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Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.
Etiology and Morphogenesis of Congenital Heart Disease by Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi Pdf
This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.
This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Cardiology Explained by Euan A. Ashley,Euan Ashley,Josef Niebauer Pdf
One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.
John L Jefferies,Anthony C Chang,Joseph W Rossano,Robert E Shaddy,Jeffrey A Towbin
Author : John L Jefferies,Anthony C Chang,Joseph W Rossano,Robert E Shaddy,Jeffrey A Towbin Publisher : Academic Press Page : 824 pages File Size : 48,9 Mb Release : 2017-12-05 Category : Medical ISBN : 9780128026137
Heart Failure in the Child and Young Adult by John L Jefferies,Anthony C Chang,Joseph W Rossano,Robert E Shaddy,Jeffrey A Towbin Pdf
Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine. Provides coverage of the basic science of heart failure, its epidemiology and economic aspects, outpatient and inpatient management, and advanced therapies, including mechanical circulatory support and heart transplantation Combines cutting-edge research with current guidelines from the field
Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.
Regulation of Cardiac Contractility by R. John Solaro Pdf
Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension generation and shortening capability of the molecular motors (myosin cross-bridges) of the sarcomeres as determined by the rates and extent of Ca activation, the turnover kinetics of the cross-bridges, and the relative Ca responsiveness of the sarcomeres. Engagement of the regulatory signaling cascades controlling contractility occurs with occupancy and signal transduction by receptors for neurohumors of the autonomic nervous system as well as growth and stress signaling pathways. Contractility is also determined by the prevailing conditions of pH, temperature, and redox state. Short-term control of contractility is fully expressed during exercise. In long-term responses to stresses on the heart, contractility is modified by cellular remodeling and altered signaling that may compensate for a time but which ultimately may fail, leading to disorders.
Advances in Cardiac Signal Processing by U. Rajendra Acharya Pdf
This book provides a comprehensive review of progress in the acquisition and extraction of electrocardiogram signals. The coverage is extensive, from a review of filtering techniques to measurement of heart rate variability, to aortic pressure measurement, to strategies for assessing contractile effort of the left ventricle and more. The book concludes by assessing the future of cardiac signal processing, leading to next generation research which directly impact cardiac health care.
Regulation of Tissue Oxygenation, Second Edition by Roland N. Pittman Pdf
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Bioelectrical Signal Processing in Cardiac and Neurological Applications by Leif Sörnmo,Pablo Laguna Pdf
The analysis of bioelectrical signals continues to receive wide attention in research as well as commercially because novel signal processing techniques have helped to uncover valuable information for improved diagnosis and therapy. This book takes a unique problem-driven approach to biomedical signal processing by considering a wide range of problems in cardiac and neurological applications-the two "heavyweight" areas of biomedical signal processing. The interdisciplinary nature of the topic is reflected in how the text interweaves physiological issues with related methodological considerations. Bioelectrical Signal Processing is suitable for a final year undergraduate or graduate course as well as for use as an authoritative reference for practicing engineers, physicians, and researchers. A problem-driven, interdisciplinary presentation of biomedical signal processing Focus on methods for processing of bioelectrical signals (ECG, EEG, evoked potentials, EMG) Covers both classical and recent signal processing techniques Emphasis on model-based statistical signal processing Comprehensive exercises and illustrations Extensive bibliography
Signal Transduction in the Cardiovascular System in Health and Disease by Ashok K. Srivastava,Madhu B. Anand-Srivastava Pdf
Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.
