members. Despite major engineering advances in controlling the spacecraft environment, some water and air contamination is inevitable. Several hundred chemical species are likely to be found in the closed environment of the spacecraft, and as the frequency, complexity, and duration of human space flight increase, identifying and understanding significant health hazards will become more complicated and more critical for the success of the missions. To protect space crews from contaminants in potable and hygiene water, NASA requested that the National Research Council NRC provide guidance on how to develop water exposure guidelines and subsequently review NASA's development of the exposure guidelines for specific chemicals. This book presents spacecraft water exposure guidelines (SWEGs) for antimony, benzene, ethylene glycol, methanol, methyl ethyl ketone, and propylene glycol.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels
Publisher : National Academies Press
Page : 293 pages
File Size : 54,8 Mb
Release : 2013-01-28
Category : Science
ISBN : 9780309290258

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Acute Exposure Guideline Levels for Selected Airborne Chemicals by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels Pdf

At the request of the Department of Defense and the Environmental Protection Agency, the National Research Council has reviewed the relevant scientific literature compiled by an expert panel and established Acute Exposure Guideline Levels (AEGLs) for several chemicals. AEGLs represent exposure levels below which adverse health effects are not likely to occur and are useful in responding to emergencies, such as accidental or intentional chemical releases in community, workplace, transportation, and military settings, and for the remediation of contaminated sites. Three AEGLs are approved for each chemical, representing exposure levels that result in: 1) notable but reversible discomfort; 2) long-lasting health effects; and 3) life-threatening health impacts. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 13 includes AEGLs for boron trifluoride, bromoacetone, chloroacetone, hexafluoroacetone, perchloryl fluoride, piperidine, propargyl alcohol, trimethoxysilane and tetramethoxysilane, and trimethylbenzenes.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels
Publisher : National Academies Press
Page : 195 pages
File Size : 51,7 Mb
Release : 2016-09-26
Category : Nature
ISBN : 9780309449182

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Acute Exposure Guideline Levels for Selected Airborne Chemicals by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Acute Exposure Guideline Levels Pdf

Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 20 reviews and updates the technical support document on acute exposure guideline levels (AEGLs) for selected chloroformates. This update focuses on establishing AEGL-3 values for n-propyl chloroformate and isopropyl chloroformate, but will also consider whether any new data are available that would affect the proposed values for the other 10 chloroformates. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Author : Committee on Acute Exposure Guideline Levels,Committee on Toxicology,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council
Publisher : National Academies Press
Page : 229 pages
File Size : 50,5 Mb
Release : 2013-10-10
Category : Medical
ISBN : 9780309291231

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Acute Exposure Guideline Levels for Selected Airborne Chemicals by Committee on Acute Exposure Guideline Levels,Committee on Toxicology,Board on Environmental Studies and Toxicology,Division on Earth and Life Studies,National Research Council Pdf

Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 15 identifies, reviews, and interprets relevant toxicologic and other scientific data for ethyl mercaptan, methyl mercaptan, phenyl mercaptan, tert-octyl mercaptan, lewisite, methyl isothiocyanate, and selected monoisocyanates in order to develop acute exposure guideline levels (AEGLs) for these high-priority, acutely toxic chemicals. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three level--AEGL-1, AEGL-2, and AEGL-3--are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites.

Review of the Department of Defense Enhanced Particulate Matter Surveillance Program Report

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee for Review of the DOD's Enhanced Particulate Matter Surveillance Program Report
Publisher : National Academies Press
Page : 106 pages
File Size : 49,6 Mb
Release : 2010-08-23
Category : Medical
ISBN : 9780309154130

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Review of the Department of Defense Enhanced Particulate Matter Surveillance Program Report by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee for Review of the DOD's Enhanced Particulate Matter Surveillance Program Report Pdf

Soldiers deployed during the 1991 Persian Gulf War were exposed to high concentrations of particulate matter (PM) and other airborne pollutants. Their exposures were largely the result of daily windblown dust, dust storms, and smoke from oil fires. On returning from deployment, many veterans complained of persistent respiratory symptoms. With the renewed activity in the Middle East over the last few years, deployed military personnel are again exposed to dust storms and daily windblown dust in addition to other types of PM, such as diesel exhaust and particles from open-pit burning. On the basis of the high concentrations observed and concerns about the potential health effects, DOD designed and implemented a study to characterize and quantify the PM in the ambient environment at 15 sites in the Middle East. The endeavor is known as the DOD Enhanced Particulate Matter Surveillance Program (EPMSP). The U.S. Army asked the National Research Council to review the EPMSP report. In response, the present evaluation considers the potential acute and chronic health implications on the basis of information presented in the report. It also considers epidemiologic and health-surveillance data collected by the USACHPPM, to assess potential health implications for deployed personnel, and recommends methods for reducing or characterizing health risks.

