Recent Advances In Biocatalysis And Metabolic Engineering For Biomanufacturing

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Recent Advances in Biocatalysis and Metabolic Engineering for Biomanufacturing

Eun Yeol Lee
Recent Advances in Biocatalysis and Metabolic Engineering for Biomanufacturing Book PDF

Author : Eun Yeol Lee
Publisher : MDPI
Page : 278 pages
File Size : 48,6 Mb
Release : 2019-09-23
Category : Science
ISBN : 9783039215744

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Recent Advances in Biocatalysis and Metabolic Engineering for Biomanufacturing by Eun Yeol Lee Pdf

The use of biocatalysts, including enzymes and metabolically engineered cells, has attracted a great deal of attention in the chemical and bio-industry, because biocatalytic reactions can be conducted under environmentally-benign conditions and in more sustainable ways. The catalytic efficiency and chemo-, regio-, and stereo-selectivity of enzymes can be enhanced and modulated using protein engineering. Metabolic engineering seeks to enhance cellular biosynthetic productivity of target metabolites via controlling and redesigning metabolic pathways using multi-omics analysis, genome-scale modeling, metabolic flux control, and reconstruction of novel pathways. The aim of this book is to cover the recent advances in biocatalysis and metabolic engineering for biomanufacturing of biofuels, chemicals, biomaterials, and pharmaceuticals. Reviews and original research articles on the development of new strategies to improve the catalytic efficiency of enzymes, biosynthetic capability of cell factories, and their applications in production of various bioproducts and chemicals are included.

Recent Advances in Biocatalysis and Metabolic Engineering for Biomanufacturing

Eun Yeol Lee
Recent Advances in Biocatalysis and Metabolic Engineering for Biomanufacturing Book PDF

Author : Eun Yeol Lee
Publisher : Unknown
Page : 1 pages
File Size : 46,7 Mb
Release : 2019
Category : Electronic books
ISBN : 3039215752

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Recent Advances in Biocatalysis and Metabolic Engineering for Biomanufacturing by Eun Yeol Lee Pdf

The use of biocatalysts, including enzymes and metabolically engineered cells, has attracted a great deal of attention in the chemical and bio-industry, because biocatalytic reactions can be conducted under environmentally-benign conditions and in more sustainable ways. The catalytic efficiency and chemo-, regio-, and stereo-selectivity of enzymes can be enhanced and modulated using protein engineering. Metabolic engineering seeks to enhance cellular biosynthetic productivity of target metabolites via controlling and redesigning metabolic pathways using multi-omics analysis, genome-scale modeling, metabolic flux control, and reconstruction of novel pathways. The aim of this book is to cover the recent advances in biocatalysis and metabolic engineering for biomanufacturing of biofuels, chemicals, biomaterials, and pharmaceuticals. Reviews and original research articles on the development of new strategies to improve the catalytic efficiency of enzymes, biosynthetic capability of cell factories, and their applications in production of various bioproducts and chemicals are included.

Metabolic Engineering

Jens Nielsen
Metabolic Engineering Book PDF

Author : Jens Nielsen
Publisher : Springer
Page : 184 pages
File Size : 44,6 Mb
Release : 2003-07-03
Category : Science
ISBN : 9783540453000

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Metabolic Engineering by Jens Nielsen Pdf

Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.

Metabolic Engineering

Sang Yup Lee,Jens Nielsen,Gregory Stephanopoulos
Metabolic Engineering Book PDF

Author : Sang Yup Lee,Jens Nielsen,Gregory Stephanopoulos
Publisher : John Wiley & Sons
Page : 1075 pages
File Size : 40,8 Mb
Release : 2021-06-02
Category : Science
ISBN : 9783527823451

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Metabolic Engineering by Sang Yup Lee,Jens Nielsen,Gregory Stephanopoulos Pdf

Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.

Exploring the Biotechnological Potential of C2 Alternative Substrates in Biocatalysis and Metabolic Engineering

Wenfa Ng
Exploring the Biotechnological Potential of C2 Alternative Substrates in Biocatalysis and Metabolic Engineering Book PDF

Author : Wenfa Ng
Publisher : Unknown
Page : 128 pages
File Size : 47,5 Mb
Release : 2022-02-10
Category : Electronic
ISBN : 168507555X

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Exploring the Biotechnological Potential of C2 Alternative Substrates in Biocatalysis and Metabolic Engineering by Wenfa Ng Pdf

