Ceramide Signaling

Author : Anthony H. Futerman
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 50,9 Mb
Release : 2002
Category : Medical
ISBN : 0306474425

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Ceramide Signaling by Anthony H. Futerman Pdf

The volume assembles current information on the role of ceramide as a signalling molecule in 16 chapters written by leading workers in this area. Specific attention is given to mechanisms of analysis of ceramide and its biophysical properties, on enzymes of ceramide metabolism and down-stream targets of ceramide, on the cross-talk of ceramide signalling with other signalling pathways, and on the role of ceramide in neuronal signalling. Finally, the book closes with a section on the therapeutic implications of ceramide action, in the areas of cannabinoid action, chemotherapy, and atherosclerosis, and illustrates the potential medical significance of delineating the roles of ceramide in cell signalling. This is the first volume specifically devoted to ceramide signalling, and will act as an invaluable resource for basic and medical researchers and graduate students wishing to get a state of the art overview of this rapidly moving field.

Author : Anthony H. Futerman
Publisher : Unknown
Page : 162 pages
File Size : 47,9 Mb
Release : 2002
Category : Cellular signal transduction
ISBN : 1587061376

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Ceramide Signaling by Anthony H. Futerman Pdf

Author : Charles Chalfant,Maurizio Del Poeta
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 47,8 Mb
Release : 2011-01-12
Category : Science
ISBN : 9781441967411

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Sphingolipids as Signaling and Regulatory Molecules by Charles Chalfant,Maurizio Del Poeta Pdf

This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.

Author : Johnny Stiban
Publisher : Springer Nature
Page : 153 pages
File Size : 47,6 Mb
Release : 2019-09-09
Category : Science
ISBN : 9783030211622

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Bioactive Ceramides in Health and Disease by Johnny Stiban Pdf

This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.

Author : Peter J. Quinn,Valerian E. Kagan
Publisher : Springer Science & Business Media
Page : 340 pages
File Size : 43,9 Mb
Release : 2006-04-18
Category : Science
ISBN : 9780306479311

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Phospholipid Metabolism in Apoptosis by Peter J. Quinn,Valerian E. Kagan Pdf

The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. The number of publications on the topic has increased from nothing in the early 1980s to more than 10,000 papers annually today. It is now well recognized that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The idea that life requires death seems somewhat paradoxical, but cell suicide is essential for an animal to survive. For example, without selective destruction of “non-self” T cells, an animal would lack immunity. Similarly, meaningful neural connections in the brain are whittled from a mass of cells. Further, developmental cell remodeling during tissue maturation involves programmed cell death as the major mechanism for functional and structural safe transition of undifferentiated cells to more specialized counterparts. Apoptosis research, with roots in biochemistry, developmental and cell biology, genetics, and immunology, embraces this long-ignored natural law. Failure to properly regulate apoptosis can have catastrophic consequences. Cancer and many diseases (AIDS, Alzheimer’s disease, Parkinson’s disease, heart attack, stroke, etc. ) are thought to arise from deregulation of apoptosis. As apoptosis emerges as a key biological regulatory mechanism, it has become harder and harder to keep up with new developments in this field.

Author : Ralph A. Bradshaw,Edward A. Dennis
Publisher : Academic Press
Page : 2560 pages
File Size : 53,9 Mb
Release : 2003-12-02
Category : Science
ISBN : 9780080533575

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Handbook of Cell Signaling, Three-Volume Set by Ralph A. Bradshaw,Edward A. Dennis Pdf

The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field): * Initiation: Extracellular and Membrane Events * Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation * Events in Intracellular Compartments * Cell-Cell and Cell-Matrix Interactions Covered in extensive detail, these areas will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Tabular and well-illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field! * Contains approximately 470 articles * Provides well-organized sections on each essential area in signaling * Includes discussion on everything from ligand/receptor interactions to organ/organism responses * Extremely user-friendly

Author : Cecilia L. Watkins
Publisher : Unknown
Page : 103 pages
File Size : 55,6 Mb
Release : 2015
Category : SCIENCE
ISBN : 1634825853

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Sphingomyelin and Ceramides by Cecilia L. Watkins Pdf

