Spine Phenotypes

Author : Dino Samartzis,Jaro I. Karppinen,Frances M.K. Williams
Publisher : Academic Press
Page : 418 pages
File Size : 46,5 Mb
Release : 2022-07-08
Category : Science
ISBN : 9780128227794

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Spine Phenotypes by Dino Samartzis,Jaro I. Karppinen,Frances M.K. Williams Pdf

The era of big data and personalized spine care has arrived. Within that, imaging and clinical phenotypes are key in establishing personalized algorithms for patient care. This is particularly important in developing novel diagnostics and therapeutics as well as predicting outcomes and establishing preventative measures for various spinal disorders. Spine Phenotypes is a comprehensive resource that outlines phenotype descriptions, their imaging measurements and classifications, and provides an in-depth discussion regarding spine pathology and its clinical relevance. Multiauthored, with multidisciplinary contributions from world leaders in the field of imaging, spine research, and clinical practice, each chapter is rich in visual depiction of imaging phenotypes, providing examples of some established phenotypic measurements with a range of normal and pathologic images and their clinical implications. Spine Phenotypes will be a first of its kind reference for spine researchers, clinicians, and industry. Book chapters devoted to specific imaging phenotypes with discussion of their clinical correlates Imaging phenotypes provided with examples of established phenotypic measurements and a range of normal and pathologic images Multiauthor, multidisciplinary contributions comprising world leaders in the field of spine imaging, research, and clinical practice

Author : Philip K. Louie,Howard S. An,Dino Samartzis
Publisher : Elsevier Health Sciences
Page : 283 pages
File Size : 55,7 Mb
Release : 2021-03-23
Category : Medical
ISBN : 9780323761123

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Atlas of Spinal Imaging Phenotypes by Philip K. Louie,Howard S. An,Dino Samartzis Pdf

Spine-related pain is the world’s leading disabling condition, affecting every population and a frequent reason for seeking medical consultation and obtaining imaging studies. Numerous spinal phenotypes (observations/traits) and their respective measurements performed on various spine imaging have been shown to directly correlate and predict clinical outcomes. Atlas of Spinal Imaging Phenotypes: Classifications and Radiographic Measurements is a comprehensive visual resource that highlights various spinal phenotypes on imaging, describes their clinical and pathophysiological relevance, and discusses and illustrates their respective measurement techniques and classifications. Helps readers better understanding spinal phenotypes and their imaging, and how today’s knowledge will facilitate new targeted drug discovery, novel diagnostics and biomarker discovery, and outcome predictions. Features step-by-step instructions on performing the radiographic measurements with examples of normal and pathologic images to demonstrate the various presentations. Presents clinical correlation of the phenotypes as well as the radiographic measurements with landmark references. Includes validated classification systems that complement the phenotypes and radiographic measurements. Complies the knowledge and expertise of Dr. Dino Samartzis, the preeminent global authority on spinal phenotypes who has discovered and proposed new phenotypes and classification schemes; Dr. Howard S. An, a leading expert in patient management and at the forefront of 3D imaging of various spinal phenotypes; and Dr. Philip Louie, a prolific surgeon who is involved in one of the largest machine learning initiatives of spinal phenotyping.

Author : Philip K. Louie, MD,Howard S. An, MD,Dino Samartzis
Publisher : Unknown
Page : 400 pages
File Size : 51,6 Mb
Release : 2021-02
Category : Medical
ISBN : 0323761119

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Atlas of Spinal Imaging by Philip K. Louie, MD,Howard S. An, MD,Dino Samartzis Pdf

