Regulation Of Red Cell Life Span Erythropoiesis Senescence And Clearance

Author : Lars Kaestner,Anna Bogdanova
Publisher : Frontiers E-books
Page : 118 pages
File Size : 50,6 Mb
Release : 2014-12-03
Category : Biology (General)
ISBN : 9782889193486

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Regulation of red cell life-span, erythropoiesis, senescence and clearance by Lars Kaestner,Anna Bogdanova Pdf

Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.

Author : Lars Kaestner,Anna Bogdanova
Publisher : Frontiers Media SA
Page : 238 pages
File Size : 52,5 Mb
Release : 2019-02-05
Category : Electronic
ISBN : 9782889457021

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The Red Cell Life-Cycle From Erythropoiesis to Clearance by Lars Kaestner,Anna Bogdanova Pdf

The eBook ‘The red cell life-cycle from erythropoiesis to clearance’ continues the discussion of questions like: What are the changes associated with red blood cell maturation, adulthood and senescence? What are the determinants of red blood cell life span and clearance? What are the mechanisms in control of red blood cell mass in healthy humans and patients with various forms of anaemia? Can red blood cells be 'trained' to provide the body with more oxygen during endurance exercises? What are the markers of circulating red blood cell senescence and in cells during storage and transfusion? And what can be learned from various species that developed advanced adaptations to maintain oxygen delivery under stress conditions such as exercising to the limit, diving or living in anaerobic aquatic habitats or at high altitude? Within the approximately 120 days (or 40 in a mouse, or 150-170 in a horse) life span of 'healthy' red blood cells, many cellular properties change leading to aged mixed cell populations in the circulation. Red blood cells seem to be genetically terminated by the time they become red blood cells and the contributions of this eBook increase the understanding of this process. There are surprisingly versatile remodeling processes happening during the red blood cell life span. Numerous disorders are associated with the premature onset of the 'ageing process' of red blood cells. Furthermore, in vitro ageing and/or modifications as well as the slowing down of the modifications is an important issue in transfusion medicine. Many of the molecular mechanisms behind such effects are elucidated in this eBook.

Author : Lodovico Balducci,William B. Ershler,John M. Bennett
Publisher : Springer Science & Business Media
Page : 148 pages
File Size : 53,8 Mb
Release : 2007-09-10
Category : Medical
ISBN : 9780387495057

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Anemia in the Elderly by Lodovico Balducci,William B. Ershler,John M. Bennett Pdf

Anemia in the elderly, known as the silent epidemic, afflicts 3 million people in the U.S. ages 65 or older. This reference, complete with the most recent findings, answers all the crucial questions regarding anemia in the elderly.

Author : Ingolf Bernhardt,J. Clive Ellory
Publisher : Springer Science & Business Media
Page : 761 pages
File Size : 51,5 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783662051818

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Red Cell Membrane Transport in Health and Disease by Ingolf Bernhardt,J. Clive Ellory Pdf

51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

Author : A.W.M.M. Koopman-van Gemert
Publisher : BoD – Books on Demand
Page : 130 pages
File Size : 42,8 Mb
Release : 2017-07-05
Category : Medical
ISBN : 9789535133193

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Transfusion Medicine and Scientific Developments by A.W.M.M. Koopman-van Gemert Pdf

Transfusion Medicine and Scientific Developments focuses on unknown aspects of blood cells and transfusion practice. Blood transfusion medicine has become a sophisticated and specialized field of medicine. Some aspects will be discussed in this book. The book has been divided into three sections. The first section includes chapters describing the immunological and coagulation-assisting functions of red blood cells and methods to measure their life span. The second section discusses the role of platelets in inflammatory processes. The third section reviews functional dose of RBC transfusions and transfusion practice in various clinical settings.

Author : Marco Malavolta,Eugenio Mocchegiani
Publisher : Springer
Page : 328 pages
File Size : 41,8 Mb
Release : 2018-11-13
Category : Medical
ISBN : 9783030037420

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Trace Elements and Minerals in Health and Longevity by Marco Malavolta,Eugenio Mocchegiani Pdf

This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.

Author : Peta Bee,Sarah Schenker
Publisher : Bloomsbury Publishing
Page : 281 pages
File Size : 53,8 Mb
Release : 2015-12-31
Category : Health & Fitness
ISBN : 9781472924421

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The Ageless Body by Peta Bee,Sarah Schenker Pdf

Discover the new goals and new rules that are the route to a healthier, better looking and better functioning body... for life! From Gwen Stefani and Cameron Diaz to Jennifer Aniston and Naomi Watts, a new breed of 40 and 50 plus women are redefining not just what an ageless body looks like, but what's entailed in achieving it. A dramatic shift in body expectations in the last few years means that, despite being plagued by a slowing metabolism and a naturally-occurring loss of muscle mass, pre- and post-menopausal women can realistically aim for the healthy, well-functioning body they crave as well as a physique that looks good with a flat stomach and sculpted arms. Peta Bee and Dr Sarah Schenker are the living embodiment of this new breed of woman: both in their forties with children, both with hectic careers and social lives. And both with the same bodies they had in their 30s. What matters, they have discovered through self-experimentation and trawling the scientific literature, is how you go about holding back the years. And the rules - for both exercise and diet - have changed.

Author : Esteban Céspedes
Publisher : Cambridge Scholars Publishing
Page : 150 pages
File Size : 49,5 Mb
Release : 2017-05-11
Category : Philosophy
ISBN : 9781443893343

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Notes on Knowledge, Indifference and Redundancy by Esteban Céspedes Pdf

What is knowledge? In what sense is the environment of a cognitive system more than a mere source of information? What are the roles of relevance and indifference for a characterisation of knowledge? How are knowledge and action related? These issues are considered and discussed in this book. Although it does not offer an account of knowledge, this work addresses a diverse range of important topics concerning that notion, seeking to connect them in a unifying way.

Author : Noah Edward Robinson,Arthur Robinson
Publisher : Unknown
Page : 454 pages
File Size : 53,6 Mb
Release : 2004
Category : Science
ISBN : STANFORD:36105120969873

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Molecular Clocks by Noah Edward Robinson,Arthur Robinson Pdf

Author : Pedro A. de Alarcón,Eric J. Werner,Robert D. Christensen,Martha C. Sola-Visner
Publisher : Cambridge University Press
Page : 501 pages
File Size : 54,6 Mb
Release : 2021-02-18
Category : Medical
ISBN : 9781108488983

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Neonatal Hematology by Pedro A. de Alarcón,Eric J. Werner,Robert D. Christensen,Martha C. Sola-Visner Pdf

An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.

Author : Kaneez Fatima Shad
Publisher : BoD – Books on Demand
Page : 120 pages
File Size : 54,7 Mb
Release : 2021-07-28
Category : Medical
ISBN : 9781839691201

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Erythrocyte by Kaneez Fatima Shad Pdf

In addition to carrying haemoglobin for gas exchange, red blood cells (RBCs) or erythrocytes contain a number of lipids, proteins, and carbohydrates, making them capable of acting as peripheral biomarkers for many pathological conditions. Early identification of key changes in erythrocytes in response to inflammatory or infectious diseases saves millions of lives worldwide. As such, this book examines the role of RBCs in immunology. Chapters cover such topics as an iron deficiency in erythrocytes, the modulation of oxidative stress (OS) in erythrocytes in bacterial and viral infections, using human foetal astrocytes (HFAs) as an experimental model to measure early predictive biomarkers for hypertension, and more.

Author : Oguz Baskurt,Björn Neu,Herbert J. Meiselman
Publisher : CRC Press
Page : 326 pages
File Size : 45,8 Mb
Release : 2011-09-28
Category : Medical
ISBN : 9781439841808

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Red Blood Cell Aggregation by Oguz Baskurt,Björn Neu,Herbert J. Meiselman Pdf

Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.

Author : Martine Extermann
Publisher : Springer
Page : 1150 pages
File Size : 47,8 Mb
Release : 2020-01-30
Category : Medical
ISBN : 3319574140

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Geriatric Oncology by Martine Extermann Pdf

This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.

Author : Melvin A. Shiffman,Alberto Di Giuseppe,Franco Bassetto
Publisher : Springer
Page : 822 pages
File Size : 46,7 Mb
Release : 2014-07-21
Category : Medical
ISBN : 9783642452079

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Stem Cells in Aesthetic Procedures by Melvin A. Shiffman,Alberto Di Giuseppe,Franco Bassetto Pdf

Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.

Author : George J. Christ,Karl-Erik Andersson
Publisher : Cambridge University Press
Page : 361 pages
File Size : 55,6 Mb
Release : 2013-04-15
Category : Medical
ISBN : 9781107354739

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Regenerative Pharmacology by George J. Christ,Karl-Erik Andersson Pdf

Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.