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Author : Quan Zou
Publisher : MDPI
Page : 305 pages
File Size : 49,9 Mb
Release : 2018-08-09
Category : Electronic books
ISBN : 9783038970439
This book is a printed edition of the Special Issue "Special Protein Molecules Computational Identification" that was published in IJMS
Author : Quan Zou
Publisher : Unknown
Page : 128 pages
File Size : 53,6 Mb
Release : 2018
Category : Electronic
ISBN : 3038970441
Special Protein Molecules Computational Identification.
Author : Taylor Watts
Publisher : Callisto Reference
Page : 0 pages
File Size : 47,5 Mb
Release : 2023-09-26
Category : Science
ISBN : 1641168005
Proteins are large and intricate molecules that perform a variety of vital functions in the human body. They are crucial for the structure, control and function of the body's organs and tissues, while carrying out the majority of the work inside the cells. They are composed of a large number of smaller components known as amino acids that are linked with each other in lengthy chains. The search for novel protein molecules can be time consuming in case of certain proteins, such as enzymes, anticancer peptides, cytokines, G protein-coupled receptors, cell-penetrating peptides and cancerlectins. Understanding the function of proteins requires the computational identification of special protein molecules. Bioinformatics is a vital part of protein analysis, including structure analysis, sequence analysis and evolution analysis. This book contains some path-breaking studies on proteins. It aims to shed light on the computational approaches and bioinformatics analysis of proteins. As this field is emerging at a rapid pace, the contents of this book will help the readers understand the modern concepts and applications of the subject.
Author : Manuel Claude Peitsch
Publisher : World Scientific
Page : 790 pages
File Size : 40,5 Mb
Release : 2008
Category : Science
ISBN : 9789812778772
This work covers the impact of computational structural biology on protein structure prediction methods, macromolecular function and protein design, and key methods in drug discovery. It also addresses the computational challenges of experimental approaches in structural biology.
Author : M Michael Gromiha
Publisher : World Scientific
Page : 424 pages
File Size : 41,8 Mb
Release : 2020-03-05
Category : Science
ISBN : 9789811211881
This book is indexed in Chemical Abstracts ServiceThe interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design.This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules.
Author : Mourad Elloumi,Costas Iliopoulos,Jason T. L. Wang,Albert Y. Zomaya
Publisher : John Wiley & Sons
Page : 656 pages
File Size : 55,7 Mb
Release : 2015-12-24
Category : Technology & Engineering
ISBN : 9781119078869
A comprehensive overview of high-performance pattern recognition techniques and approaches to Computational Molecular Biology This book surveys the developments of techniques and approaches on pattern recognition related to Computational Molecular Biology. Providing a broad coverage of the field, the authors cover fundamental and technical information on these techniques and approaches, as well as discussing their related problems. The text consists of twenty nine chapters, organized into seven parts: Pattern Recognition in Sequences, Pattern Recognition in Secondary Structures, Pattern Recognition in Tertiary Structures, Pattern Recognition in Quaternary Structures, Pattern Recognition in Microarrays, Pattern Recognition in Phylogenetic Trees, and Pattern Recognition in Biological Networks. Surveys the development of techniques and approaches on pattern recognition in biomolecular data Discusses pattern recognition in primary, secondary, tertiary and quaternary structures, as well as microarrays, phylogenetic trees and biological networks Includes case studies and examples to further illustrate the concepts discussed in the book Pattern Recognition in Computational Molecular Biology: Techniques and Approaches is a reference for practitioners and professional researches in Computer Science, Life Science, and Mathematics. This book also serves as a supplementary reading for graduate students and young researches interested in Computational Molecular Biology.
Author : Daniel Chasman
Publisher : CRC Press
Page : 534 pages
File Size : 54,6 Mb
Release : 2003-03-18
Category : Medical
ISBN : 9780824748166
This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 51,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Arthur M. Lesk
Publisher : Oxford University Press, USA
Page : 280 pages
File Size : 44,9 Mb
Release : 1988
Category : Language Arts & Disciplines
ISBN : UOM:39015014473543
An overview of the field of computing with protein and nucleic acid sequences, aimed at investigators determining sequences, those who analyze them to identify unknown proteins and interpret their function, and those interested in the three-dimensional structures of biological molecules.
Author : Mohini Gore,Umesh B. Jagtap
Publisher : Springer Nature
Page : 357 pages
File Size : 51,8 Mb
Release : 2023-10-09
Category : Medical
ISBN : 9781071634417
This second edition provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Drug Discovery and Design, Second Edition aims to effectively utilize computational methodologies in discovery and design of novel drugs.
Author : Joseph A. Marsh
Publisher : Humana
Page : 506 pages
File Size : 44,9 Mb
Release : 2019-04-15
Category : Science
ISBN : 1493992775
This volume details the importance of multiple experimental techniques and computational methods needed to obtain the comprehensive picture of protein complex structure, dynamics and assembly afforded by the emerging field of integrative structural biology. Chapters guide readers through the broad spectrum of approaches required for a complete representation of protein complexes, including expression and purification, experimental characterization of structure and assembly, and computational methods for identifying protein complexes and modelling their assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein Complex Assembly: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author : Stefan Canzar,Francisca Rojas Ringeling
Publisher : Humana
Page : 286 pages
File Size : 53,9 Mb
Release : 2020-10-18
Category : Science
ISBN : 1493998757
This volume explores techniques that study interactions between proteins in different species, and combines them with context-specific data, analysis of omics datasets, and assembles individual interactions into higher-order semantic units, i.e., protein complexes and functional modules. The chapters in this book cover computational methods that solve diverse tasks such as the prediction of functional protein-protein interactions; the alignment-based comparison of interaction networks by SANA; using the RaptorX-ComplexContact webserver to predict inter-protein residue-residue contacts; the docking of alternative confirmations of proteins participating in binary interactions and the visually-guided selection of a docking model using COZOID; the detection of novel functional units by KeyPathwayMiner and how PathClass can use such de novo pathways to classify breast cancer subtypes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary hardware- and software, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Protein-Protein Interaction Networks: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.
Author : Xiangxiang Zeng,Alfonso Rodríguez-Patón,Quan Zou
Publisher : MDPI
Page : 390 pages
File Size : 52,8 Mb
Release : 2019-07-11
Category : Science
ISBN : 9783039211951
This text will provide the most recent knowledge and advances in the area of molecular computing and bioinformatics. Molecular computing and bioinformatics have a close relationship, paying attention to the same object but working towards different orientations. The articles will range from topics such as DNA computing and membrane computing to specific biomedical applications, including drug R&D and disease analysis.
Author : Anonim
Publisher : Academic Press
Page : 754 pages
File Size : 50,7 Mb
Release : 2018-11-21
Category : Science
ISBN : 9780128156506
Intrinsically Disordered Proteins, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics of interest, including the Characterization of Structure-Function relationships in the intrinsically disordered protein complexin, Distances, distance distributions, and ensembles of IDPs from single-molecule FRET, Biophysical characterization of disordered protein liquid phases, The Use of Mass Spectrometry to Examine IDPs – Unique Insights and Caveats, Fluorescence Depolarization Kinetics to Study Conformational Preference, Structural Plasticity and Membrane Binding of Intrinsically Disordered Proteins, Characterizing the Function of Intrinsically Disordered Proteins in the Circadian Clock, and more. Breadth of experimental approaches and systems that will be covered The expertise of the contributors writing the articles
Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 45,6 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
