Trends In Signal Transduction Research

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Trends in Signal Transduction Research

Jennifer N. Meyers
Trends in Signal Transduction Research Book PDF

Author : Jennifer N. Meyers
Publisher : Nova Publishers
Page : 270 pages
File Size : 47,6 Mb
Release : 2007
Category : Cell interaction
ISBN : 1600213758

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Trends in Signal Transduction Research by Jennifer N. Meyers Pdf

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Signal Transduction Research Trends

Nickolas O. Grachevsky
Signal Transduction Research Trends Book PDF

Author : Nickolas O. Grachevsky
Publisher : Nova Publishers
Page : 330 pages
File Size : 54,7 Mb
Release : 2007
Category : Medical
ISBN : 1600214878

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Signal Transduction Research Trends by Nickolas O. Grachevsky Pdf

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs

Sundas Fayyaz,Ammad Ahmad Farooqi
Recent Trends in Cancer Biology Spotlight on Signaling Cascades and microRNAs Book PDF

Author : Sundas Fayyaz,Ammad Ahmad Farooqi
Publisher : Springer
Page : 308 pages
File Size : 42,7 Mb
Release : 2018-03-07
Category : Medical
ISBN : 9783319715537

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Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs by Sundas Fayyaz,Ammad Ahmad Farooqi Pdf

Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.

Signal Transduction in Cancer

David A. Frank
Signal Transduction in Cancer Book PDF

Author : David A. Frank
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 44,5 Mb
Release : 2002-12-31
Category : Medical
ISBN : 9781402073403

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Signal Transduction in Cancer by David A. Frank Pdf

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Integrins and Ion Channels

Andrea Becchetti,Annarosa Arcangeli
Integrins and Ion Channels Book PDF

Author : Andrea Becchetti,Annarosa Arcangeli
Publisher : Springer Science & Business Media
Page : 124 pages
File Size : 44,6 Mb
Release : 2010-12-28
Category : Medical
ISBN : 9781441960665

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Integrins and Ion Channels by Andrea Becchetti,Annarosa Arcangeli Pdf

Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Wolfgang B. Liedtke, MD, PH.D.
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Book PDF

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Page : 467 pages
File Size : 51,6 Mb
Release : 2006-09-29
Category : Science
ISBN : 9781420005844

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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by Wolfgang B. Liedtke, MD, PH.D. Pdf

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Biochemistry of Signal Transduction and Regulation

Gerhard Krauss
Biochemistry of Signal Transduction and Regulation Book PDF

Author : Gerhard Krauss
Publisher : John Wiley & Sons
Page : 558 pages
File Size : 49,8 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605767

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Biochemistry of Signal Transduction and Regulation by Gerhard Krauss Pdf

This all-new edition of a classic text has been thoroughly revised to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity the author relates the observed biological phenomena to the underlying biochemical processes. Directed to advanced students, teachers, and researchers in biochemistry and molecular biology, this book describes the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis. "Provides a comprehensive account of cell signaling and signal transduction and, where possible, explains these processes at the molecular level" (Angewandte Chemie) "The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation." (Biochemistry) "This book is actually two books: Regulation and Signal Transduction." (Drug Research)

Protein Kinase-mediated Decisions Between Life and Death

Ayse Basak Engin,Atilla Engin
Protein Kinase mediated Decisions Between Life and Death Book PDF

Author : Ayse Basak Engin,Atilla Engin
Publisher : Springer Nature
Page : 415 pages
File Size : 52,7 Mb
Release : 2021-02-04
Category : Medical
ISBN : 9783030498443

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Protein Kinase-mediated Decisions Between Life and Death by Ayse Basak Engin,Atilla Engin Pdf

Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

A Practical Guide to the Study of Calcium in Living Cells

Anonim
A Practical Guide to the Study of Calcium in Living Cells Book PDF

Author : Anonim
Publisher : Academic Press
Page : 368 pages
File Size : 43,6 Mb
Release : 1994-04-25
Category : Science
ISBN : 0080859380

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A Practical Guide to the Study of Calcium in Living Cells by Anonim Pdf

A Practical Guide to the Study of Calcium in Living Cells describes popular techniques along with helpful do's and don't's and computer programs. The volume enables investigators to evaluate confocal images, use the latest dyes, and design Calcium buffers appropriate to their research needs. This book is designed for laboratory use by graduate students, technicians, and researchers in many disciplines, ranging from molecular to cellular levels of investigation. Describes techniques for detection of [Ca2+]I: Ca2+ - sensitive microelectrodes Fluorescent dyes Luminescent proteins Includes techniques for perturbing intracellular Ca2+ Covers detailed methodology plus problems and pitfalls of each technique Contains a practical guide to preparing Ca2+ buffers with an easy-to-use computer program Color plates illustrate techniques such as Confocal ratio-imaging Use of aequorin

Histidine Kinases in Signal Transduction

Masayori Inouye,Rinku Dutta
Histidine Kinases in Signal Transduction Book PDF

Author : Masayori Inouye,Rinku Dutta
Publisher : Elsevier
Page : 539 pages
File Size : 47,6 Mb
Release : 2002-11-13
Category : Science
ISBN : 9780080534015

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Histidine Kinases in Signal Transduction by Masayori Inouye,Rinku Dutta Pdf

Living cells are constantly sensing environmental changes, and their abilities to sense these changes and adapt to them are essential for their survival. In bacteria, histidine kinases are the major sensors for these environmental stresses, enabling cells to adapt to new growth conditions. Written by leading experts in the field, this book provides an up-to-date and comprehensive review on the structure and function of histidine kinases. It also provides extensive information on the physiological roles of histidine kinases in bacteria and eukaryotes. An an essential reference for cell biologists, microbiologists, molecular biologists, and biochemists interested in signal transduction. Experimental biologists and pharmacologists studying signal transduction systems in living organisms will also find it a valuable research tool. The first comprehensive book on the roles of histidine kinases in cells 23 in-depth chapters written by leading experts in the field Describes the most recent advances in the field of signal transduction

Inflammatory Processes

L. Gordon Letts,Douglas W. Morgan
Inflammatory Processes Book PDF

Author : L. Gordon Letts,Douglas W. Morgan
Publisher : Springer Science & Business Media
Page : 164 pages
File Size : 43,6 Mb
Release : 2000
Category : Health & Fitness
ISBN : 3764360259

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Inflammatory Processes by L. Gordon Letts,Douglas W. Morgan Pdf

In October 1998, key leaders of new drug discovery for inflammatory di seases gathered at Hershey, Pennsylvania, for the 10th International C onference of the Inflammation Research Association. The conference pro vided a stimulating environment for the open exchange of important adv ances in basic inflammation research and new drug discovery and develo pment. This book encompasses highlights of several presentations made at the conference and contains some of the latest and important develo pments in the field of inflammation research.

Plant Hormones

Peter J. Davies
Plant Hormones Book PDF

Author : Peter J. Davies
Publisher : Springer Science & Business Media
Page : 802 pages
File Size : 48,9 Mb
Release : 2007-11-06
Category : Science
ISBN : 9781402026867

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Plant Hormones by Peter J. Davies Pdf

Plant hormones play a crucial role in controlling the way in which plants grow and develop. While metabolism provides the power and building blocks for plant life, it is the hormones that regulate the speed of growth of the individual parts and integrate them to produce the form that we recognize as a plant. This book is a description of these natural chemicals: how they are synthesized and metabolized, how they act at both the organismal and molecular levels, how we measure them, a description of some of the roles they play in regulating plant growth and development, and the prospects for the genetic engineering of hormone levels or responses in crop plants. This is an updated revision of the third edition of the highly acclaimed text. Thirty-three chapters, including two totally new chapters plus four chapter updates, written by a group of fifty-five international experts, provide the latest information on Plant Hormones, particularly with reference to such new topics as signal transduction, brassinosteroids, responses to disease, and expansins. The book is not a conference proceedings but a selected collection of carefully integrated and illustrated reviews describing our knowledge of plant hormones and the experimental work that is the foundation of this information. The Revised 3rd Edition adds important information that has emerged since the original publication of the 3rd edition. This includes information on the receptors for auxin, gibberellin, abscisic acid and jasmonates, in addition to new chapters on strigolactones, the branching hormones, and florigen, the flowering hormone.

Hybrid Artificial Intelligence Systems

Emilio Corchado,Ajith Abraham
Hybrid Artificial Intelligence Systems Book PDF

Author : Emilio Corchado,Ajith Abraham
Publisher : Springer
Page : 767 pages
File Size : 45,9 Mb
Release : 2008-09-30
Category : Computers
ISBN : 9783540876564

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Hybrid Artificial Intelligence Systems by Emilio Corchado,Ajith Abraham Pdf

The Third International Workshop on Hybrid Artificial Intelligence Systems (HAIS 2008) presented the most recent developments in the dynamically expanding realm of symbolic and sub-symbolic techniques aimed at the construction of highly robust and reliable problem-solving techniques. Hybrid intelligent systems have become incre- ingly popular given their capabilities to handle a broad spectrum of real-world c- plex problems which come with inherent imprecision, uncertainty and vagueness, high-dimensionality, and non stationarity. These systems provide us with the oppor- nity to exploit existing domain knowledge as well as raw data to come up with prom- ing solutions in an effective manner. Being truly multidisciplinary, the series of HAIS workshops offers a unique research forum to present and discuss the latest theoretical advances and real-world applications in this exciting research field. This volume of Lecture Notes on Artificial Intelligence (LNAI) includes accepted papers presented at HAIS 2008 held in University of Burgos, Burgos, Spain, Sept- ber 2008 The global purpose of HAIS conferences has been to form a broad and interdis- plinary forum for hybrid artificial intelligence systems and associated learning pa- digms, which are playing increasingly important roles in a large number of application areas. Since its first edition in Brazil in 2006, HAIS has become an important forum for researchers working on fundamental and theoretical aspects of hybrid artificial intel- gence systems based on the use of agents and multiagent systems, bioinformatics and bio-inspired models, fuzzy systems, artificial vision, artificial neural networks, opti- zation models and alike.

Stress Signaling in Plants: Genomics and Proteomics Perspective, Volume 1

Maryam Sarwat,Altaf Ahmad,MZ Abdin
Stress Signaling in Plants Genomics and Proteomics Perspective Volume 1 Book PDF

Author : Maryam Sarwat,Altaf Ahmad,MZ Abdin
Publisher : Springer Science & Business Media
Page : 241 pages
File Size : 41,9 Mb
Release : 2013-06-21
Category : Science
ISBN : 9781461463726

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Stress Signaling in Plants: Genomics and Proteomics Perspective, Volume 1 by Maryam Sarwat,Altaf Ahmad,MZ Abdin Pdf

Plant diseases, extreme weather caused by climate change, drought and an increase in metals in soil are amongst the major limiting factors of crop production worldwide. They devastate not only food supply but also the economy of a nation. Keeping in view of the global food scarcity, there is, an urgent need to develop crop plants with increased stress tolerance so as to meet the global food demands and to preserve the quality of our planet. In order to do this, it is necessary to understand how plants react and adapt to stress from the genomic and proteomic perspective. Plants adapt to stress conditions by activation of cascades of molecular mechanisms, which result in alterations in gene expression and synthesis of protective proteins/compounds. From the perception of the stimulus to transduction of the signal, followed by an appropriate response, the plants employ a complex network of primary and secondary messenger molecules. Cell signaling is the component of a complex system of communication that directs basic cellular activities and synchronizes cell actions. Cells exercise a large number of noticeably distinct signaling pathways to regulate their activity. In order to contend with different environmental adversities plants have developed a series of mechanisms at the physiological, cellular and molecular level. This two volume set takes an in-depth look at the Stress Signaling in Plants from a uniquely genomic and proteomics perspective. Stress Signaling in Plants offers a comprehensive treatise on the Chapter, covering all of the signaling pathways and mechanisms that have been researched so far. Each chapter provides in-depth explanation of what we currently know of a particular aspect of stress signaling and where we are headed. All authors have currently agreed and abstracts have been complied for the first volume, due out midway through 2012. We aim to have the second volume out at the beginning of 2013.​

International Textbook of Diabetes Mellitus

R. A. DeFronzo,E. Ferrannini,Paul Zimmet,George Alberti
International Textbook of Diabetes Mellitus Book PDF

Author : R. A. DeFronzo,E. Ferrannini,Paul Zimmet,George Alberti
Publisher : John Wiley & Sons
Page : 1240 pages
File Size : 43,8 Mb
Release : 2015-03-11
Category : Medical
ISBN : 9781118387672

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International Textbook of Diabetes Mellitus by R. A. DeFronzo,E. Ferrannini,Paul Zimmet,George Alberti Pdf

The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.