Severe Asthma

Author : Kian Fan Chung,Elliot Israel,Peter G. Gibson
Publisher : European Respiratory Society
Page : 360 pages
File Size : 45,6 Mb
Release : 2019-06-01
Category : Medical
ISBN : 9781849841047

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Severe Asthma by Kian Fan Chung,Elliot Israel,Peter G. Gibson Pdf

Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

Author : Antonio Anzueto,Yvonne Heijdra,John R. Hurst
Publisher : European Respiratory Society
Page : 336 pages
File Size : 40,8 Mb
Release : 2015-09-01
Category : Medical
ISBN : 9781849840644

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Controversies in COPD by Antonio Anzueto,Yvonne Heijdra,John R. Hurst Pdf

Edited by Antonio Anzueto, Yvonne Heijdra and John R. Hurst COPD is one of the most common diseases worldwide and is projected to be the third leading cause of death by 2020. But that does not mean it is easy to understand or manage. In everyday practice, pulmonologists face areas of controversy in COPD, for which evidence-based medicine is often unavailable. This ERS Monograph considers where the current controversies in COPD lie, discussing areas such as screening, premature birth, asthma–COPD overlap syndrome, treatment, rehabilitation and palliative care. This book will be of great interest to both clinicians and scientists, and aims to stimulate further discussion about this diverse and fascinating disease. "...contains a vast amount of information on the disease, its prevalence, signs and symptoms, diagnositc tests and treatment options. The book's format makes it quick and simple to find out what you need to know, and its size would make it easy to take to work for use in practice [...] invaluable for anyone working with patients with the disease." Emma Vincent, Nursing Standard

Author : Erick Forno,Sejal Saglani
Publisher : Springer Nature
Page : 365 pages
File Size : 42,9 Mb
Release : 2019-11-13
Category : Medical
ISBN : 9783030274313

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Severe Asthma in Children and Adolescents by Erick Forno,Sejal Saglani Pdf

This book provides readers with a comprehensive review of severe asthma in children and adolescents, covering epidemiology, genetics, risk factors, co-morbidities, clinical presentation, diagnosis and treatment. Written by leaders in the field, chapter discussions draw on the mechanisms driving the disease, genetics, multidisciplinary approaches, immunomodulators, and other important aspects in the management of the disease. Severe Asthma in Children and Adolescents: Mechanisms and Management is designed to be a practical guide, opening with an introduction on the epidemiology of severe childhood asthma, as well as a discussion of special considerations of the disease unique to the preschool-aged patient. The distinctions between the diagnosis and management of asthma in young children of various ages, and specific approaches for the adolescent with severe asthma, including the transition into adult care are then addressed. Finally, the book closes with a discussion on the current state and future avenues for severe asthma research. Severe Asthma in Children and Adolescents is an indispensable reference for the healthcare professional, for basic and translational researchers, as well as for students, residents and fellows.

Author : World Health Organization
Publisher : World Health Organization
Page : 442 pages
File Size : 44,6 Mb
Release : 2013
Category : Medical
ISBN : 9789241548373

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Pocket Book of Hospital Care for Children by World Health Organization Pdf

The Pocket Book is for use by doctors nurses and other health workers who are responsible for the care of young children at the first level referral hospitals. This second edition is based on evidence from several WHO updated and published clinical guidelines. It is for use in both inpatient and outpatient care in small hospitals with basic laboratory facilities and essential medicines. In some settings these guidelines can be used in any facilities where sick children are admitted for inpatient care. The Pocket Book is one of a series of documents and tools that support the Integrated Managem.