Spine-related pain is the world's leading disabling condition, affecting every population and a frequent reason for seeking medical consultation and obtaining imaging studies. Numerous spinal phenotypes (observations/traits) and their respective measurements performed on various spine imaging have been shown to directly correlate and predict clinical outcomes. Atlas of Spinal Imaging Phenotypes: Classifications and Radiographic Measurements is a comprehensive visual resource that highlights various spinal phenotypes on imaging, describes their clinical and pathophysiological relevance, and discusses and illustrates their respective measurement techniques and classifications. Helps readers better understanding spinal phenotypes and their imaging, and how today's knowledge will facilitate new targeted drug discovery, novel diagnostics and biomarker discovery, and outcome predictions. Features step-by-step instructions on performing the radiographic measurements with examples of normal and pathologic images to demonstrate the various presentations. Presents clinical correlation of the phenotypes as well as the radiographic measurements with landmark references. Includes validated classification systems that complement the phenotypes and radiographic measurements. Complies the knowledge and expertise of Dr. Dino Samartzis, the preeminent global authority on spinal phenotypes who has discovered and proposed new phenotypes and classification schemes; Dr. Howard S. An, a leading expert in patient management and at the forefront of 3D imaging of various spinal phenotypes; and Dr. Philip Louie, a prolific surgeon who is involved in one of the largest machine learning initiatives of spinal phenotyping.

Author : Alessandro Castriota-Scanderbeg,Bruno Dallapiccola
Publisher : Springer Science & Business Media
Page : 962 pages
File Size : 46,6 Mb
Release : 2006-03-20
Category : Medical
ISBN : 9783540303619

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Abnormal Skeletal Phenotypes by Alessandro Castriota-Scanderbeg,Bruno Dallapiccola Pdf

Taking a symptom-oriented approach, this book focuses on the radiographic changes of malformation syndromes and skeletal dysplasias. Its clear structure makes it an essential, practical guide for radiologists, geneticists, and pediatricians.

Author : Mara Dierssen,Rafa de la Torre
Publisher : Elsevier
Page : 273 pages
File Size : 49,9 Mb
Release : 2012-06-19
Category : Medical
ISBN : 9780444542991

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Down Syndrome: From Understanding the Neurobiology to Therapy by Mara Dierssen,Rafa de la Torre Pdf

Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author : Steven R. Garfin,Frank J. Eismont,Gordon R. Bell,Christopher M Bono,Jeffrey Fischgrund
Publisher : Elsevier Health Sciences
Page : 1956 pages
File Size : 43,9 Mb
Release : 2017-09-11
Category : Medical
ISBN : 9780323511957

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Rothman-Simeone The Spine E-Book by Steven R. Garfin,Frank J. Eismont,Gordon R. Bell,Christopher M Bono,Jeffrey Fischgrund Pdf

Get comprehensive, practical coverage of both surgical and non-surgical treatment approaches from the world’s most trusted authorities in spine surgery and care. Rothman-Simeone and Herkowitz’s The Spine, 7th Edition, edited by Drs. Steven R. Garfin, Frank J. Eismont, Gordon R. Bell, Jeffrey S. Fischgrund, and Christopher M. Bono, presents state-of-the-art techniques helping you apply today’s newest developments in your practice. Highlights critical information through the use of pearls, pitfalls, and key points throughout the text, as well as more than 2,300 full-color photographs and illustrations. Offers a newly revised, streamlined format that makes it easier than ever to find the information you need. Contains new chapters on the clinical relevance of finite element modeling and SI joint surgery. Includes an expanded section on minimally invasive spine surgery, including recent developments and future directions. Provides the latest evidence-based research from high-quality studies, including new randomized controlled trials for lumbar stenosis, surgery, fusion, and injections. Presents the knowledge and expertise of new international contributors, as well as new editorial leadership from Dr. Steven Garfin.

Author : Colin R Martin,Victor R Preedy,Rajkumar Rajendram
Publisher : Academic Press
Page : 688 pages
File Size : 42,8 Mb
Release : 2021-06-01
Category : Psychology
ISBN : 9780128179918

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Factors Affecting Neurological Aging by Colin R Martin,Victor R Preedy,Rajkumar Rajendram Pdf

Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging Features sections on the genetic components that influence aging and diseases of aging Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations Includes more than 500 illustrations and tables

Author : Etienne De Villers-Sidani,Virginia Penhune
Publisher : Frontiers E-books
Page : 167 pages
File Size : 50,8 Mb
Release : 2014-11-21
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 9782889193271

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What we learn and when we learn it: sensitive periods in development by Etienne De Villers-Sidani,Virginia Penhune Pdf

