Recombinant Antibodies For Infectious Diseases

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Recombinant Antibodies for Infectious Diseases

Theam Soon Lim
Recombinant Antibodies for Infectious Diseases Book PDF

Author : Theam Soon Lim
Publisher : Springer
Page : 296 pages
File Size : 43,7 Mb
Release : 2018-03-16
Category : Medical
ISBN : 9783319720777

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Recombinant Antibodies for Infectious Diseases by Theam Soon Lim Pdf

There are many principles and applications of recombinant antibodies for infectious diseases. The preferred technology associated to recombinant antibody generation is mainly phage display. The adaptation of antibodies for infectious diseases is an area lacking information as most literature is focused on oncology or autoimmunity. This project highlights the power and potential of antibody phage display for infectious diseases. In addition to that, supplementary information regarding technologies associated to antibody generation and engineering in the context of infectious disease will also help to provide greater insight to the potential of recombinant antibodies for infectious diseases.

Antibodies for Infectious Diseases

James E. Crowe, Jr.,Diana Boraschi,Rino Rappuoli
Antibodies for Infectious Diseases Book PDF

Author : James E. Crowe, Jr.,Diana Boraschi,Rino Rappuoli
Publisher : John Wiley & Sons
Page : 601 pages
File Size : 45,8 Mb
Release : 2015-05-01
Category : Medical
ISBN : 9781683673408

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Antibodies for Infectious Diseases by James E. Crowe, Jr.,Diana Boraschi,Rino Rappuoli Pdf

State-of-the-art reviews covering major aspects of antibodies and intervention against infectious diseases The connection between antibodies and infectious diseases has spawned entire related fields of study. Antibodies for Infectious Diseases presents perspectives from leading research scientists and summarizes the amazing progress in this area into a single definitive source. Providing a broad survey of the most important aspects of the field of antibodies for infectious diseases, this book presents general features pertaining to structure, function, isotype, and the role of complement in antibody function examines the role of antibodies in antimicrobial immunity with specific targets details new methods for expression of monoclonal antibodies, in plants or by transfer of antibody genes for in vivo expression in treated subjects Antibodies for Infectious Diseases is a comprehensive reference for researchers, pharmaceutical developers, and health care professionals on the status of the development of antibody-based therapies for treating infectious diseases. It is also useful as supplemental reading for upper level life sciences students. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.

Recombinant Antibodies for Immunotherapy

Melvyn Little
Recombinant Antibodies for Immunotherapy Book PDF

Author : Melvyn Little
Publisher : Cambridge University Press
Page : 445 pages
File Size : 44,9 Mb
Release : 2009-07-27
Category : Medical
ISBN : 9780521887328

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Recombinant Antibodies for Immunotherapy by Melvyn Little Pdf

This book provides a comprehensive overview of the field of monoclonal antibodies through twenty-five articles by recognized experts in the field.

Recombinant Antibodies for Cancer Therapy

Martin Welschof,Jürgen Krauss
Recombinant Antibodies for Cancer Therapy Book PDF

Author : Martin Welschof,Jürgen Krauss
Publisher : Springer Science & Business Media
Page : 476 pages
File Size : 41,8 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781592593347

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Recombinant Antibodies for Cancer Therapy by Martin Welschof,Jürgen Krauss Pdf

Since the advent of hybridoma technology more than two decades ago, numerous antibodies have entered the clinical setting as potent therapeutic agents. Their repeated application in humans, however, is limited by the development of human antimouse antibodies (HAMA) in the recipient, leading to allergic re- tions against the foreign murine protein and rapid neutralization. To circumvent these limitations many new antibodies have recently been tailored through recombinant antibody technology. The initial clinical data show encouraging results, thus demonstrating the potential of these new therapeutic agents. The purpose of Recombinant Antibodies for Cancer Therapy is to present a collection of detailed protocols in recombinant antibody technology. It is pri- rily addressed to scientists working on recombinant antibodies as well as cli- cians involved with antibody-based therapies. As with other volumes of this series, we placed the main focus on providing detailed protocols describing procedures step-by-step. Moreover, each protocol supplies a troubleshooting guide containing detailed information on possible problems and hints for pot- tial solutions. Antibody technology is a subject of constant and rapid change. This volume, therefore, does not attempt to cover all possible current experimental approaches in the field. Rather, we present carefully selected protocols, written by competent authors who have successfully verified the particular method described. Given our own professional backgrounds and interest in oncology, we chose to conc- trate chiefly on therapeutic agents for cancer patients.

Recombinant Antibodies

Frank Breitling,Stefan Dübel
Recombinant Antibodies Book PDF

Author : Frank Breitling,Stefan Dübel
Publisher : Wiley-Spektrum
Page : 180 pages
File Size : 50,9 Mb
Release : 1999-09-30
Category : Medical
ISBN : UOM:39015047573665

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Recombinant Antibodies by Frank Breitling,Stefan Dübel Pdf

As new recombinant DNA technology continues to join with cellular and molecular immunology, the field of antibody engineering has become a flourishing discipline. Antibody genes are now being cloned, genetically manipulated, and expressed to produce antigen binding proteins. Recombinant Antibodies addresses this burgeoning field with its comprehensive survey of the developing possibilities for producing specific antibodies by combinatorial methods. Following a comprehensive introduction to the field, the book is divided into four parts: a detailed introduction to the underlying concepts of recombinant antibodies, a description of the various methods for the generation of recombinant antibodies, their production and purification, and various designs and applications of genetically engineered proteins. The combination of these techniques substantially extends the functionality of natural antibodies. In addition, the book will focus on: Hybridoma immortalization. Generation and functional screening of highly complex antibody gene libraries. Human monoclonal antibodies to highly toxic and pathogenic antigens. Improving specificity or affinity of antibodies. New agents for cancer diagnosis and therapy. Genetic fusions for the production of bi- and multifunctional molecules. Production of large quantities of recombinant antibodies. New methods of purification. Emerging technologies. Recombinant Antibodies is the first general overview of the emerging field of antibody engineering and will serve as the definitive source for researchers and engineers in biology and medicine, biochemistry, immunology, and molecular biology, as well as anyone who is interested in biotechnology and antibody engineering.

Antibody Engineering

Patrick Chames
Antibody Engineering Book PDF

Author : Patrick Chames
Publisher : Humana Press
Page : 734 pages
File Size : 52,5 Mb
Release : 2012-08-21
Category : Medical
ISBN : 1617799734

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Antibody Engineering by Patrick Chames Pdf

More than ever, antibodies are being recognized as a major drug modality in a variety of diseases, including cancer, autoimmune diseases, infectious diseases, or even neurodegenerative disorders. Over 30 therapeutic antibodies have been approved and novel molecules are entering clinical trials at an average rate of 50 per year and that is predicted to continue well into the future. Notwithstanding the many achievements already made in the field, there is still a lot of room for improvements for these molecules in terms of activity, and a plethora of approaches have been attempted to optimize these molecules. Antibody Engineering: Methods and Protocols, Second Edition was compiled to give complete and easy access to a variety of antibody engineering techniques, starting from the creation of antibody repertoires and efficient ways to select binders from these repertoires, to their production in various hosts, their detailed characterization using various well established techniques, and to the modification and optimization of these lead molecules in terms of binding activity, specificity, size, shape, and more. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Antibody Engineering: Methods and Protocols, Second Edition serves as an invaluable resource for both experts and those new to the field, and most of all as a source of inspiration for the creation of the antibodies of tomorrow.

Nonhuman Primates I

Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt
Nonhuman Primates I Book PDF

Author : Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt
Publisher : Springer
Page : 0 pages
File Size : 50,5 Mb
Release : 2011-12-15
Category : Medical
ISBN : 3642849083

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Nonhuman Primates I by Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt Pdf

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The Mo nographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stu dies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors -strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on Nonhuman Primates, is the eleventh volume of a set pre pared under the sponsorship of the International Life Sciences Institute (ILSI).

Monoclonal Antibody Production

National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies
Monoclonal Antibody Production Book PDF

Author : National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies
Publisher : National Academies Press
Page : 74 pages
File Size : 43,8 Mb
Release : 1999-05-06
Category : Medical
ISBN : 9780309173056

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Monoclonal Antibody Production by National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies Pdf

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.

Treating Infectious Diseases in a Microbial World

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Treating Infectious Diseases in a Microbial World Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 54,6 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689

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Treating Infectious Diseases in a Microbial World by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials Pdf

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Drug-Induced Liver Injury

Anonim
Drug Induced Liver Injury Book PDF

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 46,7 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Immunologic Concepts in Transfusion Medicine

Robert W Maitta
Immunologic Concepts in Transfusion Medicine Book PDF

Author : Robert W Maitta
Publisher : Elsevier Health Sciences
Page : 380 pages
File Size : 54,7 Mb
Release : 2019-08-27
Category : Medical
ISBN : 9780323675109

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Immunologic Concepts in Transfusion Medicine by Robert W Maitta Pdf

Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. Consolidates today’s available information on this timely topic into a single, convenient resource.

Protein Therapeutics, 2 Volume Set

Tristan Vaughan,Jane Osbourn,Bahija Jallal
Protein Therapeutics 2 Volume Set Book PDF

Author : Tristan Vaughan,Jane Osbourn,Bahija Jallal
Publisher : John Wiley & Sons
Page : 762 pages
File Size : 52,8 Mb
Release : 2017-12-04
Category : Medical
ISBN : 9783527340866

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Protein Therapeutics, 2 Volume Set by Tristan Vaughan,Jane Osbourn,Bahija Jallal Pdf

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

Antibody Engineering

Thomas Böldicke
Antibody Engineering Book PDF

Author : Thomas Böldicke
Publisher : BoD – Books on Demand
Page : 314 pages
File Size : 55,6 Mb
Release : 2018-02-21
Category : Medical
ISBN : 9789535138259

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Antibody Engineering by Thomas Böldicke Pdf

Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets.

Therapy of Infectious Diseases

Larry M. Baddour,Sherwood L. Gorbach
Therapy of Infectious Diseases Book PDF

Author : Larry M. Baddour,Sherwood L. Gorbach
Publisher : Unknown
Page : 948 pages
File Size : 40,6 Mb
Release : 2003
Category : Communicable diseases
ISBN : UOM:39015056233193

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Therapy of Infectious Diseases by Larry M. Baddour,Sherwood L. Gorbach Pdf

Heres thorough, up-to-date guidance on the prevention, diagnosis, and management of infectious diseases seen around the world. Readers will find evidenced-based management recommendations as well as personal suggestions from expert contributors in areas where there is not enough data to otherwise direct treatment decisions. Emphasis is placed on syndromes and patient management instead of pathogens, making this resource very useful for clinicians. Each chapter includes an extensive list of up-to-date references. Offers evidence-based management recommendations as well as personal suggestions from expert contributors in areas where there is not enough data to otherwise direct treatment decisions. Focuses on syndromes instead of pathogens, reflecting the empiric nature of infectious disease therapy and making it very useful for clinicians. Covers infectious diseases seen around the world. Provides an extensive list of up-to-date references in each chapter.

Handbook of Therapeutic Antibodies

Stefan Dübel,Janice M. Reichert
Handbook of Therapeutic Antibodies Book PDF

Author : Stefan Dübel,Janice M. Reichert
Publisher : John Wiley & Sons
Page : 2538 pages
File Size : 40,8 Mb
Release : 2014-12-03
Category : Science
ISBN : 9783527329373

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Handbook of Therapeutic Antibodies by Stefan Dübel,Janice M. Reichert Pdf

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.