Recent Progress In Solid Dispersion Technology

Author : Kohsaku Kawakami
Publisher : MDPI
Page : 202 pages
File Size : 52,6 Mb
Release : 2019-10-01
Category : Science
ISBN : 9783039215010

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Recent Progress in Solid Dispersion Technology by Kohsaku Kawakami Pdf

Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

Author : Kohsaku Kawakami
Publisher : Unknown
Page : 1 pages
File Size : 41,6 Mb
Release : 2019
Category : Electronic books
ISBN : 3039215027

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Recent Progress in Solid Dispersion Technology by Kohsaku Kawakami Pdf

Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD's natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

Author : Ann Newman
Publisher : John Wiley & Sons
Page : 504 pages
File Size : 53,9 Mb
Release : 2015-02-27
Category : Science
ISBN : 9781118901380

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Pharmaceutical Amorphous Solid Dispersions by Ann Newman Pdf

Providing a roadmap from early to late stages of drug development,this book overviews amorphous solid dispersion technology – aleading platform to deliver poorly water soluble drugs, a majorhurdle in today’s pharmaceutical industry. • Helps readers understand amorphous solid dispersionsand apply techniques to particular pharmaceutical systems • Covers physical and chemical properties, screening,scale-up, formulation, drug product manufacture, intellectualproperty, and regulatory considerations • Has an appendix with structure and propertyinformation for polymers commonly used in drug development and withmarketed drugs developed using the amorphous sold dispersionapproach • Addresses global regulatory issues including USAregulations, ICH guidelines, and patent concerns around theworld

Author : Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick
Publisher : Springer
Page : 702 pages
File Size : 55,5 Mb
Release : 2014-11-21
Category : Medical
ISBN : 9781493915989

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Amorphous Solid Dispersions by Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick Pdf

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.

Author : Abdulkader ALHUSAINI , Mustafa Sinan KAYNAK,Asiye ULUĞ , Funda Özdemir DEĞİRMENCİ,Emrah ÇELİK ,Leyla SARIBOĞA,Çağla UYGUN,Cansu Filik İşçen,Ülküye Dudu Gül,Semra İlhan,Burak GÖKSU , K. Emrah ERGİNER,Muhammet Fatih AYHAN,Özlem AYDIN,Ahmed HASSAN ,Naci KURGAN,Musab Talha AKPINAR
Publisher : Livre de Lyon
Page : 177 pages
File Size : 41,8 Mb
Release : 2023-03-25
Category : Technology & Engineering
ISBN : 9782382365298

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Recent Advances in Natural and Engineering Sciences by Abdulkader ALHUSAINI , Mustafa Sinan KAYNAK,Asiye ULUĞ , Funda Özdemir DEĞİRMENCİ,Emrah ÇELİK ,Leyla SARIBOĞA,Çağla UYGUN,Cansu Filik İşçen,Ülküye Dudu Gül,Semra İlhan,Burak GÖKSU , K. Emrah ERGİNER,Muhammet Fatih AYHAN,Özlem AYDIN,Ahmed HASSAN ,Naci KURGAN,Musab Talha AKPINAR Pdf

Recent Advances in Natural and Engineering Sciences

Author : Prati Pal Singh
Publisher : Springer Nature
Page : 774 pages
File Size : 42,5 Mb
Release : 2023-10-13
Category : Medical
ISBN : 9789819923021

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Recent Advances in Pharmaceutical Innovation and Research by Prati Pal Singh Pdf

This book covers several important aspects of pharmaceutical research and innovations. It presents important topics on drug delivery, novel microsponge, nanocrystals, polymeric nanoparticles, peptide synthesis, biopharmaceuticals, pharmacodynamics, yeast flocculation, neuromodulators, innovative drug discovery, pharmacoinformatics, aminoquinoline, thiourea crystals for API synthesis, FDCs and formulations research, ayurveda and natural products, and innovations to militate anti-microbial resistance (AMR). A chapter is devoted to the applications of Artificial Intelligence and Machine Learning in diverse sectors of the pharmaceutical industry, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. The book also reviews the role of pharmacogenomics and pharmacogenetics in drug development and precision medicine. Further, the book presents an updated summary of recent advances in the fields of nanomedicines and nano-based drug delivery systems. This book is useful to pharmaceutical sciences students, researchers, educators, and professionals in the pharmaceutical industry to understand the intricacies of new drug research and innovations.

Author : Keservani, Raj K.,Sharma, Anil K.,Kesharwani, Rajesh Kumar
Publisher : IGI Global
Page : 510 pages
File Size : 43,5 Mb
Release : 2016-08-24
Category : Medical
ISBN : 9781522507550

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Recent Advances in Drug Delivery Technology by Keservani, Raj K.,Sharma, Anil K.,Kesharwani, Rajesh Kumar Pdf

Technological innovations have become the impetus for continuous developments in medical research. With the assistance of new technologies, effective drug delivery techniques have been improved for optimal patient care. Recent Advances in Drug Delivery Technology is a pivotal reference source for the latest scholarly research on the application of pharmaceutical technology to optimize techniques for drug delivery in patients. Focusing on novel approaches in pharmaceutical science, this book is ideally designed for medical practitioners, upper-level students, scientists, and researchers.

Author : Dennis Douroumis
Publisher : John Wiley & Sons
Page : 404 pages
File Size : 42,7 Mb
Release : 2012-04-24
Category : Science
ISBN : 9781118307878

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Hot-Melt Extrusion by Dennis Douroumis Pdf

Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.

Author : Anonim
Publisher : Elsevier
Page : 197 pages
File Size : 45,9 Mb
Release : 2019-03-14
Category : Medical
ISBN : 9780444642783

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Progress in Medicinal Chemistry by Anonim Pdf

Progress in Medicinal Chemistry, Volume 58, provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors. Topics covered in this new release include Amyotrophic lateral sclerosis (ALS), Covalent-binding Drugs, Natural Product Drug Delivery – A Special Challenge?, and SMN2 gene splicing modifier, and more. Provides extended, timely reviews of topics in medicinal chemistry Contains targets and technologies relevant to the discovery of tomorrow’s drugs Presents analyses of successful drug discovery programs

Author : Defang Ouyang,Sean C. Smith
Publisher : John Wiley & Sons
Page : 350 pages
File Size : 48,6 Mb
Release : 2015-07-20
Category : Science
ISBN : 9781118573990

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Computational Pharmaceutics by Defang Ouyang,Sean C. Smith Pdf

Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.

Author : Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lirong Liu,William Porter
Publisher : Academic Press
Page : 978 pages
File Size : 53,8 Mb
Release : 2009-03-10
Category : Medical
ISBN : 008093272X

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Developing Solid Oral Dosage Forms by Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lirong Liu,William Porter Pdf

Developing Solid Oral Dosage Forms is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies

Author : Michel Cloitre
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 55,6 Mb
Release : 2010-10-28
Category : Technology & Engineering
ISBN : 9783642163814

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High Solid Dispersions by Michel Cloitre Pdf

From Polymers to Colloids: Engineering the Dynamic Properties of Hairy Particles, by D. Vlassopoulos and G. Fytas * Nonlinear Rheological Properties of Dense Colloidal Dispersions Close to a Glass Transition Under Steady Shear, by M. Fuchs * Micromechanics of Soft Particle Glasses, by R. T. Bonnecaze and M. Cloitre * Quantitative Imaging of Concentrated Suspensions Under Flow, by L. Isa, R. Besseling, A. B. Schofield and W. C. K. Poon * Soft and Wet Materials: From Hydrogels to Biotissues, by J. P. Gong and Y. Osada

Author : Dionysios Douroumis,Alfred Fahr
Publisher : John Wiley & Sons
Page : 543 pages
File Size : 41,6 Mb
Release : 2012-12-19
Category : Science
ISBN : 9781118444672

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Drug Delivery Strategies for Poorly Water-Soluble Drugs by Dionysios Douroumis,Alfred Fahr Pdf

Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.

Author : Anonim
Publisher : Unknown
Page : 440 pages
File Size : 51,5 Mb
Release : 1995
Category : Aeronautics
ISBN : MINN:30000006324267

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Scientific and Technical Aerospace Reports by Anonim Pdf

Author : Po Li. N N
Publisher : CRC Press
Page : 303 pages
File Size : 43,5 Mb
Release : 2018-05-04
Category : Science
ISBN : 9781351084673

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Recent Developments in Separation Science by Po Li. N N Pdf

Volume two of the series focuses on the topics of extraction, filtration, heatless adsorption, hydrometallurgical extraction, interfacial phenomena, separation of gases by regenerative sorption, various polymeric membrane systems, such as electrodialysis, ultrafiltration, reverse osmosis. Gas and liquid separations by selective permeation through polymeric membrane, and the origin of separate system. The last topic, as a special feature of interest, provides an analysis of the genesis and development of new separation techniques.