Sphingolipid Mediated Signal Transduction

Author : Yusuf A. Hannun
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 42,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783662224250

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Sphingolipid-Mediated Signal Transduction by Yusuf A. Hannun Pdf

Lipid-derived molecules are increasingly appreciated as key regulators of cell responses and signal transduction. Sphingolipid-derived bioactive molecules are emerging as critical regulators of some of the most exciting and, until recently, poorly-understood areas of biology such as growth suppression, programmed cell death and tumor invasion. Written by leading investigators in these areas of study, this book presents a thorough, current and accessible review of how sphingolipids function to regulate these important activities.

Author : Yusuf A. Hannun
Publisher : Unknown
Page : 212 pages
File Size : 53,7 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 3662224267

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Sphingolipid-Mediated Signal Transduction by Yusuf A. Hannun Pdf

Author : Charles Chalfant,Maurizio Del Poeta
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 50,8 Mb
Release : 2011-01-12
Category : Science
ISBN : 9781441967411

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Sphingolipids as Signaling and Regulatory Molecules by Charles Chalfant,Maurizio Del Poeta Pdf

This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.

Author : Eric J. Murphy,Eric Murphy,Thad Rosenberger,Thad A. Rosenberger
Publisher : CRC Press
Page : 454 pages
File Size : 48,7 Mb
Release : 2010-03-05
Category : Medical
ISBN : 9780849381423

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Lipid-Mediated Signaling by Eric J. Murphy,Eric Murphy,Thad Rosenberger,Thad A. Rosenberger Pdf

As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade's worth of advances in research techniques that are pertinent in understand

Author : Alfred H. Merrill,Yusuf A. Hannun
Publisher : Unknown
Page : 0 pages
File Size : 40,8 Mb
Release : 2000
Category : Cellular signal transduction
ISBN : OCLC:873101699

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Sphingolipid Metabolism and Cell Signaling by Alfred H. Merrill,Yusuf A. Hannun Pdf

Author : Daniel G.S. Capelluto
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 42,7 Mb
Release : 2013-06-17
Category : Medical
ISBN : 9789400763319

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Lipid-mediated Protein Signaling by Daniel G.S. Capelluto Pdf

This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated to sphingolipids, followed by studies that describe the role of phosphoinositides in signaling and closing with the function of other key lipids in signaling at the plasma membrane and intracellular organelles.

Author : Anthony H. Futerman
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 53,7 Mb
Release : 2002
Category : Medical
ISBN : 0306474425

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Ceramide Signaling by Anthony H. Futerman Pdf

The volume assembles current information on the role of ceramide as a signalling molecule in 16 chapters written by leading workers in this area. Specific attention is given to mechanisms of analysis of ceramide and its biophysical properties, on enzymes of ceramide metabolism and down-stream targets of ceramide, on the cross-talk of ceramide signalling with other signalling pathways, and on the role of ceramide in neuronal signalling. Finally, the book closes with a section on the therapeutic implications of ceramide action, in the areas of cannabinoid action, chemotherapy, and atherosclerosis, and illustrates the potential medical significance of delineating the roles of ceramide in cell signalling. This is the first volume specifically devoted to ceramide signalling, and will act as an invaluable resource for basic and medical researchers and graduate students wishing to get a state of the art overview of this rapidly moving field.

Author : Alfred H. Merrill,Yusuf A. Hannun
Publisher : Unknown
Page : 128 pages
File Size : 42,8 Mb
Release : 2000
Category : Cellular signal transduction
ISBN : OCLC:873102134

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Sphingolipid Metabolism and Cell Signaling by Alfred H. Merrill,Yusuf A. Hannun Pdf

Author : Alfred Harrison Merrill,Yusuf A. Hannun
Publisher : Unknown
Page : 128 pages
File Size : 42,5 Mb
Release : 2000
Category : Cell interaction
ISBN : OCLC:326626506

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Sphingolipid Metabolism and Cell Signaling by Alfred Harrison Merrill,Yusuf A. Hannun Pdf

This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry.

Author : Peter J. Quinn
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 55,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475758061

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Membrane Dynamics and Domains by Peter J. Quinn Pdf

The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.

Author : Abel Lajtha
Publisher : Springer
Page : 516 pages
File Size : 40,5 Mb
Release : 1982-12-01
Category : Science
ISBN : 0306409720

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Experimental Neurochemistry by Abel Lajtha Pdf

The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.

Author : Johnny Stiban
Publisher : Springer Nature
Page : 153 pages
File Size : 41,5 Mb
Release : 2019-09-09
Category : Science
ISBN : 9783030211622

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Bioactive Ceramides in Health and Disease by Johnny Stiban Pdf

This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.

Author : Neale Ridgway,Roger McLeod
Publisher : Elsevier
Page : 612 pages
File Size : 50,8 Mb
Release : 2015-07-24
Category : Science
ISBN : 9780444634498

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Biochemistry of Lipids, Lipoproteins and Membranes by Neale Ridgway,Roger McLeod Pdf

Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry References from current literature will be included in each chapter to facilitate more in-depth study Key concepts are supported by figures and models to improve reader understanding Chapters provide historical perspective and current analysis of each topic

Author : Alfred H. Merrill,Alfred Harrison Merrill,Yusuf A. Hannun
Publisher : Academic Press
Page : 787 pages
File Size : 55,6 Mb
Release : 2000
Category : Cell interaction
ISBN : 9780121822125

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Sphingolipid Metabolism and Cell Signaling by Alfred H. Merrill,Alfred Harrison Merrill,Yusuf A. Hannun Pdf

Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Author : Anonim
Publisher : Elsevier
Page : 786 pages
File Size : 53,5 Mb
Release : 1999-11-01
Category : Science
ISBN : 9780080496689

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Sphingolipid Metabolism and Cell Signaling, Part A by Anonim Pdf

Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.