Spherical Nucleic Acids

Author : Chad A. Mirkin
Publisher : CRC Press
Page : 1806 pages
File Size : 44,6 Mb
Release : 2020-09-01
Category : Medical
ISBN : 9780429578069

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Spherical Nucleic Acids by Chad A. Mirkin Pdf

Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of Dr. Mirkin’s research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation. It is a reprint volume that compiles 101 key papers from high-impact journals in this research area published by the Mirkin Group at Northwestern University, Illinois, USA, within the International Institute for Nanotechnology, and collaborators. Volume 1 provides an overview and a historical framework of engineering matter from DNA-modified constructs and discusses the enabling features of nucleic acid–functionalized nanomaterials. Volume 2 covers design rules for colloidal crystallization, building blocks for crystal engineering, and DNA and RNA as programmable bonds. Volume 3 discusses colloidal crystallization processes and routes to hierarchical assembly, dynamic nanoparticle superlattices, surface-based and template-confined colloidal crystallization, optics and plasmonics with nanoparticle superlattices, and postsynthetic modification and catalysis with nanoparticle superlattices. Volume 4 covers diagnostic modalities, and intracellular therapeutic and diagnostic schemes based upon nucleic acid–functionalized nanomaterials.

Author : Chad A. Mirkin
Publisher : Unknown
Page : 0 pages
File Size : 48,9 Mb
Release : 2020
Category : DNA
ISBN : 9814877220

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Spherical Nucleic Acids by Chad A. Mirkin Pdf

"Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell. They have novel structure-dependent properties that differ from those of linear nucleic acids that makes them useful in chemistry, biology, the life sciences, medicine, materials science, and engineering." Back cover

Author : Chad A. Mirkin
Publisher : Unknown
Page : 376 pages
File Size : 54,5 Mb
Release : 2020
Category : DNA
ISBN : 1000092542

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Spherical Nucleic Acids by Chad A. Mirkin Pdf

Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of the author's research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation.

Author : Chad A. Mirkin
Publisher : CRC Press
Page : 455 pages
File Size : 49,9 Mb
Release : 2021-10-14
Category : Science
ISBN : 9781000092363

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Spherical Nucleic Acids by Chad A. Mirkin Pdf

Spherical nucleic acids (SNAs) comprise a nanoparticle core, and a densely packed and highly oriented nucleic acid shell. They have novel structure-dependent properties that differ from those of linear nucleic acids and that makes them useful in chemistry, biology, the life sciences, medicine, materials science, and engineering. This book is a reprint volume that compiles 101 key papers that have been published by the Mirkin Group at Northwestern University, USA, and their collaborators over the past more than two decades. Volume 1 provides an overview and a historical framework of SNAs and discusses their enabling features, which set them apart from all other forms of matter. Volume 2 covers the general design rules for colloidal crystal engineering with DNA, spanning the building blocks and DNA- and RNA-based "programmable bonds" that can be utilized in preparing such structures. Volume 3 continues the discussion of colloidal crystallization processes and routes to hierarchical assembly, featuring dynamic nanoparticle superlattices and lattices prepared on surfaces or via templating strategies, and explores what one can uniquely learn from and do with colloidal crystals prepared from nucleic acid–functionalized nanomaterials in optics, plasmonics, and catalysis. Volume 4 covers the role of SNAs in biomedicine, especially as diagnostic probes both inside and outside of cells, and treatments based on gene regulation and immunotherapy.

Author : Chad A. Mirkin
Publisher : CRC Press
Page : 307 pages
File Size : 47,6 Mb
Release : 2021-10-14
Category : Science
ISBN : 9781000092431

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Spherical Nucleic Acids by Chad A. Mirkin Pdf

Spherical nucleic acids (SNAs) comprise a nanoparticle core, and a densely packed and highly oriented nucleic acid shell. They have novel structure-dependent properties that differ from those of linear nucleic acids and that makes them useful in chemistry, biology, the life sciences, medicine, materials science, and engineering. This book is a reprint volume that compiles 101 key papers that have been published by the Mirkin Group at Northwestern University, USA, and their collaborators over the past more than two decades. Volume 1 provides an overview and a historical framework of SNAs and discusses their enabling features, which set them apart from all other forms of matter. Volume 2 covers the general design rules for colloidal crystal engineering with DNA, spanning the building blocks and DNA- and RNA-based "programmable bonds" that can be utilized in preparing such structures. Volume 3 continues the discussion of colloidal crystallization processes and routes to hierarchical assembly, featuring dynamic nanoparticle superlattices and lattices prepared on surfaces or via templating strategies, and explores what one can uniquely learn from and do with colloidal crystals prepared from nucleic acid–functionalized nanomaterials in optics, plasmonics, and catalysis. Volume 4 covers the role of SNAs in biomedicine, especially as diagnostic probes both inside and outside of cells, and treatments based on gene regulation and immunotherapy.

Author : Chad A. Mirkin
Publisher : Unknown
Page : 494 pages
File Size : 48,8 Mb
Release : 2020
Category : DNA
ISBN : 1003056709

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Spherical Nucleic Acids by Chad A. Mirkin Pdf

Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of the author's research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation.

Author : Jens Kurreck
Publisher : Royal Society of Chemistry
Page : 362 pages
File Size : 47,8 Mb
Release : 2008
Category : Medical
ISBN : 9780854041169

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Therapeutic Oligonucleotides by Jens Kurreck Pdf

This book provides a compelling overall update on current status of RNA interference

Author : Bin Wang
Publisher : CRC Press
Page : 466 pages
File Size : 54,9 Mb
Release : 2014-04-02
Category : Medical
ISBN : 9789814411653

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RNA Nanotechnology by Bin Wang Pdf

In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.

Author : Natassa Pippa,Costas Demetzos,Stergios Pispas
Publisher : CRC Press
Page : 418 pages
File Size : 44,9 Mb
Release : 2019-01-15
Category : Medical
ISBN : 9780429955228

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Drug Delivery Nanosystems by Natassa Pippa,Costas Demetzos,Stergios Pispas Pdf

Nanotechnology seeks to exploit distinct technological advances controlling the structure of nanoscale biomaterials at a nanodimensional scale approaching individual molecules and their aggregates or supramolecular structures. The term "nanomedicine" is used to describe those technologies under the umbrella of nanotechnology that have therapeutic applications in human health. This book presents recent trends and research achievements in the field of pharmaceutical nanotechnology and advanced drug delivery nanosystems, especially for theranostic purposes. The applications of drug delivery nanosystems considered carriers of active pharmaceutical ingredients (APIs) (e.g., proteins, peptides, and nucleic acids) are analyzed on the basis of technology, preparation protocols, and biomedical applications. The book also extensively reports on the principles, design protocols, and applications of nanosystems in drug delivery, imaging, and targeting of active molecules of pharmaceutical interest.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 51,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Aleš Prokop
Publisher : Springer Science & Business Media
Page : 867 pages
File Size : 55,7 Mb
Release : 2011-05-26
Category : Science
ISBN : 9789400712485

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Intracellular Delivery by Aleš Prokop Pdf

This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.

Author : Chad A. Mirkin,Thomas J. Meade,Sarah Hurst Petrosko,Alexander H. Stegh
Publisher : Springer
Page : 322 pages
File Size : 40,9 Mb
Release : 2015-04-20
Category : Medical
ISBN : 9783319165554

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Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer by Chad A. Mirkin,Thomas J. Meade,Sarah Hurst Petrosko,Alexander H. Stegh Pdf

This book discusses emerging nanotechnology-based tools that have the potential to dramatically impact cancer research, diagnostics, and treatment. Cancer is a complex, devastating, and debilitating disease and, although much progress has been made, novel, more effective diagnostic and treatment options are still needed, especially for advanced cancers. The ultimate goal is to detect cancer early and non-invasively and to provide efficacious and targeted precision treatments that cause fewer harmful side effects. This book explains how nanotechnology can exploit the size-, shape-, and composition-dependent properties of nanomaterials to provide novel tools for precision cancer medicine. It will be of interest to researchers and professionals working in the fields of chemistry, biology, materials science and engineering, and medicine who want to learn more about this fascinating and fast-paced area of research.

Author : Lalita Ledwani,Jitendra S. Sangwai
Publisher : Springer Nature
Page : 605 pages
File Size : 47,5 Mb
Release : 2020-03-12
Category : Technology & Engineering
ISBN : 9783030337742

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Nanotechnology for Energy and Environmental Engineering by Lalita Ledwani,Jitendra S. Sangwai Pdf

This book examines the potential applications of nanoscience and nanotechnology to promote eco-friendly processes and techniques for energy and environment sustainability. Covering various aspects of both the synthesis and applications of nanoparticles and nanofluids for energy and environmental engineering, its goal is to promote eco-friendly processes and techniques. Accordingly, the book elaborates on the development of reliable, economical, eco-friendly processes through advanced nanoscience and technological research and innovations. Gathering contributions by researchers actively engaged in various domains of nanoscience and technology, it addresses topics such as nanoparticle synthesis (both top-down and bottom-up approaches); applications of nanomaterials, nanosensors and plasma discharge in pollution control; environmental monitoring; agriculture; energy recovery; production enhancement; energy conservation and storage; surface modification of materials for energy storage; fuel cells; pollution mitigation; and CO2 capture and sequestration. Given its scope, the book will be of interest to academics and researchers whose work involves nanotechnology or nanomaterials, especially as applied to energy and/or environmental sustainability engineering. Graduate students in the same areas will also find it a valuable resource.

Author : Tamaki Endoh,Eriks Rozners,Takashi Ohtsuki
Publisher : Unknown
Page : 130 pages
File Size : 46,6 Mb
Release : 2021
Category : Electronic
ISBN : 3036515135

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Nucleic Acids Conjugates for Biotechnological Applications by Tamaki Endoh,Eriks Rozners,Takashi Ohtsuki Pdf

Life in biological systems is maintained by the cooperative actions of various biomolecules. With the development of chemical and biological technologies related to nucleic acids, the details of the mechanisms of such cooperative actions between nucleic acids and other biomolecules have been elucidated and further applied in various applications. In the papers published in this Special Issue, advanced research works involved in nucleic acid conjugates are reported in wide application fields, such as artificial gene regulation, biomolecular sensing, and therapeutics from leading scientists in nucleic acids chemistry and engineering.

Author : Yunfeng Lin,Ronghui Zhou
Publisher : Springer Nature
Page : 227 pages
File Size : 41,9 Mb
Release : 2021-08-20
Category : Medical
ISBN : 9789811626661

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Advances in Nanomaterials-based Cell Biology Research by Yunfeng Lin,Ronghui Zhou Pdf

This book aims to comprehensively summarize the current research status of nanomaterials and cell biology. It highlights the biological effects and biomedical applications of nanomaterials for specific diseases, bone tissue engineering, and skeletal muscle regeneration. It also provides the details of the biomedical applications of nucleic acid nanomaterials in drug delivery carriers, antimicrobial therapy, vaccine, and neurodegenerative diseases. Therefore, this book renders the audience a better understanding of nanomaterials along with the diverse applications in the cell biology field from recent works to perspectives.