Metabolic engineering and biocatalysis aim to produce new value-added products from biological routes through careful and deliberate genetic engineering in different microbial chassis with suitable metabolic repertoire. Hitherto, the endeavor has largely been confined to the production of new products from glucose and a few other well characterized substrates. But, as the bioeconomy gains in importance and the world seeks to explore new sources of carbon as feedstocks, a possibility exists in developing alternative C2 compounds as feedstocks in contrast to the current reliance on C6 (glucose and fructose), C5 (xylose) and C3 (glycerol) substrates. Two potential C2 alternative substrates explored in this work are ethanol and ethylene glycol. Ethanol is a biofuel whose biotechnological potential has not been fully explored. In the first part of the book, the potential of using the NADH generated from a reconstructed ethanol utilization pathway to power a biotransformation reaction is explored in Escherichia coli. Experimental results indicate that ethanol utilization delivers higher biotransformation efficiency compared to state-of-the-art glucose dehydrogenase system, which confirmed theoretical predictions of relative efficiency of the two systems. Next, the book switches attention to ethylene glycol which could be derived as breakdown products of lignocellulosic waste or from plastic waste. Here, the proposal is to demonstrate the potential of an NADH generating ethylene glycol utilization pathway that terminates at glycolate to support biocatalytic reactions in E. coli. Subsequently, the two-step ethylene glycol utilization pathway would be extended to malate and 2-phosphoglycerate to help another biotechnology workhorse, Bacillus subtilis, to grow on ethylene glycol as the sole carbon source. Different connection points to central carbon metabolism would provide a natural experiment to decipher the relative efficiencies of activating tricarboxylic acid cycle and glycolysis in supporting cell growth, and illuminate insights into the relative efficiency and evolutionary importance of different branches of metabolism in B. subtilis. Finally, ethylene glycol utilization would be combined with product formation to help B. subtilis to synthesize green fluorescent protein using flux from the C2 alternative substrate. This system would provide a platform for examining the efficacy of different ethylene glycol utilization pathways and entry points in central carbon metabolism in synthesizing amino acids and proteins. Overall, this book hopes to explore the biotechnological potential of two alternative C2 substrates (ethanol and ethylene glycol) in biocatalysis and metabolic engineering from the substrate utilization perspective.

Emerging Areas in Bioengineering

Ho Nam Chang
Emerging Areas in Bioengineering Book PDF

Author : Ho Nam Chang
Publisher : John Wiley & Sons
Page : 898 pages
File Size : 55,8 Mb
Release : 2018-03-12
Category : Science
ISBN : 9783527340880

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Emerging Areas in Bioengineering by Ho Nam Chang Pdf

With more than 40 contributions from expert authors, this is an extensive overview of all important research topics in the field of bioengineering, including metabolic engineering, biotransformations and biomedical applications. Alongside several chapters dealing with biotransformations and biocatalysis, a whole section is devoted to biofuels and the utilization of biomass. Current perspectives on synthetic biology and metabolic engineering approaches are presented, involving such example organisms as Escherichia coli and Corynebacterium glutamicum, while a further section covers topics in biomedical engineering including drug delivery systems and biopharmaceuticals. The book concludes with chapters on computer-aided bioprocess engineering and systems biology. This is a part of the Advanced Biotechnology book series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question. Invaluable reading for biotechnologists and bioengineers, as well as those working in the chemical and pharmaceutical industries. Advanced Biotechnology Biotechnology is a broad, interdisciplinary field of science, combining biological sciences and relevant engineering disciplines, that is becoming increasingly important as it benefits the environment and society as a whole. Recent years have seen substantial advances in all areas of biotechnology, resulting in the emergence of brand new fields. To reflect this progress, Sang-Yup Lee (KAIST, South Korea), Jens Nielsen (Chalmers University, Sweden), and Gregory Stephanopoulos (MIT, USA) have joined forces as the editors of a new Wiley-VCH book series. Advanced Biotechnology will cover all pertinent aspects of the field and each volume will be prepared by eminent scientists who are experts on the topic in question.

Biocatalysis for Green Chemistry and Chemical Process Development

Junhua (Alex) Tao,Romas Joseph Kazlauskas
Biocatalysis for Green Chemistry and Chemical Process Development Book PDF

Author : Junhua (Alex) Tao,Romas Joseph Kazlauskas
Publisher : John Wiley & Sons
Page : 494 pages
File Size : 49,9 Mb
Release : 2011-06-09
Category : Technology & Engineering
ISBN : 9781118028292

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Biocatalysis for Green Chemistry and Chemical Process Development by Junhua (Alex) Tao,Romas Joseph Kazlauskas Pdf

This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.

