Regulatory Rnas

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Regulatory RNAs

Bibekanand Mallick,Zhumur Ghosh
Regulatory RNAs Book PDF

Author : Bibekanand Mallick,Zhumur Ghosh
Publisher : Springer Science & Business Media
Page : 549 pages
File Size : 44,8 Mb
Release : 2012-02-01
Category : Science
ISBN : 9783642225178

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Regulatory RNAs by Bibekanand Mallick,Zhumur Ghosh Pdf

Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.

Regulatory RNAs in Prokaryotes

Anita Marchfelder,Wolfgang Hess
Regulatory RNAs in Prokaryotes Book PDF

Author : Anita Marchfelder,Wolfgang Hess
Publisher : Springer Science & Business Media
Page : 258 pages
File Size : 41,6 Mb
Release : 2012-12-23
Category : Science
ISBN : 9783709102183

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Regulatory RNAs in Prokaryotes by Anita Marchfelder,Wolfgang Hess Pdf

This book provides a comprehensive and up-to-date collection of review articles focusing on RNA-mediated regulation in prokaryotes. The various modes of action include the direct interaction with proteins, direct sensing of metabolites or of physical parameters, and the interaction with RNAs to stimulate or prevent binding of ribosomes or to stimulate degradation. Written by leading experts in the field, the book covers small RNA functions, RNA thermometers, riboswitches, the diversity of small RNA-guided CRISPR-Cas defense systems and selected RNA chaperons in both prokaryotic domains, bacteria and archaea. Recent advances towards the computational identification of regulatory RNAs and their targets are included and particular attention is paid to small RNA in pathogenic bacteria. This volume is the only one exclusively covering regulatory RNAs in the prokaryotic domains to date, making it essential literature for anyone interested in RNA function and gene regulation and a valuable resource for teaching these concepts.

Regulatory RNAs in the Nucleus

Xiao Li,Liang Chen,Wenbo Li,Yuanchao Xue,Bing Zhou
Regulatory RNAs in the Nucleus Book PDF

Author : Xiao Li,Liang Chen,Wenbo Li,Yuanchao Xue,Bing Zhou
Publisher : Frontiers Media SA
Page : 126 pages
File Size : 42,9 Mb
Release : 2021-11-30
Category : Science
ISBN : 9782889717408

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Regulatory RNAs in the Nucleus by Xiao Li,Liang Chen,Wenbo Li,Yuanchao Xue,Bing Zhou Pdf

Topic Editors Xiao Li, Bing Zhou, and Wenbo Li hold patents related to the Research Topic subject. All other Topic Editors declare no competing interests.

Regulatory RNAs

Bruce Stillman,David Johnston Stewart
Regulatory RNAs Book PDF

Author : Bruce Stillman,David Johnston Stewart
Publisher : CSHL Press
Page : 577 pages
File Size : 53,7 Mb
Release : 2006
Category : Cancer
ISBN : 9780879698188

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Regulatory RNAs by Bruce Stillman,David Johnston Stewart Pdf

Explores how the application of RNA technologies, combined with a growing understanding of the molecular basis of many RNA processes, is yielding new insights into the treatment of many human diseases.

Small RNAs:

Wolfgang Nellen,Christian Hammann
Small RNAs Book PDF

Author : Wolfgang Nellen,Christian Hammann
Publisher : Springer Science & Business Media
Page : 16 pages
File Size : 50,8 Mb
Release : 2007-11-10
Category : Science
ISBN : 9783540742708

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Small RNAs: by Wolfgang Nellen,Christian Hammann Pdf

In recent years, the discovery of functional small RNAs has brought about an unprecedented revolution within the field of molecular biology. This volume describes strategies for the discovery and validation of small RNAs. It provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs and the variations encountered in different organisms.

Regulatory RNAs

Bibekanand Mallick,Zhumur Ghosh
Regulatory RNAs Book PDF

Author : Bibekanand Mallick,Zhumur Ghosh
Publisher : Springer
Page : 554 pages
File Size : 45,9 Mb
Release : 2012-02-05
Category : Science
ISBN : 3642225187

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Regulatory RNAs by Bibekanand Mallick,Zhumur Ghosh Pdf

Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.