Sphingolipids are involved in a wide range of physiological and pathological processes none only s signaling molecules but also as key structural components regulating the lateral organization of cellular membranes. In this book, exciting new approaches that open a window to further characterize sphingolipid-enriched domains in cell membranes during both physiological and pathological processes are reviewed. Furthermore, sphingolipids (SLs) are especially important in the central nervous system (CNS) where they are a necessary structural component of membranes of brain cells or signaling molecules. Ceramides are the core constituent of most sphingolipids. The authors review the possible sources of ceramides in the central nervous system (CNS) and present information about recent preclinical clinical trials of therapies targeting the ceramide pathway in the brain. Data about significant alteration in levels of ceramides in brain cells during the development of different neurodegenerative disease are also discussed, such as in with Alzheimer's disease, Parkinson's disease multiple sclerosis, cerebral ischemia, Gaucher's and Farber's disease.

Author : Douglas Gerald Johns
Publisher : Unknown
Page : 238 pages
File Size : 45,5 Mb
Release : 1999
Category : Electronic
ISBN : UOM:39015042635857

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Ceramide Signaling and Tumor Necrosis Factor-alpha-induced Vasodilation by Douglas Gerald Johns Pdf

Author : Jürgen Langner,Siegfried Ansorge
Publisher : Springer Science & Business Media
Page : 522 pages
File Size : 50,9 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306468261

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Cellular Peptidases in Immune Functions and Diseases 2 by Jürgen Langner,Siegfried Ansorge Pdf

Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.

Author : Jean-Francois Dufour,C. Trautwein,R. Graf,Pierre-Alain Clavien
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 51,8 Mb
Release : 2005-08-15
Category : Medical
ISBN : 9783540271949

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Signaling Pathways in Liver Diseases by Jean-Francois Dufour,C. Trautwein,R. Graf,Pierre-Alain Clavien Pdf

This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Supplies in one place all the information on this active and complex research topic and may stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room. Fills the need of surgeons to understand the molecular mechanisms in hepatology. Provides a quick and comprehensive overview.

Author : Yusuf A. Hannun
Publisher : Springer Science & Business Media
Page : 346 pages
File Size : 42,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783662224250

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Sphingolipid-Mediated Signal Transduction by Yusuf A. Hannun Pdf

Lipid-derived molecules are increasingly appreciated as key regulators of cell responses and signal transduction. Sphingolipid-derived bioactive molecules are emerging as critical regulators of some of the most exciting and, until recently, poorly-understood areas of biology such as growth suppression, programmed cell death and tumor invasion. Written by leading investigators in these areas of study, this book presents a thorough, current and accessible review of how sphingolipids function to regulate these important activities.

Author : Ralph A. Bradshaw,Edward A. Dennis
Publisher : Academic Press
Page : 550 pages
File Size : 47,8 Mb
Release : 2011-04-05
Category : Science
ISBN : 9780123822147

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Regulation of Organelle and Cell Compartment Signaling by Ralph A. Bradshaw,Edward A. Dennis Pdf

This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles. Articles written and edited by experts in the field Thematic volume covering regulation of endoplasmic reticulum function, regulation of cell cycle progression, and quality control and assurance in mitochondrion events Up-to-date research on events in membrane proteins and proteins of intracellular matrix

Author : H.J. Forman,J.M. Fukuto,M. Torres
Publisher : Springer Science & Business
Page : 411 pages
File Size : 53,7 Mb
Release : 2007-05-08
Category : Science
ISBN : 9780306484124

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Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles by H.J. Forman,J.M. Fukuto,M. Torres Pdf

Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.

Author : M.P. Mattson
Publisher : Elsevier
Page : 236 pages
File Size : 51,7 Mb
Release : 2003-05-06
Category : Science
ISBN : 0080522505

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Membrane Lipid Signaling in Aging and Age-Related Disease by M.P. Mattson Pdf

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases. This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

Author : Harald Wajant
Publisher : Springer Science & Business Media
Page : 169 pages
File Size : 55,8 Mb
Release : 2007-04-03
Category : Medical
ISBN : 9780387345734

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Fas Signaling by Harald Wajant Pdf

Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.