Signal Transduction And Smooth Muscle

Author : Mohamed Trebak,Scott Earley
Publisher : CRC Press
Page : 433 pages
File Size : 45,7 Mb
Release : 2018-08-06
Category : Medical
ISBN : 9781498774239

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Signal Transduction and Smooth Muscle by Mohamed Trebak,Scott Earley Pdf

All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling. Key selling features: Focuses on smooth muscles of different types Describes ion channel signaling mechanisms Reviews calcium and receptor signaling Includes novel, cutting-edge methodologies Summarizes studies of mice with genetically encoding sensors in smooth muscle Chapter 9 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution (CC-BY) 4.0 license.

Author : C. Y. Kao,Mary E. Carsten
Publisher : Cambridge University Press
Page : 324 pages
File Size : 48,7 Mb
Release : 1997-08-28
Category : Science
ISBN : 0521482100

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Cellular Aspects of Smooth Muscle Function by C. Y. Kao,Mary E. Carsten Pdf

Smooth muscles line many internal organs and, in general, are involved in moving fluids and slurry around the body. They are controlled by the action of hormones, by nervous stimulation, and can be influenced by drugs. This 1997 book provides a review of our understanding of smooth muscle and integrates molecular, cellular and physiological information with tissue and anatomical studies. Well-known researchers have written chapters giving detailed reviews of our current knowledge of the biochemistry, pharmacology, physiology and anatomy of smooth muscle. In particular, they cover the seven most important areas of smooth muscle function including morphology, electrophysiology, mechanisms of electromechanical and pharmacomechanical coupling, calcium homeostasis, signal transduction, mechanics of contraction, and the contractile proteins. All those interested in muscular contraction will find this book worthwhile, whether they are biochemists, physiologists, or cell biologists.

Author : David Raeburn,Mark A. Giembycz
Publisher : Birkhäuser
Page : 356 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034875042

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Airways Smooth Muscle: Neurotransmitters, Amines, Lipid Mediators and Signal Transduction by David Raeburn,Mark A. Giembycz Pdf

Author : David Raeburn,Mark A. Giembycz
Publisher : Springer
Page : 425 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034873628

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Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction by David Raeburn,Mark A. Giembycz Pdf

Author : T. B. Bolton,T. Tomita
Publisher : Unknown
Page : 568 pages
File Size : 52,7 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015038154343

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Smooth Muscle Excitation by T. B. Bolton,T. Tomita Pdf

This book is a compendium of the latest electrophysiological research on smooth muscles from an international collection of authors. It includes recent discoveries in calcium stores and their relationship to contraction and to electrical changes in the membrane. A major section of the book concentrates on calcium release mechanisms in the cell, their control, and the consequences of calcium release in the cell for membrane events. Smooth Muscle Excitation also covers the effects of chemicals released from adjacent cells. Key Features * State-of-the-art volume that represents a synopsis of all work currently being undertaken in this area throughout the world * Content covers both basic and clinical research * Provides a range of drug development studies * Presents contributions from many internationally recognized smooth muscle physiologists

Author : Robert Fitridge,M. M. Thompson
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 44,8 Mb
Release : 2011
Category : Medical
ISBN : 9781922064004

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Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Author : Dr. Richard A. Murphy,M. P. Blaustein,R. Greger,H. Grunicke,R. Jahn,W. J. Lederer,L. M. Mendell,A. Miyajima,D. Pette,G. Schultz,M. Schweiger
Publisher : Springer
Page : 321 pages
File Size : 54,6 Mb
Release : 2014-08-23
Category : Medical
ISBN : 366231200X

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Reviews of Physiology Biochemistry and Pharmacology by Dr. Richard A. Murphy,M. P. Blaustein,R. Greger,H. Grunicke,R. Jahn,W. J. Lederer,L. M. Mendell,A. Miyajima,D. Pette,G. Schultz,M. Schweiger Pdf

The objectives in this special issue are (1) to critically review current information on the mechanisms coupling extracellular regulatory signals to regulation of cross-bridge cycling and proliferation in smooth muscle, and (2) identify significant gaps or unresolved issues that are important topics for future research. The experimental and analytical difficulties discussed above are increasingly recognized and surmounted. Elucidation of the molecular and cellular events underlying the biologal properties of smooth muscle is in the midst of a period of rapid progress. While the reviews reveal many gaps to be filled and illustrate areas of contention, they also capture the excitement of new discoveries.

Author : Christopher L.-H. Huang
Publisher : Cambridge University Press
Page : 327 pages
File Size : 50,6 Mb
Release : 2020-11-19
Category : Medical
ISBN : 9781108495059

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Keynes & Aidley's Nerve and Muscle by Christopher L.-H. Huang Pdf

Editions previous to this one had R.D. Keynes and David J. Aidley as primary and secondary authors.

Author : Kazuhiro Kohama,Yasuharu Sasaki
Publisher : Landes Bioscience
Page : 186 pages
File Size : 45,8 Mb
Release : 1999
Category : Medical
ISBN : STANFORD:36105022143080

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Molecular Mechanisms of Smooth Muscle Contraction by Kazuhiro Kohama,Yasuharu Sasaki Pdf

Author : Bastien D. Gomperts,Ijsbrand M. Kramer,Peter E.R. Tatham
Publisher : Gulf Professional Publishing
Page : 444 pages
File Size : 55,6 Mb
Release : 2003-10-15
Category : Medical
ISBN : 0122896327

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Signal Transduction by Bastien D. Gomperts,Ijsbrand M. Kramer,Peter E.R. Tatham Pdf

Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources, key observations and experiments that set the scene for recent and current work.

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 47,9 Mb
Release : 2011
Category : Science
ISBN : 9781615041237

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The Endothelium by Michel Félétou Pdf

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Author : Richard E. Klabunde
Publisher : Lippincott Williams & Wilkins
Page : 689 pages
File Size : 53,8 Mb
Release : 2020-12-01
Category : Medical
ISBN : 9781975150099

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Cardiovascular Physiology Concepts by Richard E. Klabunde Pdf

Praised for its concise coverage, this highly accessible monograph lays a foundation for understanding the underlying concepts of normal cardiovascular function and offers a welcome alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Clear explanations, ample illustrations and engaging clinical cases and problems provide the perfect guidance for self-directed learning and prepare you to excel in clinical practice.

Author : Kunihiro Sakuma,Nobuo Morotomi
Publisher : Unknown
Page : 0 pages
File Size : 41,7 Mb
Release : 2021
Category : Muscles
ISBN : 1839686529

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Muscle Cell and Tissue by Kunihiro Sakuma,Nobuo Morotomi Pdf

The loss of skeletal muscle mass and strength substantially impairs physical performance and quality of life. This book details some approaches to the treatment of muscle wasting. It also reviews novel applications against pulmonary arterial hypertension such as cell reprogramming and the use of anticancer drugs that induce programmed cell death. Vascular smooth muscle cells (VSMCs) are the most prevalent cell types in blood vessels and serve critical regulatory roles. This publication also introduces mathematical models concerning the molecular mechanism and targets of cyclic guanosine 3'2,5'2-monophosphate (cGMP) in the contraction of VSMCs. This book will be of interest to professionals in clinical practice, medical and health care students, and researchers working in muscle-related fields of science.

Author : Irena Levitan, PhD,Alex M. Dopico, MD, PhD
Publisher : Springer
Page : 431 pages
File Size : 40,9 Mb
Release : 2016-07-06
Category : Medical
ISBN : 9783319296357

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Vascular Ion Channels in Physiology and Disease by Irena Levitan, PhD,Alex M. Dopico, MD, PhD Pdf

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

Author : Michael Barany
Publisher : Elsevier
Page : 455 pages
File Size : 40,6 Mb
Release : 1996-01-04
Category : Science
ISBN : 9780080527895

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Biochemistry of Smooth Muscle Contraction by Michael Barany Pdf

This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.