Retinoid Therapy

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Retinoid Therapy

Author : W.J. Cunliffe,A.J. Miller
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401163491

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Retinoid Therapy by W.J. Cunliffe,A.J. Miller Pdf

The impact of the retinoids in clinical practice has primarily been in dermatology. When Dr Werner Bollag began his basic research and screening programme in the early 1960's, the expectation was that the retinoids would have a major impact on oncology. However, the laboratory and clinical experiences of Bollag and his colleagues in Switzerland, Stuttgen and Orfanos in Germany, led to publications on both etretinates (Tigason) and isotretinoin (Roaccutane) in the years between 1972 and 1976 in the field of dermatology. In fact the first symposium on retinoid research held in Berlin in 1981 was almost entirely dermatological. A year later a retinoid workshop in Iowa was designed to provide a forum for dermatolog ists from the USA involved in specific protocols investigating oral retinoids. In the UK, research into the retinoids began rather later than in Continental Europe or in the USA, although Tigason was first marketed here. It was felt in late 1982 that as many dermatologists had relatively little experience with these compounds it would be appropriate to hold an International Symposium on retinoid therapy in the UK. Thus on 16-18 May 1983 in London, 37 speakers from 11 countries addressed an audience of 300, aminly UK, dermatologists. The scientific organizing committee consisted of but two persons Dr William Cunliffe of Leeds General Infirmary, representing the European Society of Dermatolo gical Research, and myself from Roche Clinical Research. The Symposium was held under the auspices of the ESDR and of Roche Products Limited.

Retinoids

Author : C.E. Orfanos,O. Braun-Falco,E.M. Farber,C. Grupper,M.K. Polano,R. Schuppli
Publisher : Springer Science & Business Media
Page : 500 pages
File Size : 46,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642680236

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Retinoids by C.E. Orfanos,O. Braun-Falco,E.M. Farber,C. Grupper,M.K. Polano,R. Schuppli Pdf

With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels of both unchanged drug and main metabolite (corre sponding carboxylic acid) were observed up to 140 days after cessation of the therapy. An apparent half-life of elimination of 80-100 days can be calculated. The drug appears to be stored at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are excreted in the bile in high amounts (60-80% of dose). No drug appeared unchanged in the excreta after i. v. administration to rats. References 1. Bollag W (1971) Effects of vitamin A acid (NSC-122758) on transplantable and chemically-induced tumors. Cancer Chemother Rep 55:53-58 2.

Retinoids in Dermatology

Author : Ayse Serap Karadag,Berna Aksoy,Lawrence Charles Parish
Publisher : CRC Press
Page : 508 pages
File Size : 51,7 Mb
Release : 2019-10-28
Category : Medical
ISBN : 9780429852619

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Retinoids in Dermatology by Ayse Serap Karadag,Berna Aksoy,Lawrence Charles Parish Pdf

Retinoids are valuable drugs in the dermatologic armamentarium, being employed in daily clinical practice. The text provides an in-depth update on the latest thinking on pharmacology, clinical use, side effects, and follow-up of retinoid therapy in dermatology; it also addresses topics related to retinoid use in special circumstances, such as vulnerable populations, concomitant surgery, and aesthetic procedures. CONTENTS: The background of retinoids * Mechanism of action of vitamin A * Mechanism of action of topical retinoids * Mechanism of action of isotretinoin * Mechanism of action of acitretin * Mechanism of action of bexarotene * Mechanism of action of alitretinoin * Effects of retinoids at the cellular level (differentiation, apoptosis, autophagy, cell cycle regulation, and senescence) * Effects of retinoids at the systemic level * New aspects of isotretinoin teratogenicity * Mucocutaneous side effects * Ophthalmologic side effects * Musculoskeletal side effects * Neurologic side effects * Psychiatric side effects * Gastrointestinal side effects * Endocrine and metabolic side effecs * Other systemic side effects: Cardiovascular, pulmonary, otolaryngorhinologic, genitourinary, renal, and immunologic * Retinoids in acne * Retinoids in hidradenitis suppurativa/acne inversa * Retinoids in rosacea * Retinoids in hair disorders * Retinoids in psoriasis * Retinoids in keratinization disorders * Retinoids in antiaging therapy * Retinoids in other skin diseases * Retinoids in lymphoma * Retinoids in cutaneous chemoprophylaxis * Guide to good clinical practice for vulnerable populations (infancy, childhood, fertile period, elderly) * Retinoids and concomitant surgery * Retinoids and concomitant aesthetic procedures * Laboratory and clinical follow-up * Teratogenicity and registry programs * Management of vitamin A and retinoid side effects * Future and novel unexplored indications of retinoids Published in association with the Journal of Dermatological Treatment.

Retinoid Therapy

Author : W. J. CUNLIFFE,Arthur K. Miller
Publisher : Kluwer Academic Publishers
Page : 376 pages
File Size : 52,8 Mb
Release : 1983-01-01
Category : Electronic
ISBN : 085200740X

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Retinoid Therapy by W. J. CUNLIFFE,Arthur K. Miller Pdf

Retinoids, New Trends in Research and Therapy

Author : Jean-Hilaire Saurat
Publisher : S. Karger AG (Switzerland)
Page : 536 pages
File Size : 42,7 Mb
Release : 1985
Category : Cancer
ISBN : UCAL:B4529049

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Retinoids, New Trends in Research and Therapy by Jean-Hilaire Saurat Pdf

The Retinoids

Author : Pascal Dollé,Karen Niederreither
Publisher : John Wiley & Sons
Page : 608 pages
File Size : 50,5 Mb
Release : 2015-05-18
Category : Science
ISBN : 9781118627907

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The Retinoids by Pascal Dollé,Karen Niederreither Pdf

The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.

Retinoids and Carotenoids in Dermatology

Author : Anders Vahlquist,Madeleine Duvic
Publisher : CRC Press
Page : 390 pages
File Size : 54,7 Mb
Release : 2007-06-20
Category : Medical
ISBN : 9781420021189

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Retinoids and Carotenoids in Dermatology by Anders Vahlquist,Madeleine Duvic Pdf

This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology. Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of

Retinoids in Oncology

Author : Laurent Degos,David R. Parkinson
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 45,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642797064

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Retinoids in Oncology by Laurent Degos,David R. Parkinson Pdf

Recent developments with respect to the biology and clinical use of retinoids in cancer therapy and prevention are comprehensively covered by experts in this new field. Newer aspects of molecular mechanisms of retinoid effects, the cellular biology and the developmental effects of these compounds are presented together with a comprehensive description of the latest findings of retinoid pharmacology, toxicology and clinical effects in a wide range of hematological and solid malignancies.

Comprehensive Dermatologic Drug Therapy

Author : Stephen E. Wolverton,Jashin . Wu
Publisher : Elsevier Health Sciences
Page : 858 pages
File Size : 43,9 Mb
Release : 2019-12-14
Category : Medical
ISBN : 9780323612128

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Comprehensive Dermatologic Drug Therapy by Stephen E. Wolverton,Jashin . Wu Pdf

Designed with practical usability in mind, Comprehensive Dermatologic Drug Therapy, 4th Edition, helps you safely and effectively treat the skin disorders you’re likely to see in your practice. Dr. Stephen E. Wolverton and new associate editor Dr. Jashin J. Wu lead a team of global experts to bring you concise, complete guidance on today's full spectrum of topical, intralesional, and systemic drugs. You’ll prescribe with confidence thanks to expert coverage of which drugs to use, when to use them, and adverse effects to monitor. Includes new drug interaction tables, drug risk profiles, and FDA guidelines, as well as two new appendices that summarize chapter questions and summarize highest-risk drug interactions. Covers the best uses for new biologic therapeutics. Contains new chapters covering medical decision-making principles, PDE-4 and JAK inhibitors, interleukin 17 inhibitors, interleukin 23 inhibitors, additional biologic therapeutics, and hedgehog pathway inhibitors. Contains quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Features a highly detailed, disease-specific index, as well as purchase information for major drugs. Helps you assess your knowledge and prepare for certification or recertification with about 800 review questions and answers throughout the book.

Retinoids

Author : IARC Working Group on the Evaluation of Cancer-preventive Agents,World Health Organization
Publisher : IARC
Page : 360 pages
File Size : 54,6 Mb
Release : 1999
Category : Cancer
ISBN : 9283230043

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Retinoids by IARC Working Group on the Evaluation of Cancer-preventive Agents,World Health Organization Pdf

The Retinoids

Author : Pascal Dollé,Karen Niederreither
Publisher : John Wiley & Sons
Page : 608 pages
File Size : 47,7 Mb
Release : 2015-04-13
Category : Science
ISBN : 9781118628270

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The Retinoids by Pascal Dollé,Karen Niederreither Pdf

The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.

The Retinoids: v. 2

Author : BAERT ET BAERT ET AL
Publisher : Academic Press
Page : 463 pages
File Size : 49,9 Mb
Release : 2014-06-28
Category : Medical
ISBN : 9781483296371

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The Retinoids: v. 2 by BAERT ET BAERT ET AL Pdf

The Retinoids: v. 2

Retinoids in Oncology

Author : Waun Ki Hong,Reuben Lotan
Publisher : CRC Press
Page : 356 pages
File Size : 45,9 Mb
Release : 1993-05-11
Category : Science
ISBN : 0824790480

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Retinoids in Oncology by Waun Ki Hong,Reuben Lotan Pdf

This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease site, this book: describes the effects of retinoids on squamous differentiation in normal, pre-malignant, and malignant epithelial tissues; addresses the mechanisms by which cultured keratinocytes respond to retinoids; considers the antitumor activity of combination therapy with retinoids and cytokines; reviews the toxicity profiles of the vitamin A molecule and the synthetically derived retinoid compounds and their effects on humans; examines the use of retinoids in the prevention of basal cell carcinoma and squamous cell carcinoma (SCC) and in the therapy of advanced SCC; and summarizes data on the potential of retinoids to prevent epithelial cancer, to act as adjuvants to current therapies in early stages of the disease and to aid in the management of both solid tumours and hematologic malignancies.;A guide for the many disciplines involved in the preclinical studies and direct care of cancer patients, this book serves as useful reading for clinical, surgical and radiation oncologists; clinical immunologists; dermatologists; obstetricians/gynaecologists; haematologists; otolaryngologists; internists; nutritionists; and pulmonary-disease specialists.

Drug Therapy in Dermatology

Author : Larry E. Millikan
Publisher : CRC Press
Page : 498 pages
File Size : 40,8 Mb
Release : 2000-07-25
Category : Medical
ISBN : 9780203908310

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Drug Therapy in Dermatology by Larry E. Millikan Pdf

This systematically organized collection evaluates the effectiveness of prescription drugs and considers complex dermatological conditions that may require multiple approaches, providing guidance for appropriate selection, initiation, and follow-up of drug therapy. Covers treatments for psoriasis ranging from coal tar, anthralin, and phototherap

Comprehensive Dermatologic Drug Therapy

Author : Stephen E Wolverton, MD
Publisher : Elsevier Health Sciences
Page : 1015 pages
File Size : 43,5 Mb
Release : 2012-11-16
Category : Medical
ISBN : 9781437720037

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Comprehensive Dermatologic Drug Therapy by Stephen E Wolverton, MD Pdf

Safely and effectively treat a full range of skin disorders with Comprehensive Dermatologic Drug Therapy, 3rd Edition! This trusted dermatology reference provides concise, complete, up-to-date guidance on today's full spectrum of topical, intralesional, and systemic drugs. Dr. Steven E. Wolverton and a team of leading international experts clearly explain what drugs to use, when to use them, and what to watch out for. Prescribe with confidence thanks to quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Assess your knowledge and prepare for certification or recertification with more than 800 review questions and answers throughout the book. Contain costs and meet patient expectations with purchase information provided for major drugs. Quickly evaluate drug options for each disease discussed using a highly detailed, disease-specific index. Discover the best uses for new biologic therapeutics such as ustekinumab and rituximab, as well as newly improved TNF inhibitors. Offer your patients the very latest in cosmetic procedures, including chemical peels, intradermal fillers, and botulinum toxin. Use the safest and most effective drugs possible with new chapters on irritants and allergens in topical therapeutic agents, plus a new, separate chapter on mycophenolate mofetil. Review drugs recently taken off the market by the FDA, and use that knowledge to improve your current dermatologic drug therapy. Access the complete contents online at www.expertconsult.com and perform rapid searches for drug indications, interactions, monitoring guidelines, and much more.