Selected Topics In Dna Repair

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Selected Topics in DNA Repair

Author : Clark Chen
Publisher : BoD – Books on Demand
Page : 586 pages
File Size : 53,6 Mb
Release : 2011-10-26
Category : Medical
ISBN : 9789533076065

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Selected Topics in DNA Repair by Clark Chen Pdf

This book is intended for students and scientists working in the field of DNA repair, focusing on a number of topics ranging from DNA damaging agents and mechanistic insights to methods in DNA repair and insights into therapeutic strategies. These topics demonstrate how scientific ideas are developed, tested, dialogued, and matured as it is meant to discuss key concepts in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

Advances in DNA Repair

Author : Clark Chen
Publisher : BoD – Books on Demand
Page : 498 pages
File Size : 55,7 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9789535122098

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Advances in DNA Repair by Clark Chen Pdf

This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.

New Research Directions in DNA Repair

Author : Clark Chen
Publisher : BoD – Books on Demand
Page : 676 pages
File Size : 41,9 Mb
Release : 2013-05-22
Category : Medical
ISBN : 9789535111146

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New Research Directions in DNA Repair by Clark Chen Pdf

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

DNA Damage and Repair

Author : Jac A. Nickoloff,Merl F. Hoekstra
Publisher : Springer Science & Business Media
Page : 639 pages
File Size : 52,6 Mb
Release : 1998-08-12
Category : Science
ISBN : 9781592594559

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DNA Damage and Repair by Jac A. Nickoloff,Merl F. Hoekstra Pdf

Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

DNA Repair

Author : Francesca Storici
Publisher : BoD – Books on Demand
Page : 396 pages
File Size : 55,5 Mb
Release : 2011-09-09
Category : Medical
ISBN : 9789533076492

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DNA Repair by Francesca Storici Pdf

DNA repair is fundamental to all cell types to maintain genomic stability. A collection of cutting-edge reviews, DNA Repair - On the pathways to fixing DNA damage and errors covers major aspects of the DNA repair processes in a large variety of organisms, emphasizing foremost developments, questions to be solved and new directions in this rapidly evolving area of modern biology. Written by researchers at the vanguard of the DNA repair field, the chapters highlight the importance of the DNA repair mechanisms and their linkage to DNA replication, cell-cycle progression and DNA recombination. Major topics include: base excision repair, nucleotide excision repair, mismatch repair, double-strand break repair, with focus on specific inhibitors and key players of DNA repair such as nucleases, ubiquitin-proteasome enzymes, poly ADP-ribose polymerase and factors relevant for DNA repair in mitochondria and embryonic stem cells. This book is a journey into the cosmos of DNA repair and its frontiers.

Technologies for Detection of DNA Damage and Mutations

Author : G.P. Pfeifer
Publisher : Springer Science & Business Media
Page : 476 pages
File Size : 40,9 Mb
Release : 1996-07-31
Category : Medical
ISBN : 0306452375

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Technologies for Detection of DNA Damage and Mutations by G.P. Pfeifer Pdf

''Useful and timely.'' ---Mutagenesis ''Of considerable value.'' ---Journal of Medical Genetics ''Quite readable....a comprehensive overview....perfectly covers the needs of those researchers who have to decide on the best strategy to identify damage or mutations at the molecular level.'' ---Trends in Cell Biology ''The formats of the presentations are uniform and ample and up-to-date references are provided at the end of each chapter...will be welcomed by postgraduate researchers of all ages and should retain its usefulness for a long time.'' ---Endeavour, 21(4), 1997 This important resource thoroughly reviews a wide range of techniques used in mutagenesis research-ranging from established techniques to recently developed methodologies-based on the polymerase chain reaction. DNA damage analysis, DNA repair assays, and mutation detection are a few of the techniques featured. Chapters present detailed experimental protocols benefiting researchers and students in the fields of toxicology, biotechniques, molecular biology, photobiology, medical genetics, and oncology.

DNA Repair Mechanisms

Author : ICN Pharmaceuticals, inc,University of California, Los Angeles. Molecular Biology Institute
Publisher : Unknown
Page : 840 pages
File Size : 51,8 Mb
Release : 1978
Category : Science
ISBN : UOM:39015000284334

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DNA Repair Mechanisms by ICN Pharmaceuticals, inc,University of California, Los Angeles. Molecular Biology Institute Pdf

DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are ...

DNA Damage and Repair

Author : Jac A. Nickoloff,Merl F. Hoekstra
Publisher : Springer Science & Business Media
Page : 648 pages
File Size : 52,9 Mb
Release : 1998-01-21
Category : Science
ISBN : UOM:39015040351150

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DNA Damage and Repair by Jac A. Nickoloff,Merl F. Hoekstra Pdf

Continuing the tradition of presenting information on DNA damage and repair, this 3rd volume provides the latest reviews by leading researchers. They illuminate key aspects of DNA repair in mammalian systems and its relationship to human disease.

DNA Damage and Repair

Author : Jac A. Nickoloff,Merl F. Hoekstra
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 40,8 Mb
Release : 2001-03-13
Category : Science
ISBN : 9781592590957

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DNA Damage and Repair by Jac A. Nickoloff,Merl F. Hoekstra Pdf

Jac A. Nickoloff and Merl F. Hoekstra update and expand their two earlier acclaimed volumes (Vol. I: DNA Repair in Prokaryotes and Lower Eukaryotes and Vol. II: DNA Repair in Higher Eurkaryotes) with cutting-edge reviews by leading authorities of primary experimental findings about DNA repair processes in cancer biology. The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair. Authoritative and up-to-date, DNA Damage and Repair, Vol. III: Advances from Phage to Humans surveys the rapidly moving research in DNA damage and repair, and explains the important functional relationships among different DNA repair pathways and the relationship between DNA repair pathways, cancer etiology, and cancer therapies.

DNA Repair

Author : Lata Balakrishnan,Jason A. Stewart
Publisher : Unknown
Page : 352 pages
File Size : 52,6 Mb
Release : 2019
Category : DNA repair
ISBN : 1493995006

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DNA Repair by Lata Balakrishnan,Jason A. Stewart Pdf

DNA Repair and Mutagenesis

Author : Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood
Publisher : American Society for Microbiology Press
Page : 2845 pages
File Size : 47,7 Mb
Release : 2005-11-22
Category : Science
ISBN : 9781555813192

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DNA Repair and Mutagenesis by Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood Pdf

An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.

Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants

Author : Alma Balestrazzi,V. Mohan Murali Achary,Anca Macovei,Kaoru Okamoto Yoshiyama,Ayako N Sakamoto
Publisher : Frontiers Media SA
Page : 131 pages
File Size : 43,5 Mb
Release : 2016-05-06
Category : Botany
ISBN : 9782889198207

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Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants by Alma Balestrazzi,V. Mohan Murali Achary,Anca Macovei,Kaoru Okamoto Yoshiyama,Ayako N Sakamoto Pdf

Environmental stresses and metabolic by-products can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. As a consequence, plant growth and productivity are irreversibly compromised. To overcome genotoxic injury, plants have evolved complex strategies relying on a highly efficient repair machinery that responds to sophisticated damage perception/signaling networks. The DNA damage signaling network contains several key components: DNA damage sensors, signal transducers, mediators, and effectors. Most of these components are common to other eukaryotes but some features are unique to the plant kingdom. ATM and ATR are well-conserved members of PIKK family, which amplify and transduce signals to downstream effectors. ATM primarily responds to DNA double strand breaks while ATR responds to various forms of DNA damage. The signals from the activated transducer kinases are transmitted to the downstream cell-cycle regulators, such as CHK1, CHK2, and p53 in many eukaryotes. However, plants have no homologue of CHK1, CHK2 nor p53. The finding of Arabidopsis transcription factor SOG1 that seems functionally but not structurally similar to p53 suggests that plants have developed unique cell cycle regulation mechanism. The double strand break repair, recombination repair, postreplication repair, and lesion bypass, have been investigated in several plants. The DNA double strand break, a most critical damage for organisms are repaired non-homologous end joining (NHEJ) or homologous recombination (HR) pathway. Damage on template DNA makes replication stall, which is processed by translesion synthesis (TLS) or error-free postreplication repair (PPR) pathway. Deletion of the error-prone TLS polymerase reduces mutation frequencies, suggesting PPR maintains the stalled replication fork when TLS is not available. Unveiling the regulation networks among these multiple pathways would be the next challenge to be completed. Some intriguing issues have been disclosed such as the cross-talk between DNA repair, senescence and pathogen response and the involvement of non-coding RNAs in global genome stability. Several studies have highlighted the essential contribution of chromatin remodeling in DNA repair DNA damage sensing, signaling and repair have been investigated in relation to environmental stresses, seed quality issues, mutation breeding in both model and crop plants and all these studies strengthen the idea that components of the plant response to genotoxic stress might represent tools to improve stress tolerance and field performance. This focus issue gives researchers the opportunity to gather and interact by providing Mini-Reviews, Commentaries, Opinions, Original Research and Method articles which describe the most recent advances and future perspectives in the field of DNA damage sensing, signaling and repair in plants. A comprehensive overview of the current progresses dealing with the genotoxic stress response in plants will be provided looking at cellular and molecular level with multidisciplinary approaches. This will hopefully bring together valuable information for both plant biotechnologists and breeders.

DNA Damage Recognition

Author : Wolfram Siede,Paul W. Doetsch
Publisher : CRC Press
Page : 872 pages
File Size : 40,8 Mb
Release : 2005-09-19
Category : Science
ISBN : 9780849352683

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DNA Damage Recognition by Wolfram Siede,Paul W. Doetsch Pdf

Stands as the most comprehensive guide to the subject—covering every essential topic related to DNA damage identification and repair. Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employed by cells to distinguish between damaged and undamaged sites and stimulate the appropriate repair pathways. about the editors... WOLFRAM SIEDE is Associate Professor, Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth. He received the Ph.D. degree (1986) from Johann Wolfgang Goethe University, Frankfurt Germany. YOKE WAH KOW is Professor, Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia. He received the Ph.D. degree (1981) from Brandeis University, Waltham, Massachusetts. PAUL W. DOETSCH is Professor, Departments of Biochemistry, Radiation Oncology, and Hematology and Oncology, and Associate Director for Basic Research, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia. He received the Ph.D. degree (1982) from Temple University School of Medicine, Philadelphia, Pennsylvania.

DNA Repair Mechanisms

Author : Philip Hanawalt
Publisher : Elsevier
Page : 832 pages
File Size : 41,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323142328

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DNA Repair Mechanisms by Philip Hanawalt Pdf

DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are grouped with the related workshop and poster manuscripts. The first two parts generally tackle repair in terms of its identification and quantification, as well as the models, systems, and perspectives it utilizes. The following parts discuss the various types of repair including base excision, nucleotide excision repair in bacteria, excision repair in mammalian cells, inducible/error-prone repair in prokaryotes, and strand break repair in mammalian cells among others. This reference material looks into the replicative bypass mechanisms in mammalian cells, viral probes, and hereditary repair defects. It explains repair deficiency and human disease, as well as mutagenesis and carcinogenesis. The last part of this book deals with the consequences and effects of DNA repair. This volume is a helpful source of reference for students, teachers, scientists, and researchers in the different fields of genetics, radiology, biochemistry, and environmental biology.