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Stimulus Response Coupling by Vana Smith,John R. Dedman Pdf
This volume examines the role of intracellular calcium in the transmission of external chemical, physical and electrical stimuli to the interior of the cell and the role of calcium in the physiological and metabolic effects of such stimuli.
Stimulus Response Coupling by Vana L. Smith,John Dedman Pdf
This volume examines the role of intracellular calcium in the transmission of external chemical, physical and electrical stimuli to the interior of the cell and the role of calcium in the physiological and metabolic effects of such stimuli.
J. Westwick,M. F. Scully,D. E. MacIntyre,V. V. Kakkar
Author : J. Westwick,M. F. Scully,D. E. MacIntyre,V. V. Kakkar Publisher : Springer Science & Business Media Page : 440 pages File Size : 47,6 Mb Release : 2013-03-09 Category : Science ISBN : 9781461594420
Mechanisms of Stimulus—Response Coupling in Platelets by J. Westwick,M. F. Scully,D. E. MacIntyre,V. V. Kakkar Pdf
Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attri butable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function has yet to be realized. Also that if and when this problem of con trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behaviour of plate lets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechan isms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area of cell receptor/ligand interaction, induction of cell ular response by protein phosphorylation and calcium flux. The mech anism of these latter events occurs through the activity of phospho lipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eico sanoids, reinforce and make irreversible the cellular response.
The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems by T. Kenakin,J. A. Angus Pdf
This, the 148th volume of the Handbook of Experimental Pharmacology series, focuses on the very core of pharmacology, namely receptor theory. It is fitting that the originator of receptor pharmacology, A. J. CLARK, authored the fourth volume of this series 63 years ago. In that volume CLARK further developed his version of receptor theory first described four years earlier in his classic book The Mode of Action of Drugs. An examination of the topics covered in volume 4 reveals a striking similarity to the topics covered in this present volume; pharmacologists today are still as interested in unlocking the secrets of dose-response relationships to reveal the biological and che mical basis of drug action as they were over half a century ago. Sections in that 1937 volume such as "Curves relating exposure to drugs with biological effects" and "Implications of monomolecular theory" show Clark's keen insight into the essential questions that required answers to move pharma cology forward. With the advent of molecular biological cloning of human receptors has come a transformation of receptor pharmacology. Thus the expression of human receptors into surrogate host cells helped unlock secrets of receptor mechanisms and stimulus-transduction pathways. To a large extent, this elim inates the leap of faith required to apply receptor activity of drugs tested on animal receptor systems to the human therapeutic arena. However, a new leap of faith concerning the veracity of the effects found in recombinant systems with respect to natural ones is now required.
The Neutrophil: Cellular Biochemistry and Physiology by Maurice B. Hallett Pdf
A synthesis and collation of the recent material regarding the role of the neutrophil in basic pathological processes is presented in this volume. The mechanisms of chemotaxis, secretion, phagocytosis, intracellular killing, oxygen radical production and arachidonate production are comprehensively reviewed. Stimulus response coupling in the neutrophil, with chapters on intracellular Ca2+, C-Kinase, phospholipid metabolism, microfilaments and membrane electrophysiology are extensively discussed. Each chapter provides a critical review by experts with over 1,000 cited references. Invaluable to graduate students and medical and scientific researchers, this book provides a unique, up-to-date account of cellular biochemistry and physiology of the neutrophil.
Wavelets in Neuroscience by Alexander E. Hramov,Alexey A. Koronovskii,Valeri A. Makarov,Vladimir A. Maksimenko,Alexey N. Pavlov,Evgenia Sitnikova Pdf
This book illustrates how modern mathematical wavelet transform techniques offer fresh insights into the complex behavior of neural systems at different levels: from the microscopic dynamics of individual cells to the macroscopic behavior of large neural networks. It also demonstrates how and where wavelet-based mathematical tools can provide an advantage over classical approaches used in neuroscience. The authors well describe single neuron and populational neural recordings. This 2nd edition discusses novel areas and significant advances resulting from experimental techniques and computational approaches developed since 2015, and includes three new topics: • Detection of fEPSPs in multielectrode LFPs recordings. • Analysis of Visual Sensory Processing in the Brain and BCI for Human Attention Control; • Analysis and Real-time Classification of Motor-related EEG Patterns; The book is a valuable resource for neurophysiologists and physicists familiar with nonlinear dynamical systems and data processing, as well as for graduate students specializing in these and related areas.
Biochemical Actions of Hormones V8 by Gerald Litwack Pdf
Biochemical Actions of Hormones, Volume VIII is an eight-chapter text that covers the developments in the understanding of the biochemical aspects of hormonal action and regulation. This volume examines first the messenger functions of calcium in hormonal systems. The next chapters deal with the neuronal regulation of blood pressure; the regulation of protein synthesis by phosphorylation; and the hormonal control of hepatic gluconeogenesis. These topics are followed by discussions on the effects of insulin in intracellular functions, the mechanisms of steroidal hormones, and the membrane recognition and effector sites in steroid hormone action. A chapter focuses on the activation of steroid-receptor complexes. The final chapters survey the estradiol and progesterone receptors in the human endometrium. This book will be of great value to biologists, biochemists, and researchers in the field of hormonal action.
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research. Highlights changes surrounding the strategy of drug discovery to provide you with a comprehensive reference featuring advances in the methods involved in lead optimization and more effective drug discovery Includes a new chapter on data-driven drug discovery in terms of the optimal design of pharmacological experiments to identify mechanism of action of new molecules Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate. Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets and megakaryocytes. The expression and function of adhesive proteins on the platelet surface is also discussed. Comprised of 12 chapters, this book begins with a description of the morphological and metabolic responses to agonists, as well as the involvement of certain processes in the coupling of agonist-receptor interactions to platelet responses. The following chapter deals with platelet arachidonate metabolism and platelet-activating factor, focusing on the release of arachidonate from platelet lipid stores; pathways of platelet arachidonate metabolism and effects of arachidonate metabolites; and inhibition of platelet arachidonate metabolism by aspirin. The structure, function, and modification in disease of platelet membrane glycoproteins are then discussed, along with prothrombin activation on platelets and platelet regulation of thrombus formation. Secreted platelet proteins as markers for pathological disorders are also considered. This monograph is intended as a reference for investigators involved in platelet research as well as a source of information for those working in other areas of biological investigation.
This guide has been designed especially for scientists trained in molecular biology and related fields who now need to know more about the basic theories, principles and practical applications of pharmacology.
A synthesis and collation of the recent material regarding the role of the neutrophil in basic pathological processes is presented in this volume. The mechanisms of chemotaxis, secretion, phagocytosis, intracellular killing, oxygen radical production and arachidonate production are comprehensively reviewed. Stimulus response coupling in the neutrophil, with chapters on intracellular Ca2+, C-Kinase, phospholipid metabolism, microfilaments and membrane electrophysiology are extensively discussed. Each chapter provides a critical review by experts with over 1,000 cited references. Invaluable to graduate students and medical and scientific researchers, this book provides a unique, up-to-date account of cellular biochemistry and physiology of the neutrophil.
New Insights in the Cognitive Neuroscience of Attention by Tetsuo Kida,Hidehiko Okamoto Pdf
Submission closed. Guidelines We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to significant advancements in the fast-growing field of Cognitive Neuroscience. Frontiers have organized a series of Research Topics to highlight the latest advancements in research across the field of Cognitive Neuroscience. This editorial initiative of relevance, led by Dr. Kida, Associate Editor of the Cognitive Neuroscience section, together with Dr. Okamoto, Associate Editor of both the Brain-Imaging and Sensory Neuroscience sections, is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of the Cognitive Neuroscience of attention.