The impact of training or experience is not the same at all points in development. Children who receive music lessons, or learn a second language before age 7-8 are more proficient as adults. Early exposure to drugs or trauma makes people more likely to become addicted or depressed later life. Rat pups exposed to specific frequencies from 9-13 days post-partum show expanded cortical representations of these frequencies. Young birds must hear and copy their native song within 1-2 months of birth or they may never learn it at all. These are examples of sensitive periods: developmental windows where maturation and specific experience interact to produce differential long-term effects on the brain and behavior. While still controversial, evidence for the existence of sensitive periods has grown, as has our understanding of the underlying mechanisms of brain plasticity. Behavioral evidence from studies of language, psychopathology or vision in humans has been complemented by evidence elucidating molecular, gene and hormonal mechanisms in animals. It has been proposed that sensitive periods can be both opened and closed by specific experience, and that there are multiple, overlapping sensitive periods that occur through-out development as functions come on line. It is also likely that experience-dependent behavioral or brain plasticity accrued during one sensitive period can serve as a scaffold on which later experience and plasticity can build. Based on current knowledge, there are a number of broad questions and challenges to be addressed in this domain, these include: generating new information about the neurobiological mediators of structural and functional changes; proposing models of brain development that will better predict when sensitive periods should occur and what functions are implicated; investigation of the interaction between experience during a sensitive period and pre-existing individual differences; and the relationship between experience during a sensitive period and on-going experience. The goal of this Research Topic is to bring together scientists in different fields whose work addresses these issues, including animal and human developmental neuroscience, language and cognitive development, education, developmental psychopathology and sensory neuroscience.

Author : Nicolas Heck,Ruth Benavides-Piccione
Publisher : Frontiers Media SA
Page : 237 pages
File Size : 44,6 Mb
Release : 2016-02-03
Category : Cerebral cortex
ISBN : 9782889197668

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Dendritic spines: from shape to function by Nicolas Heck,Ruth Benavides-Piccione Pdf

One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dendrite reflects the levels of connectivity within the neuronal network. Furthermore, the relevance of studying dendritic spines is emphasized by the observation that their morphology changes with synaptic plasticity and is altered in many psychiatric disorders. The present Research Topic deals with some of the most recent findings concerning dendritic spine structure and function, showing that, in order to understand how brain neuronal activity operates, these two factors should be regarded as being intrinsically linked.

Author : Menahem Segal,Martine Ammassari-Teule,Carlo Sala
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 51,6 Mb
Release : 2021-03-26
Category : Science
ISBN : 9782889666331

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Dendritic Spines: from Biophysics to Neuropathology by Menahem Segal,Martine Ammassari-Teule,Carlo Sala Pdf

Author : R. J. Woolton
Publisher : Univ of California Press
Page : 280 pages
File Size : 40,7 Mb
Release : 2023-11-10
Category : Science
ISBN : 9780520335158

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A Functional Biology of Sticklebacks by R. J. Woolton Pdf

This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1984.

Author : La-Orsri Sanoamuang,Hendrik Segers,Russell J. Shiel,Ramesh D. Gulati
Publisher : Springer Science & Business Media
Page : 394 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401007566

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Rotifera IX by La-Orsri Sanoamuang,Hendrik Segers,Russell J. Shiel,Ramesh D. Gulati Pdf

This volume is a record of the proceedings of the IXth International Rotifer Symposium, which was held in Khon Kaen, Thailand, on January 16-23, 2000. The symposium was the first meeting of the international group of rotifer researchers held in Asia. The volume contains reviews and research papers dealing with diverse aspects of scientific research related to Rotifera and their ecology. Some of the topics addressed are: taxonomy and zoogeography, ecology, phylogeny and evolution, physiology, biochemistry and population genetics, aquaculture, and ecotoxicology. This book is special because it contains a unique compilation of contemporary rotifer-related research, and is the eighth of a series of rotifer symposium proceedings published in Developments of Hydrobiology. This update of Rotifera studies will be of great interest to invertebrate zoologists, hydrobiologists, ecologists, and aquaculturists, particularly those interested in freshwater habitats.

