Single Photon Imaging

Author : Peter Seitz,Albert J. P. Theuwissen
Publisher : Springer
Page : 363 pages
File Size : 49,6 Mb
Release : 2011-08-03
Category : Science
ISBN : 9783642184437

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Single-Photon Imaging by Peter Seitz,Albert J. P. Theuwissen Pdf

The acquisition and interpretation of images is a central capability in almost all scientific and technological domains. In particular, the acquisition of electromagnetic radiation, in the form of visible light, UV, infrared, X-ray, etc. is of enormous practical importance. The ultimate sensitivity in electronic imaging is the detection of individual photons. With this book, the first comprehensive review of all aspects of single-photon electronic imaging has been created. Topics include theoretical basics, semiconductor fabrication, single-photon detection principles, imager design and applications of different spectral domains. Today, the solid-state fabrication capabilities for several types of image sensors has advanced to a point, where uncoooled single-photon electronic imaging will soon become a consumer product. This book is giving a specialist ́s view from different domains to the forthcoming “single-photon imaging” revolution. The various aspects of single-photon imaging are treated by internationally renowned, leading scientists and technologists who have all pioneered their respective fields.

Author : Peter Seitz,Albert J. P. Theuwissen
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 48,8 Mb
Release : 2011-08-03
Category : Technology & Engineering
ISBN : 9783642184420

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Single-Photon Imaging by Peter Seitz,Albert J. P. Theuwissen Pdf

The acquisition and interpretation of images is a central capability in almost all scientific and technological domains. In particular, the acquisition of electromagnetic radiation, in the form of visible light, UV, infrared, X-ray, etc. is of enormous practical importance. The ultimate sensitivity in electronic imaging is the detection of individual photons. With this book, the first comprehensive review of all aspects of single-photon electronic imaging has been created. Topics include theoretical basics, semiconductor fabrication, single-photon detection principles, imager design and applications of different spectral domains. Today, the solid-state fabrication capabilities for several types of image sensors has advanced to a point, where uncoooled single-photon electronic imaging will soon become a consumer product. This book is giving a specialist ́s view from different domains to the forthcoming “single-photon imaging” revolution. The various aspects of single-photon imaging are treated by internationally renowned, leading scientists and technologists who have all pioneered their respective fields.

Author : Eric R. Fossum,Nobukazu Teranishi,Albert Theuwissen,David Stoppa,Edoardo Charbon
Publisher : MDPI
Page : 379 pages
File Size : 49,5 Mb
Release : 2018-07-06
Category : Electronic
ISBN : 9783038423744

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Photon-Counting Image Sensors by Eric R. Fossum,Nobukazu Teranishi,Albert Theuwissen,David Stoppa,Edoardo Charbon Pdf

This book is a printed edition of the Special Issue "Photon-Counting Image Sensors" that was published in Sensors

Author : Karsten König
Publisher : Walter de Gruyter GmbH & Co KG
Page : 450 pages
File Size : 50,6 Mb
Release : 2018-01-22
Category : Science
ISBN : 9783110430073

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Multiphoton Microscopy and Fluorescence Lifetime Imaging by Karsten König Pdf

This monograph focuses on modern femtosecond laser microscopes for two photon imaging and nanoprocessing, on laser tweezers for cell micromanipulation as well as on fluorescence lifetime imaging (FLIM) in Life Sciences. The book starts with an introduction by Dr. Wolfgang Kaiser, pioneer of nonlinear optics and ends with the chapter on clinical multiphoton tomography, the novel high resolution imaging technique. It includes a foreword by the nonlinear microscopy expert Dr. Colin Sheppard. Contents Part I: Basics Brief history of fluorescence lifetime imaging The long journey to the laser and its use for nonlinear optics Advanced TCSPC-FLIM techniques Ultrafast lasers in biophotonics Part II: Modern nonlinear microscopy of live cells STED microscopy: exploring fluorescence lifetime gradients for super-resolution at reduced illumination intensities Principles and applications of temporal-focusing wide-field two-photon microscopy FLIM-FRET microscopy TCSPC FLIM and PLIM for metabolic imaging and oxygen sensing Laser tweezers are sources of two-photon effects Metabolic shifts in cell proliferation and differentiation Femtosecond laser nanoprocessing Cryomultiphoton imaging Part III: Nonlinear tissue imaging Multiphoton Tomography (MPT) Clinical multimodal CARS imaging In vivo multiphoton microscopy of human skin Two-photon microscopy and fluorescence lifetime imaging of the cornea Multiscale correlative imaging of the brain Revealing interaction of dyes and nanomaterials by multiphoton imaging Multiphoton FLIM in cosmetic clinical research Multiphoton microscopy and fluorescence lifetime imaging for resection guidance in malignant glioma surgery Non-invasive single-photon and multi-photon imaging of stem cells and cancer cells in mouse models Bedside assessment of multiphoton tomography

Author : Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging,Commission on Physical Sciences, Mathematics, and Applications,Division on Engineering and Physical Sciences,National Research Council
Publisher : National Academies Press
Page : 261 pages
File Size : 54,9 Mb
Release : 1996-03-13
Category : Science
ISBN : 9780309552929

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Mathematics and Physics of Emerging Biomedical Imaging by Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging,Commission on Physical Sciences, Mathematics, and Applications,Division on Engineering and Physical Sciences,National Research Council Pdf

This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.

Author : Ron D. Frostig
Publisher : CRC Press
Page : 428 pages
File Size : 54,6 Mb
Release : 2009-05-06
Category : Science
ISBN : 9781420076851

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In Vivo Optical Imaging of Brain Function, Second Edition by Ron D. Frostig Pdf

These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques and their applications for the growing field of functional imaging in the live brain using optical imaging techniques. New in the Second Edition: Voltage-sensitive dyes imaging in awake behaving animals Imaging based on genetically encoded probes Imaging of mitochondrial auto-fluorescence as a tool for cortical mapping Using pH-sensitive dyes for functional mapping Modulated imaging Calcium imaging of neuronal activity using 2-photon microscopy Fourier approach to optical imaging Fully updated chapters from the first edition Leading Authorities Explore the Latest Techniques Updated to reflect continuous development in this emerging research area, this new edition, as with the original, reaches across disciplines to review a variety of non-invasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as biophysics, neuroscience, and cognitive science present a host of perspectives that range from a single neuron to large assemblies of millions of neurons, captured at various temporal and spatial resolutions. Introducing techniques that were not available just a few years ago, the authors describe the theory, setup, analytical methods, and examples that highlight the advantages of each particular method.

Author : Wolfgang Becker
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 50,6 Mb
Release : 2005-12-19
Category : Science
ISBN : 9783540288824

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Advanced Time-Correlated Single Photon Counting Techniques by Wolfgang Becker Pdf

In 1984 Desmond O’Connor and David Phillips published their comprehensive book „Time-correlated Single Photon Counting“. At that time time-correlated s- gle photon counting, or TCSPC, was used primarily to record fluorescence decay functions of dye solutions in cuvettes. From the beginning, TCSPC was an am- ingly sensitive and accurate technique with excellent time-resolution. However, acquisition times were relatively slow due to the low repetition rate of the light sources and the limited speed of the electronics of the 70s and early 80s. Moreover, TCSPC was intrinsically one-dimensional, i.e. limited to the recording of the wa- form of a periodic light signal. Even with these limitations, it was a wonderful te- nique. More than 20 years have elapsed, and electronics and laser techniques have made impressive progress. The number of transistors on a single chip has approximately doubled every 18 months, resulting in a more than 1,000-fold increase in compl- ity and speed. The repetition rate and power of pulsed light sources have increased by about the same factor.

Author : Desmond O'Connor
Publisher : Academic Press
Page : 298 pages
File Size : 53,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323141444

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Time-correlated single photon counting by Desmond O'Connor Pdf

Time-correlated Single Photon Counting has been written in the hope that by relating the authors' experiences with a variety of different single photon counting systems, they may provide a useful service to users and potential users of this formidably sensitive technique. Of all the techniques available to obtain information on the rates of depopulation of excited electronic singlet states of molecular species, monitoring of fluorescence provides, in principle, the simplest and most direct measure of concentration. This volume comprises eight chapters, with the first focusing on the time dependence and applications of fluorescence. Succeeding chapters go on to discuss basic principles of the single photon counting lifetime measurement; light sources; photomultipliers; electronics; data analysis; nanosecond time-resolved emission spectroscopy; time dependence of fluorescence anisotropy. This book will be of interest to practitioners in the field of chemistry.

Author : Cristiano Niclass
Publisher : Unknown
Page : 251 pages
File Size : 52,5 Mb
Release : 2008
Category : Electronic
ISBN : 3866282206

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Single-photon Image Sensors in CMOS by Cristiano Niclass Pdf

Author : Hofherr, Matthias
Publisher : KIT Scientific Publishing
Page : 213 pages
File Size : 47,6 Mb
Release : 2014-09-26
Category : Electronic
ISBN : 9783731502296

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Real-time imaging systems for superconducting nanowire single-photon detector arrays by Hofherr, Matthias Pdf

Author : Paul Levan,Ashok Sood,Priyalal Wijewarnasuriya,Manijeh Razeghi
Publisher : Unknown
Page : 1028 pages
File Size : 42,8 Mb
Release : 2011
Category : Imaging systems
ISBN : 0819487651

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Infrared Sensors, Devices, and Applications; and Single Photon Imaging II by Paul Levan,Ashok Sood,Priyalal Wijewarnasuriya,Manijeh Razeghi Pdf

Includes Proceedings Vol. 7821

Author : Robert R. Alfano,Lingyan Shi
Publisher : William Andrew
Page : 610 pages
File Size : 43,6 Mb
Release : 2018-11-22
Category : Technology & Engineering
ISBN : 9780323480680

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Neurophotonics and Biomedical Spectroscopy by Robert R. Alfano,Lingyan Shi Pdf

Neurophotonics and Biomedical Spectroscopy addresses the novel state-of-the-art work in non-invasive optical spectroscopic methods that detect the onset and progression of diseases and other conditions, including pre-malignancy, cancer, Alzheimer’s disease, tissue and cell response to therapeutic intervention, unintended injury and laser energy deposition. The book then highlights research in neurophotonics that investigates single and multi-photon excitation optical signatures of normal/diseased nerve tissues and in the brain, providing a better understanding of the underlying biochemical and structural changes of tissues and cells that are responsible for the observed spectroscopic signatures. Topics cover a wide array of well-established UV, visible, NIR and IR optical and spectroscopic techniques and novel approaches to diagnose tissue changes, including: label free in vivo and ex vivo fluorescence spectroscopy, Stoke shift spectroscopy, spectral imaging, Resonance Raman spectroscopy, multiphoton two Photon excitation, and more. Provides an overview of the spectroscopic properties of tissue and tissue-light interaction, describing techniques to exploit these properties in imaging Explores the potential and significance of molecule-specific imaging and its capacity to reveal vital new information on nanoscale structures Offers a concise overview of different spectroscopic methods and their potential benefits for solving diagnostic and therapeutic problems

Author : Peter Kapusta,Michael Wahl,Rainer Erdmann
Publisher : Springer
Page : 370 pages
File Size : 46,5 Mb
Release : 2015-04-23
Category : Science
ISBN : 9783319156361

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Advanced Photon Counting by Peter Kapusta,Michael Wahl,Rainer Erdmann Pdf

This volume focuses on Time-Correlated Single Photon Counting (TCSPC), a powerful tool allowing luminescence lifetime measurements to be made with high temporal resolution, even on single molecules. Combining spectrum and lifetime provides a “fingerprint” for identifying such molecules in the presence of a background. Used together with confocal detection, this permits single-molecule spectroscopy and microscopy in addition to ensemble measurements, opening up an enormous range of hot life science applications such as fluorescence lifetime imaging (FLIM) and measurement of Förster Resonant Energy Transfer (FRET) for the investigation of protein folding and interaction. Several technology-related chapters present both the basics and current state-of-the-art, in particular of TCSPC electronics, photon detectors and lasers. The remaining chapters cover a broad range of applications and methodologies for experiments and data analysis, including the life sciences, defect centers in diamonds, super-resolution microscopy, and optical tomography. The chapters detailing new options arising from the combination of classic TCSPC and fluorescence lifetime with methods based on intensity fluctuation represent a particularly unique highlight.

Author : Matthias Hofherr
Publisher : Unknown
Page : 208 pages
File Size : 51,8 Mb
Release : 2020-10-09
Category : Science
ISBN : 1013279603

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Real-time Imaging Systems for Superconducting Nanowire Single-photon Detector Arrays by Matthias Hofherr Pdf

Superconducting nanowire singe-photon detectors (SNSPD) are promising detectors in the field of applications, where single-photon resolution is required like in quantum optics, spectroscopy or astronomy. These cryogenic detectors gain from a broad spectrum in the optical and infrared range and deliver low dark count rates and low jitter times. This thesis improves the understanding of the detection mechanism of SNSPDs and intodruces new and promising multi-pixel readout concepts. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Author : Lijian Zhang,Hendrik Coldenstrodt-Ronge,Animesh Datta,Ian A. Walmsley
Publisher : Elsevier Inc. Chapters
Page : 616 pages
File Size : 40,7 Mb
Release : 2013-11-29
Category : Science
ISBN : 9780128058084

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Single-Photon Generation and Detection by Lijian Zhang,Hendrik Coldenstrodt-Ronge,Animesh Datta,Ian A. Walmsley Pdf

As quantum detectors evolve to become ever more sophisticated, their description in terms of a limited number of generic parameters falls short. An alternative description of the performance of a detector is provided by its positive-operator-valued measure (POVM). In this chapter we introduce a technique, quantum detector tomography, which allows us to experimentally reconstruct the POVM of the detector under test. Detailed examples on how to apply this technique to phase-insensitive detectors are given. We also discuss the challenges for the tomography of phase-sensitive detectors and possible solutions.