Renal Fibrosis Mechanisms And Therapies

Author : Bi-Cheng Liu,Hui-Yao Lan,Lin-Li Lv
Publisher : Springer
Page : 709 pages
File Size : 49,8 Mb
Release : 2019-08-09
Category : Science
ISBN : 9789811388712

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Renal Fibrosis: Mechanisms and Therapies by Bi-Cheng Liu,Hui-Yao Lan,Lin-Li Lv Pdf

This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

Author : Hui Y. Lan,David J. Nikolic-Paterson
Publisher : Frontiers Media SA
Page : 84 pages
File Size : 47,5 Mb
Release : 2018-07-26
Category : Electronic
ISBN : 9782889454990

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Advances in Mechanisms of Renal Fibrosis by Hui Y. Lan,David J. Nikolic-Paterson Pdf

Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 49,7 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1368445555

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Advances in Mechanisms of Renal Fibrosis by Anonim Pdf

Author : Mohammed S. Razzaque,Takashi Taguchi
Publisher : Karger Medical and Scientific Publishers
Page : 222 pages
File Size : 44,8 Mb
Release : 2003-01-01
Category : Medical
ISBN : 9783805575683

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Renal Fibrosis by Mohammed S. Razzaque,Takashi Taguchi Pdf

This publication provides a synopsis of the rapid progress made in the field of renal cell biology during the last decade, progress which has resulted in a better conceptual understanding of the cellular and molecular mechanisms of fibrotic renal disease. These developments have provided new therapeutic choices and led to the discovery of gene-based therapeutic options. The topics covered in this book have been carefully selected from the immense number of aspects of the disease to provide essential information on the molecular basis of renal fibrosis. Individual chapters discuss topics such as proteinuria and tubulointerstitial injury, the roles and regulation of TGF-beta, chemokines, oxidant stress, matrix remodeling, significance of renal expression of NF-kappa, and the potential impact of cell death in renal fibrosis.Written so as to present the complex information as simply as possible, this publication will be a very useful tool for general health professionals involved in the fields of immunology and cell biology, as well as for clinicians and researchers within the fields of nephrology, pathology and matrix biology.

Author : Colin Andrew Hutchison
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 52,9 Mb
Release : 2013
Category : Acute renal failure
ISBN : 1622578244

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Renal Failure by Colin Andrew Hutchison Pdf

Kidney failure represents a major health economic burden for all people and all nations. Despite the immense number of factors which can cause the initial injury to the kidneys, common response pathways are triggered which, unless broken, will ultimately lead to irreversible fibrosis within the kidneys. Unfortunately, early injuries to the kidneys can frequently be asymptomatic and chronic kidney disease has often developed before the patient has become aware there is a problem. Once established, chronic kidney disease is associated with a high morbidity and mortality for those affected. There has been a large amount of work in recent years focused on the early diagnosis and management of kidney disease to prevent its progression. The purpose of this book is to review the mechanisms which underlie both acute and chronic kidney injury, discuss their diagnosis, complications and management. The first section of this book covers the causes and complications of chronic kidney disease. Initially we review the mechanisms which underlie the progressive fibrosis by which chronic kidney disease progresses. There are then detailed discussions of the cardiovascular complications of chronic kidney disease. The second section of the book focuses on established end stage renal disease. Reviewing access to renal replacement therapies across ethnicities, the role of home therapies and how their use can be increased and finally we discuss the preparation and maintenance of access for dialysis. The third and final section of the book provides an update for the clinician into the diagnosis and management of acute kidney injury. Specifically the diagnosis and management of renal impairment in patients with plasma cell dyscrasias is reviewed and the prevention of acute kidney injury in the critically ill patient is discussed in detail.

Author : Patrick C. Baer,Benjamin Koch,Helmut Geiger
Publisher : MDPI
Page : 496 pages
File Size : 46,9 Mb
Release : 2020-04-03
Category : Medical
ISBN : 9783039285389

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Kidney Inflammation, Injury and Regeneration by Patrick C. Baer,Benjamin Koch,Helmut Geiger Pdf

Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.

Author : Michael S. Goligorsky
Publisher : Academic Press
Page : 442 pages
File Size : 49,5 Mb
Release : 2010-11-26
Category : Science
ISBN : 0123809290

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Regenerative Nephrology by Michael S. Goligorsky Pdf

Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

Author : Ellis D. Avner,William E. Harmon,Patrick Niaudet,Norishige Yoshikawa
Publisher : Springer Science & Business Media
Page : 2059 pages
File Size : 43,6 Mb
Release : 2009-08-20
Category : Medical
ISBN : 9783540763277

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Pediatric Nephrology by Ellis D. Avner,William E. Harmon,Patrick Niaudet,Norishige Yoshikawa Pdf

Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.

Author : Xin J. Zhou,Zoltan G. Laszik,Tibor Nadasdy,Vivette D. D'Agati
Publisher : Cambridge University Press
Page : 691 pages
File Size : 48,7 Mb
Release : 2017-03-02
Category : Medical
ISBN : 9781316613986

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Silva's Diagnostic Renal Pathology by Xin J. Zhou,Zoltan G. Laszik,Tibor Nadasdy,Vivette D. D'Agati Pdf

An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.

Author : Haruki Yamada,Ikuo Saiki
Publisher : CRC Press
Page : 250 pages
File Size : 41,6 Mb
Release : 2005-04-29
Category : Health & Fitness
ISBN : 1420023519

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Juzen-taiho-to (Shi-Quan-Da-Bu-Tang) by Haruki Yamada,Ikuo Saiki Pdf

Kampo is a traditional Japanese herbal medicine that takes a holistic approach to healing. Since Kampo is currently being used for the treatment of a wide range of diseases with many reports of clinical effectiveness, it is playing an increasingly important role in Japan's modern-day health care. Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications presents a concise overview of the important Kampo formula of Juzen-taiho-to. The book describes the therapeutic indications and traditional uses of Juzen-taiho-to, followed by its taxonomy, cultivation, quality assurance, and chemical constituents and pharmacological actions of raw plant material as the component herbs. Experts in the field discuss up-to-date findings and topics associated with the pharmacology and clinical application of Juzen-taiho-to, including its important immunomodulating, anti-tumor, and anti-metastatic properties, toxicology and side effects, and other related formulations. Today, Kampo medicine is steadily gaining acceptance by Japan's national health insurance system, the medical community, and contemporary society. This book provides a comprehensive review of Juzen-taiho-to and demonstrates how Kampo and other herbal medicines are becoming the popular, practical, and preferred treatments of tomorrow.

Author : G.A. Herrera
Publisher : Karger Medical and Scientific Publishers
Page : 381 pages
File Size : 54,6 Mb
Release : 2011-01-14
Category : Medical
ISBN : 9783805595384

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Experimental Models for Renal Diseases by G.A. Herrera Pdf

Our understanding of the pathogenesis of renal diseases and the ability to accurately classify and diagnose them has improved considerably over the last two decades. Until now, however, this information has not been available in a single, up-to-date and succinct yet comprehensive source. The publication at hand aims at filling this gap, condensing a vast amount of information into easily accessible chapters.After a discussion of basic concepts and principles of renal tissue reactions to injurious agents using a specific cell/compartment approach, a multitude of disorders are looked at, including renal interstitial fibrosis, glomerulosclerosis, various forms of glomerulonephritis and nephropathy, amyloidosis and renal Fanconi syndrome. Some of the chapters address controversial subjects, reporting the current situation and showing areas of future potential research interest. At the end of many of the contributions, a summary is provided, often in the form of a chart to facilitate the understanding of the information and to make it most useful for didactic purposes.This book is intended for students of various disciplines, as well as clinicians and investigators and all those trying to correlate basic research information with clinical issues.

Author : Hikaru Koide,Toshihiko Hayashi
Publisher : Unknown
Page : 244 pages
File Size : 51,6 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015032524715

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Extracellular Matrix in the Kidney by Hikaru Koide,Toshihiko Hayashi Pdf

Author : Alexis Desmouliere,Beatriz Tuchweber
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642584565

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Tissue Repair and Fibrosis by Alexis Desmouliere,Beatriz Tuchweber Pdf

With contributions by numerous experts

Author : Neil N. Turner,Norbert Lameire,David J. Goldsmith,Christopher G. Winearls,Jonathan Himmelfarb,Giuseppe Remuzzi
Publisher : Oxford University Press
Page : 3045 pages
File Size : 49,7 Mb
Release : 2015-10-29
Category : Medical
ISBN : 9780191017650

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Oxford Textbook of Clinical Nephrology by Neil N. Turner,Norbert Lameire,David J. Goldsmith,Christopher G. Winearls,Jonathan Himmelfarb,Giuseppe Remuzzi Pdf

This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

Author : Severin Ringoir,Raymond Vanholder,Shaul G. Massry
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468454451

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Uremic Toxins by Severin Ringoir,Raymond Vanholder,Shaul G. Massry Pdf

The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.