Review of the Army's Technical Guides on Assessing and Managing Chemical Hazards to Deployed Personnel

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on the Toxicological Risks to Deployed Military Personnel
Publisher : National Academies Press
Page : 215 pages
File Size : 43,6 Mb
Release : 2004-09-03
Category : Technology & Engineering
ISBN : 9780309092210

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Review of the Army's Technical Guides on Assessing and Managing Chemical Hazards to Deployed Personnel by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on the Toxicological Risks to Deployed Military Personnel Pdf

To guide mission planning, military decision makers need information on the health risks of potential exposures to individual soldiers and their potential impact on mission operations. To help with the assessment of chemical hazards, the U.S. Army Center for Health Promotion and Preventive Medicine developed three technical guides for characterizing chemicals in terms of their risks to the mission and to the health of the force. The report reviews these guides for their scientific validity and conformance with current risk-assessment practices. The report finds that the military exposure guidelines are appropriate (with some modification) for providing force health protection, but that for assessing mission risk, a new set of exposure guidelines is needed that predict concentrations at which health effects would degrade the performance of enough soldiers to hinder mission accomplishment.

Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels

Author : Committee on Acute Exposure Guideline Levels,Committee on Toxicology,National Research Council
Publisher : National Academies Press
Page : 218 pages
File Size : 43,5 Mb
Release : 2011-01-27
Category : Medical
ISBN : 9780309187626

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Nineteenth Interim Report of the Committee on Acute Exposure Guideline Levels by Committee on Acute Exposure Guideline Levels,Committee on Toxicology,National Research Council Pdf

The present report is the committee's 19th interim report. It summarizes the committee's conclusions and recommendations for improving NAC's AEGL documents for the following chemicals and chemical classes: acrylonitrile, benzonitrile, boron tribromide, BZ (3-quinuclidinyl benzilate), chloroarsenicals, chloroformates, bis-chloromethylether, chloromethylether, chlorosilanes (26 selected compounds), cyanogen, ethyl mercaptan, hexafluoroacetone, lewisites, mercury vapor, nitric acid, nitric oxide, nitrogen dioxide, nitrogen tetroxide, oleum, phenyl mercaptan, propargyl alcohol, selenium hexafluoride, silane, sulfer trioxide, sulfuric acid, tear gas, tert-octyl mercaptan, tetramethoxy silane, thionyl chloride, trimethoxysilane, trimethylbenzenes (1,2,4-; 1,2,5-;and 1,3,5-TMB), and vinyl chloride.

Review of the Toxicologic and Radiologic Risks to Military Personnel from Exposures to Depleted Uranium During and After Combat

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Toxicologic and Radiologic Effects from Exposure to Depleted Uranium During and After Combat
Publisher : National Academies Press
Page : 172 pages
File Size : 54,9 Mb
Release : 2008-06-06
Category : Political Science
ISBN : 9780309110365

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Review of the Toxicologic and Radiologic Risks to Military Personnel from Exposures to Depleted Uranium During and After Combat by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Toxicologic and Radiologic Effects from Exposure to Depleted Uranium During and After Combat Pdf

Since the 1980s, the U.S. military has used depleted uranium in munitions and in protective armor on tanks. Depleted uranium is a toxic heavy metal and is weakly radioactive. Concerns have been raised about the adverse health effects from exposure to depleted uranium that is aerosolized during combat. Some think it may be responsible for illnesses in exposed veterans and civilians. These concerns led the Army to commission a book, Depleted Uranium Aerosol Doses and Risks: Summary of U.S. Assessments, referred to as the Capstone Report that evaluates the health risks associated with depleted uranium exposure. This National Research Council book reviews the toxicologic, radiologic, epidemiologic, and toxicokinetic data on depleted uranium, and assesses the Army's estimates of health risks to personnel exposed during and after combat. The book recommends that the Army re-evaluate the basis for some of its predictions about health outcomes at low levels of exposure, but, overall, the Capstone Report was judged to provide a reasonable characterization of the exposure and risks from depleted uranium.

Review of the Department of Defense Research Program on Low-Level Exposures to Chemical Warfare Agents

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Toxicologic Assessment of Low-Level Exposures to Chemical Warfare Agents
Publisher : National Academies Press
Page : 122 pages
File Size : 49,8 Mb
Release : 2006-01-08
Category : Science
ISBN : 9780309100212

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Review of the Department of Defense Research Program on Low-Level Exposures to Chemical Warfare Agents by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Toxicologic Assessment of Low-Level Exposures to Chemical Warfare Agents Pdf

Research related to chemical warfare agents (CWAs) has historically focused on life threatening battlefield effects caused by high level exposures to the agents, not effects associated with exposures to low concentrations of them. In this report, low level concentrations refers to exposures that may not have any immediate observed health effects, but may produce delayed health effects months or years later. Recently, there has been increased concern about the potential health effects of exposures to CWAs at low concentrations. This report reviews the Department of Defense's (DOD) Research Plan for obtaining toxicologic and other relevant data to assess risk to military personnel. The CWAs of concern include the following nerve and vesicant agents: tabun, sarin, soman, cyclosarin, VX, and sulfur mustard. The report discusses the health effects of exposure to low levels of these agents and provides guidance to DOD on appropriate risk assessment methods for assessing toxicologic risk to military personnel from low-level exposures to CWAs. The report concludes that DOD's Research Plan is well planned and many of the proposed research tasks are likely to provide valuable information to DOD in protecting military personnel.

Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants
Publisher : National Academies Press
Page : 332 pages
File Size : 48,8 Mb
Release : 2008-06-09
Category : Nature
ISBN : 9780309112734

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Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants Pdf

U.S. Navy personnel who work on submarines are in an enclosed and isolated environment for days or weeks at a time when at sea. To protect workers from potential adverse health effects due to those conditions, the U.S. Navy has established exposure guidance levels for a number of contaminants. In this latest report in a series, the Navy asked the National Research Council (NRC) to review, and develop when necessary, exposure guidance levels for 11 contaminants. The report recommends exposure levels for hydrogen that are lower than current Navy guidelines. For all other contaminants (except for two for which there are insufficient data), recommended levels are similar to or slightly higher than those proposed by the Navy. The report finds that, overall, there is very little exposure data available on the submarine environment and echoes recommendations from earlier NRC reports to expand exposure monitoring in submarines.

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Spacecraft Exposure Guidelines
Publisher : National Academies Press
Page : 406 pages
File Size : 53,7 Mb
Release : 2008-12-24
Category : Technology & Engineering
ISBN : 9780309128445

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Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Spacecraft Exposure Guidelines Pdf

NASA is aware of the potential toxicologic hazards to crew that might be associated with prolonged spacecraft missions. Despite major engineering advances in controlling the atmosphere within spacecraft, some contamination of the air appears inevitable. NASA has measured numerous airborne contaminants during space missions. As the missions increase in duration and complexity, ensuring the health and well-being of astronauts traveling and working in this unique environment becomes increasingly difficult. As part of its efforts to promote safe conditions aboard spacecraft, NASA requested the National Research Council to develop guidelines for establishing spacecraft maximum allowable concentrations (SMACs) for contaminants and to review SMACs for various spacecraft contaminants to determine whether NASA's recommended exposure limits are consistent with the guidelines recommended by the committee. This book is the fifth volume in the series Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants, and presents SMACs for acrolein, C3 to C8 aliphatic saturated aldehydes, C2 to C9 alkanes, ammonia, benzene, carbon dioxide, carbon monoxide, 1,2-dichloroethane, dimethylhydrazine, ethanol, formaldehyde, limonene, methanol, methylene dichloride, n-butanol, propylene glycol, toluene, trimethylsilanol, and xylenes.

Combined Exposures to Hydrogen Cyanide and Carbon Monoxide in Army Operations

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Combined Exposures to Hydrogen Cyanide and Carbon Monoxide in Army Operations
Publisher : National Academies Press
Page : 50 pages
File Size : 54,7 Mb
Release : 2008-11-15
Category : Medical
ISBN : 9780309125604

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Combined Exposures to Hydrogen Cyanide and Carbon Monoxide in Army Operations by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Combined Exposures to Hydrogen Cyanide and Carbon Monoxide in Army Operations Pdf

To determine whether the air quality inside armored-vehicle cabins can meet exposure guidelines under deployment conditions, the Army assessed possible synergistic toxic effects from potentially harmful substances. This book, the final of two reports on the subject from the National Research Council, addresses whether the approach discussed in the technical context section of the Army's proposed guidance is appropriate, or whether an alternative assessment method should be developed. Combined Exposures to Hydrogen Cyanide and Carbon Monoxide in Army Operations provides several conclusions and recommendations, including the use of alternative instrumentation for monitoring gas, conducting experiments on human subjects, and seeking advice from additional groups involved with personnel training and field deployment.