Receptors Membrane Transport And Signal Transduction

Author : A.E. Evangelopoulos,J.P. Changeux,L. Packer,T.G. Sotiroudis,K.W.A. Wirtz
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 42,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642742002

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Receptors, Membrane Transport and Signal Transduction by A.E. Evangelopoulos,J.P. Changeux,L. Packer,T.G. Sotiroudis,K.W.A. Wirtz Pdf

A NATO Advanced study Institute on "Receptors, Membrane Trans port and Signal Transduction", was held on the Island of Spet sai, Greece, from August 16-27, 1988, in order to consider re cent developments in membrane receptor research, membrane trans port and signal transduction mechanisms. These topics were put in the larger context of current knowledge on the structure and function of membranes; connections between different fields of research were established by in-depth dis cussions of energy transduction and transport mechanisms. The general principles of regulation by signal transduction and protein phosphorylation/dephosphorylation were presented in the context of specific cellular processes. Discussions included al so the role of protein tyrosine kinases which are structurally related to oncogene products and, therefore, implicated in va rious aspects of cell development and transformation. This book presents the content of the major lectures and a se lection of the most relevant posters presented during the course of the Institute. The book is intended to make the proceedings of the Institute accessible to a larger audience and to offer a comprehensive account of those topics on receptors, membrane transport and signal transduction that were discussed extensive ly during the course of the Institute. February 1989 The Editors CONTENTS I. G-PROTEINS, ADENYLATE CYCLASE AND PROTEIN PHOSPHORYLATION Selective regulation of G proteins by Cell surface receptors ......... .

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 48,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Edward Bittar
Publisher : Elsevier
Page : 637 pages
File Size : 47,5 Mb
Release : 1997-05-12
Category : Science
ISBN : 0080536115

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Membranes and Cell Signaling by Edward Bittar Pdf

It should not come as too much of a surprise that biological membranes are considerably more complex than lipid bilayers. This has been made quite clear by the fluid-mosaic model which considers the cell membrane as a two-dimensional solution of a mosaic of integral membrane proteins and glycoproteins firmly embedded in a fluid lipid bilayer matrix. Such a model has several virtues, chief among which is that it allows membrane components to diffuse in the plane of the membrane and orient asymmetrically across the membrane. The model is also remarkable since it provokes the right sort of questions. Two such examples are: Does membrane fluidity influence enzyme activity? Does cholesterol regulate fluidity? However, it does not go far enough. As it turns out, there is now another version of this model, the so-called post-fluid mosaic model which incorporates two concepts, namely the existence in the membrane of discrete domains in which specific lipid-lipid, lipid-protein and protein-protein interactions occur and ordered regions that are in motion but remain separate from less ordered regions. We must admit that both are intriguing problems and of importance in guiding our thinking as to what the next model might be. We have chosen not to include the subject of membrane transport in the present volume. This obviously represents a break with convention. However, the intention is to have the topic covered subsequent volumes relating to organ systems. It would be right to regard this as an attempt to strengthen the integrated approach to the teaching of medicine.

Author : Michael S. Roberts,Anne E. Kruchten
Publisher : John Wiley & Sons
Page : 266 pages
File Size : 51,8 Mb
Release : 2016-05-02
Category : Science
ISBN : 9783527337262

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Receptor Biology by Michael S. Roberts,Anne E. Kruchten Pdf

This book is geared to every student in biology, pharmacy and medicine who needs to become familiar with receptor mediated signaling. The text starts with explaining some basics in membrane biochemistry, hormone biology and the concept of receptor based signaling as the main form of communication between cells and of cells with the environment. It goes on covering each receptor superfamily in detail including their structure and evolutionary context. The last part focusses exclusively on examples where thorough knowledge of receptors is critical: pharmaceutical research, developmental biology, neurobiology and evolutionary biology. Richly illustrated, the book is perfectly suited for all courses covering receptor based signaling, regardless whether they are part of the biology, medicine or pharmacology program.

Author : Bastien D. Gomperts,Ijsbrand M. Kramer,Peter E.R. Tatham
Publisher : Gulf Professional Publishing
Page : 444 pages
File Size : 49,6 Mb
Release : 2003-10-15
Category : Medical
ISBN : 0122896327

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Signal Transduction by Bastien D. Gomperts,Ijsbrand M. Kramer,Peter E.R. Tatham Pdf

Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources, key observations and experiments that set the scene for recent and current work.

Author : Krishna C. Persaud,Santiago Marco,Agustin Gutierrez-Galvez
Publisher : CRC Press
Page : 237 pages
File Size : 47,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439871720

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Neuromorphic Olfaction by Krishna C. Persaud,Santiago Marco,Agustin Gutierrez-Galvez Pdf

Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p

Author : Karel W.A. Wirtz
Publisher : Springer Science & Business Media
Page : 340 pages
File Size : 47,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642607998

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Molecular Mechanisms of Signalling and Membrane Transport by Karel W.A. Wirtz Pdf

Proceedings of the NATO Study Institute on Molecular Mechanisms of Signalling and Targeting, held on the Island of Spetsai, Greece, August 18-30, 1996

Author : Carl-Henrik Heldin,Mary Purton
Publisher : Garland Science
Page : 404 pages
File Size : 53,8 Mb
Release : 1996
Category : Cell physiology
ISBN : 0748740740

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Signal Transduction by Carl-Henrik Heldin,Mary Purton Pdf

Signal Transduction was published in association with The International Union of Biochemistry and Molecular Biology. In a series of twenty-three short chapters, leading researchers provide cutting-edge reviews of signal transduction, and form cell membrane receptors through to gene regulation. Written for those with a basic understanding of molecular and cell biology, the book will be of particular interest to graduate students and researchers who need to grasp the principles of signal transduction.

Author : Ari Sitaramayya
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 48,7 Mb
Release : 2009-12-02
Category : Science
ISBN : 9783642021121

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Signal Transduction: Pathways, Mechanisms and Diseases by Ari Sitaramayya Pdf

Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

Author : Meir Shinitzky
Publisher : Wiley-Blackwell
Page : 340 pages
File Size : 51,9 Mb
Release : 1993
Category : Science
ISBN : CORNELL:31924074099403

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Biomembranes, Signal Transduction Across Membranes by Meir Shinitzky Pdf

Biomembranes Signal Transduction Across Membranes Edited by Meir Shinitzky An up-to-date review of basic research on biomembranes. In this volume, foremost experts in the field consider the most important aspects of signal transduction across biological membranes: General Mechanistic Patterns of Signal Transduction Receptors for Neurotransmitters and Peptide Hormones G Proteins in Signal Transduction Membrane-associated Protein Kinases and Phosphatases Phospholipases in Signal Transduction The volume is an excellent supplement to "Biomembranes -- Physical Aspects" and "Biomembranes -- Structural and Functional Aspects," also edited by Meir Shinitzky. These three books together provide a comprehensive ground for understanding complex physiological processes. Meir Shinitzky, Ph.D., is Professor of Biophysics in the Department of Membrane Research and Biophysics. The Weizman Institute of Science, Rehovot, Israel. Since 1971, his research has focused on various aspects of membrane structure and dynamics.

Author : Jennifer N. Meyers
Publisher : Nova Publishers
Page : 270 pages
File Size : 53,8 Mb
Release : 2007
Category : Cell interaction
ISBN : 1600213758

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Trends in Signal Transduction Research by Jennifer N. Meyers Pdf

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Author : Bruce R. Yanson
Publisher : Nova Publishers
Page : 282 pages
File Size : 47,7 Mb
Release : 2007
Category : Cell interaction
ISBN : 1600213790

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New Research on Signal Transduction by Bruce R. Yanson Pdf

In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. In such cases the chain of steps is referred to as a "signalling cascade" or a "second messenger pathway" and often results in a small stimulus eliciting a large response. Hormones and other signalling molecules may exit the sending cell by exocytosis or other means of membrane transport. The sending cell is typically of a specialised type. Its recipients may be of one type or several, as in the case of insulin, which triggers diverse and systemic effects. This book sheds new light in this exciting field of cell transportation research.

Author : Douglas A. Lauffenburger,Jennifer Linderman
Publisher : Oxford University Press
Page : 376 pages
File Size : 47,7 Mb
Release : 1996-01-11
Category : Science
ISBN : 9780190283063

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Receptors by Douglas A. Lauffenburger,Jennifer Linderman Pdf

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.

Author : Gary B. Willars,R. A. John Challiss
Publisher : Springer Science & Business Media
Page : 420 pages
File Size : 47,8 Mb
Release : 2008-02-03
Category : Science
ISBN : 9781592597543

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Receptor Signal Transduction Protocols by Gary B. Willars,R. A. John Challiss Pdf

This second edition of Receptor Signal Transduction Protocols not only has a new editor, but also a greater focus on G-protein-coupled receptors, their properties per se, and their coupling to immediate downstream binding partners—principally, although not exclusively, the heterotrimeric G-proteins. The new edition combines updates of key chapters from the first edition, as well as a large number of new contributions covering key methodologies that have emerged, or been extended to receptor/G-protein research, in the past 5–6 years. In common with many fields, the range of methods used to assess the first steps in signal transduction are continually expanding and methods that might have been considered too specialized five years ago are now sufficiently routine to be included here. Unlike many research areas, where off-the-shelf kits have made research basically foolproof, signal transduction research still requires considerable expertise, and the methods included here are provided by internationally recognized experts in their fields who have many years of experience using the methods they describe. This not only allows each chapter to impart a clear description of the method, but also to furnish invaluable troubleshooting advice for when things do not go entirely according to plan. Once again we would like to thank the Series Editor, John Walker, for the invitation to compile this second edition, and to express our gratitude to all of the authors who have enthusiastically agreed to provide the uniformly excellent contributions.

Author : E. Wagner,H. Greppin,B. Millet
Publisher : Springer
Page : 264 pages
File Size : 54,5 Mb
Release : 1987
Category : Cell interaction
ISBN : MINN:31951D00005197L

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The Cell Surface in Signal Transduction by E. Wagner,H. Greppin,B. Millet Pdf