Spheroids In Cancer Research

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Spheroids in Cancer Research

H. Acker,J. Carlsson,R. Durand,R.M. Sutherland
Spheroids in Cancer Research Book PDF

Author : H. Acker,J. Carlsson,R. Durand,R.M. Sutherland
Publisher : Springer Science & Business Media
Page : 328 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642823404

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Spheroids in Cancer Research by H. Acker,J. Carlsson,R. Durand,R.M. Sutherland Pdf

Malignant growth of cells is often characterized by disorganization of tissue structure, abnormal blood vessel development, and insuffi cient vascular supply. As a consequence, the cancer cells grow in a three-dimensional pattern in atypical microenvironments which include physical, chemical, and nutritional stresses. Necrosis often develops some distance away from the blood vessels. In association with an inherent instability in malignant cell populations, and also because of the changing micromilieu, significant cellular heteroge neity emerges with regard to various phenotypic characteristics. Both biological behavior and responses to therapeutic agents can be affected. A variety of in vitro and in vivo experimental models exist for research on properties of cancer cells during growth. The multicell spheroid model was developed as a system of intermediate complexity in which three dimensional growth of cells enhances cell-cell interactions and creates micro environments that simulate the conditions in intervascular microregions of tumors or microme tastatic foci. Spheroids may change their cellular characteristics with changing environments during growth. These can be studied under controlled conditions in vitro. Interest in details of experimental methods for this model system stimulated the organization of the First International Conference in Rochester, NY in 1980, the Proceedings of which were summarized in Cancer Research in 1981. Since then there has been a rapid increase in the use of this model system, and increased research on the significance of cell-cell and cell-microenvironment interactions in biology in general.

Spheroid Culture in Cancer Research

Rolf Bjerkvig
Spheroid Culture in Cancer Research Book PDF

Author : Rolf Bjerkvig
Publisher : CRC-Press
Page : 352 pages
File Size : 55,9 Mb
Release : 1991-11-19
Category : Medical
ISBN : 0849364337

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Spheroid Culture in Cancer Research by Rolf Bjerkvig Pdf

Spheroid Culture in Cancer Research describes the various techniques now available for establishing spheroid tissue culture, including spheroid culture from normal tissues and from tumor cell lines. The book also describes how the spheroid system can be used to study interactions between normal and malignant cells. Microenvironmental conditions in spheroids and how this micromilieu may promote cellular heterogeneity and histiotypic structures not observed in corresponding monolayer cultures are discussed. The biological importance of oxygen tension, pH gradients, diffusions of nutrients, and cell-cell communication in spheroids are also examined. The book will be profoundly important to researchers in experimental chemotherapy, radiotherapy, immunotherapy, and hyperthermia.

Spheroid Culture in Cancer Research (1991)

Rolf Bjerkvig
Spheroid Culture in Cancer Research 1991 Book PDF

Author : Rolf Bjerkvig
Publisher : CRC Press
Page : 526 pages
File Size : 48,9 Mb
Release : 2017-11-22
Category : Medical
ISBN : 9781351357623

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Spheroid Culture in Cancer Research (1991) by Rolf Bjerkvig Pdf

Spheroid Culture in Cancer Research describes the various techniques now available for establishing spheroid tissue culture, including spheroid culture from normal tissues and from tumor cell lines. The book also describes how the spheroid system can be used to study interactions between normal and malignant cells. Microenvironmental conditions in spheroids and how this micromilieu may promote cellular heterogeneity and histiotypic structures not observed in corresponding monolayer cultures are discussed. The biological importance of oxygen tension, pH gradients, diffusions of nutrients, and cell-cell communication in spheroids are also examined. The book will be profoundly important to researchers in experimental chemotherapy, radiotherapy, immunotherapy, and hyperthermia.

