Solid Phase Synthesis And Combinatorial Technologies

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Solid-Phase Synthesis and Combinatorial Technologies

Pierfausto Seneci
Solid Phase Synthesis and Combinatorial Technologies Book PDF

Author : Pierfausto Seneci
Publisher : John Wiley & Sons
Page : 653 pages
File Size : 53,6 Mb
Release : 2003-05-28
Category : Science
ISBN : 9780471460732

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Solid-Phase Synthesis and Combinatorial Technologies by Pierfausto Seneci Pdf

A unique, integrated look at solid-phase synthesis and advances in combinatorial chemistry and technologies The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines. Designed to meet the needs of both experienced combinatorial chemists and newcomers to the field, Solid-Phase Synthesis and Combinatorial Technologies: * Surveys the most recent developments in SPS and combinatorial chemistry * Explains the entire process, from determining the need for a library to the details necessary for synthesis of the library * Discusses choice of format, size, and the rationale behind the design of each synthetic step * Surveys the analytical techniques and the purification methods used to characterize and purify combinatorial libraries * Employs a large number of examples to illustrate important concepts * Includes problems geared toward applying acquired knowledge and designing the steps to SPS/library synthesis * Describes the quality control and activity screening of combinatorial libraries for various applications * Features a detailed bibliography of more than 1,700 relevant sources

Optimization of Solid-Phase Combinatorial Synthesis

Bing Yan,Anthony W. Czarnik
Optimization of Solid Phase Combinatorial Synthesis Book PDF

Author : Bing Yan,Anthony W. Czarnik
Publisher : CRC Press
Page : 408 pages
File Size : 41,9 Mb
Release : 2001-12-04
Category : Science
ISBN : 9781482271058

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Optimization of Solid-Phase Combinatorial Synthesis by Bing Yan,Anthony W. Czarnik Pdf

"Addresses the key topic in combinatorial synthesis--how to optimize the quality of a combinatorial library--by determining the usefulness of synthesized compunds, the reliability of biological assay results, and analyzing acadmic and industrial applications, real-world examples, and case studies of successful and unsuccessful technologies."

Combinatorial Chemistry and Technologies

Stanislav Miertus,Giorgio Fassina
Combinatorial Chemistry and Technologies Book PDF

Author : Stanislav Miertus,Giorgio Fassina
Publisher : CRC Press
Page : 616 pages
File Size : 48,9 Mb
Release : 2005-04-12
Category : Medical
ISBN : 9780824758370

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Combinatorial Chemistry and Technologies by Stanislav Miertus,Giorgio Fassina Pdf

Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Combinatorial Chemistry

Stephen R. Wilson,Anthony W. Czarnik
Combinatorial Chemistry Book PDF

Author : Stephen R. Wilson,Anthony W. Czarnik
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 43,9 Mb
Release : 1997-03-28
Category : Medical
ISBN : 047112687X

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Combinatorial Chemistry by Stephen R. Wilson,Anthony W. Czarnik Pdf

The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Combinatorial Chemistry and Technology

Stanislav Miertus,Giorgio Fassina
Combinatorial Chemistry and Technology Book PDF

Author : Stanislav Miertus,Giorgio Fassina
Publisher : CRC Press
Page : 456 pages
File Size : 40,6 Mb
Release : 1999-07-01
Category : Science
ISBN : 142000056X

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Combinatorial Chemistry and Technology by Stanislav Miertus,Giorgio Fassina Pdf

"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."

Solid-Phase Organic Synthesis

Patrick H. Toy,Yulin Lam
Solid Phase Organic Synthesis Book PDF

Author : Patrick H. Toy,Yulin Lam
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 54,8 Mb
Release : 2012-01-10
Category : Science
ISBN : 9781118141632

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Solid-Phase Organic Synthesis by Patrick H. Toy,Yulin Lam Pdf

Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.

Combinatorial Chemistry

Hicham Fenniri
Combinatorial Chemistry Book PDF

Author : Hicham Fenniri
Publisher : OUP Oxford
Page : 508 pages
File Size : 44,7 Mb
Release : 2000-10-05
Category : Science
ISBN : 9780191565939

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Combinatorial Chemistry by Hicham Fenniri Pdf

Combinatorial Chemistry is a genuine practical guide covering all the major areas of combinatorial chemistry from an experimental and conceptual point of view. Being one of the most powerful of modern technologies, combinatorial chemistry has had implications to many areas of chemistry and biology and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It also contains protocols on solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation. The use of automation and robotics is also explained. It is written at a level easily accessible to novices and will enable readers to use combinatorial techniques to the best advantage.

Solid-Phase Organic Synthesis

Kevin Burgess
Solid Phase Organic Synthesis Book PDF

Author : Kevin Burgess
Publisher : John Wiley & Sons
Page : 294 pages
File Size : 48,8 Mb
Release : 2004-04-05
Category : Science
ISBN : 9780471458456

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Solid-Phase Organic Synthesis by Kevin Burgess Pdf

Solid-Phase Organic Synthesis Edited by Kevin Burgess, Texas A & M University Efficient, high-throughput chemistry is now the focus of many research laboratories. Solid-phase organic syntheses are central to many of these combinatorial and parallel screening methodologies. Consequently, they have been a major scientific theme of the 1990s and promise to remain prominent for the first part of the new millennium. Indeed, a bewildering number of papers have entered the literature on this topic; some report minor modifications enabling transformation of solution-phase methods to a solid support, while others report major innovations. Solid-Phase Organic Synthesis collects, highlights, and critiques some of the key developments in the field. Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include: * Syntheses of guanidines * Palladium-catalyzed C-C bond forming reactions * S_nAr reactions for the formation of heterocycles * Sequence-specific arylalkyne oligomers * Resin-supported capture agents and other reagents * Synthesis on pins * Monitoring of supported reactions using IR * Solid-phase syntheses of natural product derivatives Of related interest . Combinatorial Chemistry and Molecular Diversity in Drug Discovery Eric M. Gordon and James F. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial Chemistry Synthesis and Application Stephen R. Wilson and Anthony W. Czarnik 1997 (0-471-12687-X) 288 pp.

Solid-supported Combinatorial and Parallel Synthesis of Small-molecular-weight Compound Libraries

D. Obrecht,J.M. Villalgordo
Solid supported Combinatorial and Parallel Synthesis of Small molecular weight Compound Libraries Book PDF

Author : D. Obrecht,J.M. Villalgordo
Publisher : Elsevier
Page : 366 pages
File Size : 41,6 Mb
Release : 1998-10-16
Category : Science
ISBN : 0080432573

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Solid-supported Combinatorial and Parallel Synthesis of Small-molecular-weight Compound Libraries by D. Obrecht,J.M. Villalgordo Pdf

This book gives an overview of the current state of the art of combinatorial organic synthesis. While the main focus is on multicomponent and multigeneration strategies using polymeric supports, there is also a Chapter on solution strategies using polymer-grafted reagents which allow minimisation of work-up procedures. Some of the most important strategies and tools are presented and summarised, with an explanation of the pivotal role of organic synthesis in the creation of diversity.

Analytical Methods in Combinatorial Chemistry

Bing Yan,Bin Zhang
Analytical Methods in Combinatorial Chemistry Book PDF

Author : Bing Yan,Bin Zhang
Publisher : CRC Press
Page : 335 pages
File Size : 48,6 Mb
Release : 2010-08-09
Category : Science
ISBN : 9781439857601

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Analytical Methods in Combinatorial Chemistry by Bing Yan,Bin Zhang Pdf

Since the publication of the benchmark first edition of this book, chemical library and combinatorial chemistry methods have developed into mature technologies. There have also been significant shifts in emphasis in combinatorial synthesis. Reflecting the growth in the field and the heightened focus on select areas, Analytical Methods in Combinator

Combinatorial Chemistry and Molecular Diversity in Drug Discovery

Eric M. Gordon,James F. Kerwin
Combinatorial Chemistry and Molecular Diversity in Drug Discovery Book PDF

Author : Eric M. Gordon,James F. Kerwin
Publisher : Wiley-Liss
Page : 552 pages
File Size : 45,9 Mb
Release : 1998-08-27
Category : Medical
ISBN : UOM:39015039043081

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Combinatorial Chemistry and Molecular Diversity in Drug Discovery by Eric M. Gordon,James F. Kerwin Pdf

COMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY IN DRUG DISCOVERY Edited by Eric M. Gordon and James F. Kerwin, Jr. Increasing pressure to identify, optimize, develop, and commercialize novel drugs more rapidly and more cost-effectively has led to an urgent demand for technologies that can reduce the time to market for new products. Molecular diversity, of both natural and synthetic materials, provides a valuable source of compounds for identifying and optimizing new drug leads. Through the rapidly evolving technology of combinatorial chemistry, it is now possible to produce libraries of small molecules to screen for novel bioactivities. This powerful new technology has begun to help pharmaceutical companies find new drug candidates quickly, save significant dollars in preclinical development costs, and ultimately change their fundamental approach to drug discovery. Comprising the work of the leading authorities in the area of molecular diversity and combinatorial chemistry, Combinatorial Chemistry and Molecular Diversity in Drug Discovery highlights the critical concepts and issues involved in implementing combinatorial chemistry to create chemical libraries. The authors, industrial and academic experts in the field, apply combinatorial technologies to drug discovery and development and place co-evolving technologies and practices in a global framework. Included among the many topics: * Historical background. * Library strategy and design. * Solid-phase synthesis. * Small molecular libraries. * Automation, analytical, and computational methodology. * Biological diversity. * Strategies for screening combinatorial libraries. * Combinatorial drug screening and development. * Combinatorial chemistry information management. Combinatorial Chemistry and Molecular Diversity in Drug Discovery is one of the first comprehensive books to cover this explosive area. It is must reading for medicinal chemists, pharmacologists, molecular biologists, biochemists, enzymologists, and drug discovery research managers in industry, academia, and government.

Linker Strategies in Solid-Phase Organic Synthesis

Peter Scott
Linker Strategies in Solid Phase Organic Synthesis Book PDF

Author : Peter Scott
Publisher : John Wiley & Sons
Page : 706 pages
File Size : 51,9 Mb
Release : 2009-10-13
Category : Science
ISBN : 0470749059

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Linker Strategies in Solid-Phase Organic Synthesis by Peter Scott Pdf

Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis. Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include: the principles of solid phase organic synthesis electrophile and nucleophile cleavable linker units cyclative cleavage as a solid phase strategy photocleavable linker units safety-catch linker units enzyme cleavable linker units T1 and T2 –versatile triazene linker groups hydrazone linker units benzotriazole linker units phosphorus linker units sulfur linker units selenium and tellurium linker units sulfur, oxygen and selenium linker units cleaved by radical processes silicon and germanium linker units boron and stannane linker units bismuth linker units transition metal carbonyl linker units linkers releasing olefins or cycloolefins by ring-closing metathesis fluorous linker units solid-phase radiochemistry The book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis. Linker Strategies in Solid-Phase Organic Synthesis is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.

Combinatorial Chemistry and Technologies

Stanislav Miertus,Giorgio Fassina
Combinatorial Chemistry and Technologies Book PDF

Author : Stanislav Miertus,Giorgio Fassina
Publisher : CRC Press
Page : 597 pages
File Size : 52,8 Mb
Release : 2005-04-12
Category : Medical
ISBN : 9781420027846

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Combinatorial Chemistry and Technologies by Stanislav Miertus,Giorgio Fassina Pdf

Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the

New Synthetic Technologies in Medicinal Chemistry

Elizabeth Farrant
New Synthetic Technologies in Medicinal Chemistry Book PDF

Author : Elizabeth Farrant
Publisher : Royal Society of Chemistry
Page : 176 pages
File Size : 44,9 Mb
Release : 2011-10-04
Category : Medical
ISBN : 9781849733052

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New Synthetic Technologies in Medicinal Chemistry by Elizabeth Farrant Pdf

The modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs. This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. It covers both synthetic technologies currently impacting medicinal chemistry and emerging areas. The chapters focus on topics including: parallel medicinal chemistry; solid supported reagents; microwave assisted chemistry; flow synthesis, and high throughput reaction screening.

Solid-Phase Organic Syntheses

Anthony W. Czarnik
Solid Phase Organic Syntheses Book PDF

Author : Anthony W. Czarnik
Publisher : Wiley-Interscience
Page : 184 pages
File Size : 52,8 Mb
Release : 2001-02-26
Category : Mathematics
ISBN : UOM:39015053381326

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Solid-Phase Organic Syntheses by Anthony W. Czarnik Pdf

The rapid expansion of combinatorial chemistry has renewed interest in solid-phase organic synthesis, a method that lends itself well to creating and screening large numbers of lead compounds. Solid-Phase Organic Syntheses, Volume 1 is the first volume in a series that will be updated annually, filling a gap in the existing chemical literature. Providing information previously unavailable from a single resource, this series is dedicated to providing researchers in the field with validated and tested methods for the solid-phase synthesis of interesting and biologically relevant molecules. Solid-phase methods will virtually always be invented for application in combinatorial organic synthesis. To meet these specific needs, Solid-Phase Organic Syntheses, Volume 1 focuses on a single type of synthetic transformation accomplished on solid support, and indicates how procedures are optimized to work with a structurally-wide variety of reagents. Written by recognized leaders in the field who review and test all chemical protocols before publication, organic transformations are organized by type of compound synthesized and reaction type. For the first time, experimental details for proven solid-phase synthetic molecules are collected in a single, invaluable resource. Solid-Phase Organic Syntheses, Volume 1 provides combinatorial chemists and researchers in organic chemistry and medicinal chemistry with the tools and descriptive protocols to achieve syntheses of desired compounds using a variety of solid supports and reagents.