Biosystems Engineering I

Christoph Wittmann,Rainer Krull
Biosystems Engineering I Book PDF

Author : Christoph Wittmann,Rainer Krull
Publisher : Springer
Page : 250 pages
File Size : 42,9 Mb
Release : 2010-08-18
Category : Science
ISBN : 9783642142314

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Biosystems Engineering I by Christoph Wittmann,Rainer Krull Pdf

-Integration of Systems Biology with Bioprocess Engineering: L-Threonine Production by Systems Metabolic Engineering of Escherichia Coli, By Sang Yup Lee and Jin Hwan Park; -Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium glutamicum, By Christoph Wittmann; -Systems Biology of Industrial Microorganisms, Marta Papini, Margarita Salazar, and Jens Nielsen; -De Novo Metabolic Engineering and the Promise of Synthetic DNA, By Daniel Klein-Marcuschamer, Vikramaditya G. Yadav, Adel Ghaderi, and Gregory N. Stephanopoulos; -Systems Biology of Recombinant Protein Production in Bacillus megaterium, Rebekka Biedendieck, Boyke Bunk, Tobias Fürich, Ezequiel Franco-Lara, Martina Jahn, and Dieter Jahn; -Extending Synthetic Routes for Oligosaccharides by Enzyme, Substrate and Reaction Engineering; By Jürgen Seibel, Hans-Joachim Jördening, and Klaus Buchholz; -Regeneration of Nicotinamide Coenzymes: Principles and Applications for the Synthesis of Chiral Compounds; By Andrea Weckbecker, Harald Gröger, and Werner Hummel;

Current Developments in Biotechnology and Bioengineering

Swati Joshi,Ashok Pandey,Ranjna Sirohi,Sung Hoon Park
Current Developments in Biotechnology and Bioengineering Book PDF

Author : Swati Joshi,Ashok Pandey,Ranjna Sirohi,Sung Hoon Park
Publisher : Elsevier
Page : 526 pages
File Size : 48,7 Mb
Release : 2022-04-29
Category : Technology & Engineering
ISBN : 9780323885126

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Current Developments in Biotechnology and Bioengineering by Swati Joshi,Ashok Pandey,Ranjna Sirohi,Sung Hoon Park Pdf

Designer Microbial Cell Factories: Metabolic Engineering and Applications, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a detailed overview of the biotechnological approaches and strategies used to generate engineered microbes and to facilitate the acceleration, modulation and diversion of metabolic pathways to get desired output such as production of value-added compound or biodegradation of xenobiotic pollutant. The book also highlights applied aspects of designer microbes in fields as diverse as agriculture, pharmaceuticals and bioremediation. Designer microbes generated through reprogramming the microbial cell factories (MCFs) provide an edge over their natural counterparts in terms of increased molecular diversity and selective chemistry. These bugs are becoming instrumental in several areas, including agriculture, environment and human health. Engineering microbes through directed evolution not only gives freedom from evolutionary constrains but also allow introduction of regulated and foreseeable functions into MCFs. Dedicated to the designing of microbes, covering state-of-the-art technological advancements in the field Includes applications of metabolic engineering in the field of agriculture, bioremediation, value-added products, therapeutics, and more Contains chapters dedicated to innovative approaches surrounding engineered microbial consortia Provides comprehensive details and helps users understand concepts

Biocatalysis and Agricultural Biotechnology: Fundamentals, Advances, and Practices for a Greener Future

Anjali Priyadarshini,Prerna Pandey
Biocatalysis and Agricultural Biotechnology Fundamentals Advances and Practices for a Greener Future Book PDF

Author : Anjali Priyadarshini,Prerna Pandey
Publisher : CRC Press
Page : 230 pages
File Size : 40,9 Mb
Release : 2018-10-03
Category : Science
ISBN : 9781351167420

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Biocatalysis and Agricultural Biotechnology: Fundamentals, Advances, and Practices for a Greener Future by Anjali Priyadarshini,Prerna Pandey Pdf

This new volume, Biocatalysis and Agricultural Biotechnology: Fundamentals, Advances, and Practices for a Greener Future, looks at the application of a variety of technologies, both fundamental and advanced, that are being used for crop improvement, metabolic engineering, and the development of transgenic plants. The science of agriculture is among the oldest and most intensely studied by mankind. Human intervention has led to manipulation of plant gene structure for the use of plants for the production of bioenergy, food, textiles, among other industrial uses. A sound knowledge of enzymology as well as the various biosynthetic pathways is required to further utilize microbes as sources to provide the desired products for industrial utility. This volume provides an overview of all these aspects along with an updated review of the major plant biotechnology procedures and techniques, their impact on novel agricultural development, and crop plant improvement. Also discussed are the use of "white biotechnology" and "metabolic engineering" as prerequisites for a sustainable development. The importance of patenting of plant products, world food safety, and the role of several imminent organizations is also discussed. The volume provides an holistic view that makes it a valuable source of information for researchers of agriculture and biotechnology as well as agricultural engineers, environmental biologists, environmental engineers, and environmentalists. Short exercises at the end of the chapters help to make the book suitable for course work in agriculture biotechnology, genetics, biology, biotechnology, and plant science.