Author : Laura Lossi,Adalberto Merighi,Gabriella D'Arcangelo
Publisher : Frontiers Media SA
Page : 181 pages
File Size : 42,9 Mb
Release : 2017-03-14
Category : Electronic book
ISBN : 9782889451111

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Reelin-Related Neurological Disorders and Animal Models by Laura Lossi,Adalberto Merighi,Gabriella D'Arcangelo Pdf

The Reeler mutation was so named because of the alterations in gait that characterize homozygous mice. Several decades after the description of the Reeler phenotype, the mutated protein was discovered and named Reelin (Reln). Reln controls a number of fundamental steps in embryonic and postnatal brain development. A prominent embryonic function is the control of radial neuronal migration. As a consequence, homozygous Reeler mutants show disrupted cell layering in cortical brain structures. Reln also promotes postnatal neuronal maturation. Heterozygous mutants exhibit defects in dendrite extension and synapse formation, correlating with behavioral and cognitive deficits that are detectable at adult ages. The Reln-encoding gene is highly conserved between mice and humans. In humans, homozygous RELN mutations cause lissencephaly with cerebellar hypoplasia, a severe neuronal migration disorder that is reminiscent of the Reeler phenotype. In addition, RELN deficiency or dysfunction is also correlated with psychiatric and cognitive disorders, such as schizophrenia, bipolar disorder and autism, as well as some forms of epilepsy and Alzheimer's disease. Despite the wealth of anatomical studies of the Reeler mouse brain, and the molecular dissection of Reln signaling mechanisms, the consequences of Reln deficiency on the development and function of the human brain are not yet completely understood. This Research Topic include reviews that summarize our current knowledge of the molecular aspects of Reln function, original articles that advance our understanding of its expression and function in different brain regions, and reviews that critically assess the potential role of Reln in human psychiatric and cognitive disorders.

Author : Bruce Turner
Publisher : Springer Science & Business Media
Page : 651 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468446524

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Evolutionary Genetics of Fishes by Bruce Turner Pdf

It is my hope that this collection of reviews can be profitably read by all who are interested in evolutionary biology. However, I would like to specifically target it for two disparate groups of biologists seldom men tioned in the same sentence, classical ichthyologists and molecular biologists. Since classical times, and perhaps even before, ichthyologists have stood in awe at the tremendous diversity of fishes. The bulk of effort in the field has always been directed toward understanding this diversity, i. e. , extracting from it a coherent picture of evolutionary processes and lineages. This effort has, in turn, always been overwhelmingly based upon morphological comparisons. The practical advantages of such compari sons, especially the ease with which morphological data can be had from preserved museum specimens, are manifold. But considered objectively (outside its context of "tradition"), morphological analysis alone is a poor tool for probing evolutionary processes or elucidating relationships. The concepts of "relationship" and of "evolution" are inherently genetic ones, and the genetic bases of morphological traits are seldom known in detail and frequently unknown entirely. Earlier in this century, several workers, notably Gordon, Kosswig, Schmidt, and, in his salad years, Carl Hubbs, pioneered the application of genetic techniques and modes of reasoning to ichthyology. While certain that most contemporary ichth yologists are familiar with this body of work, I am almost equally certain that few of them regard it as pertinent to their own efforts.

Author : Alessandro Sale
Publisher : John Wiley & Sons
Page : 240 pages
File Size : 49,8 Mb
Release : 2016-02-04
Category : Medical
ISBN : 9781118931677

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Environmental Experience and Plasticity of the Developing Brain by Alessandro Sale Pdf

Environmental Experience and Plasticity of the Developing Brain goes beyond the genetic basis of neurodevelopment. Chapters illuminate the external factors that can dramatically impact the brain early in life and, consequently, the eventual accomplishment of developmental milestones and the construction of adult behavior and personality. Authored and edited by leaders in this rapidly growing field, Environmental Experience and Plasticity of the Developing Brain not only surveys preexisting literature on the effects of environment versus genetics, but also discusses more recent studies on the impacts of neurodevelopment in terms of maternal stimulation, environmental enrichment and sensory deprivation. The book also includes key examples of environmental impacts on preexisting genetic syndromes leading to developmental disabilities. Focus is also given to the consequences of early adverse experience in primates, as well as neurobiological and behavioral consequences in institutionalized human children and the reversibility of such consequences. Environmental Experience and Plasticity of the Developing Brain encompasses a broad area of research in the field of developmental neurobiology and offers a unique combination of different examples of environmental factors affecting brain development and behavior.