Ribozymes 2 Volume Set

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Ribozymes, 2 Volume Set

Sabine Müller,Benoît Masquida,Wade Winkler
Ribozymes 2 Volume Set Book PDF

Author : Sabine Müller,Benoît Masquida,Wade Winkler
Publisher : John Wiley & Sons
Page : 81 pages
File Size : 53,7 Mb
Release : 2021-10-18
Category : Science
ISBN : 9783527344543

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Ribozymes, 2 Volume Set by Sabine Müller,Benoît Masquida,Wade Winkler Pdf

Ribozymes Provides comprehensive coverage of a core field in the molecular biosciences, bringing together decades of knowledge from the world’s top professionals in the field Timely and unique in its breadth of content, this all-encompassing and authoritative reference on ribozymes documents the great diversity of nucleic acid-based catalysis. It integrates the knowledge gained over the past 35 years in the field and features contributions from virtually every leading expert on the subject. Ribozymes is organized into six major parts. It starts by describing general principles and strategies of nucleic acid catalysis. It then introduces naturally occurring ribozymes and includes the search for new catalytic motifs or novel genomic locations of known motifs. Next, it covers the development and design of engineered ribozymes, before moving on to DNAzymes as a close relative of ribozymes. The next part examines the use of ribozymes for medicinal and environmental diagnostics, as well as for therapeutic tools. It finishes with a look at the tools and methods in ribozyme research, including the techniques and assays for structural and functional characterization of nucleic acid catalysts. The first reference to tie together all aspects of the multi-faceted field of ribozymes Features more than 30 comprehensive chapters in two volumes Covers the chemical principles of RNA catalysis; naturally occurring ribozymes, engineered ribozymes; DNAzymes; ribozymes as tools in diagnostics and therapy, and tools and methods to study ribozymes Includes first-hand accounts of concepts, techniques, and applications by a team of top international experts from leading academic institutions Dedicates half of its content to methods and practical applications, ranging from bioanalytical tools to medical diagnostics to therapeutics Ribozymes is an unmatched resource for all biochemists, biotechnologists, molecular biologists, and bioengineers interested in the topic.

Ribozymes and RNA Catalysis

David Malcolm James Lilley,Fritz Eckstein
Ribozymes and RNA Catalysis Book PDF

Author : David Malcolm James Lilley,Fritz Eckstein
Publisher : Royal Society of Chemistry
Page : 339 pages
File Size : 42,9 Mb
Release : 2008
Category : Science
ISBN : 9780854042531

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Ribozymes and RNA Catalysis by David Malcolm James Lilley,Fritz Eckstein Pdf

Takes the reader through the origins of catalysis in RNA and necessarily includes significant discussion of structure and folding. The main focus of the book concerns chemical mechanism with extensive comment on how, despite the importance of RNA catalysis in the cell, its origins are still poorly understood and often controversial. The reader is given an outline of the important role of RNA catalysis in many aspects of cell function, including RNA processing and translation.

Thomas' Hematopoietic Cell Transplantation, 2 Volume Set

Stephen J. Forman,Robert S. Negrin,Joseph H. Antin,Frederick R. Appelbaum
Thomas Hematopoietic Cell Transplantation 2 Volume Set Book PDF

Author : Stephen J. Forman,Robert S. Negrin,Joseph H. Antin,Frederick R. Appelbaum
Publisher : John Wiley & Sons
Page : 1789 pages
File Size : 44,7 Mb
Release : 2016-12-27
Category : Medical
ISBN : 9781118416006

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Thomas' Hematopoietic Cell Transplantation, 2 Volume Set by Stephen J. Forman,Robert S. Negrin,Joseph H. Antin,Frederick R. Appelbaum Pdf

Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Upstream Industrial Biotechnology, 2 Volume Set

Michael C. Flickinger
Upstream Industrial Biotechnology 2 Volume Set Book PDF

Author : Michael C. Flickinger
Publisher : John Wiley & Sons
Page : 3600 pages
File Size : 40,9 Mb
Release : 2013-07-22
Category : Science
ISBN : 9781118619278

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Upstream Industrial Biotechnology, 2 Volume Set by Michael C. Flickinger Pdf

Biotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley's Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive resource.

Ribozymes

Sabine Müller,Benoît Masquida,Wade Winkler
Ribozymes Book PDF

Author : Sabine Müller,Benoît Masquida,Wade Winkler
Publisher : John Wiley & Sons
Page : 81 pages
File Size : 50,8 Mb
Release : 2021-07-09
Category : Science
ISBN : 9783527814534

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Ribozymes by Sabine Müller,Benoît Masquida,Wade Winkler Pdf

Ribozymes Provides comprehensive coverage of a core field in the molecular biosciences, bringing together decades of knowledge from the world’s top professionals in the field Timely and unique in its breadth of content, this all-encompassing and authoritative reference on ribozymes documents the great diversity of nucleic acid-based catalysis. It integrates the knowledge gained over the past 35 years in the field and features contributions from virtually every leading expert on the subject. Ribozymes is organized into six major parts. It starts by describing general principles and strategies of nucleic acid catalysis. It then introduces naturally occurring ribozymes and includes the search for new catalytic motifs or novel genomic locations of known motifs. Next, it covers the development and design of engineered ribozymes, before moving on to DNAzymes as a close relative of ribozymes. The next part examines the use of ribozymes for medicinal and environmental diagnostics, as well as for therapeutic tools. It finishes with a look at the tools and methods in ribozyme research, including the techniques and assays for structural and functional characterization of nucleic acid catalysts. The first reference to tie together all aspects of the multi-faceted field of ribozymes Features more than 30 comprehensive chapters in two volumes Covers the chemical principles of RNA catalysis; naturally occurring ribozymes, engineered ribozymes; DNAzymes; ribozymes as tools in diagnostics and therapy, and tools and methods to study ribozymes Includes first-hand accounts of concepts, techniques, and applications by a team of top international experts from leading academic institutions Dedicates half of its content to methods and practical applications, ranging from bioanalytical tools to medical diagnostics to therapeutics Ribozymes is an unmatched resource for all biochemists, biotechnologists, molecular biologists, and bioengineers interested in the topic.

Carbohydrate-based Drug Discovery, 2 Volume Set

Chi-Huey Wong
Carbohydrate based Drug Discovery 2 Volume Set Book PDF

Author : Chi-Huey Wong
Publisher : John Wiley & Sons
Page : 520 pages
File Size : 45,9 Mb
Release : 2003-10-17
Category : Science
ISBN : 3527306323

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Carbohydrate-based Drug Discovery, 2 Volume Set by Chi-Huey Wong Pdf

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

The Dictionary of Genomics, Transcriptomics and Proteomics, 4 Volume Set

Guenter Kahl
The Dictionary of Genomics Transcriptomics and Proteomics 4 Volume Set Book PDF

Author : Guenter Kahl
Publisher : John Wiley & Sons
Page : 2744 pages
File Size : 42,7 Mb
Release : 2015-06-08
Category : Science
ISBN : 9783527328529

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The Dictionary of Genomics, Transcriptomics and Proteomics, 4 Volume Set by Guenter Kahl Pdf

Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.

Modern Biopharmaceuticals, 4 Volume Set

Jörg Knäblein
Modern Biopharmaceuticals 4 Volume Set Book PDF

Author : Jörg Knäblein
Publisher : John Wiley & Sons
Page : 2074 pages
File Size : 46,8 Mb
Release : 2005-10-28
Category : Science
ISBN : 9783527311842

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Modern Biopharmaceuticals, 4 Volume Set by Jörg Knäblein Pdf

The biopharmaceutical market has come along way since 1982 when the first biopharmaceutical product, recombinant human insulin, was launched. Over 120 such products are currently being marketed around the world including nine blockbuster drugs. The global market for biopharmaceuticals, which is currently valued at US$41 billion, has been growing at an impressive compound annual growth rate of 21% over the previous five years. With over one third of all pipe-line products in active development are biopharmaceuticals, this segment is set to continue outperforming the total pharmaceutical market and could easily reach US$100 billion by the end of this decade.

Ribozymes

Robert J Scarborough,Anne Gatignol
Ribozymes Book PDF

Author : Robert J Scarborough,Anne Gatignol
Publisher : Humana
Page : 0 pages
File Size : 44,5 Mb
Release : 2020-07-26
Category : Medical
ISBN : 1071607154

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Ribozymes by Robert J Scarborough,Anne Gatignol Pdf

This volume provides protocols designed to study the function and the structure of diverse ribozymes. Chapters guide readers through different techniques to identify and characterize new ribozymes and methods to use ribozymes to alter the function of CRISPR-based guide RNAs, AgoshRNAs and aptamers or to study RNA capping and long non-coding RNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Ribozymes: Methods and Protocols aims to help in accelerating ribozyme research and inspiring others to develop new methods to study ribozyme structure and function.

Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set

Anonim
Burger s Medicinal Chemistry Drug Discovery and Development 8 Volume Set Book PDF

Author : Anonim
Publisher : John Wiley & Sons
Page : 6057 pages
File Size : 53,7 Mb
Release : 2021-04-20
Category : Science
ISBN : 9781119530305

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Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set by Anonim Pdf

Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

Ribozymes and siRNA protocols

Mouldy Sioud
Ribozymes and siRNA protocols Book PDF

Author : Mouldy Sioud
Publisher : Springer Science & Business Media
Page : 623 pages
File Size : 44,8 Mb
Release : 2008-02-03
Category : Science
ISBN : 9781592597468

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Ribozymes and siRNA protocols by Mouldy Sioud Pdf

In this completely updated and expanded edition of a classic bench manual, hands-on experts take advantage of the latest advances in ribozyme, DNAzyme, hammerhead ribozymes and derivatives, and RNA interference technologies to describe in detail the exciting and successful methods now available for gene inactivation in vitro and in vivo. Their optimized techniques employ hairpin ribozymes, DNAzymes, hammerhead ribozymes and derivatives, group I intron ribozymes, RNase P ribozymes, and siRNAs, as well as general methods for RNA structure analysis, delivery of oligonucleotides, and gene therapy. Also provided are novel methods for identifying accessible cellular mRNA sites; group I intron and RNAse P ribozyme protocols for effective design, selection, and therapeutic applications; and the latest RNAi methods for sequence-specific gene silencing in a wide variety of organisms. Additional techniques cover the analysis of ribozyme structures and conformational transitions using nucleotide analog interference mapping and fluorescence resonance energy transfer, the use of ribozymes in clinical and gene therapy, and the use of ribozymes and DNAzymes in rodent models of human disease. Each proven protocol includes a background introduction outlining the principle behind the technique, step-by-step instructions, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Ribozymes and siRNA Protocols details for experienced and novice investigators alike the many exciting advances in our understanding of nucleic acid enzymes, as well as demonstrating how they may be used to analyze gene function and target validation, and to productively develop novel therapeutics for human diseases.

Principles of Virology, Volume 1

Jane Flint,Vincent R. Racaniello,Glenn F. Rall,Theodora Hatziioannou,Anna Marie Skalka
Principles of Virology Volume 1 Book PDF

Author : Jane Flint,Vincent R. Racaniello,Glenn F. Rall,Theodora Hatziioannou,Anna Marie Skalka
Publisher : John Wiley & Sons
Page : 610 pages
File Size : 50,6 Mb
Release : 2020-11-03
Category : Science
ISBN : 9781683672845

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Principles of Virology, Volume 1 by Jane Flint,Vincent R. Racaniello,Glenn F. Rall,Theodora Hatziioannou,Anna Marie Skalka Pdf

Principles of Virology, the leading virology textbook in use, is an extremely valuable and highly informative presentation of virology at the interface of modern cell biology and immunology. This text utilizes a uniquely rational approach by highlighting common principles and processes across all viruses. Using a set of representative viruses to illustrate the breadth of viral complexity, students are able to under-stand viral reproduction and pathogenesis and are equipped with the necessary tools for future encounters with new or understudied viruses. This fifth edition was updated to keep pace with the ever-changing field of virology. In addition to the beloved full-color illustrations, video interviews with leading scientists, movies, and links to exciting blogposts on relevant topics, this edition includes study questions and active learning puzzles in each chapter, as well as short descriptions regarding the key messages of references of special interest. Volume I: Molecular Biology focuses on the molecular processes of viral reproduction, from entry through release. Volume II: Pathogenesis and Control addresses the interplay between viruses and their host organisms, on both the micro- and macroscale, including chapters on public health, the immune response, vaccines and other antiviral strategies, viral evolution, and a brand new chapter on the therapeutic uses of viruses. These two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to internet resources. Principles of Virology, Fifth Edition, is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. This edition carefully reflects the results of extensive vetting and feedback received from course instructors and students, making this renowned textbook even more appropriate for undergraduate and graduate courses in virology, microbiology, and infectious diseases.

Looking at Ribozymes

Benoît Masquida
Looking at Ribozymes Book PDF

Author : Benoît Masquida
Publisher : John Wiley & Sons
Page : 196 pages
File Size : 52,6 Mb
Release : 2024-02-21
Category : Science
ISBN : 9781394276622

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Looking at Ribozymes by Benoît Masquida Pdf

Behind the neologism “ribozymes” lies a family of fascinating molecules, ribo-enzymes, which have been relatively little studied. These catalytically active RNAs are found in all strata of life, from viruses to the human genome. At the end of the 1970s, the discovery of a catalytic RNA nestled in an intron, followed by another involved in the maturation of transfer RNAs, led to the discovery of new ribozymes and the transition from a strictly “proteocentric” vision, inherited from the dogma of molecular biology, to a more “nucleocentric” one. Since then, a variety of ribozymes have been identified in genomes, where their functions often remain mysterious. Looking at Ribozymes traces the discovery of these molecules and presents a picture of their functional diversity, catalytic mechanisms and distribution within the tree of life.

Ribozyme Protocols

Philip C. Turner
Ribozyme Protocols Book PDF

Author : Philip C. Turner
Publisher : Humana
Page : 492 pages
File Size : 46,5 Mb
Release : 2013-09-20
Category : Science
ISBN : 1489942858

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Ribozyme Protocols by Philip C. Turner Pdf

The purpose of Ribozyme Protocols is to provide a helpful compilation of protocols that will be of use—^not only to those with some experience of ribozymes—^but also to those wishing to use ribozymes for the first time. Although it is usually impossible to cover every aspect of a scientific field, I believe this book approaches that ideal and should help all readers perform meaningful experiments using ribozymes. To design ribozymes, one must consider whether the target site will be accessible; this task can be facilitated by using computer programs that pre dict the folding of the target RNA. Such programs are detailed in Chapters 2 and 3. If the chosen target is an RNA virus that can mutate rapidly, it makes sense to consider those parts of the genome that are least likely to change during viral replication. An example of how this can be done is described in Chapter 4. Although computer analysis may be a useful starting point to select tar get sites, there seems, at the moment, to be no guarantee that any particular chosen site will be efficiently cleaved. Some workers have deliberately bypassed this problem by using libraries of ribozyme sequences and by select ing those that actually hybridize to and/or cleave the target; these methods are described in Chapters 5 and 6.

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 1

Ganji Purnachandra Nagaraju,Sujatha Peela
Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma Volume 1 Book PDF

Author : Ganji Purnachandra Nagaraju,Sujatha Peela
Publisher : Academic Press
Page : 388 pages
File Size : 53,8 Mb
Release : 2022-02-16
Category : Psychology
ISBN : 9780323993647

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Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 1 by Ganji Purnachandra Nagaraju,Sujatha Peela Pdf

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume One: Biology and Pathophysiology provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This volume discusses topics such as tumor microenvironment in hepatocellular carcinoma, endoplasmic reticulum stress and unfolded protein response, effects of cirrhosis and hepatitis on the prognosis of HCC, mitochondrial metabolism, next generation sequencing, and telomerase. In addition, it discusses exosomes role in HCC progression, metastasis and chemokines. This is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer for their research work or clinical setting. Provides an updated literature review and detailed understanding of liver cancer tumor biology Discusses abnormal changes in the liver caused, resulting from, or associated with hepatocellular carcinoma from a holistic view Presents the content with fully colored images and summarizing tables for easy understanding of complex topics