Solid Phase Peptide Synthesis

Author : Waleed M. Hussein,Mariusz Skwarczynski,Istvan Toth
Publisher : Humana
Page : 0 pages
File Size : 54,7 Mb
Release : 2019-12-27
Category : Science
ISBN : 1071602268

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Peptide Synthesis by Waleed M. Hussein,Mariusz Skwarczynski,Istvan Toth Pdf

This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis: Methods and Protocols serves as an essential guide to the many crucial processes that will allow researchers to efficiently prepare, purify, characterize, and use peptides for chemical, biochemical, and biological studies.

Author : W. Chan,Peter White
Publisher : OUP Oxford
Page : 371 pages
File Size : 51,7 Mb
Release : 1999-12-16
Category : Science
ISBN : 9780199637249

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Fmoc Solid Phase Peptide Synthesis by W. Chan,Peter White Pdf

Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.

Author : Gregg B. Fields
Publisher : Academic Press
Page : 828 pages
File Size : 48,6 Mb
Release : 1997-10-21
Category : Medical
ISBN : UVA:X004150724

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Solid-Phase Peptide Synthesis by Gregg B. Fields Pdf

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides

Author : Fernando Albericio
Publisher : CRC Press
Page : 849 pages
File Size : 55,9 Mb
Release : 2000-04-28
Category : Medical
ISBN : 9781482270303

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Solid-Phase Synthesis by Fernando Albericio Pdf

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates,

Author : W. Chan,Peter White
Publisher : Oxford University Press
Page : 371 pages
File Size : 47,8 Mb
Release : 1999-12-16
Category : Science
ISBN : 9780191565892

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Fmoc Solid Phase Peptide Synthesis by W. Chan,Peter White Pdf

In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now for the most part, been solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers the essential procedures for the production of linear peptides and more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly. Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as t-bag, SPOT and PIN synthesis, have naturally been included. Finally, a survey of available automated instrumentation has also been provided.

Author : E. Atherton,R. C. Sheppard
Publisher : Oxford University Press, USA
Page : 203 pages
File Size : 51,7 Mb
Release : 1989
Category : Peptides
ISBN : 1852211334

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Solid Phase Peptide Synthesis by E. Atherton,R. C. Sheppard Pdf

Author : Bruce Merrifield
Publisher : Unknown
Page : 328 pages
File Size : 43,6 Mb
Release : 1993
Category : Biography & Autobiography
ISBN : STANFORD:36105003439804

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Life During a Golden Age of Peptide Chemistry by Bruce Merrifield Pdf

Thirteenth in a series of autobiographies of 22 eminent organic chemists, the present volume chronicles the life and contributions to the field of Bruce Merrifield, winner of the 1984 Nobel Prize for chemistry. Subtitled The Concept and Development of Solid-Phase Peptide Synthesis. Highly illustrated with diagrams, tables, graphs and (bandw) photographs. Annotation copyright by Book News, Inc., Portland, OR

Author : John Morrow Stewart,Janis Dillaha Young
Publisher : Unknown
Page : 204 pages
File Size : 44,5 Mb
Release : 1984
Category : Peptides
ISBN : UOM:39015016062195

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Solid Phase Peptide Synthesis by John Morrow Stewart,Janis Dillaha Young Pdf

Author : E. Atherton,R. C. Sheppard
Publisher : Oxford University Press, USA
Page : 203 pages
File Size : 45,8 Mb
Release : 1989-01-01
Category : Peptides
ISBN : 1852211342

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Solid Phase Peptide Synthesis by E. Atherton,R. C. Sheppard Pdf

Author : Roger Epton
Publisher : Unknown
Page : 778 pages
File Size : 43,5 Mb
Release : 1994
Category : Nucleic acids
ISBN : STANFORD:36105018484761

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Innovation and Perspectives in Solid Phase Synthesis by Roger Epton Pdf

Author : Knud J. Jensen,Pernille Tofteng Shelton,Søren L. Pedersen
Publisher : Humana
Page : 0 pages
File Size : 53,7 Mb
Release : 2016-08-27
Category : Science
ISBN : 1493960040

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Peptide Synthesis and Applications by Knud J. Jensen,Pernille Tofteng Shelton,Søren L. Pedersen Pdf

Peptides are used ubiquitously for studies in biology, biochemistry, chemical biology, peptide based medicinal chemistry, and many other areas of research. There is a number of marketed peptide drugs, and the prospects for the development of new peptide drugs are very encouraging. The second edition of Peptide Synthesis and Applications expands upon the previous editions with current, detailed methodologies for peptide synthesis. With new chapters on laboratory protocols for both the specialist and the non-specialist. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis and Application, Second Edition seeks to aid scientists in understanding different approaches to the synthesis of peptides by using a broad range of methods and strategies.

Author : Yi Yang
Publisher : Academic Press
Page : 376 pages
File Size : 49,6 Mb
Release : 2015-09-01
Category : Science
ISBN : 9780128011812

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Side Reactions in Peptide Synthesis by Yi Yang Pdf

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration

Author : Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt
Publisher : CRC Press
Page : 306 pages
File Size : 53,7 Mb
Release : 1997-04-23
Category : Medical
ISBN : 0849391423

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Chemical Approaches to the Synthesis of Peptides and Proteins by Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt Pdf

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

Author : P. Katsoyannis
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 54,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461345718

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The Chemistry of Polypeptides by P. Katsoyannis Pdf

Leonidas Zervas, Emeritus Professor of organic chemistry at the University of Athens, and past president of the National Academy of Greece, cele brated his seventieth birthday this past year. For almost fifty years Zervas devoted his scientific skills and perception to the advancement of chemistry, particularly in the field of peptides and proteins. Indeed, his efforts, along with those of his teacher, co-worker, and friend, Max Bergmann, laid the foundations for a new era in the chemistry of peptides and proteins. Many of his colleagues and former students felt that it would be most at this time to honor him with a commemorative volume. They appropriate have contributed to this volume chapters describing some of their work and reviewing the advancements in particular areas of polypeptide chemistry. They dedicate this volume to Leonidas Zervas as an expression of their esteem and appreciation for the role he has played for the past half-century in the field of peptides and proteins.

Author : Weng C. Chan,Peter D. White
Publisher : Unknown
Page : 346 pages
File Size : 53,7 Mb
Release : 2000
Category : Peptides
ISBN : OCLC:1193947048

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Fmoc Solid Phase Peptide Synthesis by Weng C. Chan,Peter D. White Pdf