Regenerative Nephrology

Author : Michael S. Goligorsky
Publisher : Academic Press
Page : 528 pages
File Size : 50,6 Mb
Release : 2021-06-12
Category : Science
ISBN : 9780128233191

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Regenerative Nephrology by Michael S. Goligorsky Pdf

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition. A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes A new section on tissue engineering of the kidney of interest to nephrologists and urologists An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues

Author : Giuseppe Orlando,Giuseppe Remuzzi,David F. Williams
Publisher : Academic Press
Page : 1252 pages
File Size : 47,5 Mb
Release : 2017-06-08
Category : Science
ISBN : 9780128018361

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Kidney Transplantation, Bioengineering, and Regeneration by Giuseppe Orlando,Giuseppe Remuzzi,David F. Williams Pdf

Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function

Author : Melissa Helen Little
Publisher : Academic Press
Page : 614 pages
File Size : 42,7 Mb
Release : 2015-08-06
Category : Medical
ISBN : 9780128004388

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Kidney Development, Disease, Repair and Regeneration by Melissa Helen Little Pdf

Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 41,6 Mb
Release : 2024-06-06
Category : Electronic
ISBN : 9789814467377

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Present and Future Therapies for End-Stage Renal Disease by Anonim Pdf

Author : Yoshio Terada,Takashi Wada,Kent Doi
Publisher : Springer Nature
Page : 390 pages
File Size : 46,6 Mb
Release : 2020-05-14
Category : Medical
ISBN : 9789811511080

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Acute Kidney Injury and Regenerative Medicine by Yoshio Terada,Takashi Wada,Kent Doi Pdf

This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis.Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.

Author : Eli A. Friedman,Mary C. Mallappallil
Publisher : World Scientific
Page : 202 pages
File Size : 50,7 Mb
Release : 2010
Category : Medical
ISBN : 9789814280020

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Present and Future Therapies for End-stage Renal Disease by Eli A. Friedman,Mary C. Mallappallil Pdf

The contributors include physicians who practise uremia therapy since its conception to more recent graduates, along with surgeons, pioneers and physicians who are patients themselves, thus giving readers the broadest perspective. --

Author : Phuc Van Pham
Publisher : Springer
Page : 326 pages
File Size : 49,9 Mb
Release : 2017-06-07
Category : Science
ISBN : 9783319556871

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Pancreas, Kidney and Skin Regeneration by Phuc Van Pham Pdf

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in diabetes, kidney and wound treatment. All chapters are contributed by pre-eminent scientists in the field and covers such topics as stem cells and cell therapy in the treatment of diabetes mellitus, kidney failure, wound and other skin aging diseases, characteristics of some kinds of stem/progenitor cells for therapy, future directions of the discussed therapies and much more. Pancreas, Kidney and Skin Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Author : Ena Ray Banerjee
Publisher : Springer
Page : 152 pages
File Size : 48,8 Mb
Release : 2014-10-20
Category : Science
ISBN : 9788132220534

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Perspectives in Regenerative Medicine by Ena Ray Banerjee Pdf

The information given in this book tries to capture the essence of the sheer dynamicity of the cell along with useful tips on how to address critical rate limiting steps in the process of exploration and investigation of its capacity to regenerate, rebuild and replenish from within. The definitions of stem cells, stemness, and the niche concept continue to undergo revisions. In adult vertebrates, hematopoietic and some non-hematopoietic progenitors are synthesized within specialized niches of bone marrow. They migrate to designated tissues, and are either trans-differentiated or become quiescent and settle down. These form the stem cell niche reservoir in all tissues. Not only the primary hematopoietic tissue but all organs and tissues are also capable of generating progenitors which are either synthesized from these migrants or are direct recruits from other tissues. In the niches, the cells settle down and await their turn to either make more clones like themselves or differentiate and mobilize in an exigency. Thus progenitors are important reserves, to be multiplied and deployed or travel as important message bearing molecules via blood as circulating progenitors which can home to their allocated destinations. Upon reaching, specific integrins and selectins help them “dock” and “port” and they may be reprogrammed to induce further differentiation and help repopulate the denuded tissue. In pulmonary fibrosis and asthma, progenitors from both systemic circulation and local stem cell niches have been found to participate in the myriad ramifications of repair, replacement and regeneration of lost or diseased tissue. Whether they are lung specific or global in origin and role remain to be explored. Research tools, fundamental concepts, techniques, methodologies and standard operating protocols and animal models and human extrapolations, have been discussed in a concise way along with detailed description and discussion on the appropriate rationale to introduce the subject to the casual reader and provide valuable tactical information to the specialist in Regenerative Medicine. I sincerely hope you enjoy the work and appreciate the hard work that has gone into designing and executing elegant experiments by many researchers in the field. The branch is multi-disciplinary and I hope that the readers will not be limited to biologists alone.

Author : A. Benigni,P. Romagnani,G. Remuzzi
Publisher : S. Karger AG (Switzerland)
Page : 0 pages
File Size : 49,7 Mb
Release : 2014-05-16
Category : Electronic
ISBN : 3318026778

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Kidney Regeneration by A. Benigni,P. Romagnani,G. Remuzzi Pdf

Adult stem cells and progenitor cells can respond dynamically to injury and fuel substantial regeneration of damaged tissues. For these reasons, they are thought to have important roles in the etiology of disease, malignancy, and aging. In humans, there exists a renal progenitor system consisting of bipotent progenitors, tubular progenitors, and podocyte progenitors. Growing evidence indicates that some renal disorders can be related to renal progenitor dysfunction, suggesting that renal progenitor function may be modulated for therapeutic purposes. In this publication, the roles of renal progenitors and other stem cell types involved in the response to injury, cell therapy, reprogramming, and tissue engineering are explored, presenting the current foundation of tissue engineering/regenerative medicine strategies for future therapies of untreatable kidney disorders.

Author : Walter C. Low,Catherine M. Verfaillie
Publisher : World Scientific
Page : 571 pages
File Size : 50,5 Mb
Release : 2008
Category : Medical
ISBN : 9789812775771

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Stem Cells and Regenerative Medicine by Walter C. Low,Catherine M. Verfaillie Pdf

The commercialization of biotechnology has resulted in an intensive search for new biological resources for the purposes of increasing food productivity, medicinal applications, energy production, and various other applications. Although biotechnology has produced many benefits for humanity, the exploitation of the planet's natural resources has also resulted in some undesirable consequences such as diminished species biodiversity, climate change, environmental contamination, and intellectual property right and patent concerns.This book discusses the role of biological, ecological, environmental, ethical, and economic issues in the interaction between biotechnology and biodiversity, using different contexts. No other book has discussed all of these issues in a comprehensive manner. Of special interest is their impact when biotechnology is shared between developed and developing countries, and the lack of recognition of the rights of indigenous populations and traditional farmers in developing countries by large multinational corporations.

Author : Alexander Battler,Jonathan Leor
Publisher : Springer
Page : 422 pages
File Size : 54,6 Mb
Release : 2009-10-12
Category : Medical
ISBN : 1848008783

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Stem Cell and Gene-Based Therapy by Alexander Battler,Jonathan Leor Pdf

Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Author : Mehdi Razavi
Publisher : Bentham Science Publishers
Page : 196 pages
File Size : 40,5 Mb
Release : 2017-10-02
Category : Science
ISBN : 9781681085784

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Stem Cell Biology and Regenerative Medicine by Mehdi Razavi Pdf

Tissue engineering is an interdisciplinary field which involves the fabrication of tissues by using a porous protein scaffold, cells and bioactive molecules. The aim of tissue engineering is to enhance medical applications and procedures. This volume introduces the reader to the basics of employing pluripotent stem cells in tissue engineering. Successive chapters present knowledge about relevant tissue engineering techniques in different medical and physiological specialties including dentistry, cardiovascular physiology, hepatology, nephrology, dermatology and orthopedics. The text offers a wealth of information that will be of use to all students, bioengineers, materials scientists, chemists, physicians and surgeons concerned with the properties, performance, and the application of tissue engineering scaffolds in clinical settings.

Author : Patrick C. Baer,Benjamin Koch,Helmut Geiger
Publisher : MDPI
Page : 496 pages
File Size : 54,9 Mb
Release : 2020-04-03
Category : Medical
ISBN : 9783039285389

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Kidney Inflammation, Injury and Regeneration by Patrick C. Baer,Benjamin Koch,Helmut Geiger Pdf

Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.

Author : Giuseppe Orlando,Shaf Keshavjee
Publisher : Academic Press
Page : 304 pages
File Size : 51,7 Mb
Release : 2021-01-29
Category : Science
ISBN : 9780128194515

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Organ Repair and Regeneration by Giuseppe Orlando,Shaf Keshavjee Pdf

Organ Repair and Regeneration: Preserving Organs in the Regenerative Medicine Era encompasses updates on all organs, from the kidneys, to the lungs, liver, pancreas, intestines, and beyond. Chapters cover the pathophysiology of ischemia-reperfusion, repairing organs with MSC, repairing cardiac allografts in situ, and much more. The book conceptualizes the idea that the modern approach to organ preservation is ante literam, a form of organ repair and regeneration which, per se, is referred to as a field of health sciences under the umbrella of regenerative medicine. This book demonstrates the merging of regenerative medicine and organ transplantation. Covers all aspects of organ preservation, repair and regeneration Addresses the repair of organs that experience an Ischemia/Reperfusion (I/R) injury, those that are intended for transplantation, and specific issues related to each organ Presented by editors and authors who are physicians, surgeons and researchers in the field of organ transplantation and regenerative medicine

Author : Xin J. Zhou,Zoltan G. Laszik,Tibor Nadasdy,Vivette D. D'Agati
Publisher : Cambridge University Press
Page : 691 pages
File Size : 52,8 Mb
Release : 2017-03-02
Category : Medical
ISBN : 9781316613986

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Silva's Diagnostic Renal Pathology by Xin J. Zhou,Zoltan G. Laszik,Tibor Nadasdy,Vivette D. D'Agati Pdf

An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.