Stem Cell Therapy For Autoimmune Disease

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Stem Cell Therapy for Autoimmune Disease

Richard K. Burt
Stem Cell Therapy for Autoimmune Disease Book PDF

Author : Richard K. Burt
Publisher : CRC Press
Page : 512 pages
File Size : 50,5 Mb
Release : 2019-11-11
Category : Medical
ISBN : 9781000716856

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Stem Cell Therapy for Autoimmune Disease by Richard K. Burt Pdf

Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Richard K. Burt,Dominique Farge,Milton A. Ruiz,Riccardo Saccardi,John A. Snowden
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases Book PDF

Author : Richard K. Burt,Dominique Farge,Milton A. Ruiz,Riccardo Saccardi,John A. Snowden
Publisher : CRC Press
Page : 687 pages
File Size : 53,9 Mb
Release : 2021-11-17
Category : Medical
ISBN : 9781351364768

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Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases by Richard K. Burt,Dominique Farge,Milton A. Ruiz,Riccardo Saccardi,John A. Snowden Pdf

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight

Stem Cell Transplantation for Autoimmune Diseases and Inflammation

Phuc Van Pham
Stem Cell Transplantation for Autoimmune Diseases and Inflammation Book PDF

Author : Phuc Van Pham
Publisher : Springer
Page : 163 pages
File Size : 53,8 Mb
Release : 2019-08-13
Category : Science
ISBN : 9783030234218

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Stem Cell Transplantation for Autoimmune Diseases and Inflammation by Phuc Van Pham Pdf

This book introduces many new technologies and clinical applications of hematopoietic stem cells and mesenchymal stem cell transplantation for the treatment of autoimmune diseases and inflammatory diseases. Presented in two parts, Part 1 focuses on stem cell therapies for autoimmune disease treatment; Part 2 focuses on stem cell therapies and their application in the treatment of common inflammatory diseases, including chronic knee osteoarthritis, chronic obstructive pulmonary disease, liver cirrhosis, Crohn's Disease, Multiple Sclerosis, and more. This book is an essential source for all advanced students and researchers involved with these diseases, stem cells, or both. Stem Cell Transplantation for Autoimmune Diseases and Inflammation and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine, or tissue engineering as well as cancer or genetics research.

Autoimmune Neurology

Anonim
Autoimmune Neurology Book PDF

Author : Anonim
Publisher : Elsevier
Page : 568 pages
File Size : 55,9 Mb
Release : 2016-03-11
Category : Science
ISBN : 9780444634467

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Autoimmune Neurology by Anonim Pdf

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Autoimmune Diseases

James Chan
Autoimmune Diseases Book PDF

Author : James Chan
Publisher : BoD – Books on Demand
Page : 406 pages
File Size : 50,5 Mb
Release : 2012-07-25
Category : Medical
ISBN : 9789535106937

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Autoimmune Diseases by James Chan Pdf

Autoimmune disease represents a group of more than 60 different chronic autoimmune diseases that affect approximately 6% of the population. Autoimmune diseases arise when ones immune system actively targets and destroys self tissue resulting in clinical disease with prime examples such as Lupus and Type 1 diabetes. The immune system is designed to protect us from foreign pathogens such as viruses and bacteria. However, during the process of generating immune cells for this purpose, as a negative consequence, self-reactive immune cells are also generated. This book aims to present the latest knowledge and insights regarding the different contributing factors and their interplay, discussions on several autoimmune diseases and their case studies, and therapeutic treatments, including stem cell, for autoimmune diseases.

Mesenchymal Stem Cell Therapy

Lucas G. Chase,Mohan C Vemuri
Mesenchymal Stem Cell Therapy Book PDF

Author : Lucas G. Chase,Mohan C Vemuri
Publisher : Springer Science & Business Media
Page : 458 pages
File Size : 47,6 Mb
Release : 2012-12-12
Category : Science
ISBN : 9781627032001

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Mesenchymal Stem Cell Therapy by Lucas G. Chase,Mohan C Vemuri Pdf

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives

Neil H. Riordan
Stem Cell Therapy A Rising Tide How Stem Cells Are Disrupting Medicine and Transforming Lives Book PDF

Author : Neil H. Riordan
Publisher : Neil H Riordan
Page : 302 pages
File Size : 52,8 Mb
Release : 2017-06-20
Category : Health & Fitness
ISBN : 099904530X

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Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives by Neil H. Riordan Pdf

Stem cells are the repair cells of your body. When there aren't enough of them, or they aren't working properly, chronic diseases can manifest and persist. From industry leaders, sport stars, and Hollywood icons to thousands of everyday, ordinary people, stem cell therapy has helped when standard medicine failed. Many of them had lost hope. These are their stories. Neil H Riordan, author of MSC: Clinical Evidence Leading Medicine's Next Frontier, the definitive textbook on clinical stem cell therapy, brings you an easy-to-read book about how and why stem cells work, and why they're the wave of the future.