Author : Sandhya Khurana,Fernando Holguin
Publisher : Springer Nature
Page : 334 pages
File Size : 50,8 Mb
Release : 2019-08-29
Category : Medical
ISBN : 9783030208127

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Difficult To Treat Asthma by Sandhya Khurana,Fernando Holguin Pdf

This book provides a practical, stepwise, evidence-based approach to effective management of patients with difficult to treat asthma. The impact of asthma on morbidity and healthcare utilization increases exponentially with severity. Severe refractory asthma accounts for less than 5% of all asthma. Its prevalence, however, is often overestimated as there are several other confounding factors that make asthma ‘difficult to treat’. Many novel (albeit expensive) therapies are now available and providers caring for patients with severe asthma are charged with selecting the best evidence treatment. This calls for complex and nuanced decision-making. Whether people with asthma gain and maintain control over their condition depends not only on the availability of effective drugs, but also multiple patient and healthcare provider behaviors. Therefore, now more than ever, it has become increasingly important to differentiate “difficult” from “severe refractory” asthma to allow identification of patients most likely to benefit from these therapies. This volume delves into the current understanding of mechanisms and increasingly recognized heterogeneity of this complex disease. It discusses a structured approach to identification and optimization of factors contributing to poor asthma control, including nonadherence, comorbidities and occupational/environmental triggers. The book includes ‘state of the art’ reviews on recent advances in traditional and targeted asthma therapies, as well as a glimpse into what the future may hold. Highlights include a comprehensive guide to management of severe asthma in children and pregnancy, as well as practical considerations to management of asthma based on different clinical phenotypes. Each chapter is authored by leading experts in the field who share their own clinical approach. This is an ideal guide for clinical pulmonologists and allergist/immunologists, as well as primary care providers, physician extenders in specialty practice, physicians in pulmonary/allergy training, and even industry partners.

Author : Yong Chul Lee,So Ri Kim,Seong Ho Cho
Publisher : Springer
Page : 134 pages
File Size : 50,6 Mb
Release : 2017-10-30
Category : Medical
ISBN : 9789811019982

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Severe Asthma by Yong Chul Lee,So Ri Kim,Seong Ho Cho Pdf

This book presents state of the art knowledge on severe asthma with the aim of providing readers with a clear understanding of, first, the heterogeneity of the condition and of patients’ symptom profiles and responses to therapy and, second, the future implications of this heterogeneity for individualized patient care. After an opening section that offers an overview of severe asthma, including its clinical significance, the pathogenesis, available diagnostic approaches, and treatment options are described in detail. The sections on diagnosis and treatment cover the role of biomarkers, the use of radiologic diagnostic modalities, and both pharmacologic and non-pharmacologic therapies, including emerging options that will address hitherto unmet needs of patients. The outcomes of cutting-edge preclinical and clinical research are carefully documented and numerous useful tips provided on patient management. The inclusion of many informative schematic figures will assist readers in grasping the contents easily. The book will be of high value for medical students, researchers, general physicians, specialists, and paramedical staff.

Author : Stanley J Szefler,Soren Pedersen
Publisher : CRC Press
Page : 740 pages
File Size : 46,8 Mb
Release : 2005-09-26
Category : Medical
ISBN : 9780849352249

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Childhood Asthma by Stanley J Szefler,Soren Pedersen Pdf

This reference collects the latest studies on the development, diagnosis, and treatment of childhood asthma and offers current perspectives on new technologies that will shape the management of pediatric asthma in the forthcoming decade-illustrating how advances in pulmonary function measurement, inflammatory markers, imaging, and pharmacogenetics

Author : Andrew Bush,Giorgio Piacentini,Francesca Santamaria,Nicola Ullmann,Renato Cutrera
Publisher : Frontiers Media SA
Page : 135 pages
File Size : 55,8 Mb
Release : 2019-09-23
Category : Electronic
ISBN : 9782889459865

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Difficult and Severe Asthma in Children by Andrew Bush,Giorgio Piacentini,Francesca Santamaria,Nicola Ullmann,Renato Cutrera Pdf

Globally, severe asthma is defined by the WHO as either (A) untreated severe asthma; (B) difficult-to-treat severe asthma; and (C) treatment-resistant severe asthma. Untreated severe asthma is a political problem: the children do not have access to the basic tools for asthma management, and when this is corrected, asthma outcomes are transformed. The problem in difficult-to-treat severe asthma is not the airway disease, but co-morbidities and behavioral factors. This is the group in which there are most asthma deaths, underscoring that severe asthma cannot be solely defined by levels of prescribed therapy. Treatment-resistant severe asthma is rare and challenging, and the problem is the airway pathology. These children require new and innovative therapies.

Author : Renato Cutrera,Francesca Santamaria,Andrew Bush,Nicola Ullmann,Giorgio Piacentini
Publisher : Frontiers Media SA
Page : 103 pages
File Size : 42,8 Mb
Release : 2023-04-12
Category : Medical
ISBN : 9782832520604

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Difficult and severe asthma in children, volume II by Renato Cutrera,Francesca Santamaria,Andrew Bush,Nicola Ullmann,Giorgio Piacentini Pdf

Author : J. Harrington
Publisher : Karger Medical and Scientific Publishers
Page : 50 pages
File Size : 47,6 Mb
Release : 2020-01-28
Category : Medical
ISBN : 9781912776658

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Fast Facts: Asthma for Patients and their Supporters by J. Harrington Pdf

Asthma is a long-term condition that reduces the amount of air flowing in and out of the lungs. Whether your symptoms are mild, difficult-to-control or severe, it is important to be in control of your asthma. The information in this booklet is designed to help you and your family better understand the condition, what triggers it and how to treat it. It includes clear instructions for good inhaler technique and emphasizes the importance of having an Asthma Action Plan in place so that you know: • when and how often to take your treatment • how to tell if your symptoms are getting worse • what to do when your symptoms get worse. With simple clear illustrations, explanation of medical terms and space to write down the questions you want to ask your doctor or nurse, this resource will help you take control of your asthma. Contents: • What is asthma? • What causes asthma? • What are the symptoms of asthma? • What are the tests for asthma? • What medications are used to treat asthma? • Inhalers and spacers • Your Asthma Action Plan • How do I prevent an asthma attack? • How do I manage an asthma attack? • Difficult-to-control asthma • Severe asthma • Treatment of severe asthma • Exercise-induced asthma • Occupational asthma • Asthma in older people • Asthma in pregnancy • Asthma in children

Author : S. J. Szefler,Donald Y. M. Leung
Publisher : Marcel Dekker
Page : 648 pages
File Size : 54,7 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015034870629

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Severe Asthma by S. J. Szefler,Donald Y. M. Leung Pdf

Bridging the gap between basic science and clinical research, this comprehensive and fully up-to-date reference presents new directions in asthma care - examining the pathophysiology, epidemiology, immunology, environmental control, and psychosocial impact of severe asthma.

Author : Matthew D. McEvoy,Cory M. Furse
Publisher : Oxford University Press
Page : 352 pages
File Size : 44,6 Mb
Release : 2017-07-25
Category : Medical
ISBN : 9780190226466

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Advanced Perioperative Crisis Management by Matthew D. McEvoy,Cory M. Furse Pdf

Advanced Perioperative Crisis Management is a high-yield, clinically-relevant resource for understanding the epidemiology, pathophysiology, assessment, and management of a wide variety of perioperative emergencies. Three introductory chapters review a critical thinking approach to the unstable or pulseless patient, crisis resource management principles to improve team performance and the importance of cognitive aids in adhering to guidelines during perioperative crises. The remaining sections cover six major areas of patient instability: cardiac, pulmonary, neurologic, metabolic/endocrine, and toxin-related disorders, and shock states, as well as specific emergencies for obstetrical and pediatric patients. Each chapter opens with a clinical case, followed by a discussion of the relevant evidence. Case-based learning discussion questions, which can be used for self-assessment or in the classroom, round out each chapter. Advanced Perioperative Crisis Management is an ideal resource for trainees, clinicians, and nurses who work in the perioperative arena, from the operating room to the postoperative surgical ward.

Author : Sheikh Rayees,Inshah Din
Publisher : Springer Nature
Page : 71 pages
File Size : 46,5 Mb
Release : 2021-03-26
Category : Medical
ISBN : 9783030702700

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Asthma: Pathophysiology, Herbal and Modern Therapeutic Interventions by Sheikh Rayees,Inshah Din Pdf

Asthma is a chronic airway disease affecting over 300 million people worldwide with an expected increase of an additional 100 million by 2025. Past decade has observed a notable increase in asthma prevalence on both national and global levels with highest rates observed in western countries (about 30%). Over the past 40 years, a drastic increase in global prevalence, morbidity, mortality, and economic burden have been observed due to asthma especially in children. The rising numbers of hospital admissions for asthma, especially young children, reflect an increase in severe asthma, poverty and lack of proper disease management. Worldwide, approximately 180,000 deaths annually are caused due to this condition. The financial burden on a single asthma patient per year in different western countries ranges from US$300–1,300. Asthma is an intricate respiratory disorder with differences in its severity, natural history and hence treatment response. These differences in intensities of various presentations such as bronchial hyper-responsiveness, airway inflammation, mucus production, airflow obstruction make asthma a heterogeneous disease. The mainstay of current therapies for asthma includes inhaled corticosteroids, phosphodiesterase inhibitors, leukotriene modifiers and β2-adrenoceptor agonists. Some of the currently available drugs are efficient in one or more aspects. However the associated side effects or heterogeneity of the disease limit their usefulness and efficacy, thereby putting a demand on development of new drugs and therapies. On the other hand, asthma has also been treated/managed via herbal medications. These approaches have been described in Unani, Ayurvedic or Chinese system of medicine since antiquity. In fact, several anti-asthmatic drugs were developed from herbs commonly utilized in the non-Western system of medicine. This book focuses on the pathophysiology of asthma, its medication (both herbal and modern), limitations and their future prospects.

Author : Canada. Comité consultatif national de l'immunisation,Canada. National Advisory Committee on Immunization
Publisher : Unknown
Page : 392 pages
File Size : 43,6 Mb
Release : 2006
Category : Immunization
ISBN : 0660193922

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Canadian Immunization Guide by Canada. Comité consultatif national de l'immunisation,Canada. National Advisory Committee on Immunization Pdf

The seventh edition of the Canadian Immunization Guide was developed by the National Advisory Committee on Immunization (NACI), with the support ofthe Immunization and Respiratory Infections Division, Public Health Agency of Canada, to provide updated information and recommendations on the use of vaccines in Canada. The Public Health Agency of Canada conducted a survey in 2004, which confi rmed that the Canadian Immunization Guide is a very useful and reliable resource of information on immunization.

Author : Leila Kheirandish-Gozal,David Gozal
Publisher : Springer Science & Business Media
Page : 582 pages
File Size : 47,5 Mb
Release : 2012-07-17
Category : Medical
ISBN : 9781607617259

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Sleep Disordered Breathing in Children by Leila Kheirandish-Gozal,David Gozal Pdf

Sleep Disordered Breathing in Children: A Comprehensive Clinical Guide to Evaluation and Treatment is a comprehensive, timely and up-to-date review of pediatric sleep disordered breathing (SDB) and offers a thorough focus on several key areas: namely, the normal development and maturation of the airway and breathing during sleep, the techniques that are in place for assessment of SDB in children, the clinical manifestations and characteristics of several pediatric populations at risk for SDB, the implications of SDB in various end-organ systems, and, finally, a critical review of the evidence on current therapeutic approaches. This unique and complete text is of welcome interest to all practicing physicians and healthcare professionals who evaluate children with sleep problems -- namely pulmonologists, pediatricians, sleep physicians, pediatric neurologists, pediatric otolaryngologists, and family practitioners, as well as clinical researchers, pediatric nurse practitioners and respiratory therapists. Written by a distinguished and international panel of authors who are renowned experts in their field and who offer an expanded view of the problems associated with SDB, Sleep Disordered Breathing in Children: A Comprehensive Clinical Guide to Evaluation and Treatment is an indispensible resource for all physicians who evaluate children for sleep-disordered breathing.