Reactive Oxygen Species And Male Fertility

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Reactive Oxygen Species and Male Fertility

Cristian O'Flaherty
Reactive Oxygen Species and Male Fertility Book PDF

Author : Cristian O'Flaherty
Publisher : MDPI
Page : 194 pages
File Size : 44,5 Mb
Release : 2020-12-02
Category : Science
ISBN : 9783039360246

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Reactive Oxygen Species and Male Fertility by Cristian O'Flaherty Pdf

Reactive oxygen species (ROS) are inevitable by-products of aerobic cells. A delicate balance between ROS production and antioxidant defences is essential to assure cell function. This requirement is also true for the spermatozoon, the male gamete, with the unique goal of carrying and delivering the paternal genome into the oocyte. Oxidative stress promotes damage in lipids, proteins and DNA of spermatozoa, and this oxidative damage is associated with infertility. The ROS-dependent damage could occur at different stages of the production and maturation of the sperm. On the other hand, low and controlled levels of ROS are necessary to trigger and regulate sperm function. When ejaculated, spermatozoa are incapable of fertilizing the egg. They must reside in the oviduct of the female genital tract to undergo a yet to be understood the biochemical process called capacitation. Once capacitated, the spermatozoon undergoes the exocytotic event called acrosome reaction and fertilize the oocyte. ROS regulate the different molecular mechanisms such as sperm motility, capacitation and acrosome reaction to assure fertilization. This Special Issue includes original research and reviews of literature concerning the role of reactive oxygen species in male reproduction, particularly the role of antioxidants in the regulation of male fertility as well as basic and clinical studies using antioxidant-based strategies for the treatment of male infertility.

Reactive Oxygen Species and Male Fertility

Cristian O'Flaherty
Reactive Oxygen Species and Male Fertility Book PDF

Author : Cristian O'Flaherty
Publisher : Unknown
Page : 194 pages
File Size : 55,9 Mb
Release : 2020
Category : Electronic
ISBN : 3039360256

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Reactive Oxygen Species and Male Fertility by Cristian O'Flaherty Pdf

Reactive oxygen species (ROS) are inevitable by-products of aerobic cells. A delicate balance between ROS production and antioxidant defences is essential to assure cell function. This requirement is also true for the spermatozoon, the male gamete, with the unique goal of carrying and delivering the paternal genome into the oocyte. Oxidative stress promotes damage in lipids, proteins and DNA of spermatozoa, and this oxidative damage is associated with infertility. The ROS-dependent damage could occur at different stages of the production and maturation of the sperm. On the other hand, low and controlled levels of ROS are necessary to trigger and regulate sperm function. When ejaculated, spermatozoa are incapable of fertilizing the egg. They must reside in the oviduct of the female genital tract to undergo a yet to be understood the biochemical process called capacitation. Once capacitated, the spermatozoon undergoes the exocytotic event called acrosome reaction and fertilize the oocyte. ROS regulate the different molecular mechanisms such as sperm motility, capacitation and acrosome reaction to assure fertilization. This Special Issue includes original research and reviews of literature concerning the role of reactive oxygen species in male reproduction, particularly the role of antioxidants in the regulation of male fertility as well as basic and clinical studies using antioxidant-based strategies for the treatment of male infertility.

Oxidative Stress and Toxicity in Reproductive Biology and Medicine

Kavindra Kumar Kesari,Shubhadeep Roychoudhury
Oxidative Stress and Toxicity in Reproductive Biology and Medicine Book PDF

Author : Kavindra Kumar Kesari,Shubhadeep Roychoudhury
Publisher : Springer Nature
Page : 384 pages
File Size : 46,9 Mb
Release : 2022-05-31
Category : Medical
ISBN : 9783030893408

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Oxidative Stress and Toxicity in Reproductive Biology and Medicine by Kavindra Kumar Kesari,Shubhadeep Roychoudhury Pdf

This book discusses the role of oxidative stress in human reproduction with a focus on men’s health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction . The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men’s health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.