Unraveling the Safety Profile of Nanoscale Particles and Materials

Andreia Ferreira de Castro Gomes,Marisa P. Sárria
Unraveling the Safety Profile of Nanoscale Particles and Materials Book PDF

Author : Andreia Ferreira de Castro Gomes,Marisa P. Sárria
Publisher : BoD – Books on Demand
Page : 174 pages
File Size : 46,6 Mb
Release : 2018-03-21
Category : Technology & Engineering
ISBN : 9789535139393

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Unraveling the Safety Profile of Nanoscale Particles and Materials by Andreia Ferreira de Castro Gomes,Marisa P. Sárria Pdf

As nanomaterials become increasingly present in our daily lives, pertinent questions regarding their safety arise. Nanomaterial risk assessment, as in other areas, directs much of the effort worldwide in defining guidelines that may be translated into national or international directives. Nanomaterials encompass different entities, from nanoparticles to nanostructured materials, with specific effects over cells, tissues, organisms and ecosystems depending on their biophysical characteristics. Such interactions will directly affect the impact of novel nanotechnologies. This book aims to provide the reader with a comprehensive overview of the current state of the art in nanotoxicology, featuring the most important developments and critical issues regarding the use of and exposure to nanoparticles.

Revival: Spheroid Culture in Cancer Research (1991)

Rolf Bjerkvig
Revival Spheroid Culture in Cancer Research 1991 Book PDF

Author : Rolf Bjerkvig
Publisher : CRC Press Revivals
Page : 344 pages
File Size : 43,5 Mb
Release : 2019-01-28
Category : Electronic
ISBN : 1138561908

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Revival: Spheroid Culture in Cancer Research (1991) by Rolf Bjerkvig Pdf

Spheroid Culture in Cancer Research describes the various techniques now available for establishing spheroid tissue culture, including spheroid culture from normal tissues and from tumor cell lines. The book also describes how the spheroid system can be used to study interactions between normal and malignant cells. Microenvironmental conditions in spheroids and how this micromilieu may promote cellular heterogeneity and histiotypic structures not observed in corresponding monolayer cultures are discussed. The biological importance of oxygen tension, pH gradients, diffusions of nutrients, and cell-cell communication in spheroids are also examined. The book will be profoundly important to researchers in experimental chemotherapy, radiotherapy, immunotherapy, and hyperthermia.

Cancer Cell Culture

Dania Movia,Adriele Prina-Mello
Cancer Cell Culture Book PDF

Author : Dania Movia,Adriele Prina-Mello
Publisher : Springer Nature
Page : 291 pages
File Size : 46,6 Mb
Release : 2023-05-18
Category : Medical
ISBN : 9781071630563

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Cancer Cell Culture by Dania Movia,Adriele Prina-Mello Pdf

This volume explores the latest collection of cell models that are used in preclinical cancer research, and covers both two-dimensional and three-dimensional culturing techniques. The chapters in this book are divided into two parts. Part One discusses two-dimensional cancer cell culture, cell models at the Air-Liquid Interface, and the latest advancements in three-dimensional complex spheroid models and dedicated disease animal models. Part Two contains technical chapters that illustrate step-by-step methodologies for specific cancer cell culture methods. The methods discussed range from the generation of isogenic cancer cell lines, the use of serum-free growth conditions, and three-dimensional cell cultures and their specific assays for the efficacy assessment of new anticancer therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Cancer Cell Culture: Methods and Protocols is a valuable tool to help researchers involved in this important field to further improve or advance their models for cancer research.

Tumor Microenvironment

Alexander Birbrair
Tumor Microenvironment Book PDF

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 160 pages
File Size : 41,5 Mb
Release : 2020-02-06
Category : Medical
ISBN : 9783030357276

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Tumor Microenvironment by Alexander Birbrair Pdf

This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Cancer Drug Resistance

Beverly A. Teicher
Cancer Drug Resistance Book PDF

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 47,9 Mb
Release : 2007-11-09
Category : Medical
ISBN : 9781597450355

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Cancer Drug Resistance by Beverly A. Teicher Pdf

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Cancer Cell Signaling

Martha Robles-Flores
Cancer Cell Signaling Book PDF

Author : Martha Robles-Flores
Publisher : Humana
Page : 300 pages
File Size : 46,5 Mb
Release : 2020-11-12
Category : Sports & Recreation
ISBN : 1071607588

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Cancer Cell Signaling by Martha Robles-Flores Pdf

This fully updated edition provides the most recent advances in cancer cell signaling knowledge combined with some discussion of the current challenges and prospects in cancer therapy. Beginning with an important section on cancer resistance, the main obstacle to effective cancer therapy, the book continues with chapters exploring state-of-the-art methods in epigenetic control of cancer, metastasis promotion, as well as a variety of new technologies in the study of cancer. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Cancer Cell Signaling: Methods and Protocols, Third Edition serves as an ideal guide to researchers seeking to overcome the challenges in the vital field of cancer cell signaling.