Leslie A. Pray,Institute of Medicine,Ann L. Yaktine,Food and Nutrition Board,Board on Health Sciences Policy,Diana E. Pankevich,Planning Committee for a Workshop on Potential Health Hazards Associated with Consumption of Caffeine in Food and Dietary Supplements
Author : Leslie A. Pray,Institute of Medicine,Ann L. Yaktine,Food and Nutrition Board,Board on Health Sciences Policy,Diana E. Pankevich,Planning Committee for a Workshop on Potential Health Hazards Associated with Consumption of Caffeine in Food and Dietary Supplements Publisher : Unknown Page : 0 pages File Size : 54,5 Mb Release : 2014 Category : Health & Fitness ISBN : 0309297494
Caffeine in Food and Dietary Supplements by Leslie A. Pray,Institute of Medicine,Ann L. Yaktine,Food and Nutrition Board,Board on Health Sciences Policy,Diana E. Pankevich,Planning Committee for a Workshop on Potential Health Hazards Associated with Consumption of Caffeine in Food and Dietary Supplements Pdf
Caffeine in Food and Dietary Supplements is the summary of a workshop convened by the Institute of Medicine in August 2013 to review the available science on safe levels of caffeine consumption in foods, beverages, and dietary supplements and to identify data gaps. Scientists with expertise in food safety, nutrition, pharmacology, psychology, toxicology, and related disciplines; medical professionals with pediatric and adult patient experience in cardiology, neurology, and psychiatry; public health professionals; food industry representatives; regulatory experts; and consumer advocates discussed the safety of caffeine in food and dietary supplements, including, but not limited to, caffeinated beverage products, and identified data gaps. Caffeine, a central nervous stimulant, is arguably the most frequently ingested pharmacologically active substance in the world. Occurring naturally in more than 60 plants, including coffee beans, tea leaves, cola nuts and cocoa pods, caffeine has been part of innumerable cultures for centuries. But the caffeine-in-food landscape is changing. There are an array of new caffeine-containing energy products, from waffles to sunflower seeds, jelly beans to syrup, even bottled water, entering the marketplace. Years of scientific research have shown that moderate consumption by healthy adults of products containing naturally-occurring caffeine is not associated with adverse health effects. The changing caffeine landscape raises concerns about safety and whether any of these new products might be targeting populations not normally associated with caffeine consumption, namely children and adolescents, and whether caffeine poses a greater health risk to those populations than it does for healthy adults. This report delineates vulnerable populations who may be at risk from caffeine exposure; describes caffeine exposure and risk of cardiovascular and other health effects on vulnerable populations, including additive effects with other ingredients and effects related to pre-existing conditions; explores safe caffeine exposure levels for general and vulnerable populations; and identifies data gaps on caffeine stimulant effects.
Heart Rate Variability (HRV) Signal Analysis by Markad V. Kamath,Mari Watanabe,Adrian Upton Pdf
Open a Window into the Autonomic Nervous SystemQuantifying the amount of autonomic nervous system activity in an individual patient can be extremely important, because it provides a gauge of disease severity in a large number of diseases. Heart rate variability (HRV) calculated from both short-term and longer-term electrocardiograms is an ideal win
Functional Brain-Heart Interplay by Vincenzo Catrambone,Gaetano Valenza Pdf
This monograph offers a cross-system exchange and cross-modality investigation into brain-heart interplay. Brain-Heart Interplay (BHI) is a highly interdisciplinary scientific topic, which spreads from the physiology of the Central/Autonomous Nervous Systems, especially Central Autonomic Network, to advanced signal processing and modeling for its activity quantification. Motivated by clinical evidence and supported by recent findings in neurophysiology, this monograph first explores the definition of basic Brain-Heart Interplay quantifiers, and then moves onto advanced methods for the assessment of health and disease states. Non-invasive use of brain monitoring techniques, including electroencephalogram and function Magnetic Resonance Imaging, will be described together with heartbeat dynamics monitoring through pulseoximeter and ECG signals. The audience of this book comprises especially of biomedical engineers and medical doctors with expertise in statistics and/or signal processing. Researchers in the fields of cardiology, neurology, psychiatry, and neuroscience in general may be interested as well.
Stimulus Response Coupling by Vana Smith,John R. Dedman Pdf
This volume examines the role of intracellular calcium in the transmission of external chemical, physical and electrical stimuli to the interior of the cell and the role of calcium in the physiological and metabolic effects of such stimuli.