Silk Based Drug Delivery Systems

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 46,8 Mb
Release : 2024-05-03
Category : Electronic
ISBN : 8210379456XXX

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Silk-based drug delivery system by Anonim Pdf

Author : Elia Bari,Sara Perteghella,Maria Luisa Torre
Publisher : Royal Society of Chemistry
Page : 243 pages
File Size : 46,9 Mb
Release : 2020-10-05
Category : Technology & Engineering
ISBN : 9781839162671

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Silk-based Drug Delivery Systems by Elia Bari,Sara Perteghella,Maria Luisa Torre Pdf

Silk proteins show excellent biocompatibility, controllable biodegradability and non-immunogenicity, and as such are studied extensively worldwide for biomedical applications. In particular, there is increasing interest in their use for drug delivery systems. This focussed book on silk proteins for drug delivery systems, delves into a key emerging area to outline the concepts and define the field. Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin. Showing how these proteins are employed in micro and nano drug delivery systems, their use in pre-clinical and clinical trials, and closing with chapter on sustainability- driven innovation in the pharma industry, this book is ideal for graduates and researchers in biomaterials science and pharmaceutical science.

Author : Martin Schwab
Publisher : Unknown
Page : 188 pages
File Size : 50,6 Mb
Release : 2009
Category : Electronic
ISBN : OCLC:873460159

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Degradation of Lipid Based Drug Delivery Systems and Characterization of Semi-synthetic Spider Silk Proteins for the Application in Pharmaceutical Technology by Martin Schwab Pdf

Author : Stroeve Pieter,Mahmoudi Morteza
Publisher : World Scientific
Page : 392 pages
File Size : 49,5 Mb
Release : 2017-11-27
Category : Technology & Engineering
ISBN : 9789813201064

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Drug Delivery Systems by Stroeve Pieter,Mahmoudi Morteza Pdf

With the alarming increase in cancer diagnoses and genetic illnesses, traditional drug agents and their delivery media need to be re-evaluated to address a quickly evolving field. With newer smart materials for the controlled release of macromolecules, peptides, genetic material, etc. further complications arise, such as material performance, synthesis, functionalization and targeting, biological identity, and biocompatibility. The book provides a comprehensive overview of the recent developments on "smart" targeting and drug delivery systems with a variety of carriers like nanoparticles, membranes, and hydrogels. It contains detailed descriptions on the recent trends in this field in the ongoing battle with catastrophic diseases like cancer. This field of research has been in its infancy and continues to face growth, and with it, further challenges and difficulties along the way toward maturity, which are accurately introduced in this book. Contents: Drug Delivery Systems: Possibilities and Challenges (Ryan Spitler, Saeid Zanganeh, Tahereh Jafari, Nasser Khakpash, Mohsen Erfanzadeh, Jim Q Ho, and Nastaran Sakhaie)Nanoparticles in Circulation: Blood Stability (Saeid Zanganeh, Tahereh Jafari, Nasser Khakpash, Mohsen Erfanzadeh, and Jim Q Ho)How do Nanoparticles (NPs) Pass Barriers? (Saeid Zanganeh, Ryan Spitler, Najme Javdani, and Jim Q Ho)Gated Porous Materials for Biomedical Application (Félix Sancenón, Erick Yu, Elena Aznar, M Dolores Marcos, and Ramón Martínez-Máñez)Controlled Release from Iron Oxide Nanoparticles (Masoud Rahman)The Reverse of Controlled Release: Controlled Sequestration of Species and Biotoxins into Nanoparticles (NPs) (Jenifer Gómez-Pastora, Eugenio Bringas, María Lázaro-Díez, José Ramos-Vivas, and Inmaculada Ortiz)Membranes for Controlled Release (Vida Araban, Neda Aslankoohi, and Mohammad Raoufi)Controlled Released from Hydrogel (Hossein Riahinezhad, Vida Araban, and Mohammad Raoufi)Nano Delivery Systems (Sophie Laurent, Afsaneh Lahooti, Saeed Shanehsazzadeh, and Robert N Muller)Legal Framework for Protection of Pharmaceutical Trade Marks in Europe and USA (Mohammad Hossein Erfanmanesh, and Shirin Sharifzadeh)Future Perspective on the Smart Delivery of Biomolecules (Erick Yu, Félix Sancenón, Elena Aznar, Ramón Martínez-Máñez, María Dolores Marcos, Mohammad J Hajipour, Morteza Mahmoudi, and Pieter Stroeve) Readership: Nanotechnologists; biomedical engineers; chemical engineers; materials scientists; biotechnology researchers; chemists; biological scientists; cell physiologists; medical scientists; gene therapists. Keywords: Drug Delivery Systems;Nanoparticles;Biomaterials;TargetingReview: Key Features: Comprehensive overview on "smart" targeting and drug delivery systemsUnderstanding of the biological identity of nanoparticles for drug delivery applicationsDetailed information on the legal framework for protection of pharmaceutical trade mark in Europe and the United States