Current Developments in Biotechnology and Bioengineering

Sudhir P. P. Singh,Ashok Pandey,Guocheng Du,Sudesh Kumar
Current Developments in Biotechnology and Bioengineering Book PDF

Author : Sudhir P. P. Singh,Ashok Pandey,Guocheng Du,Sudesh Kumar
Publisher : Elsevier
Page : 442 pages
File Size : 40,9 Mb
Release : 2018-11-20
Category : Technology & Engineering
ISBN : 9780444640864

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Current Developments in Biotechnology and Bioengineering by Sudhir P. P. Singh,Ashok Pandey,Guocheng Du,Sudesh Kumar Pdf

Current Developments in Biotechnology and Bioengineering: Synthetic Biology, Cell Engineering and Bioprocessing Technologies covers the current perspectives and outlook of synthetic biology in the agriculture, food and health sectors. This book begins with the basics about synthetic biology and cell engineering, and then explores this in more detail, focusing on topics like applications of synthetic biology, industrial bioprocesses, and future perspectives. Information on cell engineering is also presented, and manipulation in endogenous metabolic network is studied alongside advanced topics such as fine tuning of metabolic pathways, de novo biosynthetic pathway design, enzyme engineering targeted to improved kinetics and stability, and potential applications of the novel biological systems in bioprocess technology to achieve the production of value-added compounds with specific biological activities. Assists in developing a conceptual understanding of synthetic biology and cellular and metabolic engineering. Includes comprehensive information on new developments and advancements. Lists applications of synthetic biology in agriculture, food, and health

Biocatalysis for the Pharmaceutical Industry

Junhua (Alex) Tao,Guo-Qiang Lin,Andreas Liese
Biocatalysis for the Pharmaceutical Industry Book PDF

Author : Junhua (Alex) Tao,Guo-Qiang Lin,Andreas Liese
Publisher : John Wiley & Sons
Page : 250 pages
File Size : 50,8 Mb
Release : 2009-07-23
Category : Science
ISBN : 9780470823156

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Biocatalysis for the Pharmaceutical Industry by Junhua (Alex) Tao,Guo-Qiang Lin,Andreas Liese Pdf

Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Synthetic Biology – Metabolic Engineering

Huimin Zhao,An-Ping Zeng
Synthetic Biology Metabolic Engineering Book PDF

Author : Huimin Zhao,An-Ping Zeng
Publisher : Springer
Page : 0 pages
File Size : 51,8 Mb
Release : 2018-08-23
Category : Technology & Engineering
ISBN : 3319856286

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Synthetic Biology – Metabolic Engineering by Huimin Zhao,An-Ping Zeng Pdf

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Systems and Synthetic Metabolic Engineering

Yanfeng Liu,Guocheng Du,Long Liu
Systems and Synthetic Metabolic Engineering Book PDF

Author : Yanfeng Liu,Guocheng Du,Long Liu
Publisher : Academic Press
Page : 294 pages
File Size : 46,6 Mb
Release : 2020-07-10
Category : Science
ISBN : 9780128217528

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Systems and Synthetic Metabolic Engineering by Yanfeng Liu,Guocheng Du,Long Liu Pdf

Systems and Synthetic Metabolic Engineering provides an overview of the development of metabolic engineering within medicine that is fueled by systems and synthetic biology. These newly developed, successful strategies of metabolic engineering guide the audience on how to propose and test proper strategies for metabolic engineering research. In addition to introductory, regulatory and challenges in the field, the book also covers dynamic control and autonomous regulation to control cell metabolism, along with computational modeling and industrial applications. The book is written by leaders in the field, making it ideal for synthetic biologists, researchers, students and anyone working in this area. Discusses the current progress of metabolic engineering, focusing on systems biology and synthetic biology Covers introductory, regulatory, strategies, production and challenges in the field Written technically for synthetic biologists, researchers, students, industrialists, policymakers and stakeholders

Modern Biocatalysis

Gavin Williams,Mélanie Hall
Modern Biocatalysis Book PDF

Author : Gavin Williams,Mélanie Hall
Publisher : Royal Society of Chemistry
Page : 574 pages
File Size : 44,5 Mb
Release : 2018-05-31
Category : Science
ISBN : 9781782627265

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Modern Biocatalysis by Gavin Williams,Mélanie Hall Pdf

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current 'hot' topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.