RNA-Based Regulation in Human Health and Disease

Anonim
RNA Based Regulation in Human Health and Disease Book PDF

Author : Anonim
Publisher : Academic Press
Page : 444 pages
File Size : 47,8 Mb
Release : 2020-08-19
Category : Medical
ISBN : 9780128171943

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RNA-Based Regulation in Human Health and Disease by Anonim Pdf

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Regulation of Gene Expression by Small RNAs

Rajesh K. Gaur,John J. Rossi
Regulation of Gene Expression by Small RNAs Book PDF

Author : Rajesh K. Gaur,John J. Rossi
Publisher : CRC Press
Page : 440 pages
File Size : 49,6 Mb
Release : 2009-04-27
Category : Science
ISBN : 9781420008708

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Regulation of Gene Expression by Small RNAs by Rajesh K. Gaur,John J. Rossi Pdf

New Findings Revolutionize Concepts of Gene FunctionEndogenous small RNAs have been found in various organisms, including humans, mice, flies, worms, fungi, and bacteria. Furthermore, it's been shown that microRNAs acting as cellular rheostats have the ability to modulate gene expression. In higher eukaryotes, microRNAs may regulate as much as 50 p

Regulatory RNA

Thomas Dandekar,Kishor Sharma
Regulatory RNA Book PDF

Author : Thomas Dandekar,Kishor Sharma
Publisher : Springer Science & Business Media
Page : 270 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642979934

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Regulatory RNA by Thomas Dandekar,Kishor Sharma Pdf

This book provides an introduction to and an overview of the field of regulatory RNA, focusing on the identification of regulatory elements and motifs in such RNA molecules. Central to the book is the use of appropriate techniques to identify regulatory RNA and regulatory motifs. The prospects for this new and expanding research field - understanding regulatory RNA elements and motifs - are also explored, including new developments, medical applications, and applications in other fields.

Regulatory RNAs in Prokaryotes

Anita Marchfelder,Wolfgang Hess
Regulatory RNAs in Prokaryotes Book PDF

Author : Anita Marchfelder,Wolfgang Hess
Publisher : Springer
Page : 258 pages
File Size : 46,8 Mb
Release : 2015-04-20
Category : Science
ISBN : 3709102197

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Regulatory RNAs in Prokaryotes by Anita Marchfelder,Wolfgang Hess Pdf

This book provides a comprehensive and up-to-date collection of review articles focusing on RNA-mediated regulation in prokaryotes. The various modes of action include the direct interaction with proteins, direct sensing of metabolites or of physical parameters, and the interaction with RNAs to stimulate or prevent binding of ribosomes or to stimulate degradation. Written by leading experts in the field, the book covers small RNA functions, RNA thermometers, riboswitches, the diversity of small RNA-guided CRISPR-Cas defense systems and selected RNA chaperons in both prokaryotic domains, bacteria and archaea. Recent advances towards the computational identification of regulatory RNAs and their targets are included and particular attention is paid to small RNA in pathogenic bacteria. This volume is the only one exclusively covering regulatory RNAs in the prokaryotic domains to date, making it essential literature for anyone interested in RNA function and gene regulation and a valuable resource for teaching these concepts.

Regulatory RNAs in the Nervous System, 2nd Edition

Tommaso Pizzorusso,Alessandro Cellerino,Laure Bally-Cuif
Regulatory RNAs in the Nervous System 2nd Edition Book PDF

Author : Tommaso Pizzorusso,Alessandro Cellerino,Laure Bally-Cuif
Publisher : Frontiers Media SA
Page : 346 pages
File Size : 45,9 Mb
Release : 2018-11-13
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 9782889456574

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Regulatory RNAs in the Nervous System, 2nd Edition by Tommaso Pizzorusso,Alessandro Cellerino,Laure Bally-Cuif Pdf

Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory role of nc-RNAs exert in many biological processes. Overall, these studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory nc-RNAs represent novel layers of regulation. Particularly well-characterized is the role of microRNAs (miRNAs), small nc-RNAs, that bind to mRNAs and regulate gene expression after transcritpion. This message is particularly clear in the nervous system, where miRNAs have been involved in regulating cellular pathways controlling fundamental functions during development, synaptic plasticity and in neurodegenerative disease. It has also been shown that neuronal miRNAs are tightly regulated by electrical activity at the level of transcription, biogenesis, stability and specifically targeted to dendrites and synapses. Deregulation of expression of miRNAs is proposed not only as potential disease biomarker, but it has been implicated directly in the pathogenesis of complex neurodegenerative disease. This so-called RNA revolution also lead to the exploitation of RNA interference and the development of related tools as potential treatment of a vast array of CNS disease that could benefit from regulation of disease-associated genes. In spite of these advancements, the relatively young age of this field together with the inherent high molecular complexity of RNA regulation of biological processes have somewhat hindered its communication to the whole of the neuroscience community. This Research Topic aims at improving this aspect by putting around the same virtual table scientists covering aspects ranging from basic molecular mechanisms of regulatory RNAs in the nervous system to the analysis of the role of specific regulatory RNAs in neurobiological processes of development, plasticity and aging. Furthermore, we included papers analyzing the role of regulatory RNAs in disease models from neuromuscular to higher cognitive functions, and more technically oriented papers dealing with new methodologies to study regulatory RNA biology and its translational potential.

Bacterial Regulatory RNA

Kenneth C. Keiler
Bacterial Regulatory RNA Book PDF

Author : Kenneth C. Keiler
Publisher : Humana Press
Page : 348 pages
File Size : 49,5 Mb
Release : 2016-05-01
Category : Medical
ISBN : 1493959417

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Bacterial Regulatory RNA by Kenneth C. Keiler Pdf

The discovery of wide-spread RNA-based regulation in bacteria has led to new evaluations of the importance of bacterial regulatory RNA in every aspect of bacterial physiology. In "Bacteria Regulatory RNA: Methods and Protocols, "expert researchers in the field detail many of the methods which are now commonly used to study bacterial regulatory RNA. These include methods and techniques to identify regulatory RNAs, characterizing the function and expression of regulatory RNAs in bacterial cells, RNA structure prediction, and interactions between regulatory RNAs and proteins. Written in the highly successful "Methods in Molecular Biology " series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, "Bacteria Regulatory RNA: Methods and Protocols" seeks to aid scientists in the further study of bacterial regulatory RNA. "

RNA Motifs and Regulatory Elements

Thomas Dandekar
RNA Motifs and Regulatory Elements Book PDF

Author : Thomas Dandekar
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642562983

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RNA Motifs and Regulatory Elements by Thomas Dandekar Pdf

RNA Motifs and Regulatory Elements is the new edition of the successful book, "Regulatory RNA". It alerts the reader to the importance of regulatory RNA elements for the many different areas of cellular life. The computational and experimental methods and tools to search for new interesting regulatory RNA structures are explained and compared. The knowledge on regulatory RNA structures and elements already available is concisely summarized as well as catalogued. In addition, interesting RNA elements are analyzed in detail regarding their dynamics, regulation, and as a dominant topic of current resarch in molecular biology, including areas such as RNA mediated regulation of gene-expression, DNA/RNA chip data, and ribozymes, splicing, or telomerases in aging. Medical implications are also covered. Future progress and research are finally outlined.

Regulating with RNA in Bacteria and Archaea

Gisela Storz,Kai Papenfort
Regulating with RNA in Bacteria and Archaea Book PDF

Author : Gisela Storz,Kai Papenfort
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 46,5 Mb
Release : 2020-07-10
Category : Medical
ISBN : 9781683670247

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Regulating with RNA in Bacteria and Archaea by Gisela Storz,Kai Papenfort Pdf

Revealing the many roles of RNA in regulating gene expression For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes. Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have specific functions, including small RNAs (sRNA), RNA thermometers, and riboswitches to regulate core metabolic pathways, bacterial pathogenesis, iron homeostasis, quorum sensing, and biofilm formation. All of these functions, and more, are presented in Regulating with RNA in Bacteria and Archaea, written by RNA biologists from around the globe. Divided into eight sections-RNases and Helicases, Cis-Acting RNAs, Cis Encoded Base Pairing RNAs, Trans-Encoded Base Pairing RNAs, Protein Titration and Scaffolding, General Considerations, Emerging Topics, and Resources-this book serves as an excellent resource for established RNA biologists and for the many scientists who are studying regulated cellular systems. It is no longer a fair assumption that gene expression regulation is the provenance of proteins only or that control is exerted primarily at the level of transcription. This book makes clear that regulatory RNAs are key partners along with proteins in controlling the complex interactions and pathways found within prokaryotes.

Small RNAs:

Wolfgang Nellen,Christian Hammann
Small RNAs Book PDF

Author : Wolfgang Nellen,Christian Hammann
Publisher : Springer Science & Business Media
Page : 220 pages
File Size : 52,6 Mb
Release : 2007-09-12
Category : Science
ISBN : 9783540281306

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Small RNAs: by Wolfgang Nellen,Christian Hammann Pdf

In recent years, the discovery of functional small RNAs has brought about an unprecedented revolution within the field of molecular biology. This volume describes strategies for the discovery and validation of small RNAs. It provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs and the variations encountered in different organisms.