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Author : United States Environmental Protection Agency (EPA)
Publisher : Createspace Independent Publishing Platform
Page : 96 pages
File Size : 40,8 Mb
Release : 2018-07-06
Category : Electronic
ISBN : 1722277017
Review of EPA's Draft Framework for Inorganic Metals Risk Assessment
Author : Anonim
Publisher : DIANE Publishing
Page : 120 pages
File Size : 46,9 Mb
Release : 2002
Category : Environmental risk assessment
ISBN : 9781428900424
Author : Anonim
Publisher : Unknown
Page : 1044 pages
File Size : 48,9 Mb
Release : 2006
Category : Mineral industries
ISBN : MINN:31951D02721341J
Author : Jim E. Riviere
Publisher : CRC Press
Page : 412 pages
File Size : 45,8 Mb
Release : 2006-03-06
Category : Medical
ISBN : 9781420018448
Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicol
Author : Monica Nordberg,Gunnar F. Nordberg,Bruce A. Fowler,Lars Friberg
Publisher : Elsevier
Page : 1024 pages
File Size : 44,7 Mb
Release : 2011-04-28
Category : Science
ISBN : 9780080546100
Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more
Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review the IRIS Process
Publisher : National Academies Press
Page : 170 pages
File Size : 46,8 Mb
Release : 2014-06-25
Category : Political Science
ISBN : 9780309304177
The Integrated Risk Information System (IRIS) is a program within the US Environmental Protection Agency (EPA) that is responsible for developing toxicologic assessments of environmental contaminants. An IRIS assessment contains hazard identifications and dose-response assessments of various chemicals related to cancer and noncancer outcomes. Although the program was created to increase consistency among toxicologic assessments within the agency, federal, state, and international agencies and other organizations have come to rely on IRIS assessments for setting regulatory standards, establishing exposure guidelines, and estimating risks to exposed populations. Over the last decade, the National Research Council (NRC) has been asked to review some of the more complex and challenging IRIS assessments, including those of formaldehyde, dioxin, and tetrachloroethylene. In 2011, an NRC committee released its review of the IRIS formaldehyde assessment. Like other NRC committees that had reviewed IRIS assessments, the formaldehyde committee identified deficiencies in the specific assessment and more broadly in some of EPA's general approaches and specific methods. Although the committee focused on evaluating the IRIS formaldehyde assessment, it provided suggestions for improving the IRIS process and a roadmap for its revision in case EPA decided to move forward with changes to the process. Congress directed EPA to implement the report's recommendations and then asked the National Research Council to review the changes that EPA was making (or proposing to make) in response to the recommendations. Review of EPA's Integrated Risk Information System (IRIS) Process provides an overview of some general issues associated with IRIS assessments. This report then addresses evidence identification and evaluation for IRIS assessments and discusses evidence integration for hazard evaluation and methods for calculating reference values and unit risks. The report makes recommendations and considerations for future directions. Overall, Review of EPA's Integrated Risk Information System Process finds that substantial improvements in the IRIS process have been made, and it is clear that EPA has embraced and is acting on the recommendations in the NRC formaldehyde report. The recommendations of this report should be seen as building on the progress that EPA has already made.
Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review the OMB Risk Assessment Bulletin
Publisher : National Academies Press
Page : 302 pages
File Size : 51,8 Mb
Release : 2007-04-16
Category : Political Science
ISBN : 9780309178884
Risk assessments are often used by the federal government to estimate the risk the public may face from such things as exposure to a chemical or the potential failure of an engineered structure, and they underlie many regulatory decisions. Last January, the White House Office of Management and Budget (OMB) issued a draft bulletin for all federal agencies, which included a new definition of risk assessment and proposed standards aimed at improving federal risk assessments. This National Research Council report, written at the request of OMB, evaluates the draft bulletin and supports its overall goals of improving the quality of risk assessments. However, the report concludes that the draft bulletin is "fundamentally flawed" from a scientific and technical standpoint and should be withdrawn. Problems include an overly broad definition of risk assessment in conflict with long-established concepts and practices, and an overly narrow definition of adverse health effects-one that considers only clinically apparent effects to be adverse, ignoring other biological changes that could lead to health effects. The report also criticizes the draft bulletin for focusing mainly on human health risk assessments while neglecting assessments of technology and engineered structures.
Author : Anonim
Publisher : Unknown
Page : 94 pages
File Size : 51,6 Mb
Release : 1998
Category : Health risk assessment
ISBN : UOM:39015043186363
Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Inorganic Arsenic
Publisher : National Academies Press
Page : 128 pages
File Size : 55,9 Mb
Release : 2013-11-20
Category : Nature
ISBN : 9780309297097
The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS) program develops toxicologic assessments of environmental contaminants. IRIS assessments provide hazard identification and dose-response assessment information. The information is then used in conjunction with exposure information to characterize risks to public health and may be used in risk-based decisionmaking, in regulatory actions, and for other risk-management purposes. Since the middle 1990s, EPA has been in the process of updating the IRIS assessment of inorganic arsenic. In response to a congressional mandate for an independent review of the IRIS assessment of inorganic arsenic, EPA requested that the National Research Council convene a committee to conduct a two-phase study. Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic is the report of the first phase of that study. This report evaluates critical scientific issues in assessing cancer and noncancer effects of oral exposure to inorganic arsenic and offers recommendations on how the issues could be addressed in EPA's IRIS assessment.
Author : John B. Stephenson
Publisher : DIANE Publishing
Page : 33 pages
File Size : 41,9 Mb
Release : 2008-10
Category : Health & Fitness
ISBN : 9781437905977
The EPA¿s Integrated Risk Info. System (IRIS) contains EPA¿s position on the potential human health effects of exposure to more than 540 chemicals. Toxicity assessments in the IRIS database constitute the first 2 critical steps of the risk assessment process, which in turn provides the foundation for risk mgmt. decisions. Thus, IRIS is a critical component of EPA¿s capacity to support scientifically sound environmental decisions, policies, and regulations. This testimony discusses: (1) highlights of a 3/08 report, ¿Chemical Assessments: Low Productivity and New Interagency Review Process Limit the Usefulness and Credibility of EPA¿s Integrated Risk Info. System;¿ and (2) key aspects of EPA¿s revised IRIS assessment process, released on 4/10/08.
Author : Anonim
Publisher : Unknown
Page : 78 pages
File Size : 52,6 Mb
Release : 2004
Category : Metals
ISBN : UIUC:30112104641854
Author : Anonim
Publisher : Unknown
Page : 44 pages
File Size : 41,7 Mb
Release : 1984
Category : Environmental policy
ISBN : UCSD:31822017061680
Author : United States. Presidential/Congressional Commission on Risk Assessment and Risk Management
Publisher : Unknown
Page : 76 pages
File Size : 53,7 Mb
Release : 1997
Category : Administrative agencies
ISBN : UIUC:30112112952624
Author : United States. General Accounting Office
Publisher : Unknown
Page : 76 pages
File Size : 47,6 Mb
Release : 2002
Category : Dioxins
ISBN : STANFORD:36105127333842
Author : Anonim
Publisher : Unknown
Page : 118 pages
File Size : 44,6 Mb
Release : 2004
Category : Metals
ISBN : UIUC:30112104641821