Drug Discovery and Development

Omboon Vallisuta,Suleiman Olimat
Drug Discovery and Development Book PDF

Author : Omboon Vallisuta,Suleiman Olimat
Publisher : BoD – Books on Demand
Page : 332 pages
File Size : 42,7 Mb
Release : 2015-06-03
Category : Medical
ISBN : 9789535121282

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Drug Discovery and Development by Omboon Vallisuta,Suleiman Olimat Pdf

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 44,6 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Bio-Nanomedicine for Cancer Therapy

Flavia Fontana,Hélder A. Santos
Bio Nanomedicine for Cancer Therapy Book PDF

Author : Flavia Fontana,Hélder A. Santos
Publisher : Springer Nature
Page : 358 pages
File Size : 45,5 Mb
Release : 2021-02-04
Category : Medical
ISBN : 9783030581749

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Bio-Nanomedicine for Cancer Therapy by Flavia Fontana,Hélder A. Santos Pdf

The book covers the latest developments in biologically-inspired and derived nanomedicine for cancer therapy. The purpose of the book is to illustrate the significance of naturally-mimicking systems for enhancing the dose delivered to the tumor, to improve stability, and prolong the circulation time. Moreover, readers are presented with advanced materials such as adjuvants for immunostimulation in cancer vaccines. The book also provides a comprehensive overview of the current status of academic research. This is an ideal book for students, researchers, and professors working in nanotechnology, cancer, targeted drug delivery, controlled drug release, materials science, and biomaterials as well as companies developing cancer immunotherapy.

Chapter Nanotoxicity in Cancer Research: Technical Protocols and Tips Considerations for the Use of 3D Tumour Spheroids

Dania Movia,Adriele Prina-Mello
Chapter Nanotoxicity in Cancer Research Technical Protocols and Tips Considerations for the Use of 3D Tumour Spheroids Book PDF

Author : Dania Movia,Adriele Prina-Mello
Publisher : Unknown
Page : 128 pages
File Size : 53,8 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1286325803

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Chapter Nanotoxicity in Cancer Research: Technical Protocols and Tips Considerations for the Use of 3D Tumour Spheroids by Dania Movia,Adriele Prina-Mello Pdf

The poor clinical translation of oncological nanomedicine products is one of the greatest challenges faced by research today. The use of reductionist in vitro models of human cancer and non-predictive animal models is generally considered as one of the main causes of such very low translation rate. The integration of three-dimensional (3D) tumour spheroids in the early stages of the preclinical screening pipeline could significantly facilitate the translation of nanomedicine candidates into clinical practice, by allowing for a more reliable prediction of their efficacy and safety in humans. To lead a successful integration of 3D spheroids, protocols that satisfy issues of ease-of-use, reproducibility and compatibility with conventional and high-throughput assays, without losing the advantages offered by two-dimensional (2D) cell systems, are still needed. To address such need, protocols for the formation and characterisation of scaffold-free 3D tumour spheroids of human adenocarcinoma cells were developed and optimised in this study for their application in nanomedicine safety testing. The protocols reported in this chapter provide the ground on how 3D tumour spheroids could be implemented to design nanomedicine products and speed up experimental cancer research, eliminating those candidates that are likely to be ineffective or unsafe in human at early development stages.

The Physics of Cancer

Caterina A. M. La Porta,Stefano Zapperi
The Physics of Cancer Book PDF

Author : Caterina A. M. La Porta,Stefano Zapperi
Publisher : Cambridge University Press
Page : 187 pages
File Size : 48,7 Mb
Release : 2017-04-20
Category : Science
ISBN : 9781107109599

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The Physics of Cancer by Caterina A. M. La Porta,Stefano Zapperi Pdf

An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.

Tumor Organoids

Shay Soker,Aleksander Skardal
Tumor Organoids Book PDF

Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Page : 213 pages
File Size : 41,8 Mb
Release : 2017-10-20
Category : Medical
ISBN : 9783319605111

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Tumor Organoids by Shay Soker,Aleksander Skardal Pdf

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.