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Author : Alexandrina L. Dumitrescu,Gareth W. Davison
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 53,7 Mb
Release : 2019-12-10
Category : Electronic
ISBN : 9782889459926
Author : Pawan K. Maurya,Kamal Dua
Publisher : Springer Nature
Page : 297 pages
File Size : 52,6 Mb
Release : 2020-06-15
Category : Science
ISBN : 9789811515682
This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.
Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Page : 610 pages
File Size : 43,9 Mb
Release : 2016-04-11
Category : Science
ISBN : 9781118832486
Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.
Author : Jose Antonio Morales-Gonzalez
Publisher : BoD – Books on Demand
Page : 516 pages
File Size : 53,9 Mb
Release : 2013-05-22
Category : Science
ISBN : 9789535111238
This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.
Author : Thomas Dziubla,D Allan Butterfield
Publisher : Academic Press
Page : 404 pages
File Size : 50,9 Mb
Release : 2016-05-31
Category : Technology & Engineering
ISBN : 9780128032701
Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility
Author : David R. Riddle
Publisher : CRC Press
Page : 408 pages
File Size : 44,6 Mb
Release : 2007-04-19
Category : Medical
ISBN : 1420005529
Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Author : Carlos Bravo-Diaz
Publisher : Springer Nature
Page : 477 pages
File Size : 50,9 Mb
Release : 2022-02-06
Category : Technology & Engineering
ISBN : 9783030872229
This book offers a new physical chemistry perspective on the control of lipid oxidation reactions by antioxidants, and it further explores the application of several oxidation inhibition strategies on food and biological systems. Divided in 3 parts, the book reviews the latest methods to control lipid oxidation, it examines lipid oxidation and inhibition in different food systems, and it finishes with an overview of the biological, health and nutritional effects of lipid oxidation. Chapters from expert contributors cover topics such as the use of magnetic methods to monitor lipid and protein oxidation, the kinetics and mechanisms of lipid oxidation and antioxidant inhibition reactions, interfacial chemistry, oxidative stress and its impact in human health, nutritional, sensory and physiological aspects of lipid oxidation, and new applications of plant and marine antioxidants. While focused on lipid peroxidation in food and biological systems, the chemistry elucidated in this book is applicable also to toxicology, medicine, plant physiology and pathology, and cosmetic industry. The book will therefore appeal to researchers in the lipid oxidation field covering food, biological and medical areas.
Author : Jane Manakil
Publisher : BoD – Books on Demand
Page : 230 pages
File Size : 52,7 Mb
Release : 2017-09-20
Category : Medical
ISBN : 9789535135319
Chronic inflammation such as seen in periodontitis and its bidirectional influence on the systemic health has been of increased interest for a decade. In this text book, we have explored the biological and genetic pathways by which periodontal diseases may influence these disease processes and vice versa. Occlusal rehabilitation using the MEAW technique for the effective treatment of class II deep bite malocclusion and the timely management of cleft lip and palate to benefit the holistic welfare of the patient are presented here. The book addresses the development of bioinspired functionally graded dental restorative materials and also a simulation method that can improve clinical durability and enhance the functional capability of the dentition and indirect prostheses. In conclusion, various pathways for the promotion of oral health with evidence-based concepts are considered.
Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 489 pages
File Size : 41,8 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author : V. Tamara Perchyonok
Publisher : Nova Science Publishers
Page : 301 pages
File Size : 45,5 Mb
Release : 2016
Category : Medical
ISBN : 163484792X
Dental biomaterials and natural products represent two growing research fields, revealing that plant-derived compounds may play a role not only as nutraceuticals in affecting oral health but also in improving physicochemical properties of biomaterials used in dentistry. Recently, the role of free radicals in healthcare has attracted tremendous interest in the field of medicine, dentistry and molecular biology. Free radicals can be either harmful or helpful to the human body. When there is an imbalance between input and output of free radicals, a condition called "oxidative stress" develops. To counteract oxidative stress, the body has protective antioxidant mechanisms, which aid in lowering the incidence of various human morbidities and mortalities. The implication of oxidative stress in the etiology of many chronic and degenerative diseases suggests that antioxidant therapy represents a promising avenue for treatment. Thus, various forms of antioxidants have been introduced as an approach to fight dental diseases and improve general gingival health. The implication of oxidative stress in the etiology of chronic and degenerative diseases as well as the body's protective antioxidant mechanisms and the role dietary antioxidants play, suggests that antioxidant therapy could act as a beneficial treatment. The aim of this book is to present all available data concerning and linking free radicals, antioxidants and bio-active scaffolds in the utilization of vitamins, proteins and extracts rich in bio-active phytochemicals as an avenue for creating innovative dental biomaterials. These materials are capable of promoting genuine tissue/cell interface integration and gaining insight into molecular origin of the mechanism to combat oral diseases in vitro and eventually in vivo.
Author : W.Wolfgang Fleischhacker,David J. Brooks
Publisher : Springer Science & Business Media
Page : 154 pages
File Size : 50,7 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9783709161371
Atherosclerosis, the underlying cause of heart attacks, strokes and peripheral vascular disease, is one of the major killers in the world. By 2020 WHO statistics indicate that it will be the most common cause of morbidity and mortality in both the industrialised world and the underdeveloped world. The disease develops slowly over many years in the innermost layer of large and medium-sized arteries (Fig. 1) (Scott, 1995; Ross, 1999; Naumova and Scott, 2000; Glass and Witztum, 2001; Libby, 2001). It does not usually become manifest before the fourth of fifth decade, but then often strikes with devas tating suddenness. Fifty per cent of individuals still die (25 per cent immedi ately) from their first heart attack; and morbidity from coronary heart disease and stroke is very significant. The disease has a profound impact on health care services and on industrial economies. The lesions of atherosclerosis Autopsy studies show that in humans atherosclerosis begins in the first and second decade of life. A similar disease can be produced in experimental animals, where diet and genetics can be manipulated to produce identical lesions. The earliest lesions are fatty streaks. These consist of an accumulation of lipid-engorged macrophages (foam cells) and T and B lymphocytes in the arterial intima. With time, the fatty streaks progress to intermediate lesions, composed of foam cells and smooth muscle cells.
Author : Anonim
Publisher : BoD – Books on Demand
Page : 140 pages
File Size : 42,7 Mb
Release : 2020-08-26
Category : Science
ISBN : 9781838801250
The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.
Author : Sajal Chakraborti
Publisher : Springer Nature
Page : 4078 pages
File Size : 54,7 Mb
Release : 2022-09-28
Category : Medical
ISBN : 9789811654220
This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
Author : John F. Keaney Jr.
Publisher : Springer Science & Business Media
Page : 404 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461546498
One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.
Author : Pinar Atukeren
Publisher : BoD – Books on Demand
Page : 158 pages
File Size : 52,7 Mb
Release : 2018-05-09
Category : Science
ISBN : 9781789230864
Oxidative stress plays a crucial role in the pathophysiology of various diseases when there is a disruption of the intracellular redox balance and the homeostatic balance between cellular oxidants and antioxidants. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) react with molecular targets including proteins, lipids, and nucleic acids contributing to mitochondrial injury and cellular dysfunction. This book intends to provide the readers with an extensive overview of the novel approaches and prospects based on oxidative and nitrosative stress in the pathophysiology of various diseases and in the current treatment strategies with antioxidants.
