Screening And Risk Reduction Strategies For Breast Cancer

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Screening and Risk Reduction Strategies for Breast Cancer

Masakazu Toi
Screening and Risk Reduction Strategies for Breast Cancer Book PDF

Author : Masakazu Toi
Publisher : Unknown
Page : 0 pages
File Size : 40,7 Mb
Release : 2023
Category : Electronic
ISBN : 9811976317

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Screening and Risk Reduction Strategies for Breast Cancer by Masakazu Toi Pdf

This book provides readers with the most up-to-date practical information on breast cancer screening. Since breast cancers are highly heterogeneous, time to clinical onset from the initial carcinogenesis differs diversely between cancers. Pathological germline variants and driver mutations cause a high lifetime risk of breast cancer. The lifetime risks are various according to what genes are pathologically dysfunctional. Integrated omics and imaging technologies have established varying tumour characteristics. Thus, this book suggests that a more individualised scheme is required to improve breast cancer screening. A key aim is to demonstrate how multiple diagnostic imaging modalities such as mammography, ultrasonography, MRI, PET and dbPET improve breast cancer screening accuracy. Mammography screening alone may have a limited impact on breast cancer risk prediction. These issues are crucial to discuss. Clinical experts recommend that new modalities be incorporated for women with dense breasts, like ultrasonography, dynamic mammography, MRI and maybe breast-dedicated PET. Topics on these modalities are going to be summarized in this book. An in-depth review of these modalities is summarised in this book. In addition, new diagnostic modalities, including risk assessment tools, multi-cancer early detection tests using liquid biopsy, the role of protein biomarkers in breast cancer risk screening, challenges, and hopes for future advances, are also covered in this book.

Breast Cancer Risk Reduction and Early Detection

Edward R. Sauter,Mary B. Daly
Breast Cancer Risk Reduction and Early Detection Book PDF

Author : Edward R. Sauter,Mary B. Daly
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 53,8 Mb
Release : 2010-01-22
Category : Medical
ISBN : 9780387875835

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Breast Cancer Risk Reduction and Early Detection by Edward R. Sauter,Mary B. Daly Pdf

While many comprehensive texts have been written on the treatment of breast cancer, the most common cancer among women, there are relatively few which cover in depth the prevention and early detection of the disease. The goal of this work is to present what experts in the ?eld feel is the current knowledge and future direction of breast cancer prevention and early detection. We begin Part I of the book with a review of risk factors, both genetic and environmental. We next review progress in the use of chemoprevention. Notably, chemoprevention risk reduction studies have led to FDA approval of two medications which measurably reduce disease incidence among women at increased risk, although with some risk of treatment related side effects. Newer agents in the pipeline, which may also reduce risk among normal risk women, are also discussed. Surgical risk reducing strategies complete the section on prevention, including both the bene?ts and downsides to this more aggressive approach. Even with aggressive prevention strategies, some women will develop breast cancer. For these women, early detection is critical to minimize disease spread and maximize long term survival. Part II of this book reviews current and upcoming approaches to early detection. Imaging strategies, including mammography, breast ultrasound, MRI, and PET imaging are reviewed. The potential for molecular tumor targeting to detect disease prior to the formation of a mass visible by anatomic imaging is presented.

Breast Cancer Risk Reduction and Early Detection

Edward R. Sauter,Mary B. Daly
Breast Cancer Risk Reduction and Early Detection Book PDF

Author : Edward R. Sauter,Mary B. Daly
Publisher : Springer
Page : 260 pages
File Size : 55,6 Mb
Release : 2016-05-01
Category : Electronic
ISBN : 1489979212

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Breast Cancer Risk Reduction and Early Detection by Edward R. Sauter,Mary B. Daly Pdf

While many comprehensive texts have been written on the treatment of breast cancer, the most common cancer among women, there are relatively few which cover in depth the prevention and early detection of the disease. The goal of this work is to present what experts in the ?eld feel is the current knowledge and future direction of breast cancer prevention and early detection. We begin Part I of the book with a review of risk factors, both genetic and environmental. We next review progress in the use of chemoprevention. Notably, chemoprevention risk reduction studies have led to FDA approval of two medications which measurably reduce disease incidence among women at increased risk, although with some risk of treatment related side effects. Newer agents in the pipeline, which may also reduce risk among normal risk women, are also discussed. Surgical risk reducing strategies complete the section on prevention, including both the bene'ts and downsides to this more aggressive approach. Even with aggressive prevention strategies, some women will develop breast cancer. For these women, early detection is critical to minimize disease spread and maximize long term survival. Part II of this book reviews current and upcoming approaches to early detection. Imaging strategies, including mammography, breast ultrasound, MRI, and PET imaging are reviewed. The potential for molecular tumor targeting to detect disease prior to the formation of a mass visible by anatomic imaging is presented.

Saving Women's Lives

National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Saving Women s Lives Book PDF

Author : National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Publisher : National Academies Press
Page : 384 pages
File Size : 54,5 Mb
Release : 2005-03-18
Category : Medical
ISBN : 9780309165945

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Saving Women's Lives by National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Pdf

The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.

Cancer Prevention and Screening

Rosalind A. Eeles,Christine D. Berg,Jeffrey S. Tobias
Cancer Prevention and Screening Book PDF

Author : Rosalind A. Eeles,Christine D. Berg,Jeffrey S. Tobias
Publisher : John Wiley & Sons
Page : 456 pages
File Size : 47,6 Mb
Release : 2018-08-15
Category : Medical
ISBN : 9781118991060

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Cancer Prevention and Screening by Rosalind A. Eeles,Christine D. Berg,Jeffrey S. Tobias Pdf

Cancer Prevention and Screening offers physicians and all clinical healthcare professionals a comprehensive, useful source of the latest information on cancer screening and prevention with both a global and a multidisciplinary perspective. Includes background information on epidemiology, cancer prevention, and cancer screening, for quick reference Offers the latest information for clinical application of the most recent techniques in prevention and screening of all major and many lesser cancer types Emphasises the importance of multidisciplinary teamwork in cancer screening Highlights frequent dilemmas and difficulties encountered during cancer screening Provides clear-cut clinical strategies for optimal patient education, communication, and compliance with cancer prevention techniques

Saving Women's Lives

National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Saving Women s Lives Book PDF

Author : National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Publisher : National Academies Press
Page : 385 pages
File Size : 43,9 Mb
Release : 2005-04-18
Category : Medical
ISBN : 9780309092135

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Saving Women's Lives by National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Pdf

The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.

Saving Women's Lives

National Research Council,Institute of Medicine,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Saving Women s Lives Book PDF

Author : National Research Council,Institute of Medicine,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Publisher : National Academies Press
Page : 144 pages
File Size : 42,5 Mb
Release : 2004-12-18
Category : Medical
ISBN : 9780309094382

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Saving Women's Lives by National Research Council,Institute of Medicine,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Pdf

In this report The Breast Cancer Research Foundation (BCRF) and the Institute of Medicine (IOM) present a one-day symposium that was held at the IOM to further disseminate the conclusions and recommendations of the joint IOM and National Research Council report, Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis. The committee assembled for this event was asked to share insights and consider ways in which the objectives of the report could be achieved from the standpoint of what women need to know, the best models of screening programs, manpower, risk stratification, basic research, and payment. This symposium seeks to provide continuing food for thought and ideas for actions in support of breast cancer detection and diagnosis and saving women's lives.

Optimizing Breast Cancer Management

William J. Gradishar
Optimizing Breast Cancer Management Book PDF

Author : William J. Gradishar
Publisher : Springer
Page : 189 pages
File Size : 42,8 Mb
Release : 2018-01-19
Category : Medical
ISBN : 9783319701974

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Optimizing Breast Cancer Management by William J. Gradishar Pdf

This book presents expert opinions on a variety of key topics related to the management of breast cancer, with a focus on the implications of recent advances and research findings for clinical practice. It also explores the controversy regarding mammography screening and reviews the contribution of new imaging modalities. Considerable attention is paid to developments in surgical procedures, including the potential for the safe and effective use of sentinel lymph node dissection alone—even in patients with positive nodes—and to the advantages and contraindications of new radiotherapy techniques. Genetic aspects are discussed in detail, including an assessment of the role of genetic testing and the potential impact of genetic signatures on breast cancer management. New systemic strategies, such as anti-HER2 therapy, endocrine agents, and agents to reverse endocrine resistance, are considered, and the optimal use of chemotherapy for early-stage and advanced-stage disease is addressed. In closing, the book shares important new insights into lifestyle risk factors, risk reduction strategies, and survivor issues, including sexual dysfunction and fertility maintenance.

Management of the Patient at High Risk for Breast Cancer

Nora M. Hansen
Management of the Patient at High Risk for Breast Cancer Book PDF

Author : Nora M. Hansen
Publisher : Springer Science & Business Media
Page : 193 pages
File Size : 51,6 Mb
Release : 2013-01-08
Category : Medical
ISBN : 9781461458913

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Management of the Patient at High Risk for Breast Cancer by Nora M. Hansen Pdf

Management of the Patient at High Risk for Breast Cancer provides a state-of-the art review of patients who are at high risk for breast cancer, how to identify them, the tools available for risk assessment and quantification and indications for genetic counseling and testing. The book summarizes the high risk breast imaging options, including newest techniques and schedules. Pathologic evaluation of high risk lesions are featured as well as the management issues surrounding these lesions. The volume also covers the management of concomitant cancer risk and screening strategies. A concise, yet comprehensive overview of the current status of the topic, Management of the Patient at High Risk for Breast Cancer serves as a useful resource for physicians and researchers dealing with and interested in patients at high risk for breast cancer.

Breast Cancer

I. Craig Henderson MD
Breast Cancer Book PDF

Author : I. Craig Henderson MD
Publisher : Oxford University Press
Page : 160 pages
File Size : 44,9 Mb
Release : 2015-10-14
Category : Medical
ISBN : 9780199390854

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Breast Cancer by I. Craig Henderson MD Pdf

Breast Cancer provides an in-depth understanding of the biology of breast cancer, the natural history of the disease, the use of molecular markers, the interpretation of clinical trial data, and the integration of multiple therapeutic modalities. The single most important fact about breast cancer is the great variation in its natural history and its responsiveness to therapy from one patient to another. The clinician must integrate an assessment of the patient's likely course based on clinical and pathological staging and laboratory studies with objective evidence on the benefits of therapy. The primary aim of this book is to provide the clinician with the tools to do just that. Outcomes of clinical trials and details about commonly used drug regimens, drug dosage, and the expected side effects are summarized in generous tables and figures. Medical terminology has been defined and descriptions of the evolution in our thinking and understanding of the disease are often given to provide perspective in the interpretation of evidence from current studies for busy clinicians and trainees alike.

Breast Cancer Screening

Harri Vainio,International Agency for Research on Cancer
Breast Cancer Screening Book PDF

Author : Harri Vainio,International Agency for Research on Cancer
Publisher : World Health Organization
Page : 250 pages
File Size : 54,6 Mb
Release : 2002
Category : Breast
ISBN : UOM:39015061735240

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Breast Cancer Screening by Harri Vainio,International Agency for Research on Cancer Pdf

Breast cancer is the leading site of new cancer cases in women. Breast cancer detection is currently primarily based on physical examination by health care professionals, chance findings by women, breast self-examination and mammography used for diagnosis or for routine screening. Early enough detection through mass screening with mammography has been introduced in many countries in the hope that early intervention would lead to reduced mortality and less aggressive treatment. The aim of this publication is to provide an independent, authoritative review of the evidence of the efficacy and effectiveness of breast cancer screening. This will be of value to governments, public health officials and others concerned with policy recommendations for cancer control.

Digital Breast Tomosynthesis

Alberto Tagliafico,Nehmat Houssami,Massimo Calabrese
Digital Breast Tomosynthesis Book PDF

Author : Alberto Tagliafico,Nehmat Houssami,Massimo Calabrese
Publisher : Springer
Page : 148 pages
File Size : 44,8 Mb
Release : 2016-05-03
Category : Medical
ISBN : 9783319286310

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Digital Breast Tomosynthesis by Alberto Tagliafico,Nehmat Houssami,Massimo Calabrese Pdf

This book provides a comprehensive description of the screening and clinical applications of digital breast tomosynthesis (DBT) and offers straightforward, clear guidance on use of the technique. Informative clinical cases are presented to illustrate how to take advantage of DBT in clinical practice. The importance of DBT as a diagnostic tool for both screening and diagnosis is increasing rapidly. DBT improves upon mammography by depicting breast tissue on a video clip made of cross‐sectional images reconstructed in correspondence with their mammographic planes of acquisition. DBT results in markedly reduced summation of overlapping breast tissue and offers the potential to improve mammographic breast cancer surveillance and diagnosis. This book will be an excellent practical teaching guide for beginners and a useful reference for more experienced radiologists.

Fulfilling the Potential of Cancer Prevention and Early Detection

National Research Council,Institute of Medicine,National Cancer Policy Board
Fulfilling the Potential of Cancer Prevention and Early Detection Book PDF

Author : National Research Council,Institute of Medicine,National Cancer Policy Board
Publisher : National Academies Press
Page : 564 pages
File Size : 51,5 Mb
Release : 2003-05-07
Category : Medical
ISBN : 9780309170130

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Fulfilling the Potential of Cancer Prevention and Early Detection by National Research Council,Institute of Medicine,National Cancer Policy Board Pdf

Cancer ranks second only to heart disease as a leading cause of death in the United States, making it a tremendous burden in years of life lost, patient suffering, and economic costs. Fulfilling the Potential for Cancer Prevention and Early Detection reviews the proof that we can dramatically reduce cancer rates. The National Cancer Policy Board, part of the Institute of Medicine, outlines a national strategy to realize the promise of cancer prevention and early detection, including specific and wide-ranging recommendations. Offering a wealth of information and directly addressing major controversies, the book includes: A detailed look at how significantly cancer could be reduced through lifestyle changes, evaluating approaches used to alter eating, smoking, and exercise habits. An analysis of the intuitive notion that screening for cancer leads to improved health outcomes, including a discussion of screening methods, potential risks, and current recommendations. An examination of cancer prevention and control opportunities in primary health care delivery settings, including a review of interventions aimed at improving provider performance. Reviews of professional education and training programs, research trends and opportunities, and federal programs that support cancer prevention and early detection. This in-depth volume will be of interest to policy analysts, cancer and public health specialists, health care administrators and providers, researchers, insurers, medical journalists, and patient advocates.

Approaches to Breast Cancer Prevention

B.A. Stoll
Approaches to Breast Cancer Prevention Book PDF

Author : B.A. Stoll
Publisher : Springer
Page : 264 pages
File Size : 55,8 Mb
Release : 1991-03-31
Category : Medical
ISBN : UOM:39015021978716

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Approaches to Breast Cancer Prevention by B.A. Stoll Pdf

This book is a logical companion volume to Women at High Risk to Breast Cancer (Kluwer, 1989) edited by me previously. It distinguishes two aspects of current ap proaches to clinical breast cancer prevention. The first is the need to advise individ ual women on how they might reduce their personal risk, while the second is the design of measures aimed at reducing the total incidence of breast cancer in the community. While the former is a problem faced daily by clinicians, the latter is a goal which will involve large scale, carefully planned interventional studies. Because knowledge of the risk factors for breast cancer is incomplete and clinical trial reports are scarce, there is as yet, no scientifically-based model for personal breast cancer prevention. Nevertheless, widespread publicity associated with breast screening programmes has created a large group of highly anxious women who have been informed that they are at higher than average risk to the disease. They are con cerned by the personal threat posed by a family history of the disease and by the al leged dangers of obesity, diet, alcohol, or the use of hormonal agents such as oral contraceptives or hormone replacement therapy.

Optimizing Risk Reduction Decisions for Women at High Risk of Breast Cancer

Mehmet Ali Ergun
Optimizing Risk Reduction Decisions for Women at High Risk of Breast Cancer Book PDF

Author : Mehmet Ali Ergun
Publisher : Unknown
Page : 0 pages
File Size : 54,7 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1246252301

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Optimizing Risk Reduction Decisions for Women at High Risk of Breast Cancer by Mehmet Ali Ergun Pdf

Breast cancer is the most common non-skin cancer and a leading cause of death for U.S. women population. Depending on the personal and hereditary factors, each woman has a different risk of developing a breast cancer and the focus of recent studies has been on identifying the high-risk patients and reducing the mortality and adverse effects due to a breast cancer. For high-risk women, we can prevent breast cancer mortality either by aggressive screening and early detection or by taking preventative treatments such as hormonal therapy (i.e. Tamoxifen, Raloxifene, Exemestane) or a risk reduction surgery (i.e. Bilateral Prophylactic Mastectomy). In Chapter 3, we focus on the problem faced by clinicians and patients who are at higher risk of breast cancer: should a high-risk patient choose to go for a preventative treatment given her current risk estimates, age and treatment history? We formulate this optimal decision-making problem for preventing breast cancer as a discrete time, finite-horizon Markov Decision Process (MDP) model. The objective of this model is to maximize the total expected quality-adjusted life years (QALYs) for a patient while assuming that the decision makers are risk neutral. We use data from literature and Surveillance Epidemiology and End Results (SEER) database for estimating the model parameters. The interventions we consider in the model are tamoxifen and mastectomy for pre-menopausal women and tamoxifen, raloxifene, exemestane and mastectomy for post-menopausal women. The optimal policy in the preliminary results shows that the patients who have 47% or more risk of breast cancer should have a mastectomy if they are between 35-40 years old and have no previous history of preventative treatment. The risk threshold goes up with age for the mastectomy decisions. Among the pharmacological interventions, tamoxifen is optimal for pre-menopausal women around the age of 40 with a lifetime risk of 39% or above which also corresponds to a 5-year risk of 1.6% and above around the age of 40. Exemestane is optimal for post-menopausal women with a lifetime risk of 13% (corresponding 5-year risk of 1%) or above after age of 51. Raloxifene is optimal only when we have elevated risks after age 65 or older. In Chapter 4, we consider optimal breast cancer risk reduction policies when direct and indirect costs associated with the treatments are considered. Although exemestane is the dominant recommendation in QALY maximizing model, the results of the cost model show that it is not cost-efficient up to willingness-to-pay (WTP) ratio of $150,000. We also demonstrated that the optimal policy is very sensitive to the discount factor from which most preventative interventions suffer. In Chapter 5, we investigate the effect of risk-averse behavior on the optimal policies for breast cancer risk reduction. We use two main approaches to model risk aversion. First, we use utility functions with different forms to see the effect of aversion from uncertainty. In the second approach, we utilize dynamic risk measures and explore cases in which aversion is from the cancer risk. While purely risk-averse utility functions lead to myopic decision making, increasing risk-aversion coefficient for dynamic risk measures result in more aggressive treatment policies.