Stem Cell Therapy

Erik V. Greer
Stem Cell Therapy Book PDF

Author : Erik V. Greer
Publisher : Nova Publishers
Page : 248 pages
File Size : 40,6 Mb
Release : 2006
Category : Biyomedikal araştorma
ISBN : 159454848X

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Stem Cell Therapy by Erik V. Greer Pdf

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This new book brings together leading research from throughout the world in this frontier field.

The European Blood and Marrow Transplantation Textbook for Nurses

Michelle Kenyon,Aleksandra Babic
The European Blood and Marrow Transplantation Textbook for Nurses Book PDF

Author : Michelle Kenyon,Aleksandra Babic
Publisher : Springer
Page : 311 pages
File Size : 51,5 Mb
Release : 2018-03-14
Category : Medical
ISBN : 9783319500263

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The European Blood and Marrow Transplantation Textbook for Nurses by Michelle Kenyon,Aleksandra Babic Pdf

This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Mesenchymal Stem Cells and Immunomodulation

Charles J. Malemud,Eben Alsberg
Mesenchymal Stem Cells and Immunomodulation Book PDF

Author : Charles J. Malemud,Eben Alsberg
Publisher : Springer
Page : 85 pages
File Size : 49,5 Mb
Release : 2016-12-10
Category : Science
ISBN : 9783319467337

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Mesenchymal Stem Cells and Immunomodulation by Charles J. Malemud,Eben Alsberg Pdf

This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two. Mesenchymal Stem Cells and Immunomodulation, part of Springer’s Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.

Everyday Miracles

Dr. Richard Burt
Everyday Miracles Book PDF

Author : Dr. Richard Burt
Publisher : Simon and Schuster
Page : 250 pages
File Size : 51,5 Mb
Release : 2023-01-10
Category : Medical
ISBN : 9781637631263

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Everyday Miracles by Dr. Richard Burt Pdf

A life-changing treatment is conquering auto-immune disorders—why doesn’t anyone know about it? Thirty-five years ago, Dr. Richard Burt began a journey to treat chronic autoimmune diseases as they’d never been treated before. Using a treatment originally developed for leukemia but modified to be more gentle—a one-time combination of immune targeting drugs followed by a transplant of the patient’s blood stem cells—he has documented the successful and often dramatic reversal of multiple sclerosis, systemic sclerosis (scleroderma), chronic inflammatory demyelinating polyradiculoneuropathy (CIPD), neuromyelitis optica, and Crohn’s disease. After decades of study and randomized trials, his approach, which has been duplicated in other parts of the world, is finally being recognized as an effective means of reversing these “incurable” diseases. Some of his patients have been symptom-free for more than twenty years, and in this book Dr. Burt tells their stories alongside his own journey of developing and refining the treatment, known as hematopoietic stem cell transplant (HSCT) for autoimmune disorders. “These patients are the heroes,” Dr. Burt has said. “Their bodies and spirits faced unrelenting disease, and yet they fight valiantly against the suffering and obstacles.” What is HSCT? How does it work? What are the risks? Why aren’t more doctors talking about it? And why is it still out of reach for so many patients who could benefit from it? Dr. Burt answers these questions and many more. Written for the layperson, Everyday Miracles grants patients with autoimmune diseases and the people who love them insights into the revolutionary approach that could convert their life sentence into a one-time reversible illness.

Stem Cells – From Hype to Real Hope

Khawaja Husnain Haider,Salim Aziz, MD
Stem Cells From Hype to Real Hope Book PDF

Author : Khawaja Husnain Haider,Salim Aziz, MD
Publisher : Walter de Gruyter GmbH & Co KG
Page : 340 pages
File Size : 54,6 Mb
Release : 2018-12-17
Category : Medical
ISBN : 9783110586916

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Stem Cells – From Hype to Real Hope by Khawaja Husnain Haider,Salim Aziz, MD Pdf

This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.

Non-Myeloablative Allogeneic Transplantation

Asad Bashey,Edward D. Ball
Non Myeloablative Allogeneic Transplantation Book PDF

Author : Asad Bashey,Edward D. Ball
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 45,6 Mb
Release : 2002-02-28
Category : Medical
ISBN : 0792376463

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Non-Myeloablative Allogeneic Transplantation by Asad Bashey,Edward D. Ball Pdf

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Stem Cell-Dependent Therapies

Gerhard Gross,Thomas Häupl
Stem Cell Dependent Therapies Book PDF

Author : Gerhard Gross,Thomas Häupl
Publisher : Walter de Gruyter
Page : 428 pages
File Size : 54,7 Mb
Release : 2013-10-29
Category : Medical
ISBN : 9783110298307

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Stem Cell-Dependent Therapies by Gerhard Gross,Thomas Häupl Pdf

Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.

A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics

Xiao-Dong Chen
A Roadmap to Nonhematopoietic Stem Cell Based Therapeutics Book PDF

Author : Xiao-Dong Chen
Publisher : Academic Press
Page : 544 pages
File Size : 47,9 Mb
Release : 2018-08-31
Category : Science
ISBN : 9780128119211

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A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics by Xiao-Dong Chen Pdf

A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent. Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies