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RNA Infrastructure and Networks by Lesley J. Collins Pdf
RNAs form complexes with proteins and other RNAs. The RNA‐infrastructure represents the spatiotemporal interaction of these proteins and RNAs in a cell‐wide network. RNA Infrastructure and Networks brings together these ideas to illustrate the scope of RNA‐based biology, and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. This book is but a taste of the wide range of RNA‐based mechanisms that connect in the RNA infrastructure.
Molecular Basis of Apomixis in Plants by Diego Hojsgaard Pdf
Apomixis is the consequence of a concerted mechanism that harnesses the sexual machinery and coordinates developmental steps in the ovule to produce an asexual (clonal) seed. Altered sexual developments involve widely characterized functional and anatomical changes in meiosis, gametogenesis, and embryo and endosperm formation. The ovules of apomictic plants skip meiosis and form unreduced female gametophytes whose egg cells develop into a parthenogenetic embryo, and the central cells may or may not fuse to a sperm to develop the seed endosperm. Thus, functional apomixis involves at least three components, apomeiosis, parthenogenesis, and endosperm development, modified from sexual reproduction that must be coordinated at the molecular level to progress through the developmental steps and form a clonal seed. Despite recent progress uncovering specific genes related to apomixis-like phenotypes and the formation of clonal seeds, the molecular basis and regulatory network of apomixis is still unknown. This is a central problem underlying the current limitations of apomixis breeding. This book collates twelve publications addressing different topics around the molecular basis of apomixis, illustrating recent discoveries and advances toward understanding the genetic regulation of the trait, discussing the possible origins of apomixis and the remaining challenges for its commercial deployment in plants.
The OMICs:Applications in Neuroscience summarizes the state of the art in OMICs applications in neurology and neuroscience, attracting neurologists who are interested in the progress of this field towards clinical applications, and neuroscientists who may be not familiar with the most recent advances in this ever-changing field. The book will include an overview of most relevant high-throughput approaches (collectively known as 'OMICs') and how they relate to neurology and neuroscience. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience and medicine in general. The reader will be provided with an overview of the application or method, a perspective on the current and future applications in neurology and neuroscience, and a few published examples illustrating possible practical use. Emerging topics such as ethical issues related to personal genome sequencing, epigenetics, network analysis, and role of peripheral biomarkers in disease diagnosis and follow-up will be covered as well.
Evolutionary Genomics and Systems Biology by Gustavo Caetano-Anoll¿s Pdf
A comprehensive, authoritative look at an emergent area in post-genomic science, Evolutionary genomics is an up-and-coming, complex field that attempts to explain the biocomplexity of the living world. Evolutionary Genomics and Systems Biology is the first full-length book to blend established and emerging concepts in bioinformatics, evolution, genomics, and structural biology, with the integrative views of network and systems biology. Three key aspects of evolutionary genomics and systems biology are covered in clear detail: the study of genomic history, i.e., understanding organismal evolution at the genomic level; the study of macromolecular complements, which encompasses the evolution of the protein and RNA machinery that propels life; and the evolutionary and dynamic study of wiring diagrams—macromolecular components in interaction—in the context of genomic complements. The book also features: A solid, comprehensive treatment of phylogenomics, the evolution of genomes, and the evolution of biological networks, within the framework of systems biology A special section on RNA biology—translation, evolution of structure, and micro RNA and regulation of gene expression Chapters on the mapping of genotypes to phenotypes, the role of information in biology, protein architecture and biological function, chromosomal rearrangements, and biological networks and disease Contributions by leading authorities on each topic Evolutionary Genomics and Systems Biology is an ideal book for students and professionals in genomics, bioinformatics, evolution, structural biology, complexity, origins of life, systematic biology, and organismal diversity, as well as those individuals interested in aspects of biological sciences as they interface with chemistry, physics, and computer science and engineering.
Author : Pierre M. Durand Publisher : University of Chicago Press Page : 236 pages File Size : 43,9 Mb Release : 2020-12-09 Category : Science ISBN : 9780226747934
The Revolutionary Origins of Life and Death by Pierre M. Durand Pdf
The question of why an individual would actively kill itself has long been an evolutionary mystery. Pierre M. Durand’s ambitious book answers this question through close inspection of life and death in the earliest cellular life. As Durand shows us, cell death is a fascinating lens through which to examine the interconnectedness, in evolutionary terms, of life and death. It is a truism to note that one does not exist without the other, but just how does this play out in evolutionary history? These two processes have been studied from philosophical, theoretical, experimental, and genomic angles, but no one has yet integrated the information from these various disciplines. In this work, Durand synthesizes cellular studies of life and death looking at the origin of life and the evolutionary significance of programmed cellular death. The exciting and unexpected outcome of Durand’s analysis is the realization that life and death exhibit features of coevolution. The evolution of more complex cellular life depended on the coadaptation between traits that promote life and those that promote death. In an ironic twist, it becomes clear that, in many circumstances, programmed cell death is essential for sustaining life.
Applications of RNA-Seq and Omics Strategies by Fabio Marchi,Priscila Cirillo,Elvis Cueva Mateo Pdf
The large potential of RNA sequencing and other "omics" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine.
Biotechnology to Enhance Sugarcane Productivity and Stress Tolerance by Kalpana Sengar Pdf
Sugarcane is the most important plant source for sugar and alcohol production and is cultivated in more than 80 countries in tropical and subtropical areas. However, environmental factors negatively influence its yield and jeopardize the prospect to meet the increasing demand for sugar, other sugarcane derived by products and bioethanol. The development of stress tolerant plants is fundamental for the maintenance and increase of crop yields. Biotechnology to Enhance Sugarcane Productivity and Stress Tolerance provides a comprehensive account of both theoretical and practical aspects of sugarcane production. It contains extensive coverage of genome mapping and molecular breeding in sugarcane and presents the status of the elucidation and improvement of plant genomes of economic interest. Through 14 chapters written by eminent scientists with global influence, this book examines various methods for sugarcane improvement through biotechnology. The book focuses on genetic and physical mapping, positioning, cloning, and monitoring of desirable genes using biotechnological approaches for high sugarcane productivity and the development of stress tolerance. Additional information includes the bioengineering of sugarcane, procedures to boost productivity, genetics and assessments for resistance to drought and salinity, genetics for high yields, and various topics of research on sugarcane genetics. It serves as a detailed reference source for cane growers, sugar and sugarcane technologists, students, and professors.
Principles and Practice of Pediatric Oncology by Philip A. Pizzo,David G. Poplack Pdf
Now thoroughly updated to include new advances in the field,and with regular content updates to the eBook, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer and the diagnosis, multimodal treatment, and long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families. Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.” Reference your eBook version for key updates in the field during the life of the edition! Chapters included on palliative care and education. Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition. The most updated and authoritative information is provided by the leading experts in the field. Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy. Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families. Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.
Based on one of the leading encyclopedic resources in cell and molecular biology worldwide, this two-volume work contains more than 75% new content, not previously published in the Encyclopedia. All the other chapters have been carefully updated. The result is a comprehensive overview of the different functions of the various forms of RNA in living organisms, with each contributor carefully selected and an internationally recognized expert on his or her field. Special focus is on the different forms of expression regulation through RNA, with medical applications in the treatment of diseases -- from cancers and immune responses to infections and aging -- covered in detail. At least 45 of the 55 articles are new content previously not published in the Encyclopedia.
Data Science, Learning by Latent Structures, and Knowledge Discovery by Berthold Lausen,Sabine Krolak-Schwerdt,Matthias Böhmer Pdf
This volume comprises papers dedicated to data science and the extraction of knowledge from many types of data: structural, quantitative, or statistical approaches for the analysis of data; advances in classification, clustering and pattern recognition methods; strategies for modeling complex data and mining large data sets; applications of advanced methods in specific domains of practice. The contributions offer interesting applications to various disciplines such as psychology, biology, medical and health sciences; economics, marketing, banking and finance; engineering; geography and geology; archeology, sociology, educational sciences, linguistics and musicology; library science. The book contains the selected and peer-reviewed papers presented during the European Conference on Data Analysis (ECDA 2013) which was jointly held by the German Classification Society (GfKl) and the French-speaking Classification Society (SFC) in July 2013 at the University of Luxembourg.
Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon. This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders. Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications Integrates methods and biological topics with basic and clinical discoveries Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders
Regulating with RNA in Bacteria and Archaea by Gisela Storz,Kai Papenfort Pdf
Revealing the many roles of RNA in regulating gene expression For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes. Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have specific functions, including small RNAs (sRNA), RNA thermometers, and riboswitches to regulate core metabolic pathways, bacterial pathogenesis, iron homeostasis, quorum sensing, and biofilm formation. All of these functions, and more, are presented in Regulating with RNA in Bacteria and Archaea, written by RNA biologists from around the globe. Divided into eight sections-RNases and Helicases, Cis-Acting RNAs, Cis Encoded Base Pairing RNAs, Trans-Encoded Base Pairing RNAs, Protein Titration and Scaffolding, General Considerations, Emerging Topics, and Resources-this book serves as an excellent resource for established RNA biologists and for the many scientists who are studying regulated cellular systems. It is no longer a fair assumption that gene expression regulation is the provenance of proteins only or that control is exerted primarily at the level of transcription. This book makes clear that regulatory RNAs are key partners along with proteins in controlling the complex interactions and pathways found within prokaryotes.
A thorough overview of nanobiotechnology and its place in advances in applied science and engineering, The Nanobiotechnology Handbook combines contributions from physics, bioorganic and bioinorganic chemistry, molecular and cellular biology, materials science, and medicine as well as from mechanical, electrical, chemical, and biomedical engineering
Systems Biology by Isidore Rigoutsos,Gregory Stephanopoulos Pdf
The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes. Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for a comprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining to genomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.