Science Of Synthesis Click Chemistry

Author : Floris P. J. T. Rutjes
Publisher : Thieme
Page : 750 pages
File Size : 52,8 Mb
Release : 2021-11-24
Category : Science
ISBN : 9783132442153

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Science of Synthesis: Click Chemistry by Floris P. J. T. Rutjes Pdf

This reference work presents the state-of-the-art in the field of click chemistry, collecting the most useful, practical, and reliable methods. Click chemistry is a discipline that has grown rapidly since the introduction of this term by Barry Sharpless and Huisgen approximately two decades ago. Initially, click reactions mostly involved copper-catalyzed azide-alkyne cycloadditions and their applications to connect molecules, but gradually new types of click reactions were developed which also allowed a much wider range of applications throughout the chemical, biological, and materials sciences. This volume provides an overview of the most widely used click reactions and their scope and limitations. Written by pioneers and leaders in the field and including representative applications and experimental procedures. Newcomers to the field are enabled to instantly apply these reactions in synthesis.

Author : Srinivasan Chandrasekaran
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 46,8 Mb
Release : 2016-06-22
Category : Science
ISBN : 9783527694181

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Click Reactions in Organic Synthesis by Srinivasan Chandrasekaran Pdf

This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.

Author : Joerg Lahann
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 53,5 Mb
Release : 2009-12-15
Category : Technology & Engineering
ISBN : 0470748850

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Click Chemistry for Biotechnology and Materials Science by Joerg Lahann Pdf

Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions.

Author : A. K. Agrahari,I. V. Alabugin,T. Beke-Somfai,D. Blanco-Ania,K. M. Bratlie,J. C. T. Carlson,F. Friscourt,M.-C. Giel,T. Harris,K. N. Houk,L. J. N. Janssen,K. M. Kacprzak,N. Kann,A. Kovalová,W. Kuba,A. La Venia,R. M. J. Liskamp,T. J. Meuleman,H. Mikula,A. Mishra,J. E. Moses,F. F. Ort,K. M. Page,A. J. Paterson,J. Rutkowski,R. Singh,A. K. Sinha,I. Skiera,C. J. Smedley,D. Svatunek,V. K. Tiwari,J. C. M. van Hest,M. Vrabel,M. Wilkovitsch,Z. Xu,C. Zhang
Publisher : Unknown
Page : 744 pages
File Size : 48,5 Mb
Release : 2022
Category : Electronic
ISBN : 3132435570

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Click Chemistry by A. K. Agrahari,I. V. Alabugin,T. Beke-Somfai,D. Blanco-Ania,K. M. Bratlie,J. C. T. Carlson,F. Friscourt,M.-C. Giel,T. Harris,K. N. Houk,L. J. N. Janssen,K. M. Kacprzak,N. Kann,A. Kovalová,W. Kuba,A. La Venia,R. M. J. Liskamp,T. J. Meuleman,H. Mikula,A. Mishra,J. E. Moses,F. F. Ort,K. M. Page,A. J. Paterson,J. Rutkowski,R. Singh,A. K. Sinha,I. Skiera,C. J. Smedley,D. Svatunek,V. K. Tiwari,J. C. M. van Hest,M. Vrabel,M. Wilkovitsch,Z. Xu,C. Zhang Pdf

Author : Srinivasan Chandrasekaran
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 46,6 Mb
Release : 2016-06-22
Category : Science
ISBN : 9783527694150

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Click Reactions in Organic Synthesis by Srinivasan Chandrasekaran Pdf

This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.

Author : Joerg Lahann
Publisher : John Wiley & Sons
Page : 437 pages
File Size : 53,8 Mb
Release : 2009-11-23
Category : Technology & Engineering
ISBN : 9780470699706

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Click Chemistry for Biotechnology and Materials Science by Joerg Lahann Pdf

Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions.

Author : Chen Yu,Tong Zong Rui
Publisher : Unknown
Page : 0 pages
File Size : 51,5 Mb
Release : 2017
Category : Biocompatibility
ISBN : 1536119032

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Click Chemistry by Chen Yu,Tong Zong Rui Pdf

Click chemistry, which is also referred to as linkage chemistry, dynamic, combinatorial chemistry or quick linking combinatorial chemistry describes the reaction that joins molecular fragments as simply, efficient and versatile as clicking a mouse. The two units with specific click structures can be linked by a click reaction no matter what is attached to the structure, and only the specific click structures can be joined. It emphasises the development of new combinatorial chemistries on the basis of the synthesis of efficient and highly selective carbon-heteroatom bonds (C-X-C), and effectively prepares molecules with high diversity via these simple reactions. It significantly simplified and promoted the development of synthesis chemistry. Click chemistry has become one of the most useful and attractive synthetic strategies in many fields. In this book, the definition of click chemistry is explained, the characteristics and types of click chemistry are introduced, and some specific reaction types are focused on. The progress for using click chemistry for the synthesis and functionalisation of hydrogels, elastomers, surface modifications, membrane preparations, assemble polyaromatic structures, biomedical fields and optical sensing in biological analyses are described in detail. The problems and challenges for using click chemistry in different fields are analysed.

Author : Gopinathan Anilkumar,Salim Saranya
Publisher : John Wiley & Sons
Page : 504 pages
File Size : 45,6 Mb
Release : 2020-12-07
Category : Technology & Engineering
ISBN : 9783527347377

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Copper Catalysis in Organic Synthesis by Gopinathan Anilkumar,Salim Saranya Pdf

The most current information on growing field of copper catalysis Copper Catalysis in Organic Synthesis contains an up-to-date overview of the most important reactions in the presence of copper catalysts. The contributors—noted experts on the topic—provide an introduction to the field of copper catalysis, reviewing its development, scope, and limitations, as well as providing descriptions of various homo- and cross-coupling reactions. In addition, information is presented on copper-catalyzed C–H activation, amination, carbonylation, trifluoromethylation, cyanation, and click reactions. Comprehensive in scope, the book also describes microwave-assisted and multi-component transformations as well as copper-catalyzed reactions in green solvents and continuous flow reactors. The authors highlight the application of copper catalysis in asymmetric synthesis and total synthesis of natural products and heterocycles as well as nanocatalysis. This important book: Examines copper and its use in organic synthesis as a more cost-effective and sustainable for researchers in academia and industry Offers the first up-to-date book to explore copper as a first line catalyst for many organic reactions Presents the most significant developments in the area, including cross-coupling reactions, C–H activation, asymmetric synthesis, and total synthesis of natural products and heterocycles Contains over 20 contributions from leaders in the field Written for catalytic chemists, organic chemists, natural products chemists, pharmaceutical chemists, and chemists in industry, Copper Catalysis in Organic Synthesis offers a book on the growing field of copper catalysis, covering cross-coupling reactions, C–H activation, and applications in the total synthesis of natural products.

Author : Vinod K. Tiwari,Manoj K. Jaiswal,Sanchayita Rajkhowa,Sumit K. Singh
Publisher : Springer
Page : 0 pages
File Size : 47,5 Mb
Release : 2024-09-12
Category : Science
ISBN : 9819745950

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Click Chemistry by Vinod K. Tiwari,Manoj K. Jaiswal,Sanchayita Rajkhowa,Sumit K. Singh Pdf

This book comprehensively covers the fundamentals and latest advancements in the area of click chemistry. It discusses notable applications of click chemistry in various emerging areas ranging from chemical biology to catalysis and from medicinal chemistry to material sciences. Various topics covered in this book are catalysis in regioselectivity in click chemistry, organocatalysis in triazole synthesis, Bertozzi’s Bioorthogonal Concept, photo-triggered click chemistry, SuFFEx Click, Thiol-Ene Click, MCR Click, Intramolecular Click Chemistry, synthesis of diverse triazoles and their applications, Click's Post Functionalization, etc. The book is a valuable reference for beginners, researchers and professionals interested in sustainable click concept and its diverse applications in allied fields.

Author : E. Fernández
Publisher : Thieme
Page : 582 pages
File Size : 40,8 Mb
Release : 2020-05-22
Category : Science
ISBN : 9783132429734

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Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis by E. Fernández Pdf

The widespread use of organoboron compounds justifies the efforts devoted to their synthesis, as well as toward developing an understanding of their reactivity. The nature of the mono- or diboron species is of paramount importance in determining the reversible covalent binding properties of the boron atom with both nucleophiles and electrophiles. By wedding the rich chemical potential of organoboron compounds to the ubiquity of organic scaffolds, advanced borylation reactions have the potential to open unprecedented synthetic alternatives, and new knowledge in the field should encourage chemists to use organoboron compounds. In this volume, the main objective is to provide a collection of the most useful, practical, and reliable methods, reported mainly within the last decade, for boron activation and boron reactivity. The volume covers the main concepts of organoboron compounds and includes experimental procedures, enabling newcomers to the field the instant and reliable application of the new tools in synthesis. Rather than aiming for a comprehensive coverage, the most advanced solutions for challenging transformations are introduced. To this end, a team of pioneers and leaders in the field have been assembled who discuss both the practical and conceptual aspects of this rapidly growing field.

Author : Janez Košmrlj
Publisher : Springer
Page : 236 pages
File Size : 48,7 Mb
Release : 2012-05-30
Category : Science
ISBN : 9783642294297

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Click Triazoles by Janez Košmrlj Pdf

B. R. Buckley and H. Heaney: Mechanistic Investigations of Copper(I)- Catalyzed Alkyne–Azide Cycloaddition Reactions.- J. D. Crowley and D. A. McMorran: “Click-Triazole” Coordination Chemistry: Exploiting 1,4-Disubstituted-1,2,3-Triazoles as Ligands.- S. Lee and A. H. Flood: Binding Anions in Rigid and Reconfigurable Triazole Receptors.- M. Watkinson: Click Triazoles as Chemosensors.- H.-F. Chow, C.-M. Lo and Y. Chen: Triazole-Based Polymer Gels.- T. Zheng, S. H. Rouhanifard, A. S. Jalloh, P. Wu: Click Triazoles for Bioconjugation.- S. Mignani, Y. Zhou, T. Lecourt and L. Micouin: Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles.

Author : Timothy Jamison,Guido Koch
Publisher : Unknown
Page : 0 pages
File Size : 42,9 Mb
Release : 2018
Category : Electronic
ISBN : 3132423335

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Science of Synthesis: Flow Chemistry in Organic Synthesis by Timothy Jamison,Guido Koch Pdf

Author : G. A. Molander
Publisher : Thieme
Page : 490 pages
File Size : 45,6 Mb
Release : 2020-05-22
Category : Science
ISBN : 9783132429789

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Science of Synthesis: Dual Catalysis in Organic Synthesis 1 by G. A. Molander Pdf

The field of dual catalysis has developed rapidly over the last decade, and these volumes define its impact on organic synthesis. The most important, basic concepts of synergistic, dual catalytic cycles are introduced, providing newcomers to the field with reliable information on this new approach to facilitating the synthesis of organic molecules. Background information and reliable procedures for challenging transformations in synthesis are presented, applying the concept of cooperative dual catalysis as a means of increasing molecular complexity in the most efficient manner. The most useful, practical, and reliable methods for dual catalysis combining metal catalysts, organocatalysts, photocatalysts, and biocatalysts are presented.

Author : Anonim
Publisher : Newnes
Page : 9815 pages
File Size : 45,6 Mb
Release : 2014-02-14
Category : Science
ISBN : 9780080977430

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Comprehensive Organic Synthesis by Anonim Pdf

The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively

Author : William A. Smit,Alekseĭ Feodosʹevich Bochkov,Ron Caple
Publisher : Royal Society of Chemistry
Page : 508 pages
File Size : 53,8 Mb
Release : 1998
Category : Education
ISBN : 0854045449

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Organic Synthesis by William A. Smit,Alekseĭ Feodosʹevich Bochkov,Ron Caple Pdf

The view of organic synthesis as "a concentrated expression of predictive ability and creative capacity" was advocated in the early 1950s. A concise and readable account of the role of synthesis in modern science, Organic Synthesis: The Science Behind the Art presents the general ideology of pursuits in the area of organic synthesis, and examines the methodologies that have evolved in the search for solutions to synthetic problems. This unique book details outstanding achievements of modern organic synthesis, not only for their scientific merits, but also for the aesthetic appeal of the target molecules chosen and the intrinsic beauty of the solutions to the problems posed. By judicious selection of data covering the main areas of synthetic explorations, this book serves to illustrate both the evolution of well-known approaches as well as recently emerged trends most likely to determine the future development of organic synthesis. Special attention is given to the consideration of principles of molecular design in promising and challenging areas of current research. Primarily aimed at advanced undergraduate and graduate students, Organic Synthesis: The Science Behind the Art will also be of interest to teachers, researchers and anyone requiring an introduction to the problems of organic synthesis.