Studies on Men's Health and Fertility

Ashok Agarwal,Robert John Aitken,Juan G Alvarez
Studies on Men s Health and Fertility Book PDF

Author : Ashok Agarwal,Robert John Aitken,Juan G Alvarez
Publisher : Springer Science & Business Media
Page : 671 pages
File Size : 52,6 Mb
Release : 2012-03-17
Category : Science
ISBN : 9781617797750

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Studies on Men's Health and Fertility by Ashok Agarwal,Robert John Aitken,Juan G Alvarez Pdf

Studies on Men’s Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date. The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling on the one hand and oxidative stress on the other are also extensively reviewed and some of the first clues concerning the underlying mechanisms (age, heat, infection, cryostorage, aberrant lipid metabolism), clearly identified. From a clinical perspective there are chapters setting out the methods we should be using to diagnose oxidative stress in the male germ line, a clinical perspective on the aetiology of this condition and detailed considerations of the most suitable means of ameliorating such stress from a therapeutic point of view. Studies on Men’s Health and Fertility is intended to provide clinicians and scientists with a snap shot of the current status of this exciting, rapidly moving field. The book will be of value to clinicians interested in strategies for the management of oxidative stress in their infertility patients and scientists wishing to understand the molecular mechanisms underpinning the generation of ROS by these cells and its pathophysiological significance. It was not so long ago that the ability of spermatozoa to generate ROS was a hotly disputed topic. With the publication of this book such doubts can finally be laid to rest. There is now no doubt that these cells actively generate ROS, that oxidative stress is a major contributor to defects in male reproductive health and that the successful clinical management of this condition depends on developing a deeper understanding of the underlying molecular mechanisms. In this quest, Studies on Men’s Health and Fertility will be seen as a clear and important milestone.

New Discoveries in Embryology

Bin Wu
New Discoveries in Embryology Book PDF

Author : Bin Wu
Publisher : BoD – Books on Demand
Page : 270 pages
File Size : 40,6 Mb
Release : 2015-10-21
Category : Medical
ISBN : 9789535121824

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New Discoveries in Embryology by Bin Wu Pdf

Animal individual life begins as combination of sperm and oocyte, which results in the embryogenesis from ovum fertilization to fetal stage. Embryology has become one central discipline for many modern biotechnologies. Although this subject has been studied for more than a century, new discoveries appear continuously. This book contains some new discoveries and updates some theories and technologies in animal and human embryology. Major content include new findings in gamete biology, new theories and discoveries in embryo implantation by three-dimensional imaging technology and new concept and actual application of embryology. Thus, this book will greatly update knowledge in embryology field and provide some basic theories and technologies for animal scientists and breeders as well as embryologists and anthropologists.

Studies on Men's Health and Fertility

Ashok Agarwal,Robert John Aitken,Juan G Alvarez
Studies on Men s Health and Fertility Book PDF

Author : Ashok Agarwal,Robert John Aitken,Juan G Alvarez
Publisher : Humana Press
Page : 672 pages
File Size : 43,6 Mb
Release : 2012-03-17
Category : Science
ISBN : 1617797774

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Studies on Men's Health and Fertility by Ashok Agarwal,Robert John Aitken,Juan G Alvarez Pdf

Studies on Men’s Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date. The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling on the one hand and oxidative stress on the other are also extensively reviewed and some of the first clues concerning the underlying mechanisms (age, heat, infection, cryostorage, aberrant lipid metabolism), clearly identified. From a clinical perspective there are chapters setting out the methods we should be using to diagnose oxidative stress in the male germ line, a clinical perspective on the aetiology of this condition and detailed considerations of the most suitable means of ameliorating such stress from a therapeutic point of view. Studies on Men’s Health and Fertility is intended to provide clinicians and scientists with a snap shot of the current status of this exciting, rapidly moving field. The book will be of value to clinicians interested in strategies for the management of oxidative stress in their infertility patients and scientists wishing to understand the molecular mechanisms underpinning the generation of ROS by these cells and its pathophysiological significance. It was not so long ago that the ability of spermatozoa to generate ROS was a hotly disputed topic. With the publication of this book such doubts can finally be laid to rest. There is now no doubt that these cells actively generate ROS, that oxidative stress is a major contributor to defects in male reproductive health and that the successful clinical management of this condition depends on developing a deeper understanding of the underlying molecular mechanisms. In this quest, Studies on Men’s Health and Fertility will be seen as a clear and important milestone.

Reactive Oxygen Species (ROS) in Living Cells

Filip Cristiana,Albu Elena
Reactive Oxygen Species ROS in Living Cells Book PDF

Author : Filip Cristiana,Albu Elena
Publisher : BoD – Books on Demand
Page : 218 pages
File Size : 55,8 Mb
Release : 2018-05-23
Category : Science
ISBN : 9781789231342

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Reactive Oxygen Species (ROS) in Living Cells by Filip Cristiana,Albu Elena Pdf

Oxygen represents only 20% of the Earth's atmosphere, yet it is vital for the survival of aerobic organisms. There is a dark part of the use of oxygen that consists in generating reactive species that are potentially harmful to living organisms. Moreover, reactive oxygen species can combine with nitrogen derivatives and generate many other reactive species. Thus, living organisms are continuously assaulted by reactive species from external or internal sources. However, the real danger comes in the case of high concentrations and prolonged exposure to these species. This book presents an image of the mechanisms of action of reactive species and emphasizes their involvement in diseases. Inflammation and cancer are examined to determine when and how reactive species turn the evolution of a benign process to a malignant one. Some answers may come from recent studies indicating that reactive species are responsible for epigenetic changes.

Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction

Ralf Henkel,Luna Samanta,Ashok Agarwal
Oxidants Antioxidants and Impact of the Oxidative Status in Male Reproduction Book PDF

Author : Ralf Henkel,Luna Samanta,Ashok Agarwal
Publisher : Academic Press
Page : 324 pages
File Size : 50,8 Mb
Release : 2018-08-23
Category : Medical
ISBN : 9780128125670

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Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction by Ralf Henkel,Luna Samanta,Ashok Agarwal Pdf

Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction is an essential reference for fertility practitioners and research and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology. The book focuses on unravelling the pathophysiology of oxidative stress mediated male infertility, recruiting top researchers and clinicians to contribute chapters. This collection of expertise delves into the physico-chemical aspects of oxidative stress, including a new focus on reductive stress. Furthermore, the inclusion of clinical techniques to determine oxidative stress and the OMICS of reductive oxidative stress are also included. This is a must-have reference in the area of oxidative stress and male reproductive function. Offers comprehensive information on oxidative stress and its role in male reproduction, including new therapeutic approaches Deals with current approaches to oxidative stress using OMICS platform“/li> Designed for fertility practitioners, reproductive researchers, and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology

Oxidative Stress and Toxicity in Reproductive Biology and Medicine

Shubhadeep Roychoudhury,Kavindra Kumar Kesari
Oxidative Stress and Toxicity in Reproductive Biology and Medicine Book PDF

Author : Shubhadeep Roychoudhury,Kavindra Kumar Kesari
Publisher : Springer Nature
Page : 347 pages
File Size : 52,5 Mb
Release : 2022-12-06
Category : Medical
ISBN : 9783031129667

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Oxidative Stress and Toxicity in Reproductive Biology and Medicine by Shubhadeep Roychoudhury,Kavindra Kumar Kesari Pdf

Volume Two advances the exploration of the fundamental principles of oxidative stress and toxicity on male (and female) reproduction. It includes the advances in research on male reproductive health, the impact of environmental factors, the protective measures using bioactive compounds and traditional medicines, and how to limit toxic exposure. It includes coverage of: Oxidative stress and male infertility Environmental stressors and sexual health Heavy metals, pesticides, fine particle toxicity and male reproduction Protective measures against oxidative stress in gametes/embryos by using bioactive compounds/phytomedicines in Assisted Reproductive Technology (ART) Role of reactive oxygen species on female reproduction Radiation and mutagenic factors affecting the male reproductive system Both volumes provide a comprehensive look at the most basic concepts and advanced research being conducted by world famous scientists and researchers in male infertility and reproduction.

Antioxidants in Male Infertility

Sijo J. Parekattil,Ashok Agarwal
Antioxidants in Male Infertility Book PDF

Author : Sijo J. Parekattil,Ashok Agarwal
Publisher : Springer
Page : 0 pages
File Size : 45,9 Mb
Release : 2013-12-14
Category : Medical
ISBN : 1461491584

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Antioxidants in Male Infertility by Sijo J. Parekattil,Ashok Agarwal Pdf

This concise, truncated version of Parekattil and Agarwal's Male Infertility: Contemporary Clinical Approaches, Andrology, ART & Antioxidants is the first resource dedicated solely to antioxidants and male infertility. With select chapters that will prove invaluable to the practitioner of reproductive medicine, Antioxidants in Male Infertility addresses issues such as: - Molecular mechanisms of antioxidants in male infertility - Oxidative stress - The impact of infection, aging, obesity, and injury on male infertility - Natural and synthetic antioxidants and antioxidant therapy - Antioxidants in ICSI and IMSI Also included is a new chapter reviewing the physiological role of reactive oxygen species in sperm function. Practical for clinicians and researchers alike, Antioxidants in Male Infertility contains all of the need-to-know information about these cutting-edge topics in reproductive medicine.

Oxidative Stress and Antioxidant Protection

Donald Armstrong,Robert D. Stratton
Oxidative Stress and Antioxidant Protection Book PDF

Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Page : 610 pages
File Size : 50,8 Mb
Release : 2016-04-11
Category : Science
ISBN : 9781118832486

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Oxidative Stress and Antioxidant Protection by Donald Armstrong,Robert D. Stratton Pdf

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Novel Prospects in Oxidative and Nitrosative Stress

Pinar Atukeren
Novel Prospects in Oxidative and Nitrosative Stress Book PDF

Author : Pinar Atukeren
Publisher : BoD – Books on Demand
Page : 158 pages
File Size : 53,8 Mb
Release : 2018-05-09
Category : Science
ISBN : 9781789230864

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Novel Prospects in Oxidative and Nitrosative Stress by Pinar Atukeren Pdf

Oxidative stress plays a crucial role in the pathophysiology of various diseases when there is a disruption of the intracellular redox balance and the homeostatic balance between cellular oxidants and antioxidants. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) react with molecular targets including proteins, lipids, and nucleic acids contributing to mitochondrial injury and cellular dysfunction. This book intends to provide the readers with an extensive overview of the novel approaches and prospects based on oxidative and nitrosative stress in the pathophysiology of various diseases and in the current treatment strategies with antioxidants.

Oxidative Stress in Human Reproduction

Ashok Agarwal,Rakesh Sharma,Sajal Gupta,Avi Harlev,Gulfam Ahmad,Stefan S. du Plessis,Sandro C. Esteves,Siew May Wang,Damayanthi Durairajanayagam
Oxidative Stress in Human Reproduction Book PDF

Author : Ashok Agarwal,Rakesh Sharma,Sajal Gupta,Avi Harlev,Gulfam Ahmad,Stefan S. du Plessis,Sandro C. Esteves,Siew May Wang,Damayanthi Durairajanayagam
Publisher : Springer
Page : 190 pages
File Size : 41,6 Mb
Release : 2017-05-03
Category : Health & Fitness
ISBN : 9783319484273

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Oxidative Stress in Human Reproduction by Ashok Agarwal,Rakesh Sharma,Sajal Gupta,Avi Harlev,Gulfam Ahmad,Stefan S. du Plessis,Sandro C. Esteves,Siew May Wang,Damayanthi Durairajanayagam Pdf

This book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the human reproductive processes. Also discussed are multiple extrinsic factors that could induce oxidative stress in the reproductive system. This volume covers various clinical pathologies related to the reproductive system that arise from or produce oxidative stress, both in the male and female. The use of antioxidants as a therapeutic measure to keep ROS levels in check are highlighted, describing the outcome of various clinical studies involving antioxidant supplementation in infertile patients. Infertility is a global disease that affects 15-25% of all couples, and oxidative stress arising from a multitude of sources has been implicated as one of the major contributing factors to the decline in human fertility. As such, this book provides an up-to-date review on the significance of ROS in human reproduction.

Male Fertility and Lipid Metabolism

Stephanie R. De Vriese,Armond B. Christophe
Male Fertility and Lipid Metabolism Book PDF

Author : Stephanie R. De Vriese,Armond B. Christophe
Publisher : The American Oil Chemists Society
Page : 288 pages
File Size : 47,6 Mb
Release : 2003-05-30
Category : Medical
ISBN : 1893997391

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Male Fertility and Lipid Metabolism by Stephanie R. De Vriese,Armond B. Christophe Pdf

Interest in lipid metabolism and polyunsaturated fatty acids in relation to sperm production has increased during the last decade. The motivation for the research described in this book originates from the discovery that sperm lipids contain extremely high proportions of long-chain polyunsaturated fatty acids, thus establishing a link between lipid biochemistry and male fertility. Moreover, the fact that polyunsaturated fatty acids must, in some form, be supplied in the diet suggests a relationship between fertility and nutrition and raises the possibility of improving male fertility by dietary means. This book gives the reader an up-to-date view of several aspects of male fertility in relation to lipid and fatty acid metabolism. Researchers in the domain of male fertility, fatty acid metabolism, and antioxidants; medical personnel involved in the treatment of male infertility; fat technologists; students in nutrition, dietetics, biochemistry, pharmacy, and medicine; and everybody interested in the field will find this book useful.

Male Infertility

Sijo J. Parekattil,Sandro C. Esteves,Ashok Agarwal
Male Infertility Book PDF

Author : Sijo J. Parekattil,Sandro C. Esteves,Ashok Agarwal
Publisher : Springer Nature
Page : 895 pages
File Size : 47,7 Mb
Release : 2020-01-24
Category : Health & Fitness
ISBN : 9783030323004

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Male Infertility by Sijo J. Parekattil,Sandro C. Esteves,Ashok Agarwal Pdf

A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility. World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the book’s appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.