Author : Hriday Bera,Chowdhury Mobaswar Hossain,Sudipta Saha
Publisher : Academic Press
Page : 630 pages
File Size : 40,6 Mb
Release : 2021-01-05
Category : Business & Economics
ISBN : 9780128208755

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Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications by Hriday Bera,Chowdhury Mobaswar Hossain,Sudipta Saha Pdf

Over the past few decades, there has been unprecedented progress in the design of versatile biopolymer-based nanoplatforms for pharmaceutical and biomedical applications, particularly due to their attractive traits, including excellent biocompatibility, outstanding biodegradability, low immunogenicity, and facile chemical modifiability. Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications serves as a clear and detailed body of information on the synthesis and characterization of biopolymer-based materials in nanomedicine. This book describes various nanomaterials consisting of biopolymers including polysaccharides (i.e., derived from plants, animals, bacteria, algae, and fungi) and polypeptides in terms of their structures, synthetic protocols, and characterization and uses as therapeutic drugs and gene delivery carriers and in other biomedical fields. The chapters of this book, which are contributed by internationally renowned scholars working in the arena of biopolymer-based nanomaterials, would offer a wide vision on the potential future applications of these nanomaterials in the delivery and targeting of bioactive molecules of pharmaceutical interests and in tissue engineering, biosensing, bioimaging, and diagnostic purposes. The state-of-the-art information presented in the book would also encourage young investigators and researchers to further bring cutting-edge developments in the field of nanomedicine in the near future. Provides a scholarly insight into the recent development of biopolymer-based nanomaterials Focuses on the diverse cutting-edge techniques for the fabrication of native and modified biopolymer-based nanoplatforms and their applications in drug delivery and biomedical fields Assesses the opportunities and challenges of biopolymer-based nanocarriers in pharmaceutical and biomedical research

Author : Thidarat Wongpinyochit
Publisher : Unknown
Page : 0 pages
File Size : 45,5 Mb
Release : 2014
Category : Electronic
ISBN : OCLC:1417554009

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Silk Nanoparticles for Drug Delivery Applications by Thidarat Wongpinyochit Pdf

Silk from Bombyx mori is being used in humans for loading applications due to its excellent mechanical properties and biocompatibility. Furthermore silk is emerging as potential biomaterial for biomedical applications such as drug delivery and tissue-engineering. The aim of this thesis was to examine the potential of silk nanoparticles for drug delivery by characterizing (1) particle size, (2) zeta potential, (3) stability, (4) loading efficiency and (5) in vitro drug release. First, silk nanoparticles were generated by a desolvation method using acetone. The resulting particle size and zeta potential were measured using dynamic light scattering, which revealed nano-sized particles (104.20 ± 1.70 nm) with narrow polydispersity index (0.11 ± 0.01), and negative surface charge (-56.38 ± 5.60 mV). In water silk nanoparticles were stable over 4 weeks over wide temperature range (4°C to 37°C). Second, nanoparticles were surface modified with polyethylene glycol (PEG) by reacting cyanuric chloride activated methoxypolyethylene glycol (5000 g/mol) with silk. The amount of activated PEG grafted to particle's surface was controlled by the weight ratio to silk nanoparticles, resulting in 19.39 ± 1.93% w/w conjugated PEG. The stability of PEGylated silk nanoparticles in water and in phosphate buffered saline at pH 7.4 was studied and compared with unmodified silk nanoparticles; PEGylated silk nanoparticles had a superior stability over the unmodified nanoparticles in phosphate buffered saline. Third, the drug loading and release behavior of silk nanoparticles and PEGylated silk nanoparticles was investigated with two model drugs; propranolol HCl and doxorubicin HCl. The native and PEGylated silk nanoparticles showed high encapsulation efficiency for doxorubicin HCl (100% w/w) and propranolol HCl (> 93% w/w). The release of doxorubicin HCl over 14 days was pH dependent, and showed highest release at pH 4.5 from native and PEGylated silk nanoparticles as compared to pH 6.0 and 7.4 (pH 4.5”6.0>7.4). PEGylation significantly impacted on the release behavior of doxorubicin HCl from silk nanoparticles by showing faster release at pH 4.5 and 6.0 in comparison to unmodified silk nanoparticles. In conclusion, silk nanoparticles and PEGylated silk nanoparticles showed promise as potential anticancer drug delivery systems and warrant future in vitro studies.

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Page : 630 pages
File Size : 53,9 Mb
Release : 2018-02-14
Category : Science
ISBN : 9780128136669

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Nanostructures for the Engineering of Cells, Tissues and Organs by Alexandru Mihai Grumezescu Pdf

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

Author : Sougata Jana,Subrata Jana
Publisher : Springer Nature
Page : 524 pages
File Size : 55,9 Mb
Release : 2022-03-29
Category : Science
ISBN : 9789811671524

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Functional Biomaterials by Sougata Jana,Subrata Jana Pdf

This book explores in depth a wide range of functional biomaterials-based systems for drug, gene delivery, and biomedical aspects. The chapters cover newer technologies such as polymeric micelle, pH-responsive biomaterials, stimuli-responsive hydrogels, silk fibroin, inorganic biomaterials, synthetic biomaterials, 3D printed biomaterials, metallic biomaterials, ceramic and hybrid biomaterials. It also describes the theranostic approaches for cancer therapy, the biomaterials-based nanofibers scaffolds in tissue engineering, as well as the strategies applications of metallic biomaterials for the medical and dental prosthetic field. This newer and updated approach will be attractive for biomedical engineering students working on materials science in the development of novel drug delivery strategies. The book will be an important reference for researchers and professionals working on biomaterial research in the pharmaceutical and medical fields.

Author : Ashim Mitra,Chi H. Lee,Kun Cheng
Publisher : John Wiley & Sons
Page : 530 pages
File Size : 40,7 Mb
Release : 2013-08-26
Category : Medical
ISBN : 9781118662847

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Advanced Drug Delivery by Ashim Mitra,Chi H. Lee,Kun Cheng Pdf

Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to datewith the state of the science, presenting the basics, formulationstrategies, and therapeutic applications of advanced drug delivery.The book demonstrates how core concepts of pharmaceutical sciences,chemistry, and molecular biology can be combined and applied inorder to spark novel ideas to design and develop advanced drugdelivery systems for the treatment of a broad range of humandiseases. Advanced Drug Delivery features contributions from aninternational team of pharmaceutical scientists. Chapters reflect athorough review and analysis of the literature as well as theauthors' firsthand experience developing drug delivery systems. Thebook is divided into four parts: Part I, Introduction and Basics of Advanced DrugDelivery, explores physiological barriers, stability,transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offerstested and proven strategies for advanced delivery of both smallmolecules and macromolecules Part III, Translational Research of Advanced DrugDelivery, focuses on regulatory considerations andtranslational applications of advanced drug delivery systems forthe treatment of cardiovascular diseases, cancer, sexuallytransmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery inEmerging Research Areas, examines stem cell research,cell-based therapeutics, tissue engineering, and molecularimaging Each chapter provides objectives and assessment questions tohelp readers grasp key concepts and assess their knowledge as theyprogress through the book. Advanced Drug Delivery is recommended for graduates andupper-level undergraduates in the pharmaceutical sciences who needa solid foundation in the basics. It is also recommended forpharmaceutical professionals who want to take advantage of new andemerging applications in advanced drug delivery systems.

Author : Raphael M. Ottenbrite,Sung Wan Kim
Publisher : CRC Press
Page : 332 pages
File Size : 47,9 Mb
Release : 2019-04-30
Category : Science
ISBN : 1420010255

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Polymeric Drugs and Drug Delivery Systems by Raphael M. Ottenbrite,Sung Wan Kim Pdf

Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports w

Author : Vivek Dave,Nikita Gupta,Srija Sur
Publisher : John Wiley & Sons
Page : 467 pages
File Size : 51,9 Mb
Release : 2020-12-29
Category : Computers
ISBN : 9781119711681

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Nanopharmaceutical Advanced Delivery Systems by Vivek Dave,Nikita Gupta,Srija Sur Pdf

The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Author : Shadpour Mallakpour,Chaudery M. Hussain
Publisher : John Wiley & Sons
Page : 468 pages
File Size : 45,8 Mb
Release : 2021-09-17
Category : Technology & Engineering
ISBN : 9783527830985

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Environmental Applications of Carbon Nanomaterials-Based Devices by Shadpour Mallakpour,Chaudery M. Hussain Pdf

Environmental Applications of Carbon Nanomaterials-Based Devices Explore this insightful treatment of the function and fabrication of high-performance devices for environmental applications Environmental Applications of Carbon Nanomaterials-Based Devices delivers an overview of state-of-the-art technology in functionalized carbon nanomaterials-based devices for environmental applications. The book provides a powerful foundation, based in materials science, on functionalized carbon nanomaterials in general, and environmental science and device fabrication in particular. The book focuses on the chemical and physical methods of functionalization of carbon nanomaterials and the technology of device fabrication, including lab-on-a-chip approaches and applications such as wastewater purification and gas sensing. It provides readers with a thorough understanding of effective environmental remediation techniques performed with carbon nanomaterials-based devices. In addition to topics such as cross-linked graphene oxide membranes assembled with graphene oxide nanosheets, free-standing graphene oxide-chitin nanocrystal composite membranes for dye adsorption and oil/water separation, and in-situ grown covalent organic framework nanosheets on graphene for membrane-based dye/salt separation, readers will also benefit from the inclusion of: A thorough introduction to charge-gated ion transport through polyelectrolyte intercalated amine reduced graphene oxide membranes An exploration of hydrotalcite/graphene oxide hybrid nanosheets functionalized nanofiltration membrane for desalination A discussion of the incorporation of attapulgite nanorods into graphene oxide nanofiltration membranes for efficient dyes wastewater treatment An examination of attapulgite nanofibers and graphene oxide composite membranes for high-performance molecular separation Perfect for materials scientists, analytical chemists, and environmental chemists, Environmental Applications of Carbon Nanomaterials-Based Devices will also earn a place in the libraries of sensor developers seeking a one-stop resource for high-performance devices and sensors useful for environmental applications.

Author : Prashant Kesharwani
Publisher : Academic Press
Page : 340 pages
File Size : 46,9 Mb
Release : 2019-01-26
Category : Business & Economics
ISBN : 9780128163672

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Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer by Prashant Kesharwani Pdf

Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers

Author : Dennis M. Brown
Publisher : Springer Science & Business Media
Page : 408 pages
File Size : 54,7 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015060004671

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Drug Delivery Systems in Cancer Therapy by Dennis M. Brown Pdf

A major difficulty in successfully treating cancer with drugs is achieving adequate drug concentrations in the diseased areas without overexposing drug-sensitive normal tissues. In a number of cases, specialized drug delivery systems are required to realize a therapeutic gain. In Drug Delivery Systems in Cancer Therapy, Dennis M. Brown has assembled a panel of leading experts to survey all the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. They also profile the use of novel formulation technologies-including synthetic polymers and biomaterials for sustained drug release to achieve greater therapeutic effect-that have demonstrated efficacy in a number of approved and late-stage clinical products. They also consider the benefits of, and future opportunities for, various drug delivery systems, as well as the experimental techniques used in their evaluation. Although the focus is primarily on small molecule delivery, many of the technologies described can also be effective in delivering larger biomolecules. Comprehensive, cutting-edge, and highly practical, Drug Delivery Systems in Cancer Therapy captures for experimental oncologists, medicinal chemists, and pharmacologists the universe of approaches, technologies, and systems available for substantially enhancing the therapeutic outcome of anticancer drug delivery today.

Author : Marcos Luciano Bruschi
Publisher : Woodhead Publishing
Page : 208 pages
File Size : 45,7 Mb
Release : 2015-06-16
Category : Medical
ISBN : 9780081001127

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Strategies to Modify the Drug Release from Pharmaceutical Systems by Marcos Luciano Bruschi Pdf

Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications