Recent Results In Cancer Research

Author : K. Schwemmle,K. Aigner
Publisher : Springer
Page : 320 pages
File Size : 51,5 Mb
Release : 1983-09-01
Category : Medical
ISBN : 3540123466

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Vascular Perfusion in Cancer Therapy by K. Schwemmle,K. Aigner Pdf

Substantial relief of discomfort may be anticipated by most patients suffering from pelvic and lower-extremity pain who are treated by arterial infusion of nitrogen mustard. Seventy-three patients with intractable pain secondary to malignancy arising in the pelvis received 83 percutaneous pelvic arterial infusions of this drug. Sixty infusions (72%) resulted in marked relief from pain for periods averaging 6-8 weeks. Advantages of the procedure are low toxicity, relative simplicity and availability of technique, and an acceptable rate of complications with minimal morbidity. Patients experiencing satisfactory results may expect significant relief from a second infusion for recurrent pain. The most rewarding result is the freedom from the cyclic return of pain characterized by oral and intramuscular analgesic therapy. Little or no relief can be expected in patients with pain caused by compression fractures of the vertebrae, or where the tumor burden is so great that adequate perfusion of the involved nerves is not possible. One should consider this procedure for controlling pain before resorting to the more dangerous and potentially disabling techniques of spinal cordotomy or intrathecal alcohol injection. References Bateman JR, Hazen JG, Stolinsky DC, Steinfeld JL (1966) Advanced carcinoma of the cervix treated by intra-arterial methotrexate. Am J Obstet Gynecol 96: 181-187 Calabresi P, Parks RW Jr (1970) Alkylating agents, antimetabolites, hormones. and other antiproliferative agents. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 4th edn.

Author : H. Acker,J. Carlsson,R. Durand,R.M. Sutherland
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642823404

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Spheroids in Cancer Research by H. Acker,J. Carlsson,R. Durand,R.M. Sutherland Pdf

Malignant growth of cells is often characterized by disorganization of tissue structure, abnormal blood vessel development, and insuffi cient vascular supply. As a consequence, the cancer cells grow in a three-dimensional pattern in atypical microenvironments which include physical, chemical, and nutritional stresses. Necrosis often develops some distance away from the blood vessels. In association with an inherent instability in malignant cell populations, and also because of the changing micromilieu, significant cellular heteroge neity emerges with regard to various phenotypic characteristics. Both biological behavior and responses to therapeutic agents can be affected. A variety of in vitro and in vivo experimental models exist for research on properties of cancer cells during growth. The multicell spheroid model was developed as a system of intermediate complexity in which three dimensional growth of cells enhances cell-cell interactions and creates micro environments that simulate the conditions in intervascular microregions of tumors or microme tastatic foci. Spheroids may change their cellular characteristics with changing environments during growth. These can be studied under controlled conditions in vitro. Interest in details of experimental methods for this model system stimulated the organization of the First International Conference in Rochester, NY in 1980, the Proceedings of which were summarized in Cancer Research in 1981. Since then there has been a rapid increase in the use of this model system, and increased research on the significance of cell-cell and cell-microenvironment interactions in biology in general.

Author : Uwe M. Martens
Publisher : Springer Science & Business Media
Page : 242 pages
File Size : 43,6 Mb
Release : 2010-01-14
Category : Medical
ISBN : 9783642012228

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Small Molecules in Oncology by Uwe M. Martens Pdf

Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.

Author : Anonim
Publisher : Unknown
Page : 440 pages
File Size : 43,7 Mb
Release : 1965
Category : Cancer
ISBN : 0387576304

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Fortschritte Der Krebsforschung by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 194 pages
File Size : 55,8 Mb
Release : 1965
Category : Cancer
ISBN : 0387184554

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Fortschritte Der Krebsforschung by Anonim Pdf

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 990 pages
File Size : 45,6 Mb
Release : 2024-06-26
Category : Medicine
ISBN : UOM:39015007732137

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Current Catalog by National Library of Medicine (U.S.) Pdf

First multi-year cumulation covers six years: 1965-70.

Author : R. J. M. Fry,M. L. Griem,W. H. Kirsten
Publisher : Elsevier
Page : 252 pages
File Size : 52,5 Mb
Release : 2014-05-12
Category : Technology & Engineering
ISBN : 9781483223667

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Normal and Malignant Cell Growth by R. J. M. Fry,M. L. Griem,W. H. Kirsten Pdf

Normal and Malignant Cell Growth is a compendium of papers from the "Proceedings of the Third Cancer Training Grant" of the University of Chicago that deals with the processes associated with malignant neoplasia, as well as the cell proliferation kinetics of normal tissues. One paper presents the techniques used in the study on the proliferation kinetics of hemopoietic stem cells, suggesting that the hemopoietic stem cell population is not homogenous but consists of a "primitive pluripotential stem cell." A series of experiments at the Brookhaven National Laboratory investigates the relationship of cell survival, specifically that of stem cells, to the survival of the irradiated test animal. One result of the experiment shows a rapid migration of a number of stem cells from shielded marrow into unshielded marrow at the pressure of a rapid circulating pool. The numbers of stem cells are somewhat dependent on the dose given to the unshielded marrow, and are greater with the greater dose. Another paper also investigates the four methods that are used in the study of cellular kinetics in human tumors. This compendium can prove helpful for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

Author : R. Gross,K.P. Hellriegel
Publisher : Springer
Page : 160 pages
File Size : 50,8 Mb
Release : 1979-08-01
Category : Medical
ISBN : 3540095780

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Strategies in Clinical Hematology by R. Gross,K.P. Hellriegel Pdf

Book of Main Lectures. 5th Meeting of the European and African Division of the International Society of Hematology, Hamburg, August, 26-31, 1979

Author : E. Grundmann,H. Tulinius
Publisher : Elsevier
Page : 258 pages
File Size : 53,5 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483164182

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Current Problems in the Epidemiology of Cancer and Lymphomas by E. Grundmann,H. Tulinius Pdf

Recent Results in Cancer Research: Current Problems in the Epidemiology of Cancer and Lymphomas is a collection of papers that tackles the various areas of concerns in cancer research. The text covers the general problems, such as the histopathological definition and classification of tumors. The book also deals with the various types of cancer, such as breast, liver, and prostrate cancers. The selection will be of great use for medical researchers and practitioners, particularly those who are involved in treating and studying cancers.

Author : Hans Scheurlen,Richard Kay,Michael Baum
Publisher : Springer
Page : 0 pages
File Size : 55,8 Mb
Release : 2011-12-27
Category : Medical
ISBN : 3642834213

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Cancer Clinical Trials by Hans Scheurlen,Richard Kay,Michael Baum Pdf

The controlled clinical trial has become an essential part of the clinician's decision-making process. Clinical trials, however, still raise methodological problems that are important and at the same time controversial: subgroup analysis and interactions, meta-analy sis of similar trials, consideration of subjective clinical opinions and those of the public at large, assessment of quality of life, pre vention trials, and so on. In February 1987 we took our third step along the road to evaluating these issues in dialogues between cli nicians, psychologists, legal experts, and statisticians. The talks presented at the meeting were revised by the authors afterwards and have been rearranged by the editors to form a strictly organ 1 2 ized book. The two preceding meetings in 1978 and 1981 focused strongly on adjuvant therapy in primary breast cancer, but this top ic served merely as a nucleus in the third meeting. This meeting, although called the Third Heidelberg Symposium was forced to leave Heidelberg and in fact was held in Freiburg. Without the interest and enthusiasm of Professor Martin Schu macher and his colleagues in Freiburg the meeting would never have taken place. The meeting was generously supported again by the Federal Ministry of Research and Technology (Bundesministe rium flir Forschung und Technologie, BMFT) within the framework of the West German BMFT Breast Cancer Study Group. We are grateful, in particular, to Mr. Hans W. Herzog for his personal in volvement. Juni 1988 H. Scheurlen, R. Kay, M.

Author : Uwe M. Martens
Publisher : Springer
Page : 297 pages
File Size : 53,7 Mb
Release : 2018-08-01
Category : Medical
ISBN : 9783319914398

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Small Molecules in Hematology by Uwe M. Martens Pdf

This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.

Author : J. Reichrath,M. Friedrich,W. Tilgen
Publisher : Springer Science & Business Media
Page : 448 pages
File Size : 51,6 Mb
Release : 2003-06-23
Category : Medical
ISBN : 3540002901

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Vitamin D Analogs in Cancer Prevention and Therapy by J. Reichrath,M. Friedrich,W. Tilgen Pdf

A comprehensive, highly readable overview of the topics discussed at the First International Symposium on "Vitamin D Analogs in Cancer Prevention and Therapy" held in Homburg/Saar, Germany in May 2002. Leading researchers discuss our present knowledge of the vitamin D system in cancer. Topics range from the newest findings in molecular biology, epidemiology, synthesis and metabolism of vitamin D to new concepts for the use of vitamin D analogs in cancer prophylaxis and treatment. The book provides essential up-to-date information for every researcher or clinician interested in the biology of vitamin D or cancer.

Author : Karen L. Reckamp
Publisher : Springer
Page : 322 pages
File Size : 48,9 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9783319403892

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Lung Cancer by Karen L. Reckamp Pdf

This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer.

Author : Xin-Yuan Liu,Sidney Pestka,Yu-Fang Shi
Publisher : Elsevier
Page : 700 pages
File Size : 46,5 Mb
Release : 2012-05-18
Category : Medical
ISBN : 9780123978363

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Recent Advances in Cancer Research and Therapy by Xin-Yuan Liu,Sidney Pestka,Yu-Fang Shi Pdf

Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment. Includes a wide range of research areas including a focus on biotherapy and the development of novel cancer therapeutic strategies. Formatted for a broad audience including all working in researching cancer treatments and therapies. Discusses special traits and results of Chinese cancer research.

Author : Rolf Bjerkvig
Publisher : CRC Press
Page : 526 pages
File Size : 55,5 Mb
Release : 2017-11-22
Category : Medical
ISBN : 9781351357623

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Spheroid Culture in Cancer Research (1991) by Rolf Bjerkvig Pdf

Spheroid Culture in Cancer Research describes the various techniques now available for establishing spheroid tissue culture, including spheroid culture from normal tissues and from tumor cell lines. The book also describes how the spheroid system can be used to study interactions between normal and malignant cells. Microenvironmental conditions in spheroids and how this micromilieu may promote cellular heterogeneity and histiotypic structures not observed in corresponding monolayer cultures are discussed. The biological importance of oxygen tension, pH gradients, diffusions of nutrients, and cell-cell communication in spheroids are also examined. The book will be profoundly important to researchers in experimental chemotherapy, radiotherapy, immunotherapy, and